John I. Manchester

1.9k total citations · 1 hit paper
30 papers, 1.4k citations indexed

About

John I. Manchester is a scholar working on Molecular Biology, Computational Theory and Mathematics and Molecular Medicine. According to data from OpenAlex, John I. Manchester has authored 30 papers receiving a total of 1.4k indexed citations (citations by other indexed papers that have themselves been cited), including 21 papers in Molecular Biology, 8 papers in Computational Theory and Mathematics and 8 papers in Molecular Medicine. Recurrent topics in John I. Manchester's work include Computational Drug Discovery Methods (8 papers), Antibiotic Resistance in Bacteria (8 papers) and Cancer therapeutics and mechanisms (8 papers). John I. Manchester is often cited by papers focused on Computational Drug Discovery Methods (8 papers), Antibiotic Resistance in Bacteria (8 papers) and Cancer therapeutics and mechanisms (8 papers). John I. Manchester collaborates with scholars based in United States, Greece and France. John I. Manchester's co-authors include Grant K. Walkup, Alita A. Miller, Rubén Tommasi, Dean G. Brown, Gregory S. Bisacchi, Jeffrey P. Jones, Higgins, Joseph P. Dinnocenzo, Rick L. Ornstein and Ryszard Czermiński and has published in prestigious journals such as Journal of the American Chemical Society, The Journal of Physical Chemistry B and Nature Reviews Drug Discovery.

In The Last Decade

John I. Manchester

30 papers receiving 1.3k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

ESKAPEing the labyrinth of antibacterial discovery

2015 459 citations Rubén Tommasi, Dean G. Brown et al. Nature Reviews Drug Discovery profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
John I. Manchester United States	16	771	385	351	183	176	30	1.4k
Amit Nargotra India	22	641 0.8×	175 0.5×	326 0.9×	215 1.2×	135 0.8×	54	1.2k
Gregory S. Basarab United States	23	835 1.1×	159 0.4×	432 1.2×	211 1.2×	125 0.7×	61	1.4k
Tom Šolmajer Slovenia	23	972 1.3×	204 0.5×	605 1.7×	141 0.8×	185 1.1×	50	1.5k
Jacques Barbe France	20	600 0.8×	357 0.9×	657 1.9×	195 1.1×	57 0.3×	74	1.5k
Xu Shen China	29	1.2k 1.6×	91 0.2×	516 1.5×	163 0.9×	168 1.0×	57	2.0k
Berthold Hinzen Germany	16	940 1.2×	166 0.4×	758 2.2×	325 1.8×	143 0.8×	17	1.8k
Syed Sikander Azam Pakistan	29	1.2k 1.6×	188 0.5×	427 1.2×	140 0.8×	407 2.3×	108	2.2k
Dana E. Vanderwall United States	20	1.3k 1.7×	164 0.4×	599 1.7×	307 1.7×	367 2.1×	28	2.2k
Andrew Fosberry United Kingdom	18	853 1.1×	261 0.7×	427 1.2×	273 1.5×	46 0.3×	26	1.4k
Milton L. Hammond United States	28	666 0.9×	353 0.9×	1.1k 3.0×	499 2.7×	248 1.4×	73	2.3k

Countries citing papers authored by John I. Manchester

Since Specialization

Citations

This map shows the geographic impact of John I. Manchester's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John I. Manchester with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John I. Manchester more than expected).

Fields of papers citing papers by John I. Manchester

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John I. Manchester. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John I. Manchester. The network helps show where John I. Manchester may publish in the future.

Co-authorship network of co-authors of John I. Manchester

This figure shows the co-authorship network connecting the top 25 collaborators of John I. Manchester. A scholar is included among the top collaborators of John I. Manchester based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John I. Manchester. John I. Manchester is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Koukos, Panagiotis I., Sepehr Dehghani‐Ghahnaviyeh, Camilo Velez‐Vega, et al.. (2023). Martini 3 Force Field Parameters for Protein Lipidation Post-Translational Modifications. Journal of Chemical Theory and Computation. 19(23). 8901–8918. 9 indexed citations

Theodoropoulou, Anastasia, Stefan Doerr, John I. Manchester, et al.. (2022). Membrane Composition and Raf[CRD]-Membrane Attachment Are Driving Forces for K-Ras4B Dimer Stability. The Journal of Physical Chemistry B. 126(7). 1504–1519. 6 indexed citations

Manchester, John I., et al.. (2021). Evaluating the Efficiency of the Martini Force Field to Study Protein Dimerization in Aqueous and Membrane Environments. Journal of Chemical Theory and Computation. 17(5). 3088–3102. 41 indexed citations

Ho, Soo Yei, Weiling Wang, Fui Mee Ng, et al.. (2018). Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. European Journal of Medicinal Chemistry. 157. 610–621. 11 indexed citations

Isabella, Vincent M., Arthur J. Campbell, John I. Manchester, et al.. (2015). Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa. Chemistry & Biology. 22(4). 535–547. 52 indexed citations

Tommasi, Rubén, Dean G. Brown, Grant K. Walkup, John I. Manchester, & Alita A. Miller. (2015). Erratum: ESKAPEing the labyrinth of antibacterial discovery. Nature Reviews Drug Discovery. 14(9). 662–662. 3 indexed citations

Basarab, Gregory S., Pamela Hill, C. Edwin Garner, et al.. (2014). Optimization of Pyrrolamide Topoisomerase II Inhibitors Toward Identification of an Antibacterial Clinical Candidate (AZD5099). Journal of Medicinal Chemistry. 57(14). 6060–6082. 60 indexed citations

Bisacchi, Gregory S. & John I. Manchester. (2014). A New-Class Antibacterial—Almost. Lessons in Drug Discovery and Development: A Critical Analysis of More than 50 Years of Effort toward ATPase Inhibitors of DNA Gyrase and Topoisomerase IV. ACS Infectious Diseases. 1(1). 4–41. 145 indexed citations

Basarab, Gregory S., John I. Manchester, P. Ann Boriack‐Sjodin, et al.. (2013). Fragment-to-Hit-to-Lead Discovery of a Novel Pyridylurea Scaffold of ATP Competitive Dual Targeting Type II Topoisomerase Inhibiting Antibacterial Agents. Journal of Medicinal Chemistry. 56(21). 8712–8735. 69 indexed citations

10.

Uria-Nickelsen, Maria, Georg Neckermann, Beth Andrews, et al.. (2013). Novel topoisomerase inhibitors: microbiological characterisation and in vivo efficacy of pyrimidines. International Journal of Antimicrobial Agents. 41(4). 363–371. 24 indexed citations

11.

Buurman, Ed T., et al.. (2012). Antimicrobial Activity of Adenine-Based Inhibitors of NAD⁺-Dependent DNA Ligase. ACS Medicinal Chemistry Letters. 3(8). 663–667. 12 indexed citations

12.

Manchester, John I., Jonathan A. Rose, P. Ann Boriack‐Sjodin, et al.. (2012). Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV. Bioorganic & Medicinal Chemistry Letters. 22(15). 5150–5156. 71 indexed citations

13.

Manchester, John I., et al.. (2010). Evaluation of pK_a Estimation Methods on 211 Druglike Compounds. Journal of Chemical Information and Modeling. 50(4). 565–571. 94 indexed citations

14.

Manchester, John I. & Ryszard Czermiński. (2009). CAUTION: Popular “Benchmark” Data Sets Do Not Distinguish the Merits of 3D QSAR Methods. Journal of Chemical Information and Modeling. 49(6). 1449–1454. 10 indexed citations

15.

French, Kevin J., Dan A. Rock, Denise A. Rock, et al.. (2002). Active Site Mutations of Cytochrome P450cam Alter the Binding, Coupling, and Oxidation of the Foreign Substrates (R)- and (S)-2-Ethylhexanol. Archives of Biochemistry and Biophysics. 398(2). 188–197. 19 indexed citations

16.

Manchester, John I., Joseph P. Dinnocenzo, Higgins, & Jeffrey P. Jones. (1997). A New Mechanistic Probe for Cytochrome P450: An Application of Isotope Effect Profiles. Journal of the American Chemical Society. 119(21). 5069–5070. 118 indexed citations

17.

Manchester, John I. & Rick L. Ornstein. (1996). Rational approach to improving reductive catalysis by cytochrome P450cam. Biochimie. 78(8-9). 714–722. 7 indexed citations

18.

Manchester, John I. & Rick L. Ornstein. (1995). Enzyme-catalyzed dehalogenation of pentachloroethane: why F87W-cytochrome P450cam is faster than wild type. Protein Engineering Design and Selection. 8(8). 801–807. 18 indexed citations

19.

Manchester, John I. & Rick L. Ornstein. (1995). Molecular Dynamics Simulations Indicate that F87W,T185F-Cytochrome P450cam May Reductively Dehalogenate 1,1,1-Trichloroethane. Journal of Biomolecular Structure and Dynamics. 13(3). 413–422. 3 indexed citations

20.

Garduño‐Juárez, Ramón, et al.. (1993). Modeling Study on the Cleavage Step of the Self-Splicing Reaction in Group I Introns. Journal of Biomolecular Structure and Dynamics. 10(6). 945–972. 9 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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