Fred J. Fleitz

2.7k total citations · 1 hit paper
19 papers, 2.0k citations indexed

About

Fred J. Fleitz is a scholar working on Molecular Biology, Organic Chemistry and Inorganic Chemistry. According to data from OpenAlex, Fred J. Fleitz has authored 19 papers receiving a total of 2.0k indexed citations (citations by other indexed papers that have themselves been cited), including 11 papers in Molecular Biology, 8 papers in Organic Chemistry and 5 papers in Inorganic Chemistry. Recurrent topics in Fred J. Fleitz's work include Chemical Synthesis and Analysis (5 papers), Enzyme Catalysis and Immobilization (5 papers) and Asymmetric Hydrogenation and Catalysis (5 papers). Fred J. Fleitz is often cited by papers focused on Chemical Synthesis and Analysis (5 papers), Enzyme Catalysis and Immobilization (5 papers) and Asymmetric Hydrogenation and Catalysis (5 papers). Fred J. Fleitz collaborates with scholars based in United States and United Kingdom. Fred J. Fleitz's co-authors include Paul N. Devine, William R. Jarvis, Christopher K. Savile, Jacob M. Janey, Anke Krebber, Gjalt W. Huisman, Emily C. Mundorff, Jeffrey C. Moore, Gregory Hughes and Joseph D. Armstrong and has published in prestigious journals such as Science, Journal of the American Chemical Society and The Journal of Organic Chemistry.

In The Last Decade

Fred J. Fleitz

19 papers receiving 1.9k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

2010 1.3k citations Christopher K. Savile, Jacob M. Janey et al. Science profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Fred J. Fleitz United States	13	1.3k	954	305	219	210	19	2.0k
Christopher K. Savile Canada	14	1.6k 1.2×	588 0.6×	332 1.1×	217 1.0×	228 1.1×	21	2.0k
Matthew D. Truppo United States	18	1.5k 1.2×	880 0.9×	474 1.6×	257 1.2×	197 0.9×	28	2.1k
J. David Rozzell United States	20	1.2k 0.9×	443 0.5×	194 0.6×	138 0.6×	179 0.9×	41	1.4k
James L. Galman United Kingdom	19	1.1k 0.9×	521 0.5×	286 0.9×	180 0.8×	137 0.7×	33	1.5k
Dominik Koszelewski Poland	26	1.9k 1.4×	1.4k 1.4×	340 1.1×	348 1.6×	426 2.0×	96	2.8k
Oliver May Germany	20	1.1k 0.9×	397 0.4×	284 0.9×	146 0.7×	339 1.6×	41	1.5k
Pier Paolo Giovannini Italy	25	781 0.6×	843 0.9×	273 0.9×	142 0.6×	93 0.4×	93	1.6k
Giancarlo Fantin Italy	26	905 0.7×	1.1k 1.2×	148 0.5×	206 0.9×	173 0.8×	130	2.0k
Andrew J. Carnell United Kingdom	21	627 0.5×	727 0.8×	339 1.1×	359 1.6×	128 0.6×	58	1.6k
Subhash P. Chavan India	28	719 0.5×	2.0k 2.1×	120 0.4×	285 1.3×	213 1.0×	167	2.6k

Countries citing papers authored by Fred J. Fleitz

Since Specialization

Citations

This map shows the geographic impact of Fred J. Fleitz's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Fred J. Fleitz with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Fred J. Fleitz more than expected).

Fields of papers citing papers by Fred J. Fleitz

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Fred J. Fleitz. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Fred J. Fleitz. The network helps show where Fred J. Fleitz may publish in the future.

Co-authorship network of co-authors of Fred J. Fleitz

This figure shows the co-authorship network connecting the top 25 collaborators of Fred J. Fleitz. A scholar is included among the top collaborators of Fred J. Fleitz based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Fred J. Fleitz. Fred J. Fleitz is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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19 of 19 papers shown

Ruck, Rebecca T., Qinghao Chen, Nelo R. Rivera, et al.. (2020). Bio- and Chemocatalysis for the Synthesis of Late Stage SAR-Enabling Intermediates for ROMK Inhibitors and MK-7145 for the Treatment of Hypertension and Heart Failure. Organic Process Research & Development. 25(3). 405–410. 9 indexed citations

Mangion, Ian, Benjamin D. Sherry, Jingjun Yin, & Fred J. Fleitz. (2012). Enantioselective Synthesis of a Dual Orexin Receptor Antagonist. Organic Letters. 14(13). 3458–3461. 61 indexed citations

Baxter, Carl A., Gregory L. Beutner, Khateeta M. Emerson, et al.. (2011). Multikilogram-Scale Synthesis of a Chiral Cyclopropanol and an Investigation of the Safe Use of Lithium Acetylide–Ethylene Diamine Complex. Organic Process Research & Development. 16(1). 87–95. 30 indexed citations

Savile, Christopher K., Jacob M. Janey, Emily C. Mundorff, et al.. (2010). Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture. Science. 329(5989). 305–309. 1299 indexed citations breakdown →

Helmy, Roy, Wes Schafer, Brian Musselman, et al.. (2010). Ambient Pressure Desorption Ionization Mass Spectrometry in Support of Preclinical Pharmaceutical Development. Organic Process Research & Development. 14(2). 386–392. 19 indexed citations

Savile, Christopher K., Jacob M. Janey, Emily C. Mundorff, et al.. (2010). A Manufactured Enzyme for the Synthesis of Chiral Amines. Synfacts. 2010(10). 1197–1197. 8 indexed citations

Kuethe, Jeffrey T., Yong‐Li Zhong, Gregory L. Beutner, et al.. (2009). Development of practical syntheses of potent non-nucleoside reverse transcriptase inhibitors. Tetrahedron. 65(26). 5013–5023. 12 indexed citations

Kosjek, Birgit, Fred J. Fleitz, Peter G. Dormer, Jeffrey T. Kuethe, & Paul N. Devine. (2008). Asymmetric bioreduction of α,β-unsaturated nitriles and ketones. Tetrahedron Asymmetry. 19(12). 1403–1406. 56 indexed citations

Roberge, Christopher, Fred J. Fleitz, David Pollard, & Paul N. Devine. (2007). Asymmetric synthesis of cyanohydrin derived from pyridine aldehyde with cross-linked aggregates of hydroxynitrile lyases. Tetrahedron Letters. 48(8). 1473–1477. 15 indexed citations

10.

Roberge, Christopher, Fred J. Fleitz, David Pollard, & Paul N. Devine. (2007). Synthesis of optically active cyanohydrins from aromatic ketones: evidence of an increased substrate range and inverted stereoselectivity for the hydroxynitrile lyase from Linum usitatissimum. Tetrahedron Asymmetry. 18(2). 208–214. 15 indexed citations

11.

Ikemoto, Norihiro, Ross A. Miller, Fred J. Fleitz, et al.. (2005). Approaches to installing a N-gem-dimethylmethylene-2-oxazolyl group and application to the synthesis of a second generation HIV protease inhibitor. Tetrahedron Letters. 46(11). 1867–1871. 10 indexed citations

12.

Welch, Christopher J., Fred J. Fleitz, Firoz D. Antia, et al.. (2004). Chromatography as an Enabling Technology in Pharmaceutical Process Development: Expedited Multikilogram Preparation of a Candidate HIV Protease Inhibitor. Organic Process Research & Development. 8(2). 186–191. 24 indexed citations

13.

Gauthier, Donald R., Norihiro Ikemoto, Fred J. Fleitz, et al.. (2003). Total synthesis of a second generation HIV protease inhibitor. Tetrahedron Asymmetry. 14(22). 3557–3567. 10 indexed citations

14.

Davies, Ian W., David M. Tellers, C. Scott Shultz, et al.. (2002). A [2 + 2] Cycloaddition Route to Dimethylaminomethylene Vinamidinium Salts. Organic Letters. 4(17). 2969–2972. 12 indexed citations

15.

Fleitz, Fred J., Terry A. Lyle, Nan Zheng, Joseph D. Armstrong, & R. P. Volante. (2000). Kilogram Scale Synthesis of the Pyrazinone Acetic Acid Core of an Orally Efficacious Thrombin Inhibitor. Synthetic Communications. 30(17). 3171–3180. 21 indexed citations

16.

Maligres, Peter E., et al.. (1999). A highly catalytic robust palladium catalyzed cyanation of aryl bromides. Tetrahedron Letters. 40(47). 8193–8195. 123 indexed citations

17.

Zheng, Nan, J. Christopher McWilliams, Fred J. Fleitz, Joseph D. Armstrong, & R. P. Volante. (1998). Palladium-Catalyzed Synthesis of Aryl Sulfides from Aryl Triflates. The Journal of Organic Chemistry. 63(26). 9606–9607. 146 indexed citations

18.

Trost, Barry M., Fred J. Fleitz, & William J. Watkins. (1996). On Pd-Catalyzed Cycloisomerization versus Cycloreduction. A General Strategy for Drimane Synthesis and a Short Total Synthesis of Siccanin. Journal of the American Chemical Society. 118(21). 5146–5147. 40 indexed citations

19.

Grunwell, John R., A. Karipides, Carl T. Wigal, et al.. (1991). The formal oxidative addition of electron-rich transoid dienes to bromonaphthoquinones. The Journal of Organic Chemistry. 56(1). 91–95. 78 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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