John H. Krystal

88.1k total citations · 26 hit papers
651 papers, 60.2k citations indexed

About

John H. Krystal is a scholar working on Cellular and Molecular Neuroscience, Cognitive Neuroscience and Pharmacology. According to data from OpenAlex, John H. Krystal has authored 651 papers receiving a total of 60.2k indexed citations (citations by other indexed papers that have themselves been cited), including 203 papers in Cellular and Molecular Neuroscience, 189 papers in Cognitive Neuroscience and 148 papers in Pharmacology. Recurrent topics in John H. Krystal's work include Treatment of Major Depression (133 papers), Neuroscience and Neuropharmacology Research (114 papers) and Functional Brain Connectivity Studies (111 papers). John H. Krystal is often cited by papers focused on Treatment of Major Depression (133 papers), Neuroscience and Neuropharmacology Research (114 papers) and Functional Brain Connectivity Studies (111 papers). John H. Krystal collaborates with scholars based in United States, United Kingdom and Slovenia. John H. Krystal's co-authors include Dennis S. Charney, Gerard Sanacora, Ralitza Gueorguieva, Steven M. Southwick, Ronald S. Duman, George R. Heninger, Graeme F. Mason, Robert Berman, Amit Anand and J. Douglas Bremner and has published in prestigious journals such as Science, New England Journal of Medicine and Cell.

In The Last Decade

John H. Krystal

640 papers receiving 58.4k citations

Hit Papers

Antidepressant effects of ketamine in depressed patients 1994 2026 2004 2015 2000 1994 2016 2004 1996 500 1000 1.5k 2.0k 2.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Antidepressant effects of ketamine in depressed patients
    2000 2.9k citations John H. Krystal et al. profile →
  2. Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans
    1994 2.7k citations John H. Krystal profile →
  3. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
    2016 1.2k citations Ronald S. Duman, Gerard Sanacora et al. profile →
  4. Move Over ANOVA
    2004 1.2k citations Ralitza Gueorguieva, John H. Krystal profile →
  5. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.
    1996 980 citations Anissa Abi‐Dargham, John H. Krystal et al. Proceedings of the National Academy of Sciences profile →
  6. The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis
    2004 764 citations Ralitza Gueorguieva, John H. Krystal et al. Neuropsychopharmacology profile →
  7. The role of default network deactivation in cognition and disease
    2012 745 citations Alan Anticevic, John D. Murray et al. profile →
  8. Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study
    2018 722 citations Ralitza Gueorguieva, Martin P. Paulus et al. profile →
  9. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
    2008 683 citations Gerard Sanacora, John H. Krystal et al. profile →
  10. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments
    2019 674 citations Ronald S. Duman, Gerard Sanacora et al. profile →
  11. Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression
    2004 649 citations Gerard Sanacora, Ralitza Gueorguieva et al. profile →
  12. Increased Striatal Dopamine Transmission in Schizophrenia: Confirmation in a Second Cohort
    1998 628 citations Anissa Abi‐Dargham, John H. Krystal et al. American Journal of Psychiatry profile →
  13. Measurement of dissociative states with the Clinician‐Administered Dissociative States Scale (CADSS)
    1998 593 citations John H. Krystal, Steven M. Southwick et al. profile →
  14. Social supports and serotonin transporter gene moderate depression in maltreated children
    2004 574 citations John H. Krystal, Joel Gelernter et al. Proceedings of the National Academy of Sciences profile →
  15. Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder
    1997 545 citations John H. Krystal, Steven M. Southwick et al. American Journal of Psychiatry profile →
  16. Reduced Cortical γ-Aminobutyric Acid Levels in Depressed Patients Determined by Proton Magnetic Resonance Spectroscopy
    1999 514 citations Gerard Sanacora, Graeme F. Mason et al. profile →
  17. Cross-trial prediction of treatment outcome in depression: a machine learning approach
    2016 452 citations Adam M. Chekroud, Ralitza Gueorguieva et al. profile →
  18. Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
    2020 392 citations John H. Krystal et al. profile →
  19. Characterizing Thalamo-Cortical Disturbances in Schizophrenia and Bipolar Illness
    2013 385 citations Alan Anticevic, Grega Repovš et al. Cerebral Cortex profile →
  20. A quantitative meta-analysis of neurocognitive functioning in posttraumatic stress disorder.
    2014 369 citations Steven M. Southwick, John H. Krystal et al. profile →
  21. Lower synaptic density is associated with depression severity and network alterations
    2019 323 citations Margaret T. Davis, Nabeel Nabulsi et al. profile →
  22. Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor
    2018 266 citations Katrin H. Preller, Jie Lisa Ji et al. profile →
  23. A Non–D2-Receptor-Binding Drug for the Treatment of Schizophrenia
    2020 204 citations John H. Krystal et al. profile →
  24. Candidate biomarkers in psychiatric disorders: state of the field
    2023 133 citations Anissa Abi‐Dargham, Guillermo Horga et al. profile →
  25. Illusory generalizability of clinical prediction models
    2024 111 citations Adam M. Chekroud, Matt Hawrilenko et al. Science profile →
  26. Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms
    2023 106 citations John H. Krystal et al. Neuropsychopharmacology profile →

Peers

John H. Krystal
Wayne C. Drevets United States
Dennis S. Charney United States
J. John Mann United States
Charles B. Nemeroff United States
Robin Murray United Kingdom
Maurizio Fava United States
Nora D. Volkow United States
Daniel R. Weinberger United States
Klaus‐Peter Lesch Germany
Carlos A. Zarate United States
Wayne C. Drevets United States
John H. Krystal
Citations per year, relative to John H. Krystal John H. Krystal (= 1×) peers Wayne C. Drevets

Countries citing papers authored by John H. Krystal

Since Specialization
Citations

This map shows the geographic impact of John H. Krystal's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John H. Krystal with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John H. Krystal more than expected).

Fields of papers citing papers by John H. Krystal

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John H. Krystal. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John H. Krystal. The network helps show where John H. Krystal may publish in the future.

Co-authorship network of co-authors of John H. Krystal

This figure shows the co-authorship network connecting the top 25 collaborators of John H. Krystal. A scholar is included among the top collaborators of John H. Krystal based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John H. Krystal. John H. Krystal is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Clark, Shaunna L., Emily E. Hartwell, Doo‐Sup Choi, et al.. (2024). Next‐generation biomarkers for alcohol consumption and alcohol use disorder diagnosis, prognosis, and treatment: A critical review. Alcohol Clinical and Experimental Research. 49(1). 5–24. 1 indexed citations
2.
Chekroud, Adam M., Matt Hawrilenko, Julia Bondar, et al.. (2024). Illusory generalizability of clinical prediction models. Science. 383(6679). 164–167. 111 indexed citations breakdown →
3.
Ekhtiari, Hamed, Mehran Zare-Bidoky, Anissa Abi‐Dargham, et al.. (2024). Reporting checklists in neuroimaging: promoting transparency, replicability, and reproducibility. Neuropsychopharmacology. 50(1). 67–84. 6 indexed citations
4.
Swanberg, Kelley M., Hetty Prinsen, Christopher L. Averill, et al.. (2024). Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression. NMR in Biomedicine. 37(11). e5220–e5220.
5.
Bonomi, Robin, Ansel T. Hillmer, Eric A. Woodcock, et al.. (2024). Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings of the National Academy of Sciences. 121(35). e2406005121–e2406005121. 5 indexed citations
6.
Krystal, John H., Katrin H. Preller, Philip R. Corlett, Alan Anticevic, & Alfred P. Kaye. (2023). Psychedelics and the Neurobiology of Meaningfulness. Biological Psychiatry Cognitive Neuroscience and Neuroimaging. 9(5). 462–463. 3 indexed citations
7.
Surti, Toral, Mohini Ranganathan, Jason Johannesen, et al.. (2023). Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia. Schizophrenia Research. 256. 36–43. 7 indexed citations
8.
Fischer, Ian C., Peter J. Na, Ilan Harpaz‐Rotem, John H. Krystal, & Robert H. Pietrzak. (2023). Characterization of Mental Health in US Veterans Before, During, and 2 Years After the Onset of the COVID-19 Pandemic. JAMA Network Open. 6(2). e230463–e230463. 7 indexed citations
9.
Wunderlich, Glen, et al.. (2023). Efficacy and Safety of Iclepertin (BI 425809) in Patients With Schizophrenia: CONNEX, A Phase III Randomized Controlled Trial Program. CNS Spectrums. 28(2). 229–229. 2 indexed citations
10.
Nagamatsu, Sheila T., Robert H. Pietrzak, Ke Xu, et al.. (2022). Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort. Addiction Biology. 28(1). e13259–e13259. 2 indexed citations
11.
Averill, Lynnette A., Lihong Jiang, Prerana Purohit, et al.. (2022). Prefrontal Glutamate Neurotransmission in PTSD: A Novel Approach to Estimate Synaptic Strength in Vivo in Humans. SHILAP Revista de lepidopterología. 6. 2290714494–2290714494. 13 indexed citations
12.
Montalvo‐Ortiz, Janitza L., Joel Gelernter, Zhongshan Cheng, et al.. (2022). Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans. Translational Psychiatry. 12(1). 65–65. 18 indexed citations
13.
Hill, Kevin P., Mark S. Gold, Charles B. Nemeroff, et al.. (2021). Risks and Benefits of Cannabis and Cannabinoids in Psychiatry. American Journal of Psychiatry. 179(2). 98–109. 54 indexed citations
14.
Steine, Iris M., Dagfinn Winje, John H. Krystal, et al.. (2020). Longitudinal Relationships between Perceived Social Support and Symptom Outcomes: Findings from a sample of Adult Survivors of Childhood Sexual Abuse. Child Abuse & Neglect. 107. 104566–104566. 10 indexed citations
15.
Stone, Lauren, Matthew J. Girgenti, Jiawei Wang, et al.. (2020). Cortical Transcriptomic Alterations in Association With Appetitive Neuropeptides and Body Mass Index in Posttraumatic Stress Disorder. The International Journal of Neuropsychopharmacology. 24(2). 118–129. 9 indexed citations
16.
17.
Ji, Jie Lisa, Caroline Diehl, Charles Schleifer, et al.. (2018). Schizophrenia Exhibits Bi-directional Brain-Wide Alterations in Cortico-Striato-Cerebellar Circuits. Cerebral Cortex. 29(11). 4463–4487. 27 indexed citations
18.
Mota, Natalie, Jack Tsai, Ilan Harpaz‐Rotem, et al.. (2016). Psychological resilience in U.S. military veterans: A 2-year, nationally representative prospective cohort study. Journal of Psychiatric Research. 84. 301–309. 73 indexed citations
19.
Cosgrove, Kelly, Irina Esterlis, Tracy Kloczynski, et al.. (2014). Tobacco smoking interferes with GABA A receptor neuroadaptations during prolonged alcohol withdrawal. Proceedings of the National Academy of Sciences. 111(50). 18031–18036. 17 indexed citations
20.
Li, Chiang‐Shan R., John H. Krystal, & Daniel H. Mathalon. (2005). Fore-period effect and stop-signal reaction time. Experimental Brain Research. 167(2). 305–309. 46 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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