Richard S. Lewis

25.4k total citations · 12 hit papers
85 papers, 20.8k citations indexed

About

Richard S. Lewis is a scholar working on Molecular Biology, Sensory Systems and Cellular and Molecular Neuroscience. According to data from OpenAlex, Richard S. Lewis has authored 85 papers receiving a total of 20.8k indexed citations (citations by other indexed papers that have themselves been cited), including 52 papers in Molecular Biology, 46 papers in Sensory Systems and 32 papers in Cellular and Molecular Neuroscience. Recurrent topics in Richard S. Lewis's work include Ion Channels and Receptors (42 papers), Ion channel regulation and function (37 papers) and Neurobiology and Insect Physiology Research (15 papers). Richard S. Lewis is often cited by papers focused on Ion Channels and Receptors (42 papers), Ion channel regulation and function (37 papers) and Neurobiology and Insect Physiology Research (15 papers). Richard S. Lewis collaborates with scholars based in United States, Germany and France. Richard S. Lewis's co-authors include Ricardo E. Dolmetsch, Murali Prakriya, James I. Healy, Christopher C. Goodnow, Michael D. Cahalan, Adam Zweifach, Keli Xu, Minnie M. Wu, Anjana Rao and Patrick G. Hogan and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Richard S. Lewis

84 papers receiving 20.6k citations

Hit Papers

A mutation in Orai1 causes immune deficiency by abro... 1993 2026 2004 2015 2006 1998 1997 1997 2015 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
    2006 1.8k citations Stefan Feske, Yousang Gwack et al. Nature profile →
  2. Calcium oscillations increase the efficiency and specificity of gene expression
    1998 1.6k citations Ricardo E. Dolmetsch, Richard S. Lewis et al. Nature profile →
  3. Differential activation of transcription factors induced by Ca2+ response amplitude and duration
    1997 1.4k citations Ricardo E. Dolmetsch, Richard S. Lewis et al. Nature profile →
  4. Differential activation of transcription factors induced by Ca2+ response amplitude and duration
    1997 1.4k citations Ricardo E. Dolmetsch, Richard S. Lewis et al. Nature profile →
  5. Store-Operated Calcium Channels
    2015 889 citations Murali Prakriya, Richard S. Lewis profile →
  6. STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1
    2009 769 citations Chan Young Park, Franklin M. Mullins et al. profile →
  7. Calcium Signaling Mechanisms in T Lymphocytes
    2001 713 citations Richard S. Lewis Annual Review of Immunology profile →
  8. Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane
    2006 657 citations Minnie M. Wu, Richard S. Lewis et al. The Journal of Cell Biology profile →
  9. Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.
    1993 650 citations Adam Zweifach, Richard S. Lewis Proceedings of the National Academy of Sciences profile →
  10. Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI
    2010 606 citations Patrick G. Hogan, Richard S. Lewis et al. Annual Review of Immunology profile →
  11. The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER–plasma membrane junctions
    2006 533 citations Minnie M. Wu, Richard S. Lewis et al. The Journal of Cell Biology profile →
  12. Role of Membrane Potential and Hydrogen Bonding in the Mechanism of Translocation of Guanidinium-Rich Peptides into Cells
    2004 516 citations Richard S. Lewis et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Richard S. Lewis United States 59 11.6k 9.6k 6.2k 3.7k 2.0k 85 20.8k
Michael D. Cahalan United States 81 13.5k 1.2× 6.9k 0.7× 6.6k 1.1× 6.2k 1.7× 1.3k 0.7× 195 24.5k
Patrick G. Hogan United States 56 10.9k 0.9× 5.2k 0.5× 3.4k 0.5× 5.3k 1.4× 1.4k 0.7× 92 18.7k
James W. Putney United States 92 17.5k 1.5× 11.4k 1.2× 9.4k 1.5× 1.9k 0.5× 1.8k 0.9× 292 28.1k
Shmuel Muallem United States 80 12.1k 1.0× 6.0k 0.6× 4.4k 0.7× 799 0.2× 985 0.5× 276 20.1k
Craig Montell United States 78 8.6k 0.7× 7.2k 0.8× 10.4k 1.7× 1.0k 0.3× 543 0.3× 179 20.4k
Günter Schultz Germany 67 8.8k 0.8× 5.3k 0.6× 4.5k 0.7× 917 0.2× 447 0.2× 148 15.3k
Ricardo E. Dolmetsch United States 42 9.4k 0.8× 2.3k 0.2× 5.0k 0.8× 1.5k 0.4× 463 0.2× 69 14.6k
Michael Schaefer Germany 54 4.5k 0.4× 4.0k 0.4× 2.0k 0.3× 1.4k 0.4× 435 0.2× 131 9.5k
Martin Poenie United States 30 15.7k 1.4× 1.7k 0.2× 8.2k 1.3× 2.8k 0.7× 196 0.1× 43 25.2k
Katsuhiko Mikoshiba Japan 99 23.5k 2.0× 3.5k 0.4× 13.6k 2.2× 1.2k 0.3× 221 0.1× 553 37.0k

Countries citing papers authored by Richard S. Lewis

Since Specialization
Citations

This map shows the geographic impact of Richard S. Lewis's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Richard S. Lewis with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Richard S. Lewis more than expected).

Fields of papers citing papers by Richard S. Lewis

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Richard S. Lewis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Richard S. Lewis. The network helps show where Richard S. Lewis may publish in the future.

Co-authorship network of co-authors of Richard S. Lewis

This figure shows the co-authorship network connecting the top 25 collaborators of Richard S. Lewis. A scholar is included among the top collaborators of Richard S. Lewis based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Richard S. Lewis. Richard S. Lewis is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Qiu, Ruoyi & Richard S. Lewis. (2025). Multiple weak brakes act in concert to control STIM1 and store-operated calcium entry. Proceedings of the National Academy of Sciences. 122(50). e2518622122–e2518622122.
2.
Mullins, Franklin M., Michelle Yen, & Richard S. Lewis. (2016). Orai1 pore residues control CRAC channel inactivation independently of calmodulin. The Journal of General Physiology. 147(2). 137–152. 38 indexed citations
3.
Mullins, Franklin M. & Richard S. Lewis. (2016). The inactivation domain of STIM1 is functionally coupled with the Orai1 pore to enable Ca2+-dependent inactivation. The Journal of General Physiology. 147(2). 153–164. 40 indexed citations
4.
Wu, Minnie M., et al.. (2010). Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1. Molecular Biology of the Cell. 21(11). 1897–1907. 156 indexed citations
5.
Mullins, Franklin M., Chan Young Park, Ricardo E. Dolmetsch, & Richard S. Lewis. (2009). STIM1 and calmodulin interact with Orai1 to induce Ca 2+ -dependent inactivation of CRAC channels. Proceedings of the National Academy of Sciences. 106(36). 15495–15500. 185 indexed citations
6.
Ehrlich, Lauren I. R., David Y. Oh, Irving L. Weissman, & Richard S. Lewis. (2009). Differential Contribution of Chemotaxis and Substrate Restriction to Segregation of Immature and Mature Thymocytes. Immunity. 31(6). 986–998. 89 indexed citations
7.
Feske, Stefan, Yousang Gwack, Murali Prakriya, et al.. (2006). A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 441(7090). 179–185. 1791 indexed citations breakdown →
8.
Prakriya, Murali & Richard S. Lewis. (2003). CRAC channels: activation, permeation, and the search for a molecular identity. Cell Calcium. 33(5-6). 311–321. 139 indexed citations
9.
Prakriya, Murali & Richard S. Lewis. (2002). Separation and Characterization of Currents through Store-operated CRAC Channels and Mg2+-inhibited Cation (MIC) Channels. The Journal of General Physiology. 119(5). 487–508. 241 indexed citations
10.
Prakriya, Murali & Richard S. Lewis. (2001). Potentiation and inhibition of Ca2+ release‐activated Ca2+ channels by 2‐aminoethyldiphenyl borate (2‐APB) occurs independently of IP3 receptors. The Journal of Physiology. 536(1). 3–19. 441 indexed citations
11.
Sjaastad, M D, Richard S. Lewis, & W. James Nelson. (1996). Mechanisms of integrin-mediated calcium signaling in MDCK cells: regulation of adhesion by IP3- and store-independent calcium influx.. Molecular Biology of the Cell. 7(7). 1025–1041. 64 indexed citations
12.
Fanger, Christopher M., Markus Hoth, Gerald R. Crabtree, & Richard S. Lewis. (1995). Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.. The Journal of Cell Biology. 131(3). 655–667. 159 indexed citations
13.
Zweifach, Adam & Richard S. Lewis. (1995). Slow Calcium-dependent Inactivation of Depletion-activated Calcium Current. STORE-DEPENDENT AND -INDEPENDENT MECHANISMS. Journal of Biological Chemistry. 270(24). 14445–14451. 209 indexed citations
14.
Zweifach, Adam & Richard S. Lewis. (1995). Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback.. The Journal of General Physiology. 105(2). 209–226. 316 indexed citations
15.
Lewis, Richard S. & Michael D. Cahalan. (1995). Potassium and Calcium Channels in Lymphocytes. Annual Review of Immunology. 13(1). 623–653. 417 indexed citations
16.
Dolmetsch, Ricardo E. & Richard S. Lewis. (1994). Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes.. The Journal of General Physiology. 103(3). 365–388. 150 indexed citations
17.
Hudspeth, A. J. & Richard S. Lewis. (1988). A model for electrical resonance and frequency tuning in saccular hair cells of the bull‐frog, Rana catesbeiana.. The Journal of Physiology. 400(1). 275–297. 192 indexed citations
18.
Lewis, Richard S.. (1972). The nuclear-power rebellion : citizens vs. the atomic industrial establishment. 2 indexed citations
19.
Lewis, Richard S.. (1972). From Seaborg to Schlesinger:A Birdwatcher on the AEC. Bulletin of the Atomic Scientists. 28(4). 44–45. 1 indexed citations
20.
Lewis, Richard S.. (1971). Potassium inactivation in frog nerve membrane. Life Sciences. 10(5). 251–258. 2 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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