Thomas E. Roche

4.1k total citations · 1 hit paper
56 papers, 3.3k citations indexed

About

Thomas E. Roche is a scholar working on Biochemistry, Clinical Biochemistry and Molecular Biology. According to data from OpenAlex, Thomas E. Roche has authored 56 papers receiving a total of 3.3k indexed citations (citations by other indexed papers that have themselves been cited), including 49 papers in Biochemistry, 37 papers in Clinical Biochemistry and 26 papers in Molecular Biology. Recurrent topics in Thomas E. Roche's work include Biochemical Acid Research Studies (48 papers), Metabolism and Genetic Disorders (37 papers) and Biochemical and Molecular Research (9 papers). Thomas E. Roche is often cited by papers focused on Biochemical Acid Research Studies (48 papers), Metabolism and Genetic Disorders (37 papers) and Biochemical and Molecular Research (9 papers). Thomas E. Roche collaborates with scholars based in United States, Australia and Japan. Thomas E. Roche's co-authors include Mulchand S. Patel, Lester J. Reed, Yasuaki Hiromasa, Richard L. Cate, Flora H. Pettit, Shane A. Kasten, Aparna Dixit, Xiaohua Yan, Jason C. Baker and Ali Türkan and has published in prestigious journals such as Journal of Biological Chemistry, Gastroenterology and Hepatology.

In The Last Decade

Thomas E. Roche

56 papers receiving 3.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Molecular biology and biochemistry of pyruvate dehydrogenase complexes ¹

1990 502 citations Mulchand S. Patel, Thomas E. Roche profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Thomas E. Roche United States	30	2.0k	1.9k	1.2k	400	360	56	3.3k
Harold F. Sims United States	35	743 0.4×	2.3k 1.2×	839 0.7×	794 2.0×	277 0.8×	62	3.8k
Carlo W.T. van Roermund Netherlands	39	688 0.3×	4.5k 2.4×	1.6k 1.3×	927 2.3×	336 0.9×	91	5.2k
P. Vreken Netherlands	34	348 0.2×	3.3k 1.8×	1.2k 0.9×	594 1.5×	287 0.8×	81	4.5k
Lioubov G. Korotchkina United States	27	1.1k 0.5×	1.6k 0.9×	706 0.6×	501 1.3×	452 1.3×	44	2.7k
Reidar Wallin United States	40	436 0.2×	1.6k 0.8×	256 0.2×	448 1.1×	158 0.4×	100	4.0k
Simone Denis Netherlands	37	349 0.2×	2.5k 1.4×	1.1k 0.9×	650 1.6×	547 1.5×	80	3.6k
Mariafrancesca Scalise Italy	30	1.1k 0.6×	1.7k 0.9×	530 0.4×	190 0.5×	549 1.5×	91	2.9k
Robert C. Nordlie United States	35	917 0.5×	2.7k 1.4×	395 0.3×	627 1.6×	373 1.0×	115	4.2k
Lorena Pochini Italy	27	1.1k 0.6×	1.6k 0.8×	586 0.5×	219 0.5×	452 1.3×	70	2.8k
E.A. Siess Germany	23	585 0.3×	1.1k 0.6×	689 0.6×	649 1.6×	79 0.2×	56	2.0k

Countries citing papers authored by Thomas E. Roche

Since Specialization

Citations

This map shows the geographic impact of Thomas E. Roche's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas E. Roche with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas E. Roche more than expected).

Fields of papers citing papers by Thomas E. Roche

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas E. Roche. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas E. Roche. The network helps show where Thomas E. Roche may publish in the future.

Co-authorship network of co-authors of Thomas E. Roche

This figure shows the co-authorship network connecting the top 25 collaborators of Thomas E. Roche. A scholar is included among the top collaborators of Thomas E. Roche based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Thomas E. Roche. Thomas E. Roche is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Yu, Xuekui, et al.. (2008). Structures of the Human Pyruvate Dehydrogenase Complex Cores: A Highly Conserved Catalytic Center with Flexible N-Terminal Domains. Structure. 16(1). 104–114. 62 indexed citations

Hiromasa, Yasuaki, et al.. (2006). Ligand-induced Effects on Pyruvate Dehydrogenase Kinase Isoform 2. Journal of Biological Chemistry. 281(18). 12568–12579. 22 indexed citations

Tucker, Alec D., Chris Phillips, Peter J. Bungay, et al.. (2005). Regulatory Roles of the N-Terminal Domain Based on Crystal Structures of Human Pyruvate Dehydrogenase Kinase 2 Containing Physiological and Synthetic Ligands ^,. Biochemistry. 45(2). 402–415. 87 indexed citations

Bruggraber, Sylvaine F. A., Patrick S.C. Leung, Katsushi Amano, et al.. (2003). Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis. Gastroenterology. 125(6). 1705–1713. 61 indexed citations

Hiromasa, Yasuaki & Thomas E. Roche. (2003). Facilitated Interaction between the Pyruvate Dehydrogenase Kinase Isoform 2 and the Dihydrolipoyl Acetyltransferase. Journal of Biological Chemistry. 278(36). 33681–33693. 24 indexed citations

Roche, Thomas E., Yasuaki Hiromasa, Ali Türkan, et al.. (2003). Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1. European Journal of Biochemistry. 270(6). 1050–1056. 60 indexed citations

Türkan, Ali, Xiaoming Gong, Tao Peng, & Thomas E. Roche. (2002). Structural Requirements within the Lipoyl Domain for the Ca2+-dependent Binding and Activation of Pyruvate Dehydrogenase Phosphatase Isoform 1 or Its Catalytic Subunit. Journal of Biological Chemistry. 277(17). 14976–14985. 25 indexed citations

Roche, Thomas E., Jason C. Baker, Xiaohua Yan, et al.. (2001). Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms. Progress in nucleic acid research and molecular biology. 70. 33–75. 221 indexed citations

Gong, Xiaoming, Tao Peng, Alexander V. Yakhnin, et al.. (2000). Specificity Determinants for the Pyruvate Dehydrogenase Component Reaction Mapped with Mutated and Prosthetic Group Modified Lipoyl Domains. Journal of Biological Chemistry. 275(18). 13645–13653. 14 indexed citations

10.

Sasaki, Motoko, Aftab A. Ansari, Neil R. Pumford, et al.. (2000). Comparative Immunoreactivity of Anti-trifluoroacetyl (TFA) Antibody and Anti-lipoic Acid Antibody in Primary Biliary Cirrhosis: Searching for a Mimic. Journal of Autoimmunity. 15(1). 51–60. 15 indexed citations

11.

Yang, Da‐Qing, et al.. (1997). Assembly and Full Functionality of Recombinantly Expressed Dihydrolipoyl Acetyltransferase Component of the Human Pyruvate Dehydrogenase Complex. Journal of Biological Chemistry. 272(10). 6361–6369. 30 indexed citations

12.

Chen, Guilan, et al.. (1996). Activated Function of the Pyruvate Dehydrogenase Phosphatase through Ca2+-facilitated Binding to the Inner Lipoyl Domain of the Dihydrolipoyl Acetyltransferase. Journal of Biological Chemistry. 271(45). 28064–28070. 33 indexed citations

13.

Radke, Gary A., et al.. (1996). Lipoyl Domain-based Mechanism for the Integrated Feedback Control of the Pyruvate Dehydrogenase Complex by Enhancement of Pyruvate Dehydrogenase Kinase Activity. Journal of Biological Chemistry. 271(2). 653–662. 66 indexed citations

14.

Shenoy, Bhami C., et al.. (1995). Arginine-239 in the beta subunit is at or near the active site of bovine pyruvate dehydrogenase. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1252(2). 203–208. 10 indexed citations

15.

Shenoy, Bhami C., et al.. (1995). Identification of the Tryptophan Residue in the Thiamin Pyrophosphate Binding Site of Mammalian Pyruvate Dehydrogenase. Journal of Biological Chemistry. 270(9). 4570–4574. 23 indexed citations

16.

Grassucci, Robert A., Terence Wagenknecht, Gary A. Radke, & Thomas E. Roche. (1990). Cryoelectron Microscopy of Frozen-Hydrated Pyruvate Dehydrogenase Complexes. Proceedings annual meeting Electron Microscopy Society of America. 48(1). 260–261. 1 indexed citations

17.

Reed, Lester J., Thomas E. Roche, & Mulchand S. Patel. (1989). Alpha-keto acid dehydrogenase complexes : organization, regulation, and biomedical ramifications : a tribute to Lester J. Reed. New York Academy of Sciences eBooks. 7 indexed citations

18.

Surh, Charles D., Thomas E. Roche, Dean J. Danner, et al.. (1989). Antimitochondrial autoantibodies in primary biliary cirrhosis recognize cross-reactive epitope(s) on protein X and dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex. Hepatology. 10(2). 127–133. 108 indexed citations

19.

Roche, Thomas E.. (1989). A Tribute to Lester J. Reed. Annals of the New York Academy of Sciences. 573(1). xiv–xviii. 1 indexed citations

20.

Roche, Thomas E. & Lester J. Reed. (1972). Function of the nonidentical subunits of mammalian pyruvate dehydrogenase. Biochemical and Biophysical Research Communications. 48(4). 840–846. 81 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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