James C.H. Hardwick

12.9k citations

126 papers · 6.0k · 1 hit paper · h-index 41

Impact in

Oncology top 1%
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
Cancer Research top 2%

Papers in

Molecular Biology 38
- TGF-β signaling in diseases 12
- Wnt/β-catenin signaling in development and cancer 6
- Hedgehog Signaling Pathway Studies 6
Pulmonary and Respiratory Medicine 21
- Gastric Cancer Management and Outcomes 12

Co-authors: Gijs R. van den Brink (31 shared papers)Maikel P. Peppelenbosch (23 shared papers)Liudmila L. Kodach (24 shared papers)Sander J. H. van Deventer (8 shared papers)G. Johan A. Offerhaus (11 shared papers)Daniël W. Hommes (16 shared papers)G. J. A. Offerhaus (2 shared papers)Evelien Dekker (12 shared papers)
Journals: Gastroenterology (18 papers)Gastrointestinal Endoscopy (8 papers)Cancer Research (7 papers)Gut (7 papers)Oncogene (5 papers)
Partner nations: Netherlands United States Germany

In The Last Decade

James C.H. Hardwick

119 papers receiving 5.9k citations

James C.H. Hardwick's Hit Papers

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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors 2007 · 523 citations

Peers

Countries citing papers authored by James C.H. Hardwick

Since Specialization

Citations

This map shows the geographic impact of James C.H. Hardwick's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James C.H. Hardwick with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James C.H. Hardwick more than expected).

Fields of papers citing papers by James C.H. Hardwick

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James C.H. Hardwick. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James C.H. Hardwick. The network helps show where James C.H. Hardwick may publish in the future.

Co-authors

The 25 scholars most cited alongside James C.H. Hardwick, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with James C.H. Hardwick Line = papers co-authored together James C.H. Hardwick links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 126 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors The Journal of Experimental Medicine ·Jennifer O’Neil, Jonathan Grim, Peter R. Strack, Sudhir Rao, Deanne Tibbitts, Christopher Winter, James C.H. Hardwick, Markus Welcker, Jules P.P. Meijerink, Rob Pieters, Giulio Draetta, Rosalie C. Sears, Bruce E. Clurman, A. Thomas Look Hit paper breakdown →	2007	523
2	Leptin Is a Growth Factor for Colonic Epithelial Cells Gastroenterology ·James C.H. Hardwick, Gijs R. van den Brink, G. J. A. Offerhaus, Sander J. H. van Deventer, Maikel P. Peppelenbosch	2001	304
3	Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation Nature Genetics ·Gijs R. van den Brink, Sylvia A. Bleuming, James C.H. Hardwick, Berber L Schepman, G. Johan A. Offerhaus, Josbert J. Keller, Corinne M. Nielsen, William Gaffield, Sander J. H. van Deventer, Drucilla J. Roberts, Maikel P. Peppelenbosch	2004	293
4	ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response Cell Reports ·Jarom Heijmans, Jooske F. van Lidth de Jeude, Bon‐Kyoung Koo, Sanne L. Rosekrans, Mattheus C.B. Wielenga, (unknown), Marc Ferrante, Amy S. Lee, J. J. M. Onderwater, James C. Paton, Adrienne W. Paton, A. Mieke Mommaas, Liudmila L. Kodach, James C.H. Hardwick, Daniël W. Hommes, Hans Clevers, Vanesa Muncan, Gijs R. van den Brink	2013	228
5	Narrow-band imaging compared with conventional colonoscopy for the detection of dysplasia in patients with longstanding ulcerative colitis Endoscopy ·Evelien Dekker, F. van den Broek, Johannes B. Reitsma, James C.H. Hardwick, G. J. A. Offerhaus, Sander van Deventer, Daan W. Hommes, Paul Fockens	2007	221
6	Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon Gastroenterology ·James C.H. Hardwick, Gijs R. van den Brink, Sylvia A. Bleuming, Isabel Ballester, Jan M. H. van den Brande, Josbert J. Keller, G.J.A. Offerhaus, Sander J. H. van Deventer, Maikel P. Peppelenbosch	2003	213
7	Patterns of Metastatic Spread and Mechanisms of Resistance to Crizotinib in ROS1-Positive Non–Small-Cell Lung Cancer JCO Precision Oncology ·Justin F. Gainor, Diane Tseng, Satoshi Yoda, Ibiayi Dagogo‐Jack, Luc Friboulet, W. Marston Linehan, Harper Hubbeling, Leila Dardaei, Anna F. Farago, Katherine R. Schultz, Lorin A. Ferris, Zofia Piotrowska, James C.H. Hardwick, Donghui Huang, Mari Mino–Kenudson, A. John Iafrate, Aaron N. Hata, Beow Y. Yeap, Alice T. Shaw	2017	201
8	Sonic hedgehog regulates gastric gland morphogenesis in man and mouse Gastroenterology ·Gijs R. van den Brink, James C.H. Hardwick, Maikel P. Peppelenbosch, Sander J. H. van Deventer, Guido N.J. Tytgat, Menno A. Brink, Fiebo J. ten Kate	2001	199
9	Endoscopic tri-modal imaging for surveillance in ulcerative colitis: randomised comparison of high-resolution endoscopy and autofluorescence imaging for neoplasia detection; and evaluation of narrow-band imaging for classification of lesions Gut ·Frank J.C. van den Broek, Paul Fockens, S. van Eeden, Johannes B. Reitsma, James C.H. Hardwick, Pieter Stokkers, Evelien Dekker	2008	189
10	Bone morphogenetic protein signalling in colorectal cancer Nature reviews. Cancer ·James C.H. Hardwick, Liudmila L. Kodach, G. Johan A. Offerhaus, Gijs R. van den Brink	2008	153
11	Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis via Activation of Rho and ROCK Gastroenterology ·Philip W. Voorneveld, Liudmila L. Kodach, Rutger J. Jacobs, Nalan Liv, A.C. Zonnevylle, Jacob P. Hoogenboom, Izäk Biemond, Hein W. Verspaget, Daniël W. Hommes, Karien E. de Rooij, Carel J.M. van Noesel, Hans Morreau, Tom van Wezel, G. Johan A. Offerhaus, Gijs R. van den Brink, Maikel P. Peppelenbosch, Peter ten Dijke, James C.H. Hardwick	2014	146
12	The Bone Morphogenetic Protein Pathway Is Inactivated in the Majority of Sporadic Colorectal Cancers Gastroenterology ·Liudmila L. Kodach, Eliza Wiercinska, Noel F.C.C. de Miranda, Sylvia A. Bleuming, Alex R. Musler, Maikel P. Peppelenbosch, Evelien Dekker, Gijs R. van den Brink, Carel J.M. van Noesel, Hans Morreau, Daniël W. Hommes, Peter ten Dijke, G. Johan A. Offerhaus, James C.H. Hardwick	2008	140
13	Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis Clinical Cancer Research ·Madelon Paauwe, Mark J.A. Schoonderwoerd, Roxan F.C.P. Helderman, Tom J. Harryvan, Arwin Groenewoud, Gabi W. van Pelt, Rosalie Bor, Danielle M. Hemmer, Henri H. Versteeg, B. Ewa Snaar‐Jagalska, Charles P. Theuer, James C.H. Hardwick, Cornelis F.M. Sier, Peter ten Dijke, Lukas J.A.C. Hawinkels	2018	135
14	Blimp1 regulates the transition of neonatal to adult intestinal epithelium Nature Communications ·Vanesa Muncan, Jarom Heijmans, Stephen D. Krasinski, Nikè V.J.A. Büller, Manon E. Wildenberg, Sander Meisner, Marijana Radonjić, Kelly A. Stapleton, W.H. Lamers, Izäk Biemond, Marius A. van den Bergh Weerman, Dónal O’Carroll, James C.H. Hardwick, Daniël W. Hommes, Gijs R. van den Brink	2011	133
15	Effect of aspirin on the Wnt/β-catenin pathway is mediated via protein phosphatase 2A Oncogene ·Carina L. Bos, Liudmila L. Kodach, Gijs R. van den Brink, Sander H. Diks, Marije M. van Santen, Dick J. Richel, Maikel P. Peppelenbosch, James C.H. Hardwick	2006	127
16	Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells Carcinogenesis ·Liudmila L. Kodach, Carina L. Bos, Nelsón Durán, Maikel P. Peppelenbosch, Carmen V. Ferreira, James C.H. Hardwick	2005	122
17	Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell ‘stemness’ via the bone morphogenetic protein pathway Gut ·Liudmila L. Kodach, Rutger J. Jacobs, Philip W. Voorneveld, Manon E. Wildenberg, (unknown), Tom van Wezel, Hans Morreau, (unknown), Maikel P. Peppelenbosch, Gijs R. van den Brink, James C.H. Hardwick	2011	117
18	Quality of web-based information on inflammatory bowel diseases Inflammatory Bowel Diseases ·Sander van der Marel, Marjolijn Duijvestein, James C.H. Hardwick, Gijs R. van den Brink, Roeland A. Veenendaal, Daniël W. Hommes, Herma H. Fidder	2009	100
19	Bone Morphogenetic Protein Signaling Suppresses Tumorigenesis at Gastric Epithelial Transition Zones in Mice Cancer Research ·Sylvia A. Bleuming, Xi He, Liudmila L. Kodach, James C.H. Hardwick, Frieda A. Koopman, Fiebo J. ten Kate, Sander J. H. van Deventer, Daniël W. Hommes, Maikel P. Peppelenbosch, G. Johan A. Offerhaus, Linheng Li, Gijs R. van den Brink	2007	92
20	NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps Oncogene ·James C.H. Hardwick, Gijs R. van den Brink, G.J.A. Offerhaus, Sander JH van Deventer, Maikel P. Peppelenbosch	2001	90

About James C.H. Hardwick

James C.H. Hardwick is a scholar working on Molecular Biology, Pulmonary and Respiratory Medicine, Oncology, Cancer Research and Surgery, having authored 126 papers that have together received 6.0k indexed citations. Recurring topics across this work include Genetic factors in colorectal cancer (17 papers), TGF-β signaling in diseases (12 papers), Gastric Cancer Management and Outcomes (12 papers), Cancer, Lipids, and Metabolism (11 papers), Colorectal Cancer Treatments and Studies (7 papers), Wnt/β-catenin signaling in development and cancer (6 papers), Hedgehog Signaling Pathway Studies (6 papers) and Colorectal Cancer Screening and Detection (6 papers). The work is most often cited by research in Oncology (1.7k citations), Cancer Research (786 citations), Structural Biology (52 citations), Pathology and Forensic Medicine (583 citations) and Molecular Biology (2.4k citations). James C.H. Hardwick has collaborated with scholars based in Netherlands, United States and Germany. Frequent co-authors include Gijs R. van den Brink, Maikel P. Peppelenbosch, Liudmila L. Kodach, Sander J. H. van Deventer, G. Johan A. Offerhaus, Daniël W. Hommes, G. J. A. Offerhaus, Evelien Dekker, Sylvia A. Bleuming and Paul Fockens. Their work appears in journals such as Gastroenterology, Gastrointestinal Endoscopy, Cancer Research, Gut and Oncogene.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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James C.H. Hardwick

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