John I. Manchester

1.9k citations

30 papers · 1.4k indexed · 1 hit paper · h-index 16

Molecular Biology top 10%
Molecular Medicine top 1%
Organic Chemistry top 5%
Pharmacology top 5%
Computational Theory and Mathematics top 5%

Co-authors: Grant K. Walkup Rubén Tommasi Alita A. Miller Dean G. Brown Gregory S. Bisacchi Jeffrey P. Jones Higgins Joseph P. Dinnocenzo
Topics: Computational Drug Discovery Methods (8 papers)Antibiotic Resistance in Bacteria (8 papers)Cancer therapeutics and mechanisms (8 papers)
Cited by: Molecular Medicine Toxicology Applied Microbiology and Biotechnology
Journals: Journal of the American Chemical Society The Journal of Physical Chemistry B Nature Reviews Drug Discovery
Partner nations: United States Greece Singapore

In The Last Decade

John I. Manchester

30 papers receiving 1.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

ESKAPEing the labyrinth of antibacterial discovery

2015 459 citations Rubén Tommasi, Dean G. Brown et al. Nature Reviews Drug Discovery profile →

Peers

Countries citing papers authored by John I. Manchester

Since Specialization

Citations

This map shows the geographic impact of John I. Manchester's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John I. Manchester with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John I. Manchester more than expected).

Fields of papers citing papers by John I. Manchester

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John I. Manchester. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John I. Manchester. The network helps show where John I. Manchester may publish in the future.

Co-authorship network of co-authors of John I. Manchester

This figure shows the co-authorship network connecting the top 25 collaborators of John I. Manchester. A scholar is included among the top collaborators of John I. Manchester based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John I. Manchester. John I. Manchester is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Martini 3 Force Field Parameters for Protein Lipidation Post-Translational Modifications 2023 ·Journal of Chemical Theory and Computation ·Panagiotis I. Koukos,Sepehr Dehghani‐Ghahnaviyeh,Camilo Velez‐Vega,John I. Manchester,D. Peter Tieleman,José S. Duca,Paulo C. T. Souza,Zoe Cournia	9
2	Membrane Composition and Raf[CRD]-Membrane Attachment Are Driving Forces for K-Ras4B Dimer Stability 2022 ·The Journal of Physical Chemistry B ·(unknown),(unknown),(unknown),Anastasia Theodoropoulou,Stefan Doerr,(unknown),John I. Manchester,Camilo Velez‐Vega,José S. Duca,Zoe Cournia	6
3	Evaluating the Efficiency of the Martini Force Field to Study Protein Dimerization in Aqueous and Membrane Environments 2021 ·Journal of Chemical Theory and Computation ·(unknown),(unknown),John I. Manchester,Camilo Velez‐Vega,José S. Duca,Zoe Cournia	41
4	Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria 2018 ·European Journal of Medicinal Chemistry ·Soo Yei Ho,Weiling Wang,Fui Mee Ng,(unknown),(unknown),(unknown),Shi Hua Ang,Si Si Liew,(unknown),Yvonne Tze Fung Tan,Anders Poulsen,Vishal Pendharkar,Kanda Sangthongpitag,John I. Manchester,Gregory S. Basarab,Jeffrey Hill,Thomas H. Keller,Joseph Cherian	11
5	PathwayMap: Molecular Pathway Association with Self-Normalizing Neural Networks 2018 ·Journal of Chemical Information and Modeling ·José Jiménez-Luna,Davide Sabbadin,Alberto Cuzzolin,Gerard Martínez-Rosell,(unknown),John I. Manchester,José S. Duca,Gianni De Fabritiis	25
6	Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa 2015 ·Chemistry & Biology ·Vincent M. Isabella,Arthur J. Campbell,John I. Manchester,Mark Sylvester,Asha S. Nayar,Keith Ferguson,Rubén Tommasi,Alita A. Miller	52
7	Erratum: ESKAPEing the labyrinth of antibacterial discovery 2015 ·Nature Reviews Drug Discovery ·Rubén Tommasi,Dean G. Brown,Grant K. Walkup,John I. Manchester,Alita A. Miller	3
8	A New-Class Antibacterial—Almost. Lessons in Drug Discovery and Development: A Critical Analysis of More than 50 Years of Effort toward ATPase Inhibitors of DNA Gyrase and Topoisomerase IV 2014 ·ACS Infectious Diseases ·Gregory S. Bisacchi,John I. Manchester	145
9	Novel topoisomerase inhibitors: microbiological characterisation and in vivo efficacy of pyrimidines 2013 ·International Journal of Antimicrobial Agents ·Maria Uria-Nickelsen,Georg Neckermann,(unknown),Beth Andrews,John I. Manchester,(unknown),S. Stokes,Kenneth G. Hull	24
10	Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV 2012 ·Bioorganic & Medicinal Chemistry Letters ·John I. Manchester,(unknown),Jonathan A. Rose,P. Ann Boriack‐Sjodin,Maria Uria-Nickelsen,(unknown),(unknown),Paul Fleming,Kenneth G. Hull	71
11	Antimicrobial Activity of Adenine-Based Inhibitors of NAD⁺-Dependent DNA Ligase 2012 ·ACS Medicinal Chemistry Letters ·Ed T. Buurman,(unknown),(unknown),John I. Manchester	12
12	CAUTION: Popular “Benchmark” Data Sets Do Not Distinguish the Merits of 3D QSAR Methods 2009 ·Journal of Chemical Information and Modeling ·John I. Manchester,Ryszard Czermiński	10
13	Active Site Mutations of Cytochrome P450cam Alter the Binding, Coupling, and Oxidation of the Foreign Substrates (R)- and (S)-2-Ethylhexanol 2002 ·Archives of Biochemistry and Biophysics ·Kevin J. French,Dan A. Rock,Denise A. Rock,John I. Manchester,Barry Goldstein,Jeffrey P. Jones	19
14	A New Mechanistic Probe for Cytochrome P450: An Application of Isotope Effect Profiles 1997 ·Journal of the American Chemical Society ·John I. Manchester,Joseph P. Dinnocenzo,Higgins,Jeffrey P. Jones	118
15	[38] Using molecular modeling and molecular dynamics simulation to predict P450 oxidation products 1996 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Mark D. Paulsen,John I. Manchester,Rick L. Ornstein	11
16	Rational approach to improving reductive catalysis by cytochrome P450cam 1996 ·Biochimie ·John I. Manchester,Rick L. Ornstein	7
17	Enzyme-catalyzed dehalogenation of pentachloroethane: why F87W-cytochrome P450cam is faster than wild type 1995 ·Protein Engineering Design and Selection ·John I. Manchester,Rick L. Ornstein	18
18	Molecular Dynamics Simulations Indicate that F87W,T185F-Cytochrome P450cam May Reductively Dehalogenate 1,1,1-Trichloroethane 1995 ·Journal of Biomolecular Structure and Dynamics ·John I. Manchester,Rick L. Ornstein	3
19	Investigation of Domain Motions in Bacteriophage T4 Lysozyme 1994 ·Journal of Biomolecular Structure and Dynamics ·Gregory E. Arnold,John I. Manchester,(unknown),Rick L. Ornstein	19
20	Modeling Study on the Cleavage Step of the Self-Splicing Reaction in Group I Introns 1993 ·Journal of Biomolecular Structure and Dynamics ·(unknown),Ramón Garduño‐Juárez,John I. Manchester,Masayuki Shibata,Rick L. Ornstein,Robert Rein	9

About John I. Manchester

John I. Manchester is a scholar working on Molecular Medicine, Pharmacology and Computational Theory and Mathematics, having authored 30 papers that have together received 1.4k indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (8 papers), Antibiotic Resistance in Bacteria (8 papers) and Cancer therapeutics and mechanisms (8 papers). The work is most often cited by research in Molecular Medicine (385 citations), Toxicology (108 citations) and Applied Microbiology and Biotechnology (35 citations). John I. Manchester has collaborated with scholars based in United States, Greece and Singapore. Frequent co-authors include Grant K. Walkup, Rubén Tommasi, Alita A. Miller, Dean G. Brown, Gregory S. Bisacchi, Jeffrey P. Jones, Higgins, Joseph P. Dinnocenzo, Rick L. Ornstein and Ryszard Czermiński. Their work appears in journals such as Journal of the American Chemical Society, The Journal of Physical Chemistry B and Nature Reviews Drug Discovery.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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