Roi Isaac

1.8k total citations · 1 hit paper
20 papers, 1.1k citations indexed

About

Roi Isaac is a scholar working on Molecular Biology, Surgery and Cell Biology. According to data from OpenAlex, Roi Isaac has authored 20 papers receiving a total of 1.1k indexed citations (citations by other indexed papers that have themselves been cited), including 11 papers in Molecular Biology, 8 papers in Surgery and 6 papers in Cell Biology. Recurrent topics in Roi Isaac's work include Pancreatic function and diabetes (8 papers), Adipose Tissue and Metabolism (5 papers) and Endoplasmic Reticulum Stress and Disease (4 papers). Roi Isaac is often cited by papers focused on Pancreatic function and diabetes (8 papers), Adipose Tissue and Metabolism (5 papers) and Endoplasmic Reticulum Stress and Disease (4 papers). Roi Isaac collaborates with scholars based in United States, Israel and South Korea. Roi Isaac's co-authors include Jerrold M. Olefsky, Wei Ying, Felipe C.G. Reis, Yehiel Zick, Yun Sok Lee, Jong Bae Seo, Matthew Riopel, Joshua Wollam, Meixiang Yang and Wenxian Fu and has published in prestigious journals such as Journal of Biological Chemistry, Gastroenterology and Cell Metabolism.

In The Last Decade

Roi Isaac

19 papers receiving 1.1k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Exosomes as mediators of intercellular crosstalk in metabolism

2021 520 citations Roi Isaac, Felipe C.G. Reis et al. Cell Metabolism profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Roi Isaac United States	13	712	334	195	160	160	20	1.1k
Zhonghui Liu China	23	702 1.0×	174 0.5×	122 0.6×	215 1.3×	144 0.9×	91	1.3k
Anyonya R. Guntur United States	22	953 1.3×	293 0.9×	128 0.7×	77 0.5×	166 1.0×	36	1.6k
Di Cui China	23	990 1.4×	453 1.4×	199 1.0×	75 0.5×	149 0.9×	89	1.7k
Katarzyna Pietraszek‐Gremplewicz Poland	18	595 0.8×	250 0.7×	195 1.0×	95 0.6×	89 0.6×	29	1.2k
Chien‐Chung Huang Taiwan	23	482 0.7×	184 0.6×	93 0.5×	192 1.2×	147 0.9×	46	1.2k
Ileana Ruxandra Botusan Sweden	16	453 0.6×	315 0.9×	182 0.9×	77 0.5×	97 0.6×	21	1.3k
Katalin Éder Hungary	14	329 0.5×	165 0.5×	120 0.6×	189 1.2×	222 1.4×	19	905
Kevin Carnevale United States	19	510 0.7×	185 0.6×	280 1.4×	249 1.6×	98 0.6×	35	1.4k
Zebin Mao China	23	810 1.1×	337 1.0×	179 0.9×	57 0.4×	141 0.9×	49	1.3k
Daniel Pérez‐Cremades Spain	18	715 1.0×	433 1.3×	92 0.5×	204 1.3×	81 0.5×	38	1.2k

Countries citing papers authored by Roi Isaac

Since Specialization

Citations

This map shows the geographic impact of Roi Isaac's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Roi Isaac with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Roi Isaac more than expected).

Fields of papers citing papers by Roi Isaac

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Roi Isaac. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Roi Isaac. The network helps show where Roi Isaac may publish in the future.

Co-authorship network of co-authors of Roi Isaac

This figure shows the co-authorship network connecting the top 25 collaborators of Roi Isaac. A scholar is included among the top collaborators of Roi Isaac based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Roi Isaac. Roi Isaac is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Jeelani, Ishtiaq, Theresa V. Rohm, Chanond A. Nasamran, et al.. (2025). CCL26 and CXCL12 preserve insulin-sensitizing macrophages in subcutaneous adipose tissue in obesity. Cell Reports. 44(10). 116450–116450.

Rohm, Theresa V., Felipe C.G. Reis, Karina Cunha e Rocha, et al.. (2025). Adipose Tissue Macrophages in Metabolic Dysfunction–Associated Steatohepatitis Secrete Extracellular Vesicles That Activate Liver Fibrosis in Obese Male Mice. Gastroenterology. 169(4). 691–704.e9. 3 indexed citations

Rohm, Theresa V., Felipe C.G. Reis, Roi Isaac, et al.. (2024). Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization. Nature Metabolism. 6(5). 880–898. 23 indexed citations

Isaac, Roi, Gautam Bandyopadhyay, Theresa V. Rohm, et al.. (2024). TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis. Cell Metabolism. 36(5). 1030–1043.e7. 12 indexed citations

Isaac, Roi, Yaron Vinik, Martin Mikl, et al.. (2022). A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing. iScience. 25(11). 105270–105270. 2 indexed citations

Riopel, Matthew, et al.. (2022). HIF-2α Preserves Mitochondrial Activity and Glucose Sensing in Compensating β-Cells in Obesity. Diabetes. 71(7). 1508–1524. 7 indexed citations

Ji, Yudong, Zhenlong Luo, Hong Gao, et al.. (2021). Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075. Nature Metabolism. 3(9). 1163–1174. 71 indexed citations

Isaac, Roi, Felipe C.G. Reis, Wei Ying, & Jerrold M. Olefsky. (2021). Exosomes as mediators of intercellular crosstalk in metabolism. Cell Metabolism. 33(9). 1744–1762. 520 indexed citations breakdown →

Vinik, Yaron, et al.. (2020). The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice. Scientific Reports. 10(1). 7375–7375. 24 indexed citations

10.

Isaac, Roi, Yun Sok Lee, Da Young Oh, et al.. (2019). TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance. Cell Metabolism. 31(1). 162–173.e5. 80 indexed citations

11.

Lackey, Denise E., Felipe C.G. Reis, Roi Isaac, et al.. (2019). Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice. Scientific Reports. 9(1). 14779–14779. 9 indexed citations

12.

Ying, Wei, Yun Sok Lee, Yi Dong, et al.. (2018). Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity. Cell Metabolism. 29(2). 457–474.e5. 190 indexed citations

13.

Isaac, Roi, Yaron Vinik, Sigalit Boura‐Halfon, et al.. (2017). Prolonged Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Impairs β-Cell Function In Vivo. Diabetes. 66(7). 1879–1889. 2 indexed citations

14.

Isaac, Roi, Ido Goldstein, Noa Furth, et al.. (2016). TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response. Cell Death and Differentiation. 24(1). 132–143. 17 indexed citations

15.

Vinik, Yaron, et al.. (2015). Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells. Biochemical and Biophysical Research Communications. 465(4). 851–856. 4 indexed citations

16.

Vinik, Yaron, et al.. (2013). Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets. Diabetologia. 56(6). 1317–1326. 19 indexed citations

17.

Isaac, Roi, et al.. (2012). Selective Serotonin Reuptake Inhibitors (SSRIs) Inhibit Insulin Secretion and Action in Pancreatic β Cells*. Journal of Biological Chemistry. 288(8). 5682–5693. 68 indexed citations

18.

Isaac, Roi, Irena Lavelin, Yuval Hart, et al.. (2011). An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells. Diabetologia. 54(11). 2845–2855. 13 indexed citations

19.

Boura‐Halfon, Sigalit, Roi Isaac, Galit Shahaf, et al.. (2010). Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Improves β-Cell Function Under Stress. Diabetes. 59(9). 2188–2197. 15 indexed citations

20.

Levkovitz, Yechiel, Roi Isaac, Irit Gil‐Ad, et al.. (2007). Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases. Molecular and Cellular Neuroscience. 36(3). 305–312. 50 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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