Jack O. Egan

2.2k citations

17 papers · 944 indexed · h-index 12

Impact in

Immunology top 5%
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
Virology top 5%
- HIV Research and Treatment

Papers in ⓘ

Immunology 9
- Immune Cell Function and Interaction 7
- Immunotherapy and Immune Responses 3
- T-cell and B-cell Immunology 3
Hematology 4
- Blood Coagulation and Thrombosis Mechanisms 4
- Hemophilia Treatment and Research 3

Co-authors: Hing C. Wong (13 shared papers)Peter R. Rhode (11 shared papers)Kenneth G. Mann (2 shared papers)Michael Kalafatis (2 shared papers)Jen‐Fu Chiu (1 shared paper)Hongmin Chen (1 shared paper)Xiaoyun Zhu (7 shared papers)Kaiping Han (3 shared papers)
Journals: Critical Reviews in Eukaryotic Gene Expression (2 papers)Molecular Therapy (1 paper)Clinical Cancer Research (1 paper)Journal of Virology (1 paper)American Journal of Physiology-Lung Cellular and Molecular Physiology (1 paper)
Partner nations: United States

In The Last Decade

Jack O. Egan

16 papers receiving 915 citations

Peers

Countries citing papers authored by Jack O. Egan

Since Specialization

Citations

This map shows the geographic impact of Jack O. Egan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jack O. Egan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jack O. Egan more than expected).

Fields of papers citing papers by Jack O. Egan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jack O. Egan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jack O. Egan. The network helps show where Jack O. Egan may publish in the future.

Co-authors

The 25 scholars most cited alongside Jack O. Egan, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Jack O. Egan Line = papers co-authored together Jack O. Egan links everyone, so they are left out of the graph.

All Works

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17 of 17 papers shown

#	Work
1	Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models Cancer Immunology Research ·Peter R. Rhode, Jack O. Egan, Wenxin Xu, Hao Hong, Gabriela M. Webb, Xiaoyue Chen, Bai Liu, Xiaoyun Zhu, Jinghai Wen, Lijing You, Lin Kong, Ana C. Edwards, Kaiping Han, Sixiang Shi, Sarah Alter, Jonah B. Sacha, Emily K. Jeng, Weibo Cai, Hing C. Wong	2015	170
2	Phase I Trial of ALT-803, A Novel Recombinant IL15 Complex, in Patients with Advanced Solid Tumors Clinical Cancer Research ·Kim Margolin, Chihiro Morishima, Vamsidhar Velcheti, Jeffrey S. Miller, Sylvia M. Lee, Ann W. Silk, Shernan G. Holtan, Andreanne M. Lacroix, Steven P. Fling, Judith C. Kaiser, Jack O. Egan, Monica Jones, Peter R. Rhode, Amy D. Rock, Martin A. Cheever, Hing C. Wong, Marc S. Ernstoff	2018	146
3	Novel Human Interleukin-15 Agonists The Journal of Immunology ·Xiaoyun Zhu, Warren D. Marcus, Wenxin Xu, Hyung‐il Lee, Kaiping Han, Jack O. Egan, Jason L. Yovandich, Peter R. Rhode, Hing C. Wong	2009	123
4	The Regulation of Clotting Factors Critical Reviews in Eukaryotic Gene Expression ·Michael Kalafatis, Jack O. Egan, Cornells van't Veer, Kevin M. Cawthern, Kenneth G. Mann	1997	107
5	Regulation and Activities of α-Fetoprotein Critical Reviews in Eukaryotic Gene Expression ·Hongmin Chen, Jack O. Egan, Jen‐Fu Chiu	1997	95
6	Intravesical ALT-803 and BCG Treatment Reduces Tumor Burden in a Carcinogen Induced Bladder Cancer Rat Model; a Role for Cytokine Production and NK Cell Expansion PLoS ONE ·Evan Gomes-Giacoia, Makito Miyake, Steve Goodison, Aravindhan Sriharan, Ge Zhang, Lijing You, Jack O. Egan, Peter R. Rhode, Alexander S. Parker, Karl X. Chai, Hing C. Wong, Charles J. Rosser	2014	78
7	Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure American Journal of Physiology-Lung Cellular and Molecular Physiology ·Karen E. Welty‐Wolf, Martha Sue Carraway, Thomas L. Ortel, Andrew J. Ghio, Steven Idell, Jack O. Egan, Xiaoyun Zhu, Jin-An Jiao, Hing C. Wong, Claude A. Piantadosi	2005	65
8	ALT-803 Transiently Reduces Simian Immunodeficiency Virus Replication in the Absence of Antiretroviral Treatment Journal of Virology ·Amy Ellis, Alexis J. Balgeman, Katie R. Zarbock, Gabrielle L. Barry, Andrea M. Weiler, Jack O. Egan, Emily K. Jeng, Thomas C. Friedrich, Jeffrey S. Miller, Ashley T. Haase, Timothy W. Schacker, Hing C. Wong, Eva G. Rakasz, Shelby L. O’Connor	2017	47
9	The effect of Arg³⁰⁶ → Ala and Arg⁵⁰⁶ → Gln substitutions in the inactivation of recombinant human factor Va by activated protein C and protein S Protein Science ·Jack O. Egan, Michael Kalafatis, Kenneth G. Mann	1997	38
10	Inhibition of acute vascular thrombosis in chimpanzees by an anti-human tissue factor antibody targeting the factor X binding site Thrombosis and Haemostasis ·Jin‐an Jiao, Andrew B. Kelly, Ulla M. Marzec, Esperanza Nieves, Jorge Acevedo, Martin Burkhardt, Ana Edwards, Xiaoyun Zhu, Pierre‐André Chavaillaz, Alice Wong, Jeffrey L. Wong, Jack O. Egan, Dean Taylor, Peter R. Rhode, Hing C. Wong	2009	21
11	Immunotherapeutic HCW9218 augments anti-tumor activity of chemotherapy via NK cell-mediated reduction of therapy-induced senescent cells Molecular Therapy ·Pallavi Chaturvedi, Varghese George, Niraj Shrestha, Meng Wang, Michael J. Dee, Xiaoyun Zhu, Bai Liu, Jack O. Egan, Francesca D’Eramo, Catherine M. Spanoudis, Victor L. Gallo, Christian A. Echeverri, Lijing You, Lin Kong, Byron Fang, Emily K. Jeng, Peter R. Rhode, Hing C. Wong	2022	21
12	Hepatitis B virus DNA integration and expression of an erb B-like gene in human hepatocellular carcinoma Biochemical and Biophysical Research Communications ·Xiao-kun Zhang, Jack O. Egan, Dao-Pei Huang, Zhilin Sun, Victoria K.Y. Chien, Jen-Fu Chiu	1992	19
13	A novel interleukin-2-based fusion molecule, HCW9302, differentially promotes regulatory T cell expansion to treat atherosclerosis in mice Frontiers in Immunology ·Xiaoyun Zhu, Qiongzhen Li, Varghese George, Catherine M. Spanoudis, Crystal Gilkes, Niraj Shrestha, Bai Liu, Lin Kong, Lijing You, Christian A. Echeverri, Liying Li, Zheng Wang, Pallavi Chaturvedi, Gabriela J. Muniz, Jack O. Egan, Peter R. Rhode, Hing C. Wong	2023	6
14	Abstract CT146: First-in-human phase I combination of the IL-15 receptor super agonist complex ALT-803 with a therapeutic (anti-CD20) monoclonal antibody (mAb) for patients with relapsed or refractory indolent non-Hodgkin lymphoma (iNHL) Cancer Research ·Todd A. Fehniger, Brian Hess, Veronika Bachanová, Michelle Becker‐Hapak, Ethan McClain, Melissa M. Berrien-Elliott, Julia A. Wagner, Nancy L. Bartlett, Brad S. Kahl, Neha Mehta–Shah, Amanda F. Cashen, Feng Gao, Kyle Conradi, Amy D. Rock, Emily K. Jeng, Liza Hernandez, Jack O. Egan, Peter R. Rhode, Hing C. Wong	2018	6
15	Novel antitumor mechanism-of-action of an IL-2 fusion protein mediated by tumor associated macrophage repolarization and innate-like CD8+ memory T cells Journal for ImmunoTherapy of Cancer ·Wenxin Xu, Jack O. Egan, Bai Liu, Xiaoyue Chen, Lijing You, Kaiping Han, Warren D. Marcus, Lin Kong, Monica Jones, Emily K. Jeng, Peter R. Rhode, Hing C. Wong	2014	1
16	724 A phase I study of HCW9218, a bifunctional TGF-β Antagonist/IL-15 protein complex, in advanced solid tumors Regular and Young Investigator Award Abstracts ·Melissa A. Geller, Manish R. Patel, Hing C. Wong, Peter R. Rhode, Philip M. Arlen, Pallavi Chaturvedi, Jack O. Egan, Giles Leclerc, Martin Felices, Shannon Lunn, Bethany Hanke, Deepa Kolseri, Rose Wangen, Jeffrey T. Miller	2022	1
17	767 Pre-clinical and first-in-human studies of HCW9218, a bifunctional TGF-β antagonist/IL-15 protein complex, in advanced solid tumors SHILAP Revista de lepidopterología ·Melissa A. Geller, Manish R. Patel, Hing C. Wong, Peter R. Rhode, Philip M. Arlen, (unknown), Karen Kage, Delsy G Gaetano, Jack O. Egan, Giles M Leclerc, Pallavi Chaturvedi, Niraj Shrestha, Xiaoyun Zhu, Martin Felices, Shannon Lunn, Bethany Hanke, Kelsey Mullen, Deepa Kolaseri Krishnadas, Rose Wangen, Jeffrey S. Miller	2023	0

About Jack O. Egan

Jack O. Egan is a scholar working on Immunology, Hematology, Biotechnology, Virology and Genetics, having authored 17 papers that have together received 944 indexed citations. Recurring topics across this work include Immune Cell Function and Interaction (7 papers), CAR-T cell therapy research (4 papers), Blood Coagulation and Thrombosis Mechanisms (4 papers), Hemophilia Treatment and Research (3 papers), Immunotherapy and Immune Responses (3 papers), T-cell and B-cell Immunology (3 papers), Histone Deacetylase Inhibitors Research (2 papers) and Cancer Research and Treatments (2 papers). The work is most often cited by research in Immunology (521 citations), Virology (81 citations), Hematology (166 citations), Oncology (386 citations) and Genetics (59 citations). Jack O. Egan has collaborated with scholars based in United States. Frequent co-authors include Hing C. Wong, Peter R. Rhode, Kenneth G. Mann, Michael Kalafatis, Jen‐Fu Chiu, Hongmin Chen, Xiaoyun Zhu, Kaiping Han, Wenxin Xu and Kevin M. Cawthern. Their work appears in journals such as Critical Reviews in Eukaryotic Gene Expression, Molecular Therapy, Clinical Cancer Research, Journal of Virology and American Journal of Physiology-Lung Cellular and Molecular Physiology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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