Citation Impact
Citing Papers
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
2003 StandoutNobel
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
2017 StandoutNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Cutting Edge: Antigen-Dependent Regulation of Telomerase Activity in Murine T Cells
1998
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses
2007
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4
1992
Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responses
1995
Effect of interleukin‐10 on dendritic cell maturation and function
1997
Activation of naive, memory and effector T cells
1994
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
CD28-B7 interactions in T-cell activation
1994 StandoutNobel
Developmental regulation of MHC class II transport in mouse dendritic cells
1997 StandoutNatureNobel
Signals and signs for lymphocyte responses
1994
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Lipopolysaccharide interferes with the induction of peripheral T cell death
1995
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
2016 Standout
T Cell–Mediated Elimination of B7.2 Transgenic B Cells
1997 StandoutNobel
The immunological synapse and CD28-CD80 interactions
2001
CTLA-4 can function as a negative regulator of T cell activation
1994 Standout
Alternative Antigen Receptor (TCR) Signaling in T Cells Derived from ZAP-70-deficient Patients Expressing High Levels of Syk
2000
The Role of CTLA‐4 in the Regulation and Initiation of T‐Cell Responses
1996 StandoutNobel
Reciprocal expression of co‐stimulatory molecules, B7‐1 and B7‐2, on murine T cells following activation
1995
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1β
2006
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
1994
Tolerance, not immunity, crucially depends on IL-2
2004
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Cancer-related inflammation
2008 StandoutNature
Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity
1995
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
1995
The B7 and CD28 receptor families
1994
Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo
1996 StandoutNobel
In vivoblockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
1999 StandoutNobel
Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
2002 StandoutNobel
Thymocyte development is normal in CTLA-4-deficient mice
1997 StandoutNobel
Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer
1997 StandoutNobel
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4+T cell responses
1999 StandoutNobel
Haploinsufficiency of mTR results in defects in telomere elongation
2002 StandoutNobel
Major histocompatibility complex class II+B7-1+ tumor cells are potent vaccines for stimulating tumor rejection in tumor-bearing mice.
1995
Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.
1994
Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.
1994
CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
1998 StandoutNobel
Expression and functional significance of an additional ligand for CTLA-4.
1993
Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.
1996
B7x: A widely expressed B7 family member that inhibits T cell activation
2003 StandoutNobel
B7–CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge
1998
Integrated NY-ESO-1 antibody and CD8+T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
2011 StandoutNobel
CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.
1993 StandoutNobel
CTLA-4–B7 Interaction Is Sufficient to Costimulate T Cell Clonal Expansion
1997
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
1997 StandoutNobel
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
1995 StandoutNobel
CD28/B7 SYSTEM OF T CELL COSTIMULATION
1996 Standout
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
2011 StandoutNobel
Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation
2001 StandoutNobel
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
2008 StandoutNobel
Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model
2012 StandoutNobel
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
Uncovering of Functional Alternative CTLA-4 Counter-Receptor in B7-Deficient Mice
1993 Science
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg
1992 StandoutScience
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome
2007 StandoutNobel
Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.
1992
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
CTLA-4 ligation blocks CD28-dependent T cell activation.
1996
B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
1995
A major costimulatory molecule on antigen-presenting cells, CTLA4 ligand A, is distinct from B7.
1993
The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen
1994
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
2000 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.
1994 StandoutNobel
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+T cells
2000 StandoutNobel
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.
1994
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit
2008 StandoutNobel
Single dose of anti–CTLA-4 enhances CD8 + T-cell memory formation, function, and maintenance
2010 StandoutNobel
Fas-independent death of activated CD4+T lymphocytes induced by CTLA-4 crosslinking
1998
Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation
1993 Science
Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules.
1993
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability
2007 StandoutNobel
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
Enhancement of Antitumor Immunity by CTLA-4 Blockade
1996 StandoutScienceNobel
Antibody to Langerin/CD207 localizes large numbers of CD8α + dendritic cells to the marginal zone of mouse spleen
2009 StandoutNobel
Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy
1999 StandoutNobel
Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.
1993
Works of Z Razi-Wolf being referenced
Expression and function of the costimulatory molecule B7 on murine Langerhans cells: Evidence for an alternative CTLA‐4 ligand
1994
Induction of Manganese Superoxide Dismutase in Human Dermal Fibroblasts
2002
Chronological ageing and photoageing of the fibroblasts and the dermal connective tissue
2001
Activation of CD4+ T lymphocytes form interleukin 2-deficient mice by costimulatory B7 molecules.
1996
Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.
1992 Nobel
Effects of cyclosporin A, FK 506, and mycalamide A on the activation of murine CD4+ T cells by the murine B7 antigen
1993 Nobel
Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation.
1992 Nobel
Costimulation of IL-4 production by murine B7-1 and B7-2 molecules
1996
Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells.
1992 Nobel
Evidence for an additional ligand, distinct from B7, for the CTLA-4 receptor.
1993