James N. Topper

8.0k total citations · 3 hit papers
45 papers, 6.5k citations indexed

About

James N. Topper is a scholar working on Molecular Biology, Surgery and Cardiology and Cardiovascular Medicine. According to data from OpenAlex, James N. Topper has authored 45 papers receiving a total of 6.5k indexed citations (citations by other indexed papers that have themselves been cited), including 37 papers in Molecular Biology, 6 papers in Surgery and 6 papers in Cardiology and Cardiovascular Medicine. Recurrent topics in James N. Topper's work include Angiogenesis and VEGF in Cancer (9 papers), TGF-β signaling in diseases (9 papers) and RNA and protein synthesis mechanisms (8 papers). James N. Topper is often cited by papers focused on Angiogenesis and VEGF in Cancer (9 papers), TGF-β signaling in diseases (9 papers) and RNA and protein synthesis mechanisms (8 papers). James N. Topper collaborates with scholars based in United States, Germany and Taiwan. James N. Topper's co-authors include Michael A. Gimbrone, Jiexing Cai, Tobi Nagel, David A. Clayton, Keith R. Anderson, D Falb, Dean Falb, Guillermo García‐Cardeña, YongYao Xu and Yubin Qiu and has published in prestigious journals such as Science, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

James N. Topper

45 papers receiving 6.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 1.2k citations Hidetoshi Hayashi, Yubin Qiu et al. Cell profile →
Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.

1996 670 citations James N. Topper, Jiexing Cai et al. profile →
Endothelial Dysfunction, Hemodynamic Forces, and Atherogenesis^a

2000 656 citations Michael A. Gimbrone, James N. Topper et al. Annals of the New York Academy of Sciences profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
James N. Topper United States	36	4.0k	957	904	736	683	45	6.5k
Hikaru Ueno Japan	46	4.7k 1.2×	1.0k 1.1×	783 0.9×	645 0.9×	1.2k 1.7×	109	7.7k
Bruce A. Keyt United States	31	5.1k 1.3×	680 0.7×	514 0.6×	599 0.8×	950 1.4×	79	9.9k
M Chiariello Italy	43	4.5k 1.1×	869 0.9×	1.6k 1.7×	771 1.0×	907 1.3×	215	8.6k
Enrico V. Avvedimento Italy	47	3.9k 1.0×	466 0.5×	369 0.4×	989 1.3×	644 0.9×	93	7.5k
Christopher D. Kontos United States	40	3.2k 0.8×	662 0.7×	584 0.6×	538 0.7×	574 0.8×	88	5.1k
Xiaoping Du United States	50	2.3k 0.6×	841 0.9×	1.4k 1.5×	1.2k 1.7×	452 0.7×	104	7.2k
Catherine Butterfield United States	22	3.8k 1.0×	847 0.9×	546 0.6×	682 0.9×	1.4k 2.1×	33	6.5k
Anton J.G. Horrevoets Netherlands	43	4.2k 1.0×	1.0k 1.1×	1.1k 1.2×	1.3k 1.7×	373 0.5×	106	7.1k
Yutaka Nakashima Japan	38	2.0k 0.5×	1.6k 1.7×	955 1.1×	1.4k 1.9×	793 1.2×	124	6.7k
Wei Kong China	48	2.9k 0.7×	913 1.0×	1.1k 1.2×	1.1k 1.6×	607 0.9×	224	7.3k

Countries citing papers authored by James N. Topper

Since Specialization

Citations

This map shows the geographic impact of James N. Topper's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James N. Topper with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James N. Topper more than expected).

Fields of papers citing papers by James N. Topper

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James N. Topper. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James N. Topper. The network helps show where James N. Topper may publish in the future.

Co-authorship network of co-authors of James N. Topper

This figure shows the co-authorship network connecting the top 25 collaborators of James N. Topper. A scholar is included among the top collaborators of James N. Topper based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James N. Topper. James N. Topper is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Smart, Nora G., Åsa Apelqvist, Xueying Gu, et al.. (2006). Conditional Expression of Smad7 in Pancreatic β Cells Disrupts TGF-β Signaling and Induces Reversible Diabetes Mellitus. PLoS Biology. 4(2). e39–e39. 104 indexed citations

Tsai, Ming-Tzu, et al.. (2004). A Novel Secreted, Cell-surface Glycoprotein Containing Multiple Epidermal Growth Factor-like Repeats and One CUB Domain Is Highly Expressed in Primary Osteoblasts and Bones. Journal of Biological Chemistry. 279(36). 37485–37490. 79 indexed citations

Depre, C., et al.. (2003). Characterization of pDJA1, a cardiac-specific chaperone found by genomic profiling of the post-ischemic swine heart. Cardiovascular Research. 58(1). 126–135. 16 indexed citations

Yang, Ruey‐Bing, et al.. (2003). A Novel Interleukin-17 Receptor-like Protein Identified in Human Umbilical Vein Endothelial Cells Antagonizes Basic Fibroblast Growth Factor-induced Signaling. Journal of Biological Chemistry. 278(35). 33232–33238. 82 indexed citations

Tomlinson, James & James N. Topper. (2003). New insights into endothelial diversity. Current Atherosclerosis Reports. 5(3). 223–229. 4 indexed citations

Wasserman, Scott M., Fuad Mehraban, László G. Kömüves, et al.. (2002). Gene expression profile of human endothelial cells exposed to sustained fluid shear stress. Physiological Genomics. 12(1). 13–23. 102 indexed citations

Yang, Ruey‐Bing, Scott M. Wasserman, Steven D. Colman, et al.. (2002). Identification of a Novel Family of Cell-surface Proteins Expressed in Human Vascular Endothelium. Journal of Biological Chemistry. 277(48). 46364–46373. 132 indexed citations

Feinberg, Mark W., Nicholas Sibinga, Philippe Wiesel, et al.. (2000). Transforming Growth Factor-β1 Inhibits Cytokine-mediated Induction of Human Metalloelastase in Macrophages. Journal of Biological Chemistry. 275(33). 25766–25773. 143 indexed citations

Gimbrone, Michael A., James N. Topper, Tobi Nagel, Keith R. Anderson, & Guillermo García‐Cardeña. (2000). Endothelial Dysfunction, Hemodynamic Forces, and Atherogenesis^a. Annals of the New York Academy of Sciences. 902(1). 230–240. 656 indexed citations breakdown →

10.

Jain, Mukesh K., Mark W. Feinberg, Nicholas Sibinga, et al.. (2000). Transforming Growth Factor-β1 Inhibition of Macrophage Activation Is Mediated via Smad3. Journal of Biological Chemistry. 275(47). 36653–36658. 146 indexed citations

11.

Topper, James N.. (2000). TGF-β in the Cardiovascular System. Trends in Cardiovascular Medicine. 10(3). 132–137. 44 indexed citations

12.

Brown, Jonathan D., et al.. (1999). MEKK-1, a Component of the Stress (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Pathway, Can Selectively Activate Smad2-mediated Transcriptional Activation in Endothelial Cells. Journal of Biological Chemistry. 274(13). 8797–8805. 142 indexed citations

13.

Topper, James N. & Michael A. Gimbrone. (1999). Blood flow and vascular gene expression: fluid shear stress as a modulator of endothelial phenotype. Molecular Medicine Today. 5(1). 40–46. 294 indexed citations

14.

Gimbrone, Michael A., Nitzan Resnick, Tobi Nagel, et al.. (1997). Hemodynamics, Endothelial Gene Expression, and Atherogenesis^a. Annals of the New York Academy of Sciences. 811(1). 1–11. 93 indexed citations

15.

Hayashi, Hidetoshi, Yubin Qiu, Jiexing Cai, et al.. (1997). The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling. Cell. 89(7). 1165–1173. 1158 indexed citations breakdown →

16.

Gimbrone, Michael A., Tobi Nagel, & James N. Topper. (1997). Biomechanical activation: an emerging paradigm in endothelial adhesion biology.. Journal of Clinical Investigation. 99(8). 1809–1813. 268 indexed citations

17.

Topper, James N., Jeffrey Bennett, & David A. Clayton. (1992). A role for RNAse MRP in mitochondrial RNA processing. Cell. 70(1). 16–20. 66 indexed citations

18.

Hsieh, Chih‐Lin, Tim Donlon, Basil T. Darras, et al.. (1990). The gene for the RNA component of the mitochondrial RNA-processing endoribonuclease is located on human chromosome 9p and on mouse chromosome 4. Genomics. 6(3). 540–544. 27 indexed citations

19.

Topper, James N. & David A. Clayton. (1990). Characterization of human MRP/Th RNA and its nuclear gene: full length MRP/Th RNA is an active endoribonuclease when assembled as an RNP. Nucleic Acids Research. 18(4). 793–799. 92 indexed citations

20.

Gold, H., James N. Topper, David A. Clayton, & Joe Craft. (1989). The RNA Processing Enzyme RNase MRP Is Identical to the Th RNP and Related to RNase P. Science. 245(4924). 1377–1380. 134 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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