Daniel J. Siegwart

16.2k total citations · 14 hit papers
98 papers, 12.1k citations indexed

About

Daniel J. Siegwart is a scholar working on Molecular Biology, Organic Chemistry and Genetics. According to data from OpenAlex, Daniel J. Siegwart has authored 98 papers receiving a total of 12.1k indexed citations (citations by other indexed papers that have themselves been cited), including 65 papers in Molecular Biology, 19 papers in Organic Chemistry and 17 papers in Genetics. Recurrent topics in Daniel J. Siegwart's work include RNA Interference and Gene Delivery (53 papers), Advanced biosensing and bioanalysis techniques (34 papers) and Advanced Polymer Synthesis and Characterization (17 papers). Daniel J. Siegwart is often cited by papers focused on RNA Interference and Gene Delivery (53 papers), Advanced biosensing and bioanalysis techniques (34 papers) and Advanced Polymer Synthesis and Characterization (17 papers). Daniel J. Siegwart collaborates with scholars based in United States, China and Japan. Daniel J. Siegwart's co-authors include Qiang Cheng, Sean A. Dilliard, Krzysztof Matyjaszewski, Jung Kwon Oh, Tuo Wei, Lukas Farbiak, Lindsay T. Johnson, Ray Drumright, Daniel G. Anderson and Hu Xiong and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

Daniel J. Siegwart

93 papers receiving 11.9k citations

Hit Papers

Selective organ targeting (... 2008 2026 2014 2020 2020 2008 2021 2011 2021 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing
    2020 1.6k citations Qiang Cheng, Tuo Wei et al. profile →
  2. The development of microgels/nanogels for drug delivery applications
    2008 1.3k citations Jung Kwon Oh, Daniel J. Siegwart et al. Progress in Polymer Science profile →
  3. On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles
    2021 655 citations Sean A. Dilliard, Qiang Cheng et al. Proceedings of the National Academy of Sciences profile →
  4. ATRP in the design of functional materials for biomedical applications
    2011 506 citations Daniel J. Siegwart, Jung Kwon Oh et al. Progress in Polymer Science profile →
  5. Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing
    2021 483 citations Shuai Liu, Qiang Cheng et al. Nature Materials profile →
  6. Strategies, design, and chemistry in siRNA delivery systems
    2019 456 citations Yizhou Dong, Daniel J. Siegwart et al. profile →
  7. Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
    2020 448 citations Tuo Wei, Qiang Cheng et al. Nature Communications profile →
  8. Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA
    2016 447 citations Jason B. Miller, Shuyuan Zhang et al. Angewandte Chemie International Edition profile →
  9. Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs
    2023 413 citations Sean A. Dilliard, Daniel J. Siegwart Nature Reviews Materials profile →
  10. Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery
    2022 328 citations Xu Wang, Shuai Liu et al. profile →
  11. Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy
    2022 183 citations Xueliang Yu, Tuo Wei et al. profile →
  12. Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models
    2023 103 citations Tuo Wei, Yehui Sun et al. Nature Communications profile →
  13. The interplay of quaternary ammonium lipid structure and protein corona on lung-specific mRNA delivery by selective organ targeting (SORT) nanoparticles
    2023 85 citations Sean A. Dilliard, Yehui Sun et al. Journal of Controlled Release profile →
  14. High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics
    2025 21 citations Yufen Xiao, Xizhen Lian et al. Nature Materials profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Daniel J. Siegwart United States 51 7.3k 2.6k 2.2k 1.8k 1.4k 98 12.1k
David Oupický United States 54 5.1k 0.7× 2.2k 0.8× 2.2k 1.0× 1.1k 0.6× 1.3k 0.9× 195 8.9k
Niren Murthy United States 54 5.2k 0.7× 2.1k 0.8× 2.8k 1.3× 1.2k 0.6× 850 0.6× 142 11.9k
Suzie H. Pun United States 57 7.5k 1.0× 2.8k 1.1× 3.0k 1.3× 1.0k 0.6× 1.7k 1.2× 168 12.2k
Lichen Yin China 56 5.3k 0.7× 4.5k 1.7× 3.5k 1.6× 1.9k 1.0× 518 0.4× 195 11.6k
Chong‐Su Cho South Korea 52 4.1k 0.6× 3.2k 1.2× 2.1k 0.9× 838 0.5× 1.0k 0.8× 273 9.4k
Kanjiro Miyata Japan 58 7.2k 1.0× 4.2k 1.6× 2.7k 1.2× 1.8k 1.0× 1.1k 0.8× 152 11.0k
Ji Hoon Jeong South Korea 55 4.7k 0.6× 2.2k 0.8× 2.2k 1.0× 598 0.3× 978 0.7× 183 9.0k
Huayu Tian China 57 4.1k 0.6× 3.8k 1.5× 5.0k 2.3× 1.1k 0.6× 723 0.5× 252 10.9k
Yiyun Cheng China 60 6.3k 0.9× 3.6k 1.4× 5.1k 2.3× 1.7k 0.9× 623 0.5× 223 14.0k
Hamidreza Ghandehari United States 62 5.1k 0.7× 6.0k 2.3× 3.7k 1.7× 927 0.5× 743 0.5× 210 12.8k

Countries citing papers authored by Daniel J. Siegwart

Since Specialization
Citations

This map shows the geographic impact of Daniel J. Siegwart's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Daniel J. Siegwart with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Daniel J. Siegwart more than expected).

Fields of papers citing papers by Daniel J. Siegwart

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Daniel J. Siegwart. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Daniel J. Siegwart. The network helps show where Daniel J. Siegwart may publish in the future.

Co-authorship network of co-authors of Daniel J. Siegwart

This figure shows the co-authorship network connecting the top 25 collaborators of Daniel J. Siegwart. A scholar is included among the top collaborators of Daniel J. Siegwart based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Daniel J. Siegwart. Daniel J. Siegwart is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
2.
Xiao, Yufen, Xizhen Lian, Yehui Sun, et al.. (2025). High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics. Nature Materials. 24(11). 1840–1851. 21 indexed citations breakdown →
3.
Lin, Lixin, Kexin Su, Xinyue Zhang, et al.. (2025). A Versatile Strategy to Transform Cationic Polymers for Efficient and Organ‐Selective mRNA Delivery. Angewandte Chemie International Edition. 64(17). e202500306–e202500306. 9 indexed citations
4.
Lin, Lixin, Kexin Su, Xinyue Zhang, et al.. (2025). A Versatile Strategy to Transform Cationic Polymers for Efficient and Organ‐Selective mRNA Delivery. Angewandte Chemie. 137(17).
5.
Dilliard, Sean A., Yehui Sun, Yun‐Chieh Sung, et al.. (2023). The interplay of quaternary ammonium lipid structure and protein corona on lung-specific mRNA delivery by selective organ targeting (SORT) nanoparticles. Journal of Controlled Release. 361. 361–372. 85 indexed citations breakdown →
6.
Chen, Shuying, Xiangang Huang, Yonger Xue, et al.. (2023). Nanotechnology-based mRNA vaccines. Nature Reviews Methods Primers. 3(1). 98 indexed citations
7.
Cheng, Qiang, Lukas Farbiak, Amogh Vaidya, et al.. (2023). In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma. Proceedings of the National Academy of Sciences. 120(52). e2313009120–e2313009120. 11 indexed citations
8.
Lin, Yu-Hsuan, Yuemeng Jia, Zixi Wang, et al.. (2023). In vivo screening identifies SPP2, a secreted factor that negatively regulates liver regeneration. Hepatology. 78(4). 1133–1148. 4 indexed citations
9.
Álvarez‐Benedicto, Ester, Zeru Tian, Sumanta Chatterjee, et al.. (2023). Spleen SORT LNP Generated in situ CAR T Cells Extend Survival in a Mouse Model of Lymphoreplete B Cell Lymphoma. Angewandte Chemie International Edition. 62(44). e202310395–e202310395. 80 indexed citations
10.
Álvarez‐Benedicto, Ester, Zeru Tian, Sumanta Chatterjee, et al.. (2023). Spleen SORT LNP Generated in situ CAR T Cells Extend Survival in a Mouse Model of Lymphoreplete B Cell Lymphoma. Angewandte Chemie. 135(44). 12 indexed citations
11.
Dilliard, Sean A. & Daniel J. Siegwart. (2023). Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs. Nature Reviews Materials. 8(4). 282–300. 413 indexed citations breakdown →
12.
Wei, Tuo, Yehui Sun, Qiang Cheng, et al.. (2023). Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models. Nature Communications. 14(1). 7322–7322. 103 indexed citations breakdown →
13.
Jia, Yuemeng, Lin Li, Yu-Hsuan Lin, et al.. (2022). In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration. Cell stem cell. 29(3). 372–385.e8. 35 indexed citations
14.
Miller, Jason B., Shuyuan Zhang, Petra Kós, et al.. (2016). Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA. Angewandte Chemie International Edition. 56(4). 1059–1063. 447 indexed citations breakdown →
15.
Miller, Jason B., Shuyuan Zhang, Petra Kós, et al.. (2016). Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA. Angewandte Chemie. 129(4). 1079–1083. 60 indexed citations
16.
Hao, Jing, Petra Kós, Ke‐Jin Zhou, et al.. (2015). Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery. Journal of the American Chemical Society. 137(29). 9206–9209. 97 indexed citations
17.
Eltoukhy, Ahmed A., et al.. (2012). Effect of molecular weight of amine end-modified poly(β-amino ester)s on gene delivery efficiency and toxicity. Biomaterials. 33(13). 3594–3603. 142 indexed citations
18.
Siegwart, Daniel J., Jung Kwon Oh, & Krzysztof Matyjaszewski. (2011). ATRP in the design of functional materials for biomedical applications. Progress in Polymer Science. 37(1). 18–37. 506 indexed citations breakdown →
19.
Ma, Minglin, Wendy F. Liu, Paulina S. Hill, et al.. (2011). Development of Cationic Polymer Coatings to Regulate Foreign‐Body Responses. Advanced Materials. 23(24). H189–94. 50 indexed citations
20.
Bencherif, Sidi A., Daniel J. Siegwart, Abiraman Srinivasan, et al.. (2009). Nanostructured hybrid hydrogels prepared by a combination of atom transfer radical polymerization and free radical polymerization. Biomaterials. 30(29). 5270–5278. 110 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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