Stephen M. Keyse

12.1k total citations · 4 hit papers
86 papers, 10.1k citations indexed

About

Stephen M. Keyse is a scholar working on Molecular Biology, Cell Biology and Cancer Research. According to data from OpenAlex, Stephen M. Keyse has authored 86 papers receiving a total of 10.1k indexed citations (citations by other indexed papers that have themselves been cited), including 71 papers in Molecular Biology, 20 papers in Cell Biology and 10 papers in Cancer Research. Recurrent topics in Stephen M. Keyse's work include Protein Tyrosine Phosphatases (39 papers), Melanoma and MAPK Pathways (20 papers) and Protein Kinase Regulation and GTPase Signaling (20 papers). Stephen M. Keyse is often cited by papers focused on Protein Tyrosine Phosphatases (39 papers), Melanoma and MAPK Pathways (20 papers) and Protein Kinase Regulation and GTPase Signaling (20 papers). Stephen M. Keyse collaborates with scholars based in United Kingdom, Norway and Switzerland. Stephen M. Keyse's co-authors include Rex M. Tyrrell, David M. Owens, Elizabeth Emslie, Robin J. Dickinson, Dario R. Alessi, Christopher J. Caunt, Ole Morten Seternes, Andrew M. Kidger, Alan A. Sneddon and R M Tyrrell and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

In The Last Decade

Stephen M. Keyse

86 papers receiving 9.9k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 1.1k citations Stephen M. Keyse, Rex M. Tyrrell Proceedings of the National Academy of Sciences profile →
Protein phosphatases and the regulation of mitogen-activated protein kinase signalling

2000 696 citations Stephen M. Keyse profile →
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases

2007 652 citations David M. Owens, Stephen M. Keyse profile →
Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1992 560 citations Stephen M. Keyse, Elizabeth Emslie Nature profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Stephen M. Keyse United Kingdom	50	8.3k	1.5k	1.2k	1.1k	1.0k	86	10.1k
Bob van de Water Netherlands	48	4.7k 0.6×	1.4k 0.9×	1.5k 1.3×	1.3k 1.2×	709 0.7×	224	8.2k
Lucio Cocco Italy	58	8.8k 1.1×	2.1k 1.4×	1.8k 1.5×	1.2k 1.1×	1.2k 1.2×	344	12.0k
Wilfried Bursch Austria	38	4.4k 0.5×	665 0.5×	1.5k 1.3×	1.0k 1.0×	816 0.8×	91	7.8k
Deepak Nijhawan United States	19	6.8k 0.8×	749 0.5×	1.4k 1.2×	955 0.9×	1.2k 1.2×	28	9.1k
Xiao‐Jian Sun United States	51	8.1k 1.0×	1.1k 0.7×	1.4k 1.2×	854 0.8×	1.1k 1.1×	127	11.4k
Matías A. Ávila Spain	58	4.9k 0.6×	564 0.4×	1.5k 1.2×	1.3k 1.2×	670 0.7×	220	9.8k
Nika N. Danial United States	35	7.2k 0.9×	801 0.5×	1.5k 1.3×	1.2k 1.1×	1.5k 1.5×	56	10.4k
Steven Pelech Canada	64	8.0k 1.0×	1.9k 1.3×	1.5k 1.2×	843 0.8×	1.4k 1.4×	216	12.4k
Nick Morrice United Kingdom	65	10.5k 1.3×	1.8k 1.2×	1.5k 1.3×	1.0k 1.0×	977 1.0×	113	13.1k
Shigeru Taketani Japan	49	5.5k 0.7×	1.1k 0.7×	687 0.6×	467 0.4×	793 0.8×	225	8.0k

Countries citing papers authored by Stephen M. Keyse

Since Specialization

Citations

This map shows the geographic impact of Stephen M. Keyse's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Stephen M. Keyse with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Stephen M. Keyse more than expected).

Fields of papers citing papers by Stephen M. Keyse

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Stephen M. Keyse. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Stephen M. Keyse. The network helps show where Stephen M. Keyse may publish in the future.

Co-authorship network of co-authors of Stephen M. Keyse

This figure shows the co-authorship network connecting the top 25 collaborators of Stephen M. Keyse. A scholar is included among the top collaborators of Stephen M. Keyse based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Stephen M. Keyse. Stephen M. Keyse is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Kidger, Andrew M., Linda Rushworth, Chris Bryant, et al.. (2017). Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling. Proceedings of the National Academy of Sciences. 114(3). E317–E326. 67 indexed citations

Kidger, Andrew M. & Stephen M. Keyse. (2016). The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs). Seminars in Cell and Developmental Biology. 50. 125–132. 163 indexed citations

Rushworth, Linda, Andrew M. Kidger, Laurent Delavaine, et al.. (2014). Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas ^Q61L )-driven SerpinB2 expression. Proceedings of the National Academy of Sciences. 111(51). 18267–18272. 65 indexed citations

Caunt, Christopher J. & Stephen M. Keyse. (2012). Dual‐specificity MAP kinase phosphatases (MKPs). FEBS Journal. 280(2). 489–504. 402 indexed citations

Dickinson, Robin J., et al.. (2011). Regulation of Caenorhabditis elegans p53/CEP-1–Dependent Germ Cell Apoptosis by Ras/MAPK Signaling. PLoS Genetics. 7(8). e1002238–e1002238. 60 indexed citations

Staples, Christopher J., David M. Owens, Jana V. Maier, Andrew C.B. Cato, & Stephen M. Keyse. (2010). Cross-talk between the p38α and JNK MAPK Pathways Mediated by MAP Kinase Phosphatase-1 Determines Cellular Sensitivity to UV Radiation. Journal of Biological Chemistry. 285(34). 25928–25940. 67 indexed citations

Keyse, Stephen M.. (2008). Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer and Metastasis Reviews. 27(2). 253–261. 392 indexed citations

Dickinson, Robin J., et al.. (2007). DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5. Cellular Signalling. 20(5). 836–843. 72 indexed citations

Dickinson, Robin J., Maxwell C. Eblaghie, Stephen M. Keyse, & Gillian Morriss‐Kay. (2002). Expression of the ERK-specific MAP kinase phosphatase PYST1/MKP3 in mouse embryos during morphogenesis and early organogenesis. Mechanisms of Development. 113(2). 193–196. 50 indexed citations

10.

MacIsaac, Fiona, et al.. (2002). YIL113w encodes a functional dual‐specificity protein phosphatase which specifically interacts with and inactivates the Slt2/Mpk1p MAP kinase in S. cerevisiae. FEBS Letters. 527(1-3). 186–192. 28 indexed citations

11.

Seternes, Ole Morten, et al.. (2001). Distinct Binding Determinants for ERK2/p38α and JNK MAP Kinases Mediate Catalytic Activation and Substrate Selectivity of MAP Kinase Phosphatase-1. Journal of Biological Chemistry. 276(19). 16491–16500. 239 indexed citations

12.

Glading, Angela, Florian Überall, Stephen M. Keyse, Douglas A. Lauffenburger, & Alan Wells. (2001). Membrane Proximal ERK Signaling Is Required for M-calpain Activation Downstream of Epidermal Growth Factor Receptor Signaling. Journal of Biological Chemistry. 276(26). 23341–23348. 182 indexed citations

13.

Keyse, Stephen M.. (2000). Stress response : methods and protocols. Humana Press eBooks. 15 indexed citations

14.

McDonald, Neil Q., et al.. (1999). Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation.. Nature Structural Biology. 6(2). 174–181. 128 indexed citations

15.

Fisher, Daniel, Ariane Abrieu, Marie‐Noëlle Simon, et al.. (1998). MAP Kinase Inactivation Is Required Only for G2–M Phase Transition in Early Embryogenesis Cell Cycles of the StarfishesMarthasterias glacialisandAstropecten aranciacus. Developmental Biology. 202(1). 1–13. 27 indexed citations

16.

Alessi, Dario R., Néstor Gómez, Greg B. G. Moorhead, et al.. (1995). Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines. Current Biology. 5(3). 283–295. 312 indexed citations

17.

Keyse, Stephen M. & Elizabeth Emslie. (1992). Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. Nature. 359(6396). 644–647. 560 indexed citations breakdown →

18.

Moraes, Eduardo Cruz, et al.. (1990). Mutagenesis by hydrogen peroxide treatment of mammalian cells: a molecular analysis. Carcinogenesis. 11(2). 283–293. 99 indexed citations

19.

Moraes, Eduardo Cruz, Stephen M. Keyse, Mireille Pidoux, & Rex M. Tyrrell. (1989). The spectrum of mutations generated by passage of a hydrogen peroxide damaged shuttle vector plasmid through a mammalian host. Nucleic Acids Research. 17(20). 8301–8312. 61 indexed citations

20.

Keyse, Stephen M., Maeve A. McAleer, D.J.G. Davies, & S. H. Moss. (1985). The Response of Normal and Ataxia-telangiectasia Human Fibroblasts to the Lethal Effects of Far, Mid and Near Ultraviolet Radiations. International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine. 48(6). 975–985. 13 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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