Daryl E. Klein

2.2k citations

21 papers · 1.3k indexed · h-index 14

Impact in

Cell Biology top 2%
- Cellular transport and secretion
Molecular Biology top 10%
- Protein Kinase Regulation and GTPase Signaling
- Lipid Membrane Structure and Behavior
- Glycosylation and Glycoproteins Research

Papers in ⓘ

Molecular Biology 13
- Protein Degradation and Inhibitors 2
- Receptor Mechanisms and Signaling 2
- Protein Kinase Regulation and GTPase Signaling 2
- RNA modifications and cancer 2
Oncology 6
- HER2/EGFR in Cancer Research 6

Co-authors: Mark A. Lemmon (11 shared papers)Anthony Lee (2 shared papers)Diego Alvarado (4 shared papers)Marco Falasca (1 shared paper)Jennifer M. Kavran (1 shared paper)Edward Y. Skolnik (1 shared paper)Steven J. Isakoff (1 shared paper)Stephen C. Harrison (2 shared papers)
Journals: Nature (4 papers)Molecular Cell (2 papers)Journal of Biological Chemistry (2 papers)Nature Communications (1 paper)Science Advances (1 paper)
Partner nations: United States Germany China

In The Last Decade

Daryl E. Klein

19 papers receiving 1.3k citations

Peers

Countries citing papers authored by Daryl E. Klein

Since Specialization

Citations

This map shows the geographic impact of Daryl E. Klein's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Daryl E. Klein with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Daryl E. Klein more than expected).

Fields of papers citing papers by Daryl E. Klein

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Daryl E. Klein. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Daryl E. Klein. The network helps show where Daryl E. Klein may publish in the future.

Co-authors

The 25 scholars most cited alongside Daryl E. Klein, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Daryl E. Klein Line = papers co-authored together Daryl E. Klein links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 21 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains Journal of Biological Chemistry ·Jennifer M. Kavran, Daryl E. Klein, Anthony Lee, Marco Falasca, Steven J. Isakoff, Edward Y. Skolnik, Mark A. Lemmon	1998	374
2	The Pleckstrin Homology Domains of Dynamin Isoforms Require Oligomerization for High Affinity Phosphoinositide Binding Journal of Biological Chemistry ·Daryl E. Klein, Anthony Lee, David W. Frank, Michael S. Marks, Mark A. Lemmon	1998	168
3	Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor Cell ·Diego Alvarado, Daryl E. Klein, Mark A. Lemmon	2010	143
4	Argos inhibits epidermal growth factor receptor signalling by ligand sequestration Nature ·Daryl E. Klein, Valerie M. Nappi, Gregory T. Reeves, Stanislav Y. Shvartsman, Mark A. Lemmon	2004	115
5	Structure of a Dengue Virus Envelope Protein Late-Stage Fusion Intermediate Journal of Virology ·Daryl E. Klein, Jason Choi, Stephen C. Harrison	2012	112
6	High-Affinity Binding of a FYVE Domain to Phosphatidylinositol 3-Phosphate Requires Intact Phospholipid but Not FYVE Domain Oligomerization Biochemistry ·Vijay G. Sankaran, Daryl E. Klein, Mira M. Sachdeva, Mark A. Lemmon	2001	71
7	Sequential conformational rearrangements in flavivirus membrane fusion eLife ·Luke H. Chao, Daryl E. Klein, Aaron G. Schmidt, Jennifer M Peña, Stephen C. Harrison	2014	66
8	ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor Nature ·Diego Alvarado, Daryl E. Klein, Mark A. Lemmon	2009	64
9	Structural basis for EGFR ligand sequestration by Argos Nature ·Daryl E. Klein, Steven E. Stayrook, Fumin Shi, Kartik Narayan, Mark A. Lemmon	2008	42
10	Kinetics of receptor tyrosine kinase activation define ERK signaling dynamics Science Signaling ·Anatoly Kiyatkin, Iris K. van Alderwerelt van Rosenburgh, Daryl E. Klein, Mark A. Lemmon	2020	42
11	Computational analysis of EGFR inhibition by Argos Developmental Biology ·Gregory T. Reeves, Rachel Kalifa, Daryl E. Klein, Mark A. Lemmon, Stanislav Y. Shvartsman	2005	36
12	Structural basis for ligand reception by anaplastic lymphoma kinase Nature ·Tongqing Li, Steven E. Stayrook, Yuko Tsutsui, Jianan Zhang, Yueyue Wang, Hengyi Li, Andrew Proffitt, S.G. Krimmer, Mansoor Ahmed, Olivia Belliveau, Ian X. Walker, Krishna C. Mudumbi, Yoshihisa Suzuki, Irit Lax, Diego Alvarado, Mark A. Lemmon, Joseph Schlessinger, Daryl E. Klein	2021	22
13	Infantile Myelofibrosis and Myeloproliferation with CDC42Dysfunction Journal of Clinical Immunology ·Jeffrey M. Verboon, Dilnar Mahmut, Ah Ram Kim, Mitsutoshi Nakamura, Nour J. Abdulhay, Satish K. Nandakumar, Namrata Gupta, Thomas E. Akie, Amy E. Geddis, Becky Manes, Meghan Kapp, Inga Hofmann, Stacey Gabriel, Daryl E. Klein, David A. Williams, Haydar Frangoul, Susan M. Parkhurst, Genevieve M. Crane, Alan Cantor, Vijay G. Sankaran	2020	20
14	7SK methylation by METTL3 promotes transcriptional activity Science Advances ·Marcelo Pérez-Pepe, Anthony W. Desotell, Hengyi Li, Wenxue Li, Bing Han, Qishan Lin, Daryl E. Klein, Yansheng Liu, Hani Goodarzi, Claudio R. Alarcón	2023	14
15	Structural Basis of Neurohormone Perception by the Receptor Tyrosine Kinase Torso Molecular Cell ·Simon Jenni, Yogesh Goyal, Marcin von Grotthuss, Stanislav Y. Shvartsman, Daryl E. Klein	2015	11
16	The monomer of the yeast transcriptional activator GCN4 recognizes its dimer binding DNA target sites without dimerization Thermochimica Acta ·Wei Cao, Liang Liu, Daryl E. Klein, Linyi Wei, Luhua Lai	2000	4
17	Discovery of the First Pathogenic Human EPO Mutation Provides Mechanistic Insight into Cytokine Signaling Blood ·Ah Ram Kim, Jacob C. Ulirsch, Stephan Wilmes, Ekrem Ünal, Ignacio Moraga, Musa Karakükçü, Daniel Yuan, Shideh Kazerounian, Namrata Gupta, Stacey Gabriel, Eric S. Lander, Türkan Patıroğlu, Alper Özcan, Mehmet Akif Özdemir, K. Christopher García, Jacob Piehler, Hanna T. Gazda, Daryl E. Klein, Vijay G. Sankaran	2016	2
18	GABAA receptor π forms channels that stimulate ERK through a G-protein-dependent pathway Molecular Cell ·Yueyue Wang, Yalan Zhang, Wenxue Li, Barbora Šalovská, Jianan Zhang, Tongqing Li, Hengyi Li, Yansheng Liu, Leonard K. Kaczmarek, Lajos Pusztai, Daryl E. Klein	2024	1
19	RAMIHM generates fully human monoclonal antibodies by rapid mRNA immunization of humanized mice and BCR-seq Cell chemical biology ·Ping Ren, Lei Peng, Luojia Yang, Kazushi Suzuki, Zhenhao Fang, Paul Renauer, Qianqian Lin, Meizhu Bai, Tongqing Li, Paul Clark, Daryl E. Klein, Sidi Chen	2023	1
20	ErbB2/HER2/Neu resembles an autoinhibited invertebrate EGF receptor The FASEB Journal ·Diego Alvarado, Daryl E. Klein, Mark A. Lemmon	2009	0

About Daryl E. Klein

Daryl E. Klein is a scholar working on Molecular Biology, Oncology, Radiology, Nuclear Medicine and Imaging, Cell Biology and Infectious Diseases, having authored 21 papers that have together received 1.3k indexed citations. Recurring topics across this work include HER2/EGFR in Cancer Research (6 papers), Monoclonal and Polyclonal Antibodies Research (4 papers), Cellular transport and secretion (3 papers), Protein Degradation and Inhibitors (2 papers), Bioactive Compounds and Antitumor Agents (2 papers), Receptor Mechanisms and Signaling (2 papers), Protein Kinase Regulation and GTPase Signaling (2 papers) and RNA modifications and cancer (2 papers). The work is most often cited by research in Cell Biology (507 citations), Molecular Biology (891 citations), Aging (15 citations), Physiology (38 citations) and Immunology and Allergy (48 citations). Daryl E. Klein has collaborated with scholars based in United States, Germany and China. Frequent co-authors include Mark A. Lemmon, Anthony Lee, Diego Alvarado, Marco Falasca, Jennifer M. Kavran, Edward Y. Skolnik, Steven J. Isakoff, Stephen C. Harrison, Jason Choi and Michael S. Marks. Their work appears in journals such as Nature, Molecular Cell, Journal of Biological Chemistry, Nature Communications and Science Advances.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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