Ayal Hendel

4.2k total citations · 2 hit papers
37 papers, 2.8k citations indexed

About

Ayal Hendel is a scholar working on Molecular Biology, Genetics and Immunology. According to data from OpenAlex, Ayal Hendel has authored 37 papers receiving a total of 2.8k indexed citations (citations by other indexed papers that have themselves been cited), including 32 papers in Molecular Biology, 11 papers in Genetics and 7 papers in Immunology. Recurrent topics in Ayal Hendel's work include CRISPR and Genetic Engineering (28 papers), Virus-based gene therapy research (8 papers) and DNA Repair Mechanisms (8 papers). Ayal Hendel is often cited by papers focused on CRISPR and Genetic Engineering (28 papers), Virus-based gene therapy research (8 papers) and DNA Repair Mechanisms (8 papers). Ayal Hendel collaborates with scholars based in Israel, United States and Germany. Ayal Hendel's co-authors include Matthew H. Porteus, Rasmus O. Bak, Alec B. Wilkens, Joseph T. Clark, Israel Steinfeld, Laurakay Bruhn, Daniel E. Ryan, Andrew Kennedy, Robert Kaiser and Rosa Bacchetta and has published in prestigious journals such as Nature, Science and Nucleic Acids Research.

In The Last Decade

Ayal Hendel

37 papers receiving 2.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

2015 813 citations Ayal Hendel, Rasmus O. Bak et al. Nature Biotechnology profile →
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

2016 641 citations Daniel P. Dever, Rasmus O. Bak et al. Nature profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Ayal Hendel Israel	22	2.6k	782	405	238	221	37	2.8k
Han Xu United States	21	3.1k 1.2×	528 0.7×	403 1.0×	526 2.2×	99 0.4×	44	3.7k
Claudio Mussolino Germany	22	2.6k 1.0×	909 1.2×	292 0.7×	65 0.3×	210 1.0×	55	3.0k
Eva K. Brinkman Netherlands	8	2.1k 0.8×	423 0.5×	262 0.6×	119 0.5×	82 0.4×	11	2.4k
Jiazhi Hu China	21	1.9k 0.7×	349 0.4×	255 0.6×	107 0.4×	178 0.8×	40	2.2k
Cynthia C. Bartholomae Germany	20	2.5k 0.9×	2.0k 2.6×	673 1.7×	69 0.3×	70 0.3×	33	3.0k
Pietro Genovese United States	16	2.4k 0.9×	1.4k 1.8×	853 2.1×	32 0.1×	158 0.7×	35	3.0k
Mara Pavel-Dinu United States	9	1.9k 0.7×	766 1.0×	362 0.9×	23 0.1×	214 1.0×	16	2.1k
Michael A. Collingwood United States	10	1.5k 0.6×	444 0.6×	184 0.5×	77 0.3×	143 0.6×	11	1.6k
Joab Camarena United States	11	2.1k 0.8×	807 1.0×	328 0.8×	21 0.1×	231 1.0×	16	2.3k
Andrea Calabria Italy	17	1.1k 0.4×	736 0.9×	400 1.0×	92 0.4×	39 0.2×	35	1.6k

Countries citing papers authored by Ayal Hendel

Since Specialization

Citations

This map shows the geographic impact of Ayal Hendel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ayal Hendel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ayal Hendel more than expected).

Fields of papers citing papers by Ayal Hendel

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ayal Hendel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ayal Hendel. The network helps show where Ayal Hendel may publish in the future.

Co-authorship network of co-authors of Ayal Hendel

This figure shows the co-authorship network connecting the top 25 collaborators of Ayal Hendel. A scholar is included among the top collaborators of Ayal Hendel based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ayal Hendel. Ayal Hendel is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Fuster‐García, Carla, Anderson Tadeu Silva, Giandomenico Turchiano, et al.. (2025). Off-target effects in CRISPR-Cas genome editing for human therapeutics: Progress and challenges. Molecular Therapy — Nucleic Acids. 36(3). 102636–102636. 7 indexed citations

Rosenberg, Michael K., et al.. (2024). Quantifying allele-specific CRISPR editing activity with CRISPECTOR2.0. Nucleic Acids Research. 52(16). e78–e78. 3 indexed citations

Eisenberg, Vasyl, Iris Kamer, Jair Bar, et al.. (2024). Targeting Tumor-Associated Sialic Acids Using Chimeric Switch Receptors Based on Siglec-9 Enhances the Antitumor Efficacy of Engineered T Cells. Cancer Immunology Research. 12(10). 1380–1391. 3 indexed citations

Allen, Daniel, et al.. (2023). Homology-Directed-Repair-Based Genome Editing in HSPCs for the Treatment of Inborn Errors of Immunity and Blood Disorders. Pharmaceutics. 15(5). 1329–1329. 13 indexed citations

Hodis, Eran, Elena Torlai Triglia, John Kwon, et al.. (2022). Stepwise-edited, human melanoma models reveal mutations’ effect on tumor and microenvironment. Science. 376(6592). eabi8175–eabi8175. 32 indexed citations

Allen, Daniel, Lucien E. Weiss, Michael A. Rosenberg, et al.. (2022). High-Throughput Imaging of CRISPR- and Recombinant Adeno-Associated Virus–Induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells. The CRISPR Journal. 5(1). 80–94. 16 indexed citations

Allen, Daniel, Atar Lev, Yu Nee Lee, et al.. (2022). Multiplex HDR for disease and correction modeling of SCID by CRISPR genome editing in human HSPCs. Molecular Therapy — Nucleic Acids. 31. 105–121. 23 indexed citations

Jacobi, Ashley M., Matthew McNeill, Rolf Turk, et al.. (2020). Increasing CRISPR Efficiency and Measuring Its Specificity in HSPCs Using a Clinically Relevant System. Molecular Therapy — Methods & Clinical Development. 17. 1097–1107. 42 indexed citations

Lev, Atar, Anthony Simon, Ortal Barel, et al.. (2019). Reduced Function and Diversity of T Cell Repertoire and Distinct Clinical Course in Patients With IL7RA Mutation. Frontiers in Immunology. 10. 1672–1672. 10 indexed citations

10.

Cromer, M. Kyle, Sriram Vaidyanathan, Daniel E. Ryan, et al.. (2018). Global Transcriptional Response to CRISPR/Cas9-AAV6-Based Genome Editing in CD34+ Hematopoietic Stem and Progenitor Cells. Molecular Therapy. 26(10). 2431–2442. 87 indexed citations

11.

Vaidyanathan, Sriram, A.K.M. Ashiqul Haque, Jordana M. Henderson, et al.. (2018). Uridine Depletion and Chemical Modification Increase Cas9 mRNA Activity and Reduce Immunogenicity without HPLC Purification. Molecular Therapy — Nucleic Acids. 12. 530–542. 192 indexed citations

12.

Dever, Daniel P., Rasmus O. Bak, Andreas Reinisch, et al.. (2016). CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells. Nature. 539(7629). 384–389. 641 indexed citations breakdown →

13.

Hendel, Ayal, Rasmus O. Bak, Joseph T. Clark, et al.. (2015). Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells. Nature Biotechnology. 33(9). 985–989. 813 indexed citations breakdown →

14.

Hendel, Ayal, Eric Kildebeck, Eli J. Fine, et al.. (2014). Quantifying Genome-Editing Outcomes at Endogenous Loci with SMRT Sequencing. Cell Reports. 7(1). 293–305. 95 indexed citations

15.

Voit, Richard A., Ayal Hendel, Shondra M. Pruett‐Miller, & Matthew H. Porteus. (2013). Nuclease-mediated gene editing by homologous recombination of the human globin locus. Nucleic Acids Research. 42(2). 1365–1378. 76 indexed citations

16.

Hendel, Ayal, Peter H.L. Krijger, Petra Langerak, et al.. (2011). PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells. PLoS Genetics. 7(9). e1002262–e1002262. 107 indexed citations

17.

Hendel, Ayal, et al.. (2011). DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity. Nucleic Acids Research. 40(1). 170–180. 92 indexed citations

18.

Hendel, Ayal, et al.. (2008). Single-stranded DNA-binding Protein Recruits DNA Polymerase V to Primer Termini on RecA-coated DNA. Journal of Biological Chemistry. 283(13). 8274–8282. 35 indexed citations

19.

Hendel, Ayal, et al.. (2008). Reduced efficiency and increased mutagenicity of translesion DNA synthesis across a TT cyclobutane pyrimidine dimer, but not a TT 6-4 photoproduct, in human cells lacking DNA polymerase η. DNA repair. 7(10). 1636–1646. 43 indexed citations

20.

Stanhill, Ariel, Vladimir Levin, Ayal Hendel, et al.. (2005). Ha-rasval12 induces HSP70b transcription via the HSE/HSF1 system, but HSP70b expression is suppressed in Ha-rasval12-transformed cells. Oncogene. 25(10). 1485–1495. 21 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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