C. Leah B. Kline

1.4k citations

25 papers · 855 indexed · h-index 16

Co-authors: Wafik S. El‐Deiry David T. Dicker Joshua E. Allen Varun V. Prabhu A. Pieter J. van den Heuvel Jessica Wagner Rosalyn Irby Marie D. Ralff
Topics: Cell death mechanisms and regulation (8 papers)Cancer-related Molecular Pathways (4 papers)Cancer, Stress, Anesthesia, and Immune Response (3 papers)
Cited by: Oncology Cancer Research Molecular Biology
Journals: Journal of Clinical Investigation Blood PLoS ONE
Partner nations: United States Ireland United Kingdom

In The Last Decade

C. Leah B. Kline

23 papers receiving 848 citations

Peers

Countries citing papers authored by C. Leah B. Kline

Since Specialization

Citations

This map shows the geographic impact of C. Leah B. Kline's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by C. Leah B. Kline with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites C. Leah B. Kline more than expected).

Fields of papers citing papers by C. Leah B. Kline

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by C. Leah B. Kline. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by C. Leah B. Kline. The network helps show where C. Leah B. Kline may publish in the future.

Co-authorship network of co-authors of C. Leah B. Kline

This figure shows the co-authorship network connecting the top 25 collaborators of C. Leah B. Kline. A scholar is included among the top collaborators of C. Leah B. Kline based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with C. Leah B. Kline. C. Leah B. Kline is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Anti-tumor effects of ONC201 in combination with VEGF-inhibitors significantly impacts colorectal cancer growth and survival in vivo through complementary non-overlapping mechanisms 2018 ·Journal of Experimental & Clinical Cancer Research ·Jessica Wagner,C. Leah B. Kline,Lanlan Zhou,Vladimir Khazak,Wafik S. El‐Deiry	29
2	Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment 2018 ·Journal of Clinical Investigation ·Jessica Wagner,C. Leah B. Kline,Lanlan Zhou,Kerry S. Campbell,Alexander W. Macfarlane,Anthony J. Olszanski,Kathy Q. Cai,Harvey H. Hensley,Eric A. Ross,Marie D. Ralff,Andrew Zloza,Charles B. Chesson,Jenna H. Newman,Howard L. Kaufman,(unknown),Mark N. Stein,Wafik S. El‐Deiry	55
3	ONC201 Demonstrates Antitumor Effects in Both Triple-Negative and Non–Triple-Negative Breast Cancers through TRAIL-Dependent and TRAIL-Independent Mechanisms 2017 ·Molecular Cancer Therapeutics ·Marie D. Ralff,C. Leah B. Kline,(unknown),Jessica Wagner,Bora Lim,David T. Dicker,Varun V. Prabhu,Wolfgang Oster,Wafik S. El‐Deiry	38
4	Role of Dopamine Receptors in the Anticancer Activity of ONC201 2017 ·Neoplasia ·C. Leah B. Kline,Marie D. Ralff,Amriti R. Lulla,Jessica Wagner,Philip H. Abbosh,David T. Dicker,Joshua E. Allen,Wafik S. El‐Deiry	94
5	Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors 2017 ·PLoS ONE ·Varun V. Prabhu,Amriti R. Lulla,Neel S. Madhukar,Marie D. Ralff,Dan Zhao,C. Leah B. Kline,A. Pieter J. van den Heuvel,Avital Lev,Mathew J. Garnett,Ultan McDermott,Cyril H. Benes,Tracy T. Batchelor,S. Andrew,Olivier Elemento,Joshua E. Allen,Wafik S. El‐Deiry	30
6	Abstract 124: Imipridone ONC201 promotes intra-tumoral accumulation of CD3+/NK+ cells that contribute to its anti-tumor efficacy 2017 ·Cancer Research ·Jessica Wagner,C. Leah B. Kline,Lanlan Zhou,Andrew Zloza,Charles B. Chesson,Jenna H. Newman,Howard L. Kaufman,Joseph Bertino,Mark N. Stein,Wafik S. El‐Deiry	0
7	Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212 2017 ·Cell Cycle ·Jessica Wagner,C. Leah B. Kline,Marie D. Ralff,Avital Lev,Amriti R. Lulla,Lanlan Zhou,Gary L. Olson,(unknown),Cyril H. Benes,Joshua E. Allen,Varun V. Prabhu,Martin Stogniew,Wolfgang Oster,Wafik S. El‐Deiry	56
8	Abstract 3000: Intra-tumoral accumulation of NK1.1/CD3+ cells and anti-metastasis effects of dose-intensified ONC201 in tumor-bearing mice 2016 ·Cancer Research ·Jessica Wagner,C. Leah B. Kline,(unknown),Wafik S. El‐Deiry	2
9	Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53 2015 ·Cancer Research ·Shengliang Zhang,Lanlan Zhou,Bo Hong,A. Pieter J. van den Heuvel,Varun V. Prabhu,Noel A. Warfel,C. Leah B. Kline,David T. Dicker,Levy Kopelovich,Wafik S. El‐Deiry	92
10	The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity 2014 ·Oncotarget ·Jessica Wagner,C. Leah B. Kline,Richard S. Pottorf,(unknown),Gary L. Olson,David T. Dicker,Joshua E. Allen,Wafik S. El‐Deiry	35
11	Small Molecule ONC201/TIC10 Induces Caspase-Dependent Apoptosis in Acute Lymphoblastic Leukemia Cells Via Modulation of Bcl-2 and IAP Family Proteins 2014 ·Blood ·Varun V. Prabhu,Amriti R. Lulla,Jessica Wagner,(unknown),Mala K. Talekar,C. Leah B. Kline,David T. Dicker,Brian M. Barth,Jeffrey J. Pu,David F. Claxton,Joshua E. Allen,Wafik S. El‐Deiry	0
12	Personalized Dosing via Pharmacokinetic Monitoring of 5-Fluorouracil Might Reduce Toxicity in Early- or Late-Stage Colorectal Cancer Patients Treated With Infusional 5–Fluorouracil-Based Chemotherapy Regimens 2013 ·Clinical Colorectal Cancer ·C. Leah B. Kline,(unknown),Junjia Zhu,(unknown),(unknown),Harold A. Harvey,Heath B. Mackley,Kevin J. McKenna,Kevin F. Staveley-O’Carroll,Lisa S. Poritz,Evangelos Messaris,David B. Stewart,Jeffrey Sivik,Wafik S. El‐Deiry	34
13	The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU 2011 ·APOPTOSIS ·C. Leah B. Kline,Rosalyn Irby	12
14	Preliminary observations indicate variable patterns of plasma 5-fluorouracil (5-FU) levels during dose optimization of infusional 5-FU in colorectal cancer patients 2011 ·Cancer Biology & Therapy ·C. Leah B. Kline,(unknown),(unknown),(unknown),(unknown),Niklas K. Finnberg,Jason Liao,Jeffrey Sivik,Wafik S. El‐Deiry	18
15	Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NFκB and microRNA network 2010 ·Molecular Cancer ·Bi‐Dar Wang,C. Leah B. Kline,Danielle M. Pastor,(unknown),Bryan Frank,Truong Luu,Arun Sharma,Gavin P. Robertson,Matthew T. Weirauch,Steven R. Patierno,Joshua M. Stuart,Rosalyn Irby,Norman H. Lee	44
16	Primary cell lines: false representation or model system? a comparison of four human colorectal tumors and their coordinately established cell lines. 2010 ·PubMed ·Danielle M. Pastor,Lisa S. Poritz,Thomas L. Olson,C. Leah B. Kline,Leonard Harris,Walter A. Koltun,Vernon M. Chinchilli,Rosalyn Irby	28
17	Delivery of PAR-4 plasmid in vivo via nanoliposomes sensitizes colon tumor cells subcutaneously implanted into nude mice to 5-FU 2009 ·Cancer Biology & Therapy ·C. Leah B. Kline,Sriram S. Shanmugavelandy,Mark Kester,Rosalyn Irby	27
18	Src kinase induces tumor formation in the c‐SRC C57BL/6 mouse 2008 ·International Journal of Cancer ·C. Leah B. Kline,Rosalind J. Jackson,Robert W. Engelman,W. J. Pledger,Timothy J. Yeatman,Rosalyn Irby	13
19	Src activity alters α3 integrin expression in colon tumor cells 2008 ·Clinical & Experimental Metastasis ·C. Leah B. Kline,Thomas L. Olson,Rosalyn Irby	8
20	Glucosamine-induced phosphorylation of the α-subunit of eukaryotic initiation factor 2 is mediated by the protein kinase R-like endoplasmic-reticulum associated kinase 2005 ·The International Journal of Biochemistry & Cell Biology ·C. Leah B. Kline,(unknown),Leonard S. Jefferson,Scot R. Kimball	14

About C. Leah B. Kline

C. Leah B. Kline is a scholar working on Oncology, Cancer Research and Molecular Biology, having authored 25 papers that have together received 855 indexed citations. Recurring topics across this work include Cell death mechanisms and regulation (8 papers), Cancer-related Molecular Pathways (4 papers) and Cancer, Stress, Anesthesia, and Immune Response (3 papers). The work is most often cited by research in Oncology (298 citations), Cancer Research (159 citations) and Molecular Biology (566 citations). C. Leah B. Kline has collaborated with scholars based in United States, Ireland and United Kingdom. Frequent co-authors include Wafik S. El‐Deiry, David T. Dicker, Joshua E. Allen, Varun V. Prabhu, A. Pieter J. van den Heuvel, Jessica Wagner, Rosalyn Irby, Marie D. Ralff, Lanlan Zhou and Amriti R. Lulla. Their work appears in journals such as Journal of Clinical Investigation, Blood and PLoS ONE.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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