Standout Papers
Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
IRE1 Signaling Is Essential for Ischemia-Induced Vascular Endothelial Growth Factor-A Expression and Contributes to Angiogenesis and Tumor Growth In vivo
2007
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels
1997
Interleukin-8 Induction by Helicobacter pylori in Gastric Epithelial Cells is Dependent on Apurinic/Apyrimidinic Endonuclease-1/Redox Factor-1
2006
Stimulation of HIF-1α, HIF-2α, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells
2005
RGS5, a Hypoxia-inducible Apoptotic Stimulator in Endothelial Cells
2009
Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1
1996 StandoutNobel
Perivenous expression of the mRNA of the three hypoxia-inducible factor α-subunits, HIF1α, HIF2α and HIF3α, in rat liver
2001
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development
1997
Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs
2002 StandoutNobel
The Mouse Gene for Hypoxia‐Inducible Factor‐1α
1997
HLF/HIF-2α is a key factor in retinopathy of prematurity in association with erythropoietin
2003
Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300
1999
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Administration of a CO-releasing molecule induces late preconditioning against myocardial infarction
2004
Oxygen sensing and response to hypoxia by mammalian cells
1996 StandoutNobel
Normoxic Stabilization of Hypoxia-Inducible Factor-1 Expression and Activity: Redox-Dependent Effect of Nitrogen Oxides
2000
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
The heme oxygenase system and cellular defense mechanisms
2001
The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway
2004 StandoutNobel
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo
2004
Ischemia-Driven Angiogenesis
1997
The Mouse Gene for Vascular Endothelial Growth Factor
1996
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Mitochondrial Respiratory Chain and NAD(P)H Oxidase Are Targets for theAntiproliferative Effect of Carbon Monoxide in Human Airway SmoothMuscle
2005
Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit
1997 StandoutNobel
Molecular mechanisms of blood vessel growth
2001
Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature
1997
Laminar Flow Induction of Antioxidant Response Element-mediated Genes in Endothelial Cells
2003
Hypoxia Regulates Expression of the Endothelin-1 Gene through a Proximal Hypoxia-Inducible Factor-1 Binding Site on the Antisense Strand
1998
Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α
1997 StandoutNobel
Acetylation of Apurinic/Apyrimidinic Endonuclease-1 Regulates Helicobacterpylori-Mediated Gastric Epithelial Cell Apoptosis
2009
Oxygen sensing and signaling: impact on the regulation of physiologically important genes
1999
Oxygen-regulated Transferrin Expression Is Mediated by Hypoxia-inducible Factor-1
1997
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
2008
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Vasoregulatory function of the heme-heme oxygenase-carbon monoxide system
2001
Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1
1998 StandoutNobel
Vasoactive properties of CORM‐3, a novel water‐soluble carbon monoxide‐releasing molecule
2004
Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-Δ12,14-prostaglandin J2-induced heme oxygenase-1 expression
2004
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Carbon Monoxide Suppresses Bleomycin-Induced Lung Fibrosis
2005
Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells
2010
Regulation of Cardiovascular Development and Physiology by Hypoxia‐Inducible Factor 1a
1999 StandoutNobel
Heme oxygenase–carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide?
1999
HIF-1 and mechanisms of hypoxia sensing
2001 StandoutNobel
HIF-1, O2, and the 3 PHDs
2001 StandoutNobel
Resistance to hyperoxia with heme oxygenase-1 disruption: role of iron
2002
Inhibition of Hypoxia-inducible Factor 1 Activation by Carbon Monoxide and Nitric Oxide
1999
Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress
2000
Carbon monoxide‐induced vasorelaxation and the underlying mechanisms
1997
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
2006 Standout
Heme oxygenase-1 prevents superoxide anion-associated endothelial cell sloughing in diabetic rats
2004
Mapping of the Chick Heme Oxygenase-1 Proximal Promoter for Responsiveness to Metalloporphyrins
2002
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
HIF-1alpha is required for solid tumor formation and embryonic vascularization
1998
A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology
2002
Structural and functional analysis of hypoxia-inducible factor 1
1997 StandoutNobel
Nuclear Factor Interleukin 6 Motifs Mediate Tissue-specific Gene Transcription in Hypoxia
1997
Defective Vascularization of HIF-1α-Null Embryos Is Not Associated with VEGF Deficiency but with Mesenchymal Cell Death
1999 StandoutNobel
Heme Oxygenase-1 Gene Promoter Microsatellite Polymorphism is Associated with Restenosis after Percutaneous Transluminal Angioplasty
2001
Vascular endothelial growth factor
1996
Heme oxygenase-1 protects against vascular constriction and proliferation
2001
Hypoxia-driven selection of the metastatic phenotype
2007
Role of Hypoxia-inducible Factor-1 in Transcriptional Activation of Ceruloplasmin by Iron Deficiency
2000
A Redox Mechanism Controls Differential DNA Binding Activities of Hypoxia-inducible Factor (HIF) 1α and the HIF-like Factor
2000
HIF-1α-prolyl hydroxylase: molecular target of nitric oxide in the hypoxic signal transduction pathway
2002
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
1999 StandoutNobel
Transcriptional Regulation by Hypoxia-Inducible Factor 1 Molecular Mechanisms of Oxygen Homeostasis
1996 StandoutNobel
Reversible inhibition of hypoxia‐inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane
2001 StandoutNobel
The von Hippel–Lindau protein, HIF hydroxylation, and oxygen sensing
2005 StandoutNobel
Carbon monoxide in biology and medicine
2004
The Immunology of Macrophage Activation Syndrome
2019
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
1998 StandoutNobel
Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice
1999
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Perspectives on Oxygen Sensing
1999 StandoutNobel
The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression
1996 StandoutNobel
Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes
1997
Heme oxygenase-1 and carbon monoxide in pulmonary medicine
2003
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Effects of nitric oxide donors on vascular endothelial growth factor gene induction
2002
The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1)DNA recognition site
1995
Caveolin-1 expression by means of p38β mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide
2005
Hypoxic Regulation of Inducible Nitric Oxide Synthase via Hypoxia Inducible Factor-1 in Cardiac Myocytes
2000
Heme Oxygenase-1: Molecular Mechanisms of Gene Expression in Oxygen-Related Stress
2002
The Heme-Bach1 Pathway in the Regulation of Oxidative Stress Response and Erythroid Differentiation
2006
Heme Oxygenase-1: Redox Regulation of a Stress Protein in Lung and Cell Culture Models
2004
Mitogen Activated Protein Kinase (MAPK) Pathway Regulates Heme Oxygenase-1 Gene Expression by Hypoxia in Vascular Cells
2002
Hypoxia-Inducible Factor-1 (HIF-1) Up-Regulates Adrenomedullin Expression in Human Tumor Cell Lines during Oxygen Deprivation: A Possible Promotion Mechanism of Carcinogenesis
2000
Prevention of Hypoxia-Induced Pulmonary Hypertension by Enhancement of Endogenous Heme Oxygenase-1 in the Rat
2000
Mammalian Oxygen Sensing, Signalling and Gene Regulation
2000
Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury
2002
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression
2000 StandoutNobel
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
1999 StandoutScienceNobel
Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia
1997 StandoutNobel
Carbon Monoxide Inhibits T Lymphocyte Proliferation via Caspase-Dependent Pathway
2004
Response of VEGF expression to amino acid deprivation and inducers of endoplasmic reticulum stress.
2002
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
Absence of Heme Oxygenase-1 Exacerbates Myocardial Ischemia/Reperfusion Injury in Diabetic Mice
2005
Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression.
1999 StandoutNobel
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
2011 StandoutNobel
The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.
2003
PROLINE HYDROXYLATION AND GENE EXPRESSION
2005 StandoutNobel
Absence of heme oxygenase‐1 exacerbates atherosclerotic lesion formation and vascular remodeling
2003
The Biology of Vascular Endothelial Growth Factor
1997 Standout
Methods for Measurements of Heme Oxygenase (HO) Isoforms-Mediated Synthesis of Carbon Monoxide and HO-1 and HO-2 Proteins
2003
Cellular adaptation to hypoxia: O 2 ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O 2 ‐regulated gene expression
2002
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
1996 StandoutNobel
Functional Interference between Hypoxia and Dioxin Signal Transduction Pathways: Competition for Recruitment of the Arnt Transcription Factor
1996
Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene
2005
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Cardioprotective Actions by a Water-Soluble Carbon Monoxide–Releasing Molecule
2003
Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
2014 Standout
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
1996 StandoutNobel
Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases
2003
Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide
2000
Accumulation of HIF-1α under the influence of nitric oxide
2001
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
1997 StandoutNobel
Regulation of Mammalian O2Homeostasis by Hypoxia-Inducible Factor 1
1999 StandoutNobel
Induction of the Plasminogen Activator Inhibitor-1 Gene Expression by Mild Hypoxia Via a Hypoxia Response Element Binding the Hypoxia-Inducible Factor-1 in Rat Hepatocytes
1999
Role of nitric oxide in the regulation of HIF-1α expression during hypoxia
2002
Perivenous expression of the mRNA of the three hypoxia-inducible factor α-subunits, HIF1α, HIF2α and HIF3α, in rat liver
2001
Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1
1996 StandoutNobel
Adenovirus-Mediated Heme Oxygenase-1 Gene Delivery Inhibits Injury-Induced Vascular Neointima Formation
2001
Hypoxia-inducible factor 1: master regulator of O2 homeostasis
1998 StandoutNobel
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
CORM‐A1: a new pharmacologically active carbon monoxide‐releasing molecule
2004
Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance
2002
Carbon monoxide and the nervous system
2002
Modulating Hypoxia-Inducible Transcription by Disrupting the HIF-1–DNA Interface
2007
Heme oxygenase-1 is upregulated in the rat heart in response to chronic administration of angiotensin II
2000
Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: Evidence from genomic deletion of biosynthetic enzymes
2000
Platelet-Derived Growth Factor Stimulates Heme Oxygenase-1 Gene Expression and Carbon Monoxide Production in Vascular Smooth Muscle Cells
1999
Induction of Hypoxia-Inducible Factor-1, Erythropoietin, Vascular Endothelial Growth Factor, and Glucose Transporter-1 by Hypoxia: Evidence Against a Regulatory Role for Src Kinase
1997 StandoutNobel
Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung
1998 StandoutNobel
Selective Regulation of Blood Pressure by Heme Oxygenase-1 in Hypertension
2002
Works of Yuxiang Liu being referenced
Generation of a Dominant-negative Mutant of Endothelial PAS Domain Protein 1 by Deletion of a Potent C-terminal Transactivation Domain
1999
Hypoxic Responses of Vascular Cells
1998
Carbon Monoxide Controls the Proliferation of Hypoxic Vascular Smooth Muscle Cells
1997
Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer
1998 StandoutNobel
Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis
2002
Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia
2001
Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells
1995