Debra F. Higgins

2.7k citations

18 papers · 2.3k indexed · 1 hit paper · h-index 16

Molecular Biology top 10%
Cancer Research top 2%
Nephrology top 1%
Pulmonary and Respiratory Medicine top 10%
Surgery

Co-authors: Volker H. Haase Randall S. Johnson Yasuhiro Akai Kuniko Kimura Masayuki Iwano Matthias Kretzler Wanja M. Bernhardt Kai-Uwe Eckardt
Topics: Cancer, Hypoxia, and Metabolism (7 papers)Renal and related cancers (4 papers)Connective Tissue Growth Factor Research (3 papers)
Cited by: Nephrology Cancer Research Biochemistry
Journals: Journal of Clinical Investigation Molecular and Cellular Biology Development
Partner nations: Ireland United States United Kingdom

In The Last Decade

Debra F. Higgins

18 papers receiving 2.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

2007 828 citations Debra F. Higgins, Kuniko Kimura et al. Journal of Clinical Investigation profile →

Peers

Countries citing papers authored by Debra F. Higgins

Since Specialization

Citations

This map shows the geographic impact of Debra F. Higgins's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Debra F. Higgins with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Debra F. Higgins more than expected).

Fields of papers citing papers by Debra F. Higgins

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Debra F. Higgins. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Debra F. Higgins. The network helps show where Debra F. Higgins may publish in the future.

Co-authorship network of co-authors of Debra F. Higgins

This figure shows the co-authorship network connecting the top 25 collaborators of Debra F. Higgins. A scholar is included among the top collaborators of Debra F. Higgins based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Debra F. Higgins. Debra F. Higgins is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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18 of 18 papers shown

#	Work	Indexed citations
1	Development, Validation, and Clinical Utility of a Six-gene Signature to Predict Aggressive Prostate Cancer 2023 ·European Urology Focus ·Agnieszka Krzyzanowska,Stephen Barron,Debra F. Higgins,Tony Loughman,Amanda O’Neill,Katherine M. Sheehan,(unknown),(unknown),(unknown),Joanna Fay,Anthony O’Grady,(unknown),R. William G. Watson,Anders Bjartell,William M. Gallagher	1
2	Future of biomarker evaluation in the realm of artificial intelligence algorithms: application in improved therapeutic stratification of patients with breast and prostate cancer 2021 ·Journal of Clinical Pathology ·(unknown),Debra F. Higgins,Claudia Mazo,William Watson,Catherine Mooney,Arman Rahman,(unknown),A. Connolly,Claudia Aura Gonzalez,William M. Gallagher	27
3	Profibrotic IHG-1 complexes with renal disease associated HSPA5 and TRAP1 in mitochondria 2017 ·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ·(unknown),Brenda Walker Griffin,Eoin Brennan,(unknown),Debra F. Higgins,Madeline Murphy	12
4	BMP7-induced-Pten inhibits Akt and prevents renal fibrosis 2017 ·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ·Debra F. Higgins,(unknown),(unknown),(unknown),(unknown),Marco Prunotto,(unknown),Karin Conde‐Knape,Finian Martin,Catherine Godson	57
5	Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis 2016 ·American Journal of Physiology-Renal Physiology ·(unknown),Darrell Andrews,Martin Parsons,Mary Murphy,(unknown),David Kavanagh,Gareth J. McKay,Alexander P. Maxwell,Cormac T. Taylor,Eoin P. Cummins,Catherine Godson,Debra F. Higgins,Paula Murphy,John Crean	24
6	Hypoxia promotes production of neural crest cells in the embryonic head 2016 ·Development ·Deirdre Scully,(unknown),(unknown),(unknown),Debra F. Higgins,Nobue Itasaki	33
7	IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses 2013 ·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·(unknown),(unknown),Brenda Walker Griffin,(unknown),(unknown),Emma Börgeson,Fionnuala B. Hickey,Neil G. Docherty,Debra F. Higgins,Fiona Furlong,Finian Martin,Catherine Godson,Madeline Murphy	17
8	Lipoxins Attenuate Renal Fibrosis by Inducing let-7c and Suppressing TGFβR1 2013 ·Journal of the American Society of Nephrology ·Eoin Brennan,Karen A. Nolan,Emma Börgeson,(unknown),Caitríona M. McEvoy,Neil G. Docherty,Debra F. Higgins,Madeline Murphy,Denise M. Sadlier,Syed Tasadaque Ali Shah,Patrick J. Guiry,David A. Savage,Alexander P. Maxwell,Finian Martin,Catherine Godson	138
9	Lipoxin A ₄ attenuates adipose inflammation 2012 ·The FASEB Journal ·Emma Börgeson,Fiona C. McGillicuddy,Karen A. Harford,Niamh Corrigan,Debra F. Higgins,P. Maderna,Helen M. Roche,Catherine Godson	88
10	Lipoxin A ₄ and benzo‐lipoxin A ₄ attenuate experimental renal fibrosis 2011 ·The FASEB Journal ·Emma Börgeson,Neil G. Docherty,Madeline Murphy,(unknown),(unknown),Timothy P. O’Sullivan,Patrick J. Guiry,Roel Goldschmeding,Debra F. Higgins,Catherine Godson	94
11	Stable expression of HIF-1α in tubular epithelial cells promotes interstitial fibrosis 2008 ·American Journal of Physiology-Renal Physiology ·Kuniko Kimura,Masayuki Iwano,Debra F. Higgins,Yukinari Yamaguchi,Kimihiko Nakatani,Koji Harada,Atsushi Kubo,Yasuhiro Akai,Erinn B. Rankin,Eric G. Neilson,Volker H. Haase,Yoshihiko Saito	228
12	Hypoxia-inducible factor signaling in the development of tissue fibrosis 2008 ·Cell Cycle ·Debra F. Higgins,Kuniko Kimura,Masayuki Iwano,Volker H. Haase	157
13	Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transitionbreakdown → 2007 ·Journal of Clinical Investigation ·Debra F. Higgins,Kuniko Kimura,Wanja M. Bernhardt,(unknown),Yasuhiro Akai,Bernd Hohenstein,Yoshihiko Saito,Randall S. Johnson,Matthias Kretzler,Clemens D. Cohen,Kai-Uwe Eckardt,Masayuki Iwano,Volker H. Haase	828
14	Inactivation of the Arylhydrocarbon Receptor Nuclear Translocator (Arnt) Suppresses von Hippel-Lindau Disease-Associated Vascular Tumors in Mice 2005 ·Molecular and Cellular Biology ·Erinn B. Rankin,Debra F. Higgins,Jacqueline A. Walisser,Randall S. Johnson,Christopher A. Bradfield,Volker H. Haase	122
15	Hypoxic induction ofCtgfis directly mediated by Hif-1 2004 ·American Journal of Physiology-Renal Physiology ·Debra F. Higgins,Mangatt P. Biju,Yasuhiro Akai,Anton Wutz,Randall S. Johnson,Volker H. Haase	238
16	Mechanical Deformation Induced Apoptosis in Human Proximal Renal Tubular Epithelial Cells is Caspase Dependent 2004 ·The Journal of Urology ·Richard Power,(unknown),Debra F. Higgins,Hugh R. Brady,John M. Fitzpatrick,R. William G. Watson	36
17	Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog 2003 ·Kidney International ·Niamh E. Kieran,Peter Doran,Susan Connolly,(unknown),Debra F. Higgins,Martin O. Leonard,Catherine Godson,Cormac T. Taylor,Anna Henger,Matthias Kretzler,Melissa J. Burne,Hamid Rabb,Hugh R. Brady	129
18	DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): Modulation during epithelial-mesenchymal transition 2003 ·Kidney International ·Debra F. Higgins,David Lappin,Niamh E. Kieran,Hans‐Joachim Anders,R. William G. Watson,Frank Strutz,Detlef Schlöndorff,Volker H. Haase,John M. Fitzpatrick,Catherine Godson,Hugh R. Brady	43

About Debra F. Higgins

Debra F. Higgins is a scholar working on Nephrology, Cancer Research and Molecular Biology, having authored 18 papers that have together received 2.3k indexed citations. Recurring topics across this work include Cancer, Hypoxia, and Metabolism (7 papers), Renal and related cancers (4 papers) and Connective Tissue Growth Factor Research (3 papers). The work is most often cited by research in Nephrology (430 citations), Cancer Research (771 citations) and Biochemistry (164 citations). Debra F. Higgins has collaborated with scholars based in Ireland, United States and United Kingdom. Frequent co-authors include Volker H. Haase, Randall S. Johnson, Yasuhiro Akai, Kuniko Kimura, Masayuki Iwano, Matthias Kretzler, Wanja M. Bernhardt, Kai-Uwe Eckardt, Clemens D. Cohen and Bernd Hohenstein. Their work appears in journals such as Journal of Clinical Investigation, Molecular and Cellular Biology and Development.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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