Defen Lu

1.2k citations

22 papers · 834 indexed · h-index 15

Impact in

Immunology top 5%
- interferon and immune responses
- Immune Response and Inflammation
Endocrinology top 5%
- Vibrio bacteria research studies

Papers in ⓘ

Molecular Biology 10
- Ubiquitin and proteasome pathways 4
- RNA modifications and cancer 2
Infectious Diseases 7
- Viral Infections and Vectors 5

Co-authors: Guijun Shang (14 shared papers)Xuewu Zhang (5 shared papers)Xiao‐chen Bai (3 shared papers)Lichuan Gu (6 shared papers)Deyu Zhu (3 shared papers)Sujuan Xu (6 shared papers)Qian Yu (4 shared papers)Yanyu Zhao (4 shared papers)
Journals: Journal of Biological Chemistry (3 papers)Nature Communications (2 papers)Virus Research (1 paper)Molecular Microbiology (1 paper)Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (1 paper)
Partner nations: China United States Pakistan

In The Last Decade

Defen Lu

20 papers receiving 826 citations

Peers

Countries citing papers authored by Defen Lu

Since Specialization

Citations

This map shows the geographic impact of Defen Lu's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Defen Lu with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Defen Lu more than expected).

Fields of papers citing papers by Defen Lu

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Defen Lu. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Defen Lu. The network helps show where Defen Lu may publish in the future.

Co-authors

The 25 scholars most cited alongside Defen Lu, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Defen Lu Line = papers co-authored together Defen Lu links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 22 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP Nature Structural & Molecular Biology ·Guijun Shang, Deyu Zhu, Ning Li, Junbing Zhang, Chunyuan Zhu, Defen Lu, Cuilan Liu, Qian Yu, Yanyu Zhao, Sujuan Xu, Lichuan Gu	2012	189
2	Activation of STING by targeting a pocket in the transmembrane domain Nature ·Defen Lu, Guijun Shang, Jie Li, Yong Lu, Xiao‐chen Bai, Xuewu Zhang	2022	116
3	Characterization of Nuclear Localization Signal in the N Terminus of CUL4B and Its Essential Role in Cyclin E Degradation and Cell Cycle Progression Journal of Biological Chemistry ·Yongxin Zou, Jun Mi, Jinpeng Cui, Defen Lu, Xiyu Zhang, Chenhong Guo, Guimin Gao, Qiji Liu, Bingxi Chen, Changshun Shao, Yaoqin Gong	2009	102
4	Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates Molecular Cell ·Deyu Zhu, Lijun Wang, Guijun Shang, Xue Liu, Jing Zhu, Defen Lu, Lei Wang, Biao Kan, Jing‐Ren Zhang, Ye Xiang	2014	56
5	Cullin 4B Protein Ubiquitin Ligase Targets Peroxiredoxin III for Degradation Journal of Biological Chemistry ·Xi Li, Defen Lu, Fengjuan He, Haibin Zhou, Qiao Liu, Yu Wang, Changshun Shao, Yaoqin Gong	2011	45
6	A conserved ion channel function of STING mediates noncanonical autophagy and cell death EMBO Reports ·Jinrui Xun, Zhichao Zhang, Bo Lv, Defen Lu, Haoxiang Yang, Guijun Shang, Xiaojun Tan	2024	41
7	Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex eLife ·Guijun Shang, Chad A. Brautigam, Rui Chen, Defen Lu, Jesús Torres‐Vázquez, Xuewu Zhang	2017	39
8	Structural Insights into a Unique Legionella pneumophila Effector LidA Recognizing Both GDP and GTP Bound Rab1 in Their Active State PLoS Pathogens ·Wei Cheng, Kun Yin, Defen Lu, Bingqing Li, Deyu Zhu, Yuzhen Chen, Hao Zhang, Sujuan Xu, Jijie Chai, Lichuan Gu	2012	37
9	Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex Nature Communications ·Defen Lu, Guijun Shang, Xiaojing He, Xiao‐chen Bai, Xuewu Zhang	2021	35
10	Structural insights into the T6SS effector protein Tse3 and the Tse3–Tsi3 complex from Pseudomonas aeruginosa reveal a calcium‐dependent membrane‐binding mechanism Molecular Microbiology ·Defen Lu, Guijun Shang, Heqiao Zhang, Qian Yu, Xiaoyan Cong, Jupeng Yuan, Fengjuan He, Chunyuan Zhu, Yanyu Zhao, Kun Yin, Yuanyuan Chen, Junqiang Hu, Xiaodan Zhang, Zenglin Yuan, Sujuan Xu, Wei Hu, Huaixing Cang, Lichuan Gu	2014	31
11	The structural basis of the Tle4–Tli4 complex reveals the self-protection mechanism of H2-T6SS inPseudomonas aeruginosa Acta Crystallographica Section D Biological Crystallography ·Defen Lu, Youshi Zheng, Naishun Liao, Ling Wei, Bo Xu, Xiaolong Liu, Jingfeng Liu	2014	25
12	Crystal structures of porcine STINGCBD–CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins Journal of Biological Chemistry ·Xiaoyan Cong, Zenglin Yuan, Yijun Du, Bo Wu, Defen Lu, Xiangju Wu, Youjia Zhang, Feng Li, Bin Wei, Jun Li, Jiaqiang Wu, Sujuan Xu, Jinbao Wang, Jing Qi, Guijun Shang, Lichuan Gu	2019	25
13	Activation of STING Based on Its Structural Features Frontiers in Immunology ·Behzad Hussain, Yufeng Xie, Uzma Jabeen, Defen Lu, Bo Yang, Changxin Wu, Guijun Shang	2022	24
14	X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ·Fengjuan He, Defen Lu, Baichun Jiang, Yan Wang, Qiao Liu, Qiji Liu, Changshun Shao, Xi Li, Yaoqin Gong	2013	20
15	Structural insight into how Pseudomonas aeruginosa peptidoglycanhydrolase Tse1 and its immunity protein Tsi1 function Biochemical Journal ·Guijun Shang, Xiuhua Liu, Defen Lu, Junbing Zhang, Ning Li, Chunyuan Zhu, Shiheng Liu, Qian Yu, Yanyu Zhao, Heqiao Zhang, Junqiang Hu, Huaixing Cang, Sujuan Xu, Lichuan Gu	2012	20
16	Structural and Functional Analyses of the FAM46C/Plk4 Complex Structure ·Hua Chen, Defen Lu, Guijun Shang, Guoming Gao, Xuewu Zhang	2020	11
17	Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold Science Advances ·Shun Liu, Hua Chen, Yan Yin, Defen Lu, Guoming Gao, Jie Li, Xiao‐chen Bai, Xuewu Zhang	2023	7
18	cGAS-STING: mechanisms and therapeutic opportunities Science China Life Sciences ·Mengyuan Zhang, Changxin Wu, Defen Lu, Xing Wang, Guijun Shang	2025	5
19	Expression, purification and preliminary crystallographic analysis of the T6SS effector protein Tse3 fromPseudomonas aeruginosa Acta Crystallographica Section F Structural Biology and Crystallization Communications ·Defen Lu, Guijun Shang, Qian Yu, Heqiao Zhang, Yanyu Zhao, Huaixing Cang, Lichuan Gu, Sujuan Xu, Yan Huang	2013	4
20	Structural plasticity of human leptin binding to its receptor LepR Yufeng Xie, Xiaoxiong Li, Jianxun Qi, Guijun Shang, Defen Lu, George F. Gao	2023	2

About Defen Lu

Defen Lu is a scholar working on Molecular Biology, Infectious Diseases, Immunology, Endocrinology and Molecular Medicine, having authored 22 papers that have together received 834 indexed citations. Recurring topics across this work include interferon and immune responses (7 papers), Vibrio bacteria research studies (5 papers), Viral Infections and Vectors (5 papers), Escherichia coli research studies (4 papers), Antibiotic Resistance in Bacteria (4 papers), Ubiquitin and proteasome pathways (4 papers), Immune Response and Inflammation (2 papers) and RNA modifications and cancer (2 papers). The work is most often cited by research in Immunology (456 citations), Endocrinology (89 citations), Infectious Diseases (235 citations), Molecular Medicine (44 citations) and Molecular Biology (518 citations). Defen Lu has collaborated with scholars based in China, United States and Pakistan. Frequent co-authors include Guijun Shang, Xuewu Zhang, Xiao‐chen Bai, Lichuan Gu, Deyu Zhu, Sujuan Xu, Qian Yu, Yanyu Zhao, Chunyuan Zhu and Jie Li. Their work appears in journals such as Journal of Biological Chemistry, Nature Communications, Virus Research, Molecular Microbiology and Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.

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