Christopher D. Heinen

3.1k total citations · 2 hit papers
39 papers, 2.1k citations indexed

About

Christopher D. Heinen is a scholar working on Pathology and Forensic Medicine, Molecular Biology and Oncology. According to data from OpenAlex, Christopher D. Heinen has authored 39 papers receiving a total of 2.1k indexed citations (citations by other indexed papers that have themselves been cited), including 29 papers in Pathology and Forensic Medicine, 24 papers in Molecular Biology and 16 papers in Oncology. Recurrent topics in Christopher D. Heinen's work include Genetic factors in colorectal cancer (29 papers), DNA Repair Mechanisms (12 papers) and Cancer Genomics and Diagnostics (12 papers). Christopher D. Heinen is often cited by papers focused on Genetic factors in colorectal cancer (29 papers), DNA Repair Mechanisms (12 papers) and Cancer Genomics and Diagnostics (12 papers). Christopher D. Heinen collaborates with scholars based in United States, Denmark and United Kingdom. Christopher D. Heinen's co-authors include Carrie Snyder, Trudy G. Shaw, Henry T. Lynch, Megan P. Hitchins, Richard Fishel, Dipika Gupta, Christoph Schmütte, Joanna Groden, Adam S. Mastrocola and Daniel W. Rosenberg and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Nature Communications.

In The Last Decade

Christopher D. Heinen

38 papers receiving 2.0k citations

Hit Papers

Milestones of Lynch syndrome: 1895–2015 2015 2026 2018 2022 2015 2019 100 200 300 400 500
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Milestones of Lynch syndrome: 1895–2015
    2015 521 citations Henry T. Lynch, Carrie Snyder et al. Nature reviews. Cancer profile →
  2. Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework
    2019 310 citations Christopher D. Heinen et al. profile →

Peers

Christopher D. Heinen
Sara González Spain
Tineke van der Sluis Netherlands
Petra Platzer United States
Cristina Alenda Spain
F Kasumi Japan
Takako Kawasaki United States
Fabienne Lesueur France
Harald Blegen Sweden
Valgarður Egilsson Iceland
Masachika Tani Japan
Sara González Spain
Christopher D. Heinen
Citations per year, relative to Christopher D. Heinen Christopher D. Heinen (= 1×) peers Sara González

Countries citing papers authored by Christopher D. Heinen

Since Specialization
Citations

This map shows the geographic impact of Christopher D. Heinen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christopher D. Heinen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christopher D. Heinen more than expected).

Fields of papers citing papers by Christopher D. Heinen

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christopher D. Heinen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christopher D. Heinen. The network helps show where Christopher D. Heinen may publish in the future.

Co-authorship network of co-authors of Christopher D. Heinen

This figure shows the co-authorship network connecting the top 25 collaborators of Christopher D. Heinen. A scholar is included among the top collaborators of Christopher D. Heinen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christopher D. Heinen. Christopher D. Heinen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Szabo, Elizabeth, et al.. (2025). A Cell‐Based Functional Assay Calibrated for Analysis of MSH6 and MSH2 Mismatch Repair Gene Variants. Human Mutation. 2025(1). 3923193–3923193.
2.
Gupta, Dipika & Christopher D. Heinen. (2019). The mismatch repair-dependent DNA damage response: Mechanisms and implications. DNA repair. 78. 60–69. 78 indexed citations
3.
Taghbalout, Aziz, Menghan Du, Nathaniel Jillette, et al.. (2019). Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways. Nature Communications. 10(1). 4296–4296. 40 indexed citations
4.
Klapacz, Joanna, Lynn H. Pottenger, Bevin P. Engelward, et al.. (2015). Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents. Mutation Research/Reviews in Mutation Research. 767. 77–91. 37 indexed citations
5.
Lynch, Henry T., Carrie Snyder, Trudy G. Shaw, Christopher D. Heinen, & Megan P. Hitchins. (2015). Milestones of Lynch syndrome: 1895–2015. Nature reviews. Cancer. 15(3). 181–194. 521 indexed citations breakdown →
6.
Heinen, Christopher D.. (2015). Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer. DNA repair. 38. 127–134. 41 indexed citations
7.
Heinen, Christopher D.. (2014). Translating Mismatch Repair Mechanism into Cancer Care. Current Drug Targets. 15(1). 53–64. 13 indexed citations
8.
Heinen, Christopher D., Christopher Cook, Miho Sakato, et al.. (2011). Human MSH2 (hMSH2) Protein Controls ATP Processing by hMSH2-hMSH6. Journal of Biological Chemistry. 286(46). 40287–40295. 27 indexed citations
9.
Heinen, Christopher D., et al.. (2011). The predicted truncation from a cancer‐associated variant of the MSH2 initiation codon alters activity of the MSH2‐MSH6 mismatch repair complex. Molecular Carcinogenesis. 51(8). 647–658. 11 indexed citations
10.
Anderson, Joseph C., T. V. Rajan, Petr Protiva, et al.. (2010). Increased Frequency of Serrated Aberrant Crypt Foci Among Smokers. The American Journal of Gastroenterology. 105(7). 1648–1654. 23 indexed citations
11.
Heinen, Christopher D.. (2009). Genotype to phenotype: Analyzing the effects of inherited mutations in colorectal cancer families. Mutation research. Fundamental and molecular mechanisms of mutagenesis. 693(1-2). 32–45. 42 indexed citations
12.
Mastrocola, Adam S. & Christopher D. Heinen. (2009). Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage. DNA repair. 9(2). 120–133. 19 indexed citations
13.
Heinen, Christopher D., et al.. (2008). Hereditary Cancer-associated Missense Mutations in hMSH6 Uncouple ATP Hydrolysis from DNA Mismatch Binding. Journal of Biological Chemistry. 283(46). 31641–31648. 21 indexed citations
14.
Stevens, Richard G., Helen Swede, Christopher D. Heinen, et al.. (2006). Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer. Cancer Letters. 248(2). 262–268. 33 indexed citations
15.
Greenspan, Emily J., et al.. (2006). Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer. Carcinogenesis. 28(4). 769–776. 24 indexed citations
16.
Lins, Laurence, Benoît Charloteaux, Christopher D. Heinen, A. G. Thomas, & Robert Brasseur. (2005). “De Novo” Design of Peptides with Specific Lipid-Binding Properties. Biophysical Journal. 90(2). 470–479. 27 indexed citations
17.
Shim, Kang Sup, Christoph Schmütte, Gregory Tombline, Christopher D. Heinen, & Richard Fishel. (2004). hXRCC2 Enhances ADP/ATP Processing and Strand Exchange by hRAD51. Journal of Biological Chemistry. 279(29). 30385–30394. 42 indexed citations
18.
Heinen, Christopher D., et al.. (2002). HNPCC mutations in hMSH2 result in reduced hMSH2-hMSH6 molecular switch functions. Cancer Cell. 1(5). 469–478. 51 indexed citations
19.
Heinen, Christopher D., Christoph Schmütte, & Richard Fishel. (2002). DNA Repair and Tumorigenesis: Lessons from Hereditary Cancer Syndromes. Cancer Biology & Therapy. 1(5). 477–485. 88 indexed citations
20.
Heinen, Christopher D., Kathleen H. Goss, James Cornelius, et al.. (2002). The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway. Gastroenterology. 123(3). 751–763. 59 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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