J.M. Ostrem

3.5k total citations · 2 hit papers
8 papers, 2.4k citations indexed

About

J.M. Ostrem is a scholar working on Molecular Biology, Organic Chemistry and Genetics. According to data from OpenAlex, J.M. Ostrem has authored 8 papers receiving a total of 2.4k indexed citations (citations by other indexed papers that have themselves been cited), including 7 papers in Molecular Biology, 1 paper in Organic Chemistry and 1 paper in Genetics. Recurrent topics in J.M. Ostrem's work include Protein Kinase Regulation and GTPase Signaling (4 papers), Biochemical and Molecular Research (3 papers) and Ubiquitin and proteasome pathways (2 papers). J.M. Ostrem is often cited by papers focused on Protein Kinase Regulation and GTPase Signaling (4 papers), Biochemical and Molecular Research (3 papers) and Ubiquitin and proteasome pathways (2 papers). J.M. Ostrem collaborates with scholars based in United States, Switzerland and China. J.M. Ostrem's co-authors include Kevan M. Shokat, Ulf Peters, Martin L. Sos, James A. Wells, Courtney M. Schroeder, Nicholas T. Hertz, Ronald D. Vale, John Kurhanewicz, Kaveh Ashrafi and Youcai Zhang and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

J.M. Ostrem

8 papers receiving 2.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

2013 1.7k citations J.M. Ostrem, Ulf Peters et al. Nature profile →
Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

2016 449 citations J.M. Ostrem, Kevan M. Shokat Nature Reviews Drug Discovery profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
J.M. Ostrem United States	6	1.9k	818	301	254	225	8	2.4k
Lian‐Sheng Li United States	19	1.4k 0.7×	557 0.7×	241 0.8×	314 1.2×	172 0.8×	49	1.9k
Ulf Peters United States	12	2.4k 1.3×	917 1.1×	331 1.1×	517 2.0×	236 1.0×	17	3.0k
Harshani R. Lawrence United States	35	2.1k 1.1×	1.3k 1.6×	286 1.0×	369 1.5×	283 1.3×	75	3.5k
Pingda Ren United States	21	2.3k 1.2×	570 0.7×	216 0.7×	636 2.5×	246 1.1×	49	3.2k
Elena Ardini Italy	21	1.0k 0.5×	537 0.7×	343 1.1×	211 0.8×	160 0.7×	38	1.6k
Melanie Valenti United Kingdom	30	1.7k 0.9×	1.1k 1.3×	197 0.7×	383 1.5×	302 1.3×	61	2.6k
Paul Wan United Kingdom	9	1.9k 1.0×	991 1.2×	226 0.8×	234 0.9×	228 1.0×	9	2.5k
Matthew R. Janes United States	15	2.2k 1.2×	594 0.7×	251 0.8×	163 0.6×	273 1.2×	26	2.7k
Martin L. Sos Germany	19	2.2k 1.2×	1.3k 1.6×	995 3.3×	314 1.2×	456 2.0×	34	3.2k
Astrid M. Kral United States	18	2.5k 1.3×	415 0.5×	389 1.3×	251 1.0×	196 0.9×	22	2.9k

Countries citing papers authored by J.M. Ostrem

Since Specialization

Citations

This map shows the geographic impact of J.M. Ostrem's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by J.M. Ostrem with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites J.M. Ostrem more than expected).

Fields of papers citing papers by J.M. Ostrem

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by J.M. Ostrem. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by J.M. Ostrem. The network helps show where J.M. Ostrem may publish in the future.

Co-authorship network of co-authors of J.M. Ostrem

This figure shows the co-authorship network connecting the top 25 collaborators of J.M. Ostrem. A scholar is included among the top collaborators of J.M. Ostrem based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with J.M. Ostrem. J.M. Ostrem is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

8 of 8 papers shown

1.

Garcia-Rivera, Enrique, Dylan C. Mitchell, Joel M. Chick, et al.. (2025). Highly specific intracellular ubiquitination of a small molecule. Nature Chemical Biology. 1 indexed citations

2.

Ostrem, J.M., Ulf Peters, & Kevan M. Shokat. (2024). Direct RAS inhibitors turn 10. Nature Chemical Biology. 20(10). 1238–1241. 4 indexed citations

3.

Liu, Shuang, Bingqi Tong, J.M. Ostrem, et al.. (2023). Rational Screening for Cooperativity in Small-Molecule Inducers of Protein–Protein Associations. Journal of the American Chemical Society. 145(42). 23281–23291. 35 indexed citations

4.

Ostrem, J.M. & Kevan M. Shokat. (2021). Targeting KRAS G12C with Covalent Inhibitors. 6(1). 49–64. 27 indexed citations

5.

Ostrem, J.M. & Kevan M. Shokat. (2016). Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design. Nature Reviews Drug Discovery. 15(11). 771–785. 449 indexed citations breakdown →

6.

Chen, Ligong, Yan Shu, Xiaomin Liang, et al.. (2014). OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proceedings of the National Academy of Sciences. 111(27). 9983–9988. 182 indexed citations

7.

Schroeder, Courtney M., J.M. Ostrem, Nicholas T. Hertz, & Ronald D. Vale. (2014). A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region. eLife. 3. e03351–e03351. 64 indexed citations

8.

Ostrem, J.M., Ulf Peters, Martin L. Sos, James A. Wells, & Kevan M. Shokat. (2013). K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 503(7477). 548–551. 1679 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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