Helmut Holtmann

6.7k total citations · 2 hit papers
54 papers, 5.4k citations indexed

About

Helmut Holtmann is a scholar working on Molecular Biology, Immunology and Oncology. According to data from OpenAlex, Helmut Holtmann has authored 54 papers receiving a total of 5.4k indexed citations (citations by other indexed papers that have themselves been cited), including 27 papers in Molecular Biology, 22 papers in Immunology and 16 papers in Oncology. Recurrent topics in Helmut Holtmann's work include Immune Response and Inflammation (15 papers), Cytokine Signaling Pathways and Interactions (15 papers) and RNA Research and Splicing (13 papers). Helmut Holtmann is often cited by papers focused on Immune Response and Inflammation (15 papers), Cytokine Signaling Pathways and Interactions (15 papers) and RNA Research and Splicing (13 papers). Helmut Holtmann collaborates with scholars based in Germany, Israel and United States. Helmut Holtmann's co-authors include David Wallach, Michael Kracht, Oliver Dittrich‐Breiholz, Elke Hoffmann, Reinhard Winzen, Y. Nophar, Klaus Resch, Cord Brakebusch, Hartmut Engelmann and Matthias Gaestel and has published in prestigious journals such as Nucleic Acids Research, Journal of Biological Chemistry and Nature Communications.

In The Last Decade

Helmut Holtmann

54 papers receiving 5.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 999 citations Eugene Varfolomeev, Marcus Schuchmann et al. Immunity profile →
Multiple control of interleukin-8 gene expression

2002 922 citations Elke Hoffmann, Oliver Dittrich‐Breiholz et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Helmut Holtmann Germany	30	2.8k	2.5k	1.0k	937	622	54	5.4k
Franco Di Padova Switzerland	34	2.8k 1.0×	2.3k 0.9×	908 0.9×	720 0.8×	520 0.8×	70	6.1k
Laura DeForge United States	33	3.2k 1.1×	2.5k 1.0×	789 0.8×	1.1k 1.2×	877 1.4×	54	5.8k
Brian M. J. Foxwell United Kingdom	40	1.7k 0.6×	3.2k 1.3×	1.3k 1.2×	1.0k 1.1×	710 1.1×	69	5.8k
Michael J. Lenardo United States	8	2.1k 0.7×	2.5k 1.0×	1.2k 1.1×	877 0.9×	413 0.7×	12	4.8k
P H Krammer Germany	30	3.0k 1.1×	3.8k 1.5×	677 0.6×	958 1.0×	881 1.4×	38	6.5k
Martine A. Collart Switzerland	41	4.5k 1.6×	1.8k 0.7×	969 0.9×	718 0.8×	562 0.9×	76	7.4k
Richard C. Duke United States	31	3.5k 1.2×	2.5k 1.0×	603 0.6×	942 1.0×	631 1.0×	51	6.5k
G H Wong United States	26	3.3k 1.2×	3.8k 1.5×	1.1k 1.0×	917 1.0×	902 1.5×	54	7.7k
Nancy C. Fiore United States	17	1.4k 0.5×	2.3k 0.9×	588 0.6×	929 1.0×	465 0.7×	23	4.6k
Ottmar Janßen Germany	42	2.3k 0.8×	3.0k 1.2×	490 0.5×	1.1k 1.2×	460 0.7×	135	5.6k

Countries citing papers authored by Helmut Holtmann

Since Specialization

Citations

This map shows the geographic impact of Helmut Holtmann's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Helmut Holtmann with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Helmut Holtmann more than expected).

Fields of papers citing papers by Helmut Holtmann

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Helmut Holtmann. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Helmut Holtmann. The network helps show where Helmut Holtmann may publish in the future.

Co-authorship network of co-authors of Helmut Holtmann

This figure shows the co-authorship network connecting the top 25 collaborators of Helmut Holtmann. A scholar is included among the top collaborators of Helmut Holtmann based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Helmut Holtmann. Helmut Holtmann is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Essig, Katharina, Joao C. Guimaraes, Claudia Lohs, et al.. (2018). Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation. Nature Communications. 9(1). 3810–3810. 41 indexed citations

Tiedje, Christopher, Helmut Holtmann, & Matthias Gaestel. (2014). The Role of Mammalian MAPK Signaling in Regulation of Cytokine mRNA Stability and Translation. Journal of Interferon & Cytokine Research. 34(4). 220–232. 65 indexed citations

Schwarzer, Adrian, Helmut Holtmann, Martijn H. Brugman, et al.. (2014). Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia. Oncogene. 34(27). 3593–3604. 21 indexed citations

Dhamija, Sonam, Reinhard Winzen, Oliver Dittrich‐Breiholz, et al.. (2011). Interleukin-1 Activates Synthesis of Interleukin-6 by Interfering with a KH-type Splicing Regulatory Protein (KSRP)-dependent Translational Silencing Mechanism. Journal of Biological Chemistry. 286(38). 33279–33288. 47 indexed citations

Dhamija, Sonam, Reinhard Winzen, Oliver Dittrich‐Breiholz, et al.. (2010). IL-1-induced Post-transcriptional Mechanisms Target Overlapping Translational Silencing and Destabilizing Elements in IκBζ mRNA*. Journal of Biological Chemistry. 285(38). 29165–29178. 28 indexed citations

Gowrishankar, Gayatri, et al.. (2006). Inhibition of mRNA deadenylation and degradation by different types of cell stress. Biological Chemistry. 387(3). 323–7. 37 indexed citations

Winzen, Reinhard, et al.. (2004). Distinct Domains of AU-Rich Elements Exert Different Functions in mRNA Destabilization and Stabilization by p38 Mitogen-Activated Protein Kinase or HuR. Molecular and Cellular Biology. 24(11). 4835–4847. 111 indexed citations

Bollig, Frank, Reinhard Winzen, Matthias Gaestel, et al.. (2003). Affinity purification of ARE-binding proteins identifies poly(A)-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization. Biochemical and Biophysical Research Communications. 301(3). 665–670. 59 indexed citations

Neininger, Armin, Dimitris L. Kontoyiannis, Alexey Kotlyarov, et al.. (2002). MK2 Targets AU-rich Elements and Regulates Biosynthesis of Tumor Necrosis Factor and Interleukin-6 Independently at Different Post-transcriptional Levels. Journal of Biological Chemistry. 277(5). 3065–3068. 340 indexed citations

10.

Holtmann, Helmut, Jost Enninga, Anneke Dörrie, et al.. (2001). The MAPK Kinase Kinase TAK1 Plays a Central Role in Coupling the Interleukin-1 Receptor to Both Transcriptional and RNA-targeted Mechanisms of Gene Regulation. Journal of Biological Chemistry. 276(5). 3508–3516. 85 indexed citations

11.

Holtmann, Helmut, Reinhard Winzen, Pamela M. Holland, et al.. (1999). Induction of Interleukin-8 Synthesis Integrates Effects on Transcription and mRNA Degradation from at Least Three Different Cytokine- or Stress-Activated Signal Transduction Pathways. Molecular and Cellular Biology. 19(10). 6742–6753. 269 indexed citations

12.

Varfolomeev, Eugene, Marcus Schuchmann, Victor Luria, et al.. (1998). Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally. Immunity. 9(2). 267–276. 999 indexed citations breakdown →

13.

Krause, Andréa, Helmut Holtmann, Reinhard Winzen, et al.. (1998). Stress-activated Protein Kinase/Jun N-terminal Kinase Is Required for Interleukin (IL)-1-induced IL-6 and IL-8 Gene Expression in the Human Epidermal Carcinoma Cell Line KB. Journal of Biological Chemistry. 273(37). 23681–23689. 85 indexed citations

14.

Holtmann, Helmut & Klaus Resch. (1995). Cytokines. Die Naturwissenschaften. 82(4). 178–187. 26 indexed citations

15.

Beletsky, Igor P., et al.. (1994). Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity.. The Journal of Experimental Medicine. 180(2). 445–460. 119 indexed citations

16.

König, M., David Wallach, Klaus Resch, & Helmut Holtmann. (1991). Induction of hyporesponsiveness to an early post‐binding effect of tumor necrosis factor by tumor necrosis factor itself and interleukin 1. European Journal of Immunology. 21(7). 1741–1745. 6 indexed citations

17.

Holtmann, Helmut, Cord Brakebusch, M. König, et al.. (1991). Mechanisms controlling the level of receptors for tumor necrosis factor. Inflammation Research. 32(1-2). 106–108. 4 indexed citations

18.

Eife, R., et al.. (1989). Natural Killer Cell Function and Interferon Production in Familial Hemophagocyticlymphohistiocytosis. Pediatric Hematology and Oncology. 6(3). 265–272. 37 indexed citations

19.

Holtmann, Helmut, et al.. (1988). Modulation of cell response to tumor necrosis factor tnf by interleukin 1 il 1 and 4 beta phorbol 12 myristate 13 acetate pma. 7(3). 300. 1 indexed citations

20.

Wallach, David, Helmut Holtmann, Dan Aderka, et al.. (1988). Sensitizing effects and mechanisms of desensitization in regulation of the in vivo response to TNF. Annales de l Institut Pasteur Immunologie. 139(3). 323–327. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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