Alex J. Vecchio

1.6k total citations · 1 hit paper
27 papers, 972 citations indexed

About

Alex J. Vecchio is a scholar working on Molecular Biology, Neurology and Infectious Diseases. According to data from OpenAlex, Alex J. Vecchio has authored 27 papers receiving a total of 972 indexed citations (citations by other indexed papers that have themselves been cited), including 11 papers in Molecular Biology, 10 papers in Neurology and 6 papers in Infectious Diseases. Recurrent topics in Alex J. Vecchio's work include Barrier Structure and Function Studies (10 papers), Clostridium difficile and Clostridium perfringens research (6 papers) and Inflammatory mediators and NSAID effects (5 papers). Alex J. Vecchio is often cited by papers focused on Barrier Structure and Function Studies (10 papers), Clostridium difficile and Clostridium perfringens research (6 papers) and Inflammatory mediators and NSAID effects (5 papers). Alex J. Vecchio collaborates with scholars based in United States, Switzerland and Australia. Alex J. Vecchio's co-authors include Michael G. Malkowski, Benjamin J. Orlando, Michael J. Lucido, Robert M. Stroud, Joseph H. Hotchkiss, Liang Dong, Narayan Prasad Sharma, William L. Smith, Daphne A. Roe and Sourav Roy and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Alex J. Vecchio

27 papers receiving 948 citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Computational design of soluble and functional membrane protein analogues

2024 40 citations Casper A. Goverde, Martin Pačesa et al. Nature profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Alex J. Vecchio United States	16	406	326	165	117	105	27	972
Ziru Dai China	21	823 2.0×	236 0.7×	167 1.0×	96 0.8×	91 0.9×	45	1.7k
Cláudia A. Simões‐Pires Switzerland	22	721 1.8×	261 0.8×	246 1.5×	93 0.8×	34 0.3×	47	1.4k
Françoise Heymans France	19	467 1.2×	194 0.6×	219 1.3×	87 0.7×	53 0.5×	54	1.0k
Ean‐Jeong Seo Germany	22	686 1.7×	185 0.6×	314 1.9×	75 0.6×	56 0.5×	57	1.5k
Victor Kenyon United States	16	451 1.1×	271 0.8×	248 1.5×	182 1.6×	58 0.6×	26	1.0k
K. Yamaguchi Japan	23	1000 2.5×	167 0.5×	314 1.9×	54 0.5×	98 0.9×	89	1.7k
Koichi Takao Japan	19	560 1.4×	410 1.3×	338 2.0×	137 1.2×	20 0.2×	83	1.1k
Benjamin J. Orlando United States	15	801 2.0×	322 1.0×	322 2.0×	63 0.5×	23 0.2×	24	1.6k
Gui‐Shan Tan China	21	1.0k 2.5×	367 1.1×	180 1.1×	62 0.5×	27 0.3×	114	1.6k
Takahiko Hada Japan	25	653 1.6×	172 0.5×	165 1.0×	215 1.8×	20 0.2×	48	1.4k

Countries citing papers authored by Alex J. Vecchio

Since Specialization

Citations

This map shows the geographic impact of Alex J. Vecchio's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alex J. Vecchio with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alex J. Vecchio more than expected).

Fields of papers citing papers by Alex J. Vecchio

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alex J. Vecchio. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alex J. Vecchio. The network helps show where Alex J. Vecchio may publish in the future.

Co-authorship network of co-authors of Alex J. Vecchio

This figure shows the co-authorship network connecting the top 25 collaborators of Alex J. Vecchio. A scholar is included among the top collaborators of Alex J. Vecchio based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alex J. Vecchio. Alex J. Vecchio is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Liu, Xiangdong, Srajan Kapoor, Charles R. Sanders, et al.. (2025). Biophysical basis of tight junction barrier modulation by a pan-claudin-binding molecule. PNAS Nexus. 4(6). pgaf189–pgaf189. 1 indexed citations

Erramilli, Satchal K., et al.. (2024). Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4. Structure. 32(11). 1936–1951.e5. 7 indexed citations

Goverde, Casper A., Martin Pačesa, L Dornfeld, et al.. (2024). Computational design of soluble and functional membrane protein analogues. Nature. 631(8020). 449–458. 40 indexed citations breakdown →

Erramilli, Satchal K., et al.. (2024). Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment. Communications Biology. 7(1). 733–733. 12 indexed citations

Kapoor, Srajan, et al.. (2023). Structural Basis of Clostridium perfringens Enterotoxin Activation and Oligomerization by Trypsin. Toxins. 15(11). 637–637. 4 indexed citations

Liu, Xiangdong, Saiprasad Gowrikumar, Iram Fatima, et al.. (2023). Claudin-1 interacts with EPHA2 to promote cancer stemness and chemoresistance in colorectal cancer. Cancer Letters. 579. 216479–216479. 28 indexed citations

Fatima, Iram, Yashpal S. Chhonker, Saiprasad Gowrikumar, et al.. (2023). Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis. Biomedicine & Pharmacotherapy. 159. 114255–114255. 9 indexed citations

Orlando, Benjamin J., Pawel K. Dominik, Sourav Roy, et al.. (2022). Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes. Journal of Biological Chemistry. 298(9). 102357–102357. 7 indexed citations

Roy, Sourav, et al.. (2022). Disruption of Claudin-Made Tight Junction Barriers by Clostridium perfringens Enterotoxin: Insights from Structural Biology. Cells. 11(5). 903–903. 15 indexed citations

10.

Bony, Badrul Alam, Hunter A. Miller, Saiprasad Gowrikumar, et al.. (2021). Claudin-1-Targeted Nanoparticles for Delivery to Aging-Induced Alterations in the Blood–Brain Barrier. ACS Nano. 15(11). 18520–18531. 28 indexed citations

11.

Li, Fei, Pascal F. Egea, Alex J. Vecchio, et al.. (2021). Highlighting membrane protein structure and function: A celebration of the Protein Data Bank. Journal of Biological Chemistry. 296. 100557–100557. 47 indexed citations

12.

Vecchio, Alex J., et al.. (2021). Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut. Proceedings of the National Academy of Sciences. 118(15). 33 indexed citations

13.

Vecchio, Alex J. & Robert M. Stroud. (2019). Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown. Proceedings of the National Academy of Sciences. 116(36). 17817–17824. 50 indexed citations

14.

Lucido, Michael J., Benjamin J. Orlando, Alex J. Vecchio, & Michael G. Malkowski. (2016). Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. Biochemistry. 55(8). 1226–1238. 173 indexed citations

15.

Vecchio, Alex J., et al.. (2012). Investigating Substrate Promiscuity in Cyclooxygenase-2. Journal of Biological Chemistry. 287(29). 24619–24630. 48 indexed citations

16.

Vecchio, Alex J. & Michael G. Malkowski. (2011). The Structural Basis of Endocannabinoid Oxygenation by Cyclooxygenase-2. Journal of Biological Chemistry. 286(23). 20736–20745. 46 indexed citations

17.

Dong, Liang, et al.. (2011). Human Cyclooxygenase-2 Is a Sequence Homodimer That Functions as a Conformational Heterodimer. Journal of Biological Chemistry. 286(21). 19035–19046. 87 indexed citations

18.

Vecchio, Alex J. & Michael G. Malkowski. (2011). The structure of NS-398 bound to cyclooxygenase-2. Journal of Structural Biology. 176(2). 254–258. 28 indexed citations

19.

Vecchio, Alex J., et al.. (2010). Structural Basis of Fatty Acid Substrate Binding to Cyclooxygenase-2. Journal of Biological Chemistry. 285(29). 22152–22163. 134 indexed citations

20.

Babish, John G., Joseph H. Hotchkiss, Timothy Wachs, et al.. (1983). N‐nitrosamines and mutagens in rubber nursing nipples. Journal of Toxicology and Environmental Health. 11(2). 167–177. 10 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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