Luc M. Hondeghem

6.9k total citations · 2 hit papers
73 papers, 5.3k citations indexed

About

Luc M. Hondeghem is a scholar working on Cardiology and Cardiovascular Medicine, Molecular Biology and Cellular and Molecular Neuroscience. According to data from OpenAlex, Luc M. Hondeghem has authored 73 papers receiving a total of 5.3k indexed citations (citations by other indexed papers that have themselves been cited), including 64 papers in Cardiology and Cardiovascular Medicine, 36 papers in Molecular Biology and 11 papers in Cellular and Molecular Neuroscience. Recurrent topics in Luc M. Hondeghem's work include Cardiac electrophysiology and arrhythmias (61 papers), Ion channel regulation and function (35 papers) and Cardiac Arrhythmias and Treatments (15 papers). Luc M. Hondeghem is often cited by papers focused on Cardiac electrophysiology and arrhythmias (61 papers), Ion channel regulation and function (35 papers) and Cardiac Arrhythmias and Treatments (15 papers). Luc M. Hondeghem collaborates with scholars based in United States, Belgium and Switzerland. Luc M. Hondeghem's co-authors include Bertram G. Katzung, Dirk J. Snyders, C W Clarkson, Göran Duker, Leif Carlsson, Paul B. Bennett, Jay W. Mason, Peter Hoffmann, Rashmi R. Shah and D. E. Hansen and has published in prestigious journals such as Circulation, Circulation Research and Journal of Applied Physiology.

In The Last Decade

Luc M. Hondeghem

71 papers receiving 5.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

1977 742 citations Luc M. Hondeghem, Bertram G. Katzung profile →
Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence.

1990 507 citations Luc M. Hondeghem et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Luc M. Hondeghem United States	35	4.3k	3.5k	1.3k	471	438	73	5.3k
E. M. Vaughan Williams United Kingdom	39	3.6k 0.8×	2.1k 0.6×	972 0.7×	358 0.8×	288 0.7×	115	5.5k
David Rampe United States	37	2.4k 0.6×	3.1k 0.9×	1.3k 0.9×	69 0.1×	150 0.3×	84	4.4k
Julius Gy. Papp Hungary	38	3.4k 0.8×	2.4k 0.7×	631 0.5×	171 0.4×	196 0.4×	233	5.1k
David A. Lathrop United States	25	1.9k 0.5×	1.5k 0.4×	489 0.4×	109 0.2×	145 0.3×	81	2.8k
Pieter A. van Zwieten Netherlands	37	1.9k 0.4×	2.4k 0.7×	1.5k 1.1×	27 0.1×	430 1.0×	312	5.3k
Icilio Cavero France	38	1.9k 0.4×	2.2k 0.6×	1.2k 0.9×	35 0.1×	232 0.5×	193	4.8k
Dierk Thomas Germany	40	3.8k 0.9×	3.0k 0.9×	1.0k 0.8×	81 0.2×	449 1.0×	222	5.3k
James J. Heger United States	36	4.4k 1.0×	810 0.2×	134 0.1×	63 0.1×	664 1.5×	101	5.0k
Helge Refsum Norway	26	807 0.2×	505 0.1×	288 0.2×	61 0.1×	153 0.3×	106	2.2k
Robert Dumaine Canada	33	2.8k 0.7×	2.6k 0.7×	786 0.6×	56 0.1×	348 0.8×	53	3.6k

Countries citing papers authored by Luc M. Hondeghem

Since Specialization

Citations

This map shows the geographic impact of Luc M. Hondeghem's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Luc M. Hondeghem with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Luc M. Hondeghem more than expected).

Fields of papers citing papers by Luc M. Hondeghem

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Luc M. Hondeghem. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Luc M. Hondeghem. The network helps show where Luc M. Hondeghem may publish in the future.

Co-authorship network of co-authors of Luc M. Hondeghem

This figure shows the co-authorship network connecting the top 25 collaborators of Luc M. Hondeghem. A scholar is included among the top collaborators of Luc M. Hondeghem based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Luc M. Hondeghem. Luc M. Hondeghem is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Hondeghem, Luc M.. (2017). Drug-Induced QT Prolongation and Torsades de Pointes: An All-Exclusive Relationship or Time for an Amicable Separation?. Drug Safety. 41(1). 11–17. 18 indexed citations

Hondeghem, Luc M.. (2016). Disturbances of cardiac wavelength and repolarization precede Torsade de Pointes and ventricular fibrillation in Langendorff perfused rabbit hearts. Progress in Biophysics and Molecular Biology. 121(1). 3–10. 7 indexed citations

Hondeghem, Luc M. & Fred De Clerck. (2012). Preclinical Cardiovascular Safety Evaluations of Biologics. BioDrugs. 26(5). 275–282. 3 indexed citations

Hondeghem, Luc M., Bérengère Dumotier, & Martin Traebert. (2010). Oscillations of cardiac wave length and proarrhythmia. Naunyn-Schmiedeberg s Archives of Pharmacology. 382(4). 367–376. 10 indexed citations

Dujardin, Karl, et al.. (2008). Ultrafast sodium channel block by dietary fish oil prevents dofetilide-induced ventricular arrhythmias in rabbit hearts. American Journal of Physiology-Heart and Circulatory Physiology. 295(4). H1414–H1421. 20 indexed citations

Hondeghem, Luc M.. (2006). Thorough QT/QTc Not So Thorough: Removes Torsadogenic Predictors from the T‐Wave, Incriminates Safe Drugs, and Misses Profibrillatory Drugs. Journal of Cardiovascular Electrophysiology. 17(3). 337–340. 62 indexed citations

Shah, Rashmi R. & Luc M. Hondeghem. (2005). Refining detection of drug-induced proarrhythmia: QT interval and TRIaD. Heart Rhythm. 2(7). 758–772. 152 indexed citations

Hondeghem, Luc M., Hua Rong Lu, Koen van Rossem, & Fred De Clerck. (2003). Detection of Proarrhythmia in the Female Rabbit Heart:. Journal of Cardiovascular Electrophysiology. 14(3). 287–294. 79 indexed citations

Hondeghem, Luc M.. (2000). Classification of antiarrhythmic agents and the two laws of pharmacology. Cardiovascular Research. 45(1). 57–60. 8 indexed citations

10.

Hondeghem, Luc M.. (1992). Development of Class III Antiarrhythmic Agents. Journal of Cardiovascular Pharmacology. 20(Supplement). 17–22. 35 indexed citations

11.

Hondeghem, Luc M.. (1989). Molecular and cellular mechanisms of antiarrhythmic agents. 32 indexed citations

12.

Hondeghem, Luc M., et al.. (1988). Quinidine blocks cardiac sodium channels during opening and slow inactivation in guinea‐pig papillary muscle. British Journal of Pharmacology. 93(2). 311–318. 30 indexed citations

13.

Stroobandt, Roland, Paul B. Bennett, Luc M. Hondeghem, & Hugo Kesteloot. (1987). Evaluation of the efficacy and tolerance of the antiarrhythmic agent transcainide (R 54718). European Journal of Clinical Pharmacology. 32(5). 449–456. 1 indexed citations

14.

Clarkson, C W, et al.. (1987). Lidocaine blocks open and inactivated cardiac sodium channels. Naunyn-Schmiedeberg s Archives of Pharmacology. 336(2). 224–231. 40 indexed citations

15.

Bennett, Paul B., Roland Stroobandt, Hugo Kesteloot, & Luc M. Hondeghem. (1987). Sodium Channel Block by a Potent, New Antiarrhythmic Agent, Transcainide, in Guinea Pig Ventricular Myocytes. Journal of Cardiovascular Pharmacology. 9(6). 661–667. 7 indexed citations

16.

Hondeghem, Luc M., et al.. (1986). Verapamil, diltiazem and nifedipine block the depolarization-induced potentiation of norepinephrine contractions in rabbit aorta and porcine coronary arteries.. Journal of Pharmacology and Experimental Therapeutics. 239(3). 808–813. 12 indexed citations

17.

Grant, Augustus O., Luc M. Hondeghem, & Bertram G. Katzung. (1978). Effects of droperidol on depolarization-induced automaticity, maximum upstroke velocity (Vmax) and the kinetics of recovery of Vmax in guinea-pig ventricular myocardium.. Journal of Pharmacology and Experimental Therapeutics. 205(1). 193–203. 7 indexed citations

18.

Hondeghem, Luc M., et al.. (1978). Measurement of Vmax of the cardiac action potential with a sample/hold peak detector. American Journal of Physiology-Heart and Circulatory Physiology. 234(3). H312–H314. 9 indexed citations

19.

Hondeghem, Luc M.. (1976). Effects of lidocaine, phenytoin and quinidine on the ischemic canine myocardium. Journal of Electrocardiology. 9(3). 203–209. 24 indexed citations

20.

Hondeghem, Luc M.. (1975). Selective depression of the ischemic and hypoxic myocardium by lidocaine.. PubMed. 18. 27–30. 3 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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