Defen Lu

1.2k total citations
22 papers, 834 citations indexed

About

Defen Lu is a scholar working on Molecular Biology, Infectious Diseases and Immunology. According to data from OpenAlex, Defen Lu has authored 22 papers receiving a total of 834 indexed citations (citations by other indexed papers that have themselves been cited), including 10 papers in Molecular Biology, 7 papers in Infectious Diseases and 7 papers in Immunology. Recurrent topics in Defen Lu's work include interferon and immune responses (7 papers), Vibrio bacteria research studies (5 papers) and Viral Infections and Vectors (5 papers). Defen Lu is often cited by papers focused on interferon and immune responses (7 papers), Vibrio bacteria research studies (5 papers) and Viral Infections and Vectors (5 papers). Defen Lu collaborates with scholars based in China, United States and Pakistan. Defen Lu's co-authors include Guijun Shang, Xuewu Zhang, Xiao‐chen Bai, Deyu Zhu, Sujuan Xu, Lichuan Gu, Qian Yu, Yanyu Zhao, Jie Li and Chunyuan Zhu and has published in prestigious journals such as Nature, Journal of Biological Chemistry and Nature Communications.

In The Last Decade

Defen Lu

20 papers receiving 826 citations

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Defen Lu China 15 518 456 235 89 74 22 834
Nikolay Burnaevskiy United States 8 408 0.8× 495 1.1× 253 1.1× 58 0.7× 53 0.7× 10 793
Lucien Cabanié France 11 332 0.6× 242 0.5× 122 0.5× 70 0.8× 49 0.7× 14 738
L.Vincent Collins Australia 9 469 0.9× 399 0.9× 96 0.4× 59 0.7× 68 0.9× 9 991
Kessler McCoy-Simandle United States 8 329 0.6× 134 0.3× 110 0.5× 111 1.2× 36 0.5× 11 567
Maxime Wéry France 21 807 1.6× 161 0.4× 46 0.2× 102 1.1× 97 1.3× 44 1.1k
Varadharajan Sundaramurthy India 12 255 0.5× 178 0.4× 198 0.8× 29 0.3× 37 0.5× 21 679
James R. Birtley United Kingdom 15 449 0.9× 180 0.4× 155 0.7× 28 0.3× 188 2.5× 24 1.0k
Jens Eriksson Sweden 15 258 0.5× 78 0.2× 70 0.3× 76 0.9× 24 0.3× 36 531
Angela Rodgers United Kingdom 17 330 0.6× 277 0.6× 259 1.1× 18 0.2× 24 0.3× 22 837
William W. Hwang United States 6 662 1.3× 115 0.3× 319 1.4× 35 0.4× 56 0.8× 6 998

Countries citing papers authored by Defen Lu

Since Specialization
Citations

This map shows the geographic impact of Defen Lu's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Defen Lu with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Defen Lu more than expected).

Fields of papers citing papers by Defen Lu

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Defen Lu. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Defen Lu. The network helps show where Defen Lu may publish in the future.

Co-authorship network of co-authors of Defen Lu

This figure shows the co-authorship network connecting the top 25 collaborators of Defen Lu. A scholar is included among the top collaborators of Defen Lu based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Defen Lu. Defen Lu is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Qi, Ruxi, et al.. (2026). Molecular mechanism of phosphate import by the bacterial PstSCAB transporter. Nature Communications. 17(1).
2.
Zhang, Mengyuan, Changxin Wu, Defen Lu, Xing Wang, & Guijun Shang. (2025). cGAS-STING: mechanisms and therapeutic opportunities. Science China Life Sciences. 68(5). 1309–1323. 5 indexed citations
3.
Liu, Yu, Xiaoxiong Li, Zhichao Zhang, et al.. (2025). Evaluation of IgG binding capability to SARS-CoV-2 variants in early COVID-19 convalescent sera using an indirect ELISA. Virus Research. 352. 199520–199520.
4.
Zhang, Zhichao, et al.. (2024). A conserved ion channel function of STING mediates noncanonical autophagy and cell death. EMBO Reports. 25(2). 544–569. 41 indexed citations
5.
Xie, Yufeng, Xiaoxiong Li, Jianxun Qi, et al.. (2023). Structural plasticity of human leptin binding to its receptor LepR. 1(2). 115–123. 2 indexed citations
6.
Liu, Shun, Yan Yin, Defen Lu, et al.. (2023). Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold. Science Advances. 9(14). eadf5583–eadf5583. 7 indexed citations
7.
Lu, Defen, Guijun Shang, Jie Li, et al.. (2022). Activation of STING by targeting a pocket in the transmembrane domain. Nature. 604(7906). 557–562. 116 indexed citations
8.
Xie, Yufeng, Uzma Jabeen, Defen Lu, et al.. (2022). Activation of STING Based on Its Structural Features. Frontiers in Immunology. 13. 808607–808607. 24 indexed citations
9.
Lu, Defen, Guijun Shang, Xiaojing He, Xiao‐chen Bai, & Xuewu Zhang. (2021). Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex. Nature Communications. 12(1). 3172–3172. 35 indexed citations
10.
Chen, Hua, et al.. (2020). Structural and Functional Analyses of the FAM46C/Plk4 Complex. Structure. 28(8). 910–921.e4. 11 indexed citations
11.
Cong, Xiaoyan, Yijun Du, Bo Wu, et al.. (2019). Crystal structures of porcine STINGCBD–CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins. Journal of Biological Chemistry. 294(30). 11420–11432. 25 indexed citations
12.
Shang, Guijun, Chad A. Brautigam, Rui Chen, et al.. (2017). Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex. eLife. 6. 39 indexed citations
13.
Lu, Defen, Youshi Zheng, Naishun Liao, et al.. (2014). The structural basis of the Tle4–Tli4 complex reveals the self-protection mechanism of H2-T6SS inPseudomonas aeruginosa. Acta Crystallographica Section D Biological Crystallography. 70(12). 3233–3243. 25 indexed citations
14.
Zhu, Deyu, Lijun Wang, Guijun Shang, et al.. (2014). Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates. Molecular Cell. 55(6). 931–937. 56 indexed citations
15.
Lu, Defen, Baichun Jiang, Yan Wang, et al.. (2013). X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1832(5). 595–605. 20 indexed citations
16.
Lu, Defen, Guijun Shang, Qian Yu, et al.. (2013). Expression, purification and preliminary crystallographic analysis of the T6SS effector protein Tse3 fromPseudomonas aeruginosa. Acta Crystallographica Section F Structural Biology and Crystallization Communications. 69(5). 524–527. 4 indexed citations
17.
Cheng, Wei, Kun Yin, Defen Lu, et al.. (2012). Structural Insights into a Unique Legionella pneumophila Effector LidA Recognizing Both GDP and GTP Bound Rab1 in Their Active State. PLoS Pathogens. 8(3). e1002528–e1002528. 37 indexed citations
18.
Shang, Guijun, Deyu Zhu, Ning Li, et al.. (2012). Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP. Nature Structural & Molecular Biology. 19(7). 725–727. 189 indexed citations
19.
Li, Xi, Defen Lu, Haibin Zhou, et al.. (2011). Cullin 4B Protein Ubiquitin Ligase Targets Peroxiredoxin III for Degradation. Journal of Biological Chemistry. 286(37). 32344–32354. 45 indexed citations
20.
Zou, Yongxin, Jun Mi, Defen Lu, et al.. (2009). Characterization of Nuclear Localization Signal in the N Terminus of CUL4B and Its Essential Role in Cyclin E Degradation and Cell Cycle Progression. Journal of Biological Chemistry. 284(48). 33320–33332. 102 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Nikolay Burnaevskiy Breakdown of academic impact, for papers by Lucien Cabanié Breakdown of academic impact, for papers by L.Vincent Collins Breakdown of academic impact, for papers by Kessler McCoy-Simandle Breakdown of academic impact, for papers by Maxime Wéry Breakdown of academic impact, for papers by Varadharajan Sundaramurthy Breakdown of academic impact, for papers by James R. Birtley Breakdown of academic impact, for papers by Jens Eriksson Breakdown of academic impact, for papers by Angela Rodgers Breakdown of academic impact, for papers by William W. Hwang
Rankless by CCL
2026