John F.X. Diffley

20.4k total citations · 6 hit papers
139 papers, 16.0k citations indexed

About

John F.X. Diffley is a scholar working on Molecular Biology, Cell Biology and Genetics. According to data from OpenAlex, John F.X. Diffley has authored 139 papers receiving a total of 16.0k indexed citations (citations by other indexed papers that have themselves been cited), including 126 papers in Molecular Biology, 40 papers in Cell Biology and 26 papers in Genetics. Recurrent topics in John F.X. Diffley's work include DNA Repair Mechanisms (112 papers), Genomics and Chromatin Dynamics (49 papers) and Microtubule and mitosis dynamics (40 papers). John F.X. Diffley is often cited by papers focused on DNA Repair Mechanisms (112 papers), Genomics and Chromatin Dynamics (49 papers) and Microtubule and mitosis dynamics (40 papers). John F.X. Diffley collaborates with scholars based in United Kingdom, United States and Austria. John F.X. Diffley's co-authors include José Antonio Tercero, Corrado Santocanale, Bruce Stillman, Karim Labib, Philip Zegerman, Lucy S. Drury, Kim Nasmyth, Gordon R. Perkins, Adele Rowley and Dirk Remus and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

John F.X. Diffley

137 papers receiving 15.7k citations

Hit Papers

Regulation of DNA replication fork progression through da... 1994 2026 2004 2015 2001 1998 2000 1994 2015 100 200 300 400 500
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
    2001 563 citations José Antonio Tercero, John F.X. Diffley Nature profile →
  2. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
    1998 535 citations Corrado Santocanale, John F.X. Diffley Nature profile →
  3. Uninterrupted MCM2-7 Function Required for DNA Replication Fork Progression
    2000 521 citations Karim Labib, José Antonio Tercero et al. Science profile →
  4. Two steps in the assembly of complexes at yeast replication origins in vivo
    1994 500 citations John F.X. Diffley et al. profile →
  5. Regulated eukaryotic DNA replication origin firing with purified proteins
    2015 384 citations Joseph T.P. Yeeles, Tom Deegan et al. Nature profile →
  6. The Initiation of Eukaryotic DNA Replication
    2022 126 citations Alessandro Costa, John F.X. Diffley profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
John F.X. Diffley United Kingdom 71 15.1k 4.3k 2.4k 2.0k 1.2k 139 16.0k
J. Julian Blow United Kingdom 65 12.4k 0.8× 4.2k 1.0× 3.1k 1.3× 1.4k 0.7× 1.0k 0.8× 140 14.0k
Stephen P. Bell United States 56 14.3k 0.9× 2.2k 0.5× 1.4k 0.6× 2.8k 1.4× 1.4k 1.1× 110 16.0k
Antony M. Carr United Kingdom 74 14.1k 0.9× 3.8k 0.9× 3.3k 1.3× 1.6k 0.8× 1.6k 1.3× 200 15.3k
Hongtao Yu United States 74 14.6k 1.0× 7.5k 1.7× 2.4k 1.0× 1.0k 0.5× 2.1k 1.7× 172 17.0k
Raymond L. Erikson United States 62 10.5k 0.7× 4.0k 0.9× 2.5k 1.0× 2.6k 1.3× 1.0k 0.8× 154 13.6k
Philip Hieter United States 69 18.3k 1.2× 5.0k 1.2× 1.9k 0.8× 1.8k 0.9× 3.6k 2.9× 167 21.8k
Rodney Rothstein United States 64 21.6k 1.4× 2.8k 0.6× 1.8k 0.8× 2.7k 1.3× 3.5k 2.9× 158 22.9k
Marco Foiani Italy 58 12.3k 0.8× 2.5k 0.6× 2.3k 1.0× 1.2k 0.6× 1.2k 1.0× 124 13.3k
Simon J. Boulton United Kingdom 66 13.8k 0.9× 1.5k 0.3× 4.0k 1.7× 1.5k 0.7× 1.3k 1.1× 152 15.7k
Peter Burgers United States 77 14.8k 1.0× 1.3k 0.3× 1.8k 0.7× 2.5k 1.2× 1.4k 1.1× 191 16.0k

Countries citing papers authored by John F.X. Diffley

Since Specialization
Citations

This map shows the geographic impact of John F.X. Diffley's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John F.X. Diffley with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John F.X. Diffley more than expected).

Fields of papers citing papers by John F.X. Diffley

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John F.X. Diffley. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John F.X. Diffley. The network helps show where John F.X. Diffley may publish in the future.

Co-authorship network of co-authors of John F.X. Diffley

This figure shows the co-authorship network connecting the top 25 collaborators of John F.X. Diffley. A scholar is included among the top collaborators of John F.X. Diffley based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John F.X. Diffley. John F.X. Diffley is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Drury, Lucy S., María I. Martínez-Jiménez, Luis Blanco, et al.. (2025). S-phase checkpoint protects from aberrant replication fork processing and degradation. Nucleic Acids Research. 53(14). 1 indexed citations
2.
Henrikus, Sarah S., Oliver Willhöft, Jacob S. Lewis, et al.. (2024). Unwinding of a eukaryotic origin of replication visualized by cryo-EM. Nature Structural & Molecular Biology. 31(8). 1265–1276. 12 indexed citations
3.
Weissmann, Florian, et al.. (2024). MCM double hexamer loading visualized with human proteins. Nature. 636(8042). 499–508. 11 indexed citations
4.
Lewis, Jacob S., Joana S. Sousa, Sarah S. Henrikus, et al.. (2022). Mechanism of replication origin melting nucleated by CMG helicase assembly. Nature. 606(7916). 1007–1014. 57 indexed citations
5.
Miller, Thomas C. R., Julia Locke, Fabrizio Martino, et al.. (2021). Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase. Nature Structural & Molecular Biology. 29(1). 10–20. 28 indexed citations
6.
Diffley, John F.X., et al.. (2021). Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation. eLife. 10. 34 indexed citations
7.
Tan, Kang Wei, Mary Wu, Rachel Ulferts, et al.. (2021). Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease. Biochemical Journal. 478(13). 2517–2531. 42 indexed citations
8.
Canal, Berta, Ryo Fujisawa, Tom Deegan, et al.. (2021). Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease. Biochemical Journal. 478(13). 2465–2479. 50 indexed citations
9.
Canal, Berta, Mary Wu, Rachel Ulferts, et al.. (2021). Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease. Biochemical Journal. 478(13). 2445–2464. 32 indexed citations
10.
Gómez‐González, Belén, Harshil Patel, Anne Early, & John F.X. Diffley. (2018). Rpd3L Contributes to the DNA Damage Sensitivity of Saccharomyces cerevisiae Checkpoint Mutants. Genetics. 211(2). 503–513. 8 indexed citations
11.
Coster, Gideon & John F.X. Diffley. (2017). Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading. Science. 357(6348). 314–318. 90 indexed citations
12.
Deegan, Tom, Joseph T.P. Yeeles, & John F.X. Diffley. (2016). Phosphopeptide binding by Sld3 links Dbf4‐dependent kinase to MCM replicative helicase activation. The EMBO Journal. 35(9). 961–973. 101 indexed citations
13.
Diffley, John F.X., et al.. (2014). DNA Replication and Oncogene-Induced Replicative Stress. Current Biology. 24(10). R435–R444. 275 indexed citations
14.
Boos, Dominik, Mona Yekezare, & John F.X. Diffley. (2013). Identification of a Heteromeric Complex That Promotes DNA Replication Origin Firing in Human Cells. Science. 340(6135). 981–984. 77 indexed citations
15.
Wang, Xuan, Grzegorz Ira, José Antonio Tercero, et al.. (2004). Role of DNA Replication Proteins in Double-Strand Break-Induced Recombination in Saccharomyces cerevisiae. Molecular and Cellular Biology. 24(16). 6891–6899. 99 indexed citations
16.
Diffley, John F.X.. (2004). Regulation of Early Events in Chromosome Replication. Current Biology. 14(18). R778–R786. 320 indexed citations
17.
Ferreira, Miguel Godinho, Corrado Santocanale, Lucy S. Drury, & John F.X. Diffley. (2000). Dbf4p, an Essential S Phase-Promoting Factor, Is Targeted for Degradation by the Anaphase-Promoting Complex. Molecular and Cellular Biology. 20(1). 242–248. 103 indexed citations
18.
Diffley, John F.X.. (1998). Replication control: Choreographing replication origins. Current Biology. 8(21). R771–R773. 37 indexed citations
19.
Santocanale, Corrado & John F.X. Diffley. (1996). ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae.. PubMed Central. 15(23). 6671–9. 148 indexed citations
20.
Diffley, John F.X.. (1996). Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells.. Genes & Development. 10(22). 2819–2830. 215 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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