Thomas A. Down

20.9k total citations · 5 hit papers
53 papers, 8.1k citations indexed

About

Thomas A. Down is a scholar working on Molecular Biology, Genetics and Aging. According to data from OpenAlex, Thomas A. Down has authored 53 papers receiving a total of 8.1k indexed citations (citations by other indexed papers that have themselves been cited), including 49 papers in Molecular Biology, 16 papers in Genetics and 4 papers in Aging. Recurrent topics in Thomas A. Down's work include Epigenetics and DNA Methylation (23 papers), Genomics and Chromatin Dynamics (19 papers) and Genomics and Phylogenetic Studies (12 papers). Thomas A. Down is often cited by papers focused on Epigenetics and DNA Methylation (23 papers), Genomics and Chromatin Dynamics (19 papers) and Genomics and Phylogenetic Studies (12 papers). Thomas A. Down collaborates with scholars based in United Kingdom, United States and Germany. Thomas A. Down's co-authors include Tim Hubbard, Vardhman K. Rakyan, Stephan Beck, Nazneen Rahman, Mhairi Marshall, P. Andrew Futreal, Michael R. Stratton, Lachlan Coin, Richard Wooster and David J. Balding and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

In The Last Decade

Thomas A. Down

52 papers receiving 8.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A census of human cancer genes

2004 2.2k citations P. Andrew Futreal, Lachlan Coin et al. Nature reviews. Cancer profile →
Epigenome-wide association studies for common human diseases

2011 863 citations Vardhman K. Rakyan, Thomas A. Down et al. Nature Reviews Genetics profile →
Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine

2012 570 citations Thomas A. Down et al. profile →
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

2010 556 citations Vardhman K. Rakyan, Thomas A. Down et al. Genome Research profile →
Differential chromatin marking of introns and expressed exons by H3K36me3

2009 503 citations Paulina Kolasinska-Zwierz, Thomas A. Down et al. Nature Genetics profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Thomas A. Down United Kingdom	38	6.6k	2.1k	1.4k	753	472	53	8.1k
John M. Greally United States	53	6.8k 1.0×	2.3k 1.1×	1.0k 0.7×	936 1.2×	533 1.1×	196	9.1k
Hengmi Cui United States	30	5.5k 0.8×	1.9k 0.9×	1.6k 1.1×	710 0.9×	472 1.0×	56	6.5k
Peter L. Molloy Australia	41	7.7k 1.2×	2.0k 0.9×	1.6k 1.1×	814 1.1×	899 1.9×	98	9.8k
Liying Yan China	45	4.8k 0.7×	1.1k 0.5×	1.3k 0.9×	1.1k 1.4×	772 1.6×	189	7.8k
Jörg Tost France	52	6.0k 0.9×	1.6k 0.8×	1.6k 1.1×	1.3k 1.7×	874 1.9×	189	8.9k
François Fuks Belgium	42	9.4k 1.4×	2.1k 1.0×	1.6k 1.1×	597 0.8×	1.1k 2.3×	83	11.0k
Jonathan S. Berg United States	38	4.0k 0.6×	4.5k 2.1×	1.4k 1.0×	904 1.2×	380 0.8×	133	9.3k
Marina Bibikova United States	37	9.2k 1.4×	2.6k 1.3×	1.2k 0.8×	1.3k 1.7×	655 1.4×	87	11.3k
Bo Wen China	36	5.7k 0.9×	2.0k 1.0×	1.2k 0.9×	294 0.4×	324 0.7×	95	7.4k
Melanie Ehrlich United States	52	10.3k 1.6×	2.4k 1.1×	1.6k 1.1×	605 0.8×	907 1.9×	176	12.2k

Countries citing papers authored by Thomas A. Down

Since Specialization

Citations

This map shows the geographic impact of Thomas A. Down's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas A. Down with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas A. Down more than expected).

Fields of papers citing papers by Thomas A. Down

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas A. Down. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas A. Down. The network helps show where Thomas A. Down may publish in the future.

Co-authorship network of co-authors of Thomas A. Down

This figure shows the co-authorship network connecting the top 25 collaborators of Thomas A. Down. A scholar is included among the top collaborators of Thomas A. Down based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Thomas A. Down. Thomas A. Down is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Huang, Ni, et al.. (2016). Stable Caenorhabditis elegans chromatin domains separate broadly expressed and developmentally regulated genes. Proceedings of the National Academy of Sciences. 113(45). E7020–E7029. 48 indexed citations

Chen, Ron A.-J., Przemysław Stempor, Thomas A. Down, et al.. (2014). Extreme HOT regions are CpG-dense promoters in C. elegans and humans. Genome Research. 24(7). 1138–1146. 42 indexed citations

Crepaldi, Luca, et al.. (2013). Binding of TFIIIC to SINE Elements Controls the Relocation of Activity-Dependent Neuronal Genes to Transcription Factories. PLoS Genetics. 9(8). e1003699–e1003699. 59 indexed citations

Koohy, Hashem, Thomas A. Down, & Tim Hubbard. (2013). Chromatin Accessibility Data Sets Show Bias Due to Sequence Specificity of the DNase I Enzyme. PLoS ONE. 8(7). e69853–e69853. 49 indexed citations

Chen, Ron A.-J., Thomas A. Down, Przemysław Stempor, et al.. (2013). The landscape of RNA polymerase II transcription initiation in C. elegans reveals promoter and enhancer architectures. Genome Research. 23(8). 1339–1347. 71 indexed citations

Häsler, Robert, Zhe Feng, Liselotte Bäckdahl, et al.. (2012). A functional methylome map of ulcerative colitis. Genome Research. 22(11). 2130–2137. 98 indexed citations

Beyan, Huriya, Thomas A. Down, Sreeram V. Ramagopalan, et al.. (2012). Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans. Genome Research. 22(11). 2138–2145. 54 indexed citations

Movassagh, Mehregan, Mun‐Kit Choy, David A. Knowles, et al.. (2011). Distinct Epigenomic Features in End-Stage Failing Human Hearts. Circulation. 124(22). 2411–2422. 217 indexed citations

Down, Thomas A., et al.. (2011). Systematic bias in high-throughput sequencing data and its correction by BEADS. Nucleic Acids Research. 39(15). e103–e103. 118 indexed citations

10.

Rakyan, Vardhman K., Thomas A. Down, David J. Balding, & Stephan Beck. (2011). Epigenome-wide association studies for common human diseases. Nature Reviews Genetics. 12(8). 529–541. 863 indexed citations breakdown →

11.

Carbajosa, Guillermo, Graham Heap, Francis L. W. Ratnieks, et al.. (2011). Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates. Genome Research. 21(11). 1841–1850. 46 indexed citations

12.

Beyan, Huriya, Thomas A. Down, Siarhei Maslau, et al.. (2010). Identification of type 1 diabetes-associated methylation variable positions that precede disease diagnosis. Diabetologia. 53. 2 indexed citations

13.

Bell, Christopher G., Sarah Finer, Cecilia M. Lindgren, et al.. (2010). Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus. PLoS ONE. 5(11). e14040–e14040. 185 indexed citations

14.

Novakovic, Boris, Nicholas C. Wong, Ruth Morley, et al.. (2010). DNA Methylation-mediated Down-regulation of DNA Methyltransferase-1 (DNMT1) Is Coincident with, but Not Essential for, Global Hypomethylation in Human Placenta. Journal of Biological Chemistry. 285(13). 9583–9593. 76 indexed citations

15.

Piipari, Matias, Thomas A. Down, & Tim Hubbard. (2010). Metamotifs - a generative model for building families of nucleotide position weight matrices. BMC Bioinformatics. 11(1). 348–348. 6 indexed citations

16.

Novakovic, Boris, Hong Kiat Ng, Ursula Manuelpillai, et al.. (2009). Placenta-specific Methylation of the Vitamin D 24-Hydroxylase Gene. Journal of Biological Chemistry. 284(22). 14838–14848. 198 indexed citations

17.

Bruce, Alexander W., Andrés J. López‐Contreras, Paul Flicek, et al.. (2009). Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level. Genome Research. 19(6). 994–1005. 70 indexed citations

18.

Kolasinska-Zwierz, Paulina, Thomas A. Down, Isabel Latorre, et al.. (2009). Differential chromatin marking of introns and expressed exons by H3K36me3. Nature Genetics. 41(3). 376–381. 503 indexed citations breakdown →

19.

Futreal, P. Andrew, Lachlan Coin, Mhairi Marshall, et al.. (2004). A census of human cancer genes. Nature reviews. Cancer. 4(3). 177–183. 2214 indexed citations breakdown →

20.

Down, Thomas A. & Tim Hubbard. (2002). Computational Detection and Location of Transcription Start Sites in Mammalian Genomic DNA. Genome Research. 12(3). 458–461. 208 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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