Citation Impact
Citing Papers
Copper‐Mediated CH/CH Biaryl Coupling of Benzoic Acid Derivatives and 1,3‐Azoles
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Nickel‐Catalyzed Site‐Selective Amidation of Unactivated C(sp3)H Bonds
2014
Towards mild metal-catalyzed C–H bond activation
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Copper/Silver‐Mediated Direct ortho‐Ethynylation of Unactivated (Hetero)aryl CH Bonds with Terminal Alkyne
2014
Copper as a Powerful Catalyst in the Direct Alkynylation of Azoles
2009
Ethynyl Benziodoxolones for the Direct Alkynylation of Heterocycles: Structural Requirement, Improved Procedure for Pyrroles, and Insights into the Mechanism
2012
C–C, C–O and C–N bond formation via rhodium(iii)-catalyzed oxidative C–H activation
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Recent advances in homogeneous nickel catalysis
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Formal Inverse Sonogashira Reaction: Direct Alkynylation of Arenes and Heterocycles with Alkynyl Halides
2010
Generation and reaction of cyano-substituted aryllithium compounds using microreactors
2010
CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals
2012 Standout
OH‐Directed Alkynylation of 2‐Vinylphenols with Ethynyl Benziodoxolones: A Fast Access to Terminal 1,3‐Enynes
2015
Palladium‐Catalyzed Amidation by Chemoselective C(sp3)H Activation: Concise Route to Oxindoles Using a Carbamoyl Chloride Precursor
2012
Directed arene/alkyne annulation reactions via aerobic copper catalysis
2014
An Efficient Palladium‐Catalyzed CH Alkoxylation of Unactivated Methylene and Methyl Groups with Cyclic Hypervalent Iodine (I3+) Oxidants
2013
Selection of boron reagents for Suzuki–Miyaura coupling
2013 Standout
Palladium‐ and Nickel‐Catalyzed Direct Alkylation of Azoles with Unactivated Alkyl Bromides and Chlorides
2010
Introduction of Fluorine and Fluorine‐Containing Functional Groups
2013 Standout
Direct Alkynylation of Indole and Pyrrole Heterocycles
2009
Copper‐Catalyzed Site‐Selective Intramolecular Amidation of Unactivated C(sp3)H Bonds
2014
Nickel-catalyzed alkyne annulation by anilines: versatile indole synthesis by C–H/N–H functionalization
2013
Palladium‐Catalyzed Oxidative Cross‐Coupling between Heterocycles and Terminal Alkynes with Low Catalyst Loading
2013
Recent advances in the transition metal-catalyzed twofold oxidative C–H bond activation strategy for C–C and C–N bond formation
2011 Standout
Mild CH Halogenation of Anilides and the Isolation of an Unusual Palladium(I)–Palladium(II) Species
2011
Palladium‐Catalyzed Cross‐Coupling: A Historical Contextual Perspective to the 2010 Nobel Prize
2012 Standout
Palladium‐Catalyzed Addition of Silyl‐Substituted Chloroalkynes to Terminal Alkynes
2010
Palladium‐Catalyzed Direct Functionalization of 2‐Aminobutanoic Acid Derivatives: Application of a Convenient and Versatile Auxiliary
2013
On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition‐Metal Complexes
2012 Standout
Electrophilic alkynylation: the dark side of acetylene chemistry
2012
8‐Aminoquinoline: A Powerful Directing Group in Metal‐Catalyzed Direct Functionalization of CH Bonds
2013
Chiral Cp‐Rhodium(III)‐Catalyzed Asymmetric Hydroarylations of 1,1‐Disubstituted Alkenes
2013
Mechanistic Study of a Switch in the Regioselectivity of Hydroheteroarylation of Styrene Catalyzed by Bimetallic Ni–Al through CH Activation
2014
Controllable Mono‐/Dialkenylation of Benzyl Thioethers through Rh‐Catalyzed Aryl CH Activation
2013
Nickel‐Catalyzed Insertion of Alkynes and Electron‐Deficient Olefins into Unactivated sp3 CH Bonds
2015
Palladium‐Catalyzed ortho‐Acylation of Acetanilides with Aldehydes through Direct CH Bond Activation
2011
Readily Removable Directing Group Assisted Chemo‐ and Regioselective C(sp 3 )H Activation by Palladium Catalysis
2015
Gold‐Catalyzed Regioselective Synthesis of 2‐ and 3‐Alkynyl Furans
2013
A Practical Strategy for the Structural Diversification of Aliphatic Scaffolds through the Palladium‐Catalyzed Picolinamide‐Directed Remote Functionalization of Unactivated C(sp3)H Bonds
2011
Scandium‐Catalyzed Silylation of Aromatic CH Bonds
2011
Use of a Readily Removable Auxiliary Group for the Synthesis of Pyrrolidones by the Palladium‐Catalyzed Intramolecular Amination of Unactivated γ C(sp3)H Bonds
2013
CH Bond Arylation in the Synthesis of Aryltetralin Lignans: A Short Total Synthesis of Podophyllotoxin
2014
β-Carbon activation of saturated carboxylic esters through N-heterocyclic carbene organocatalysis
2013
Benziodoxole-based hypervalent iodine reagents for atom-transfer reactions
2010
Cobalt‐Catalyzed, Aminoquinoline‐Directed C(sp2)H Bond Alkenylation by Alkynes
2014
A CuBr-mediated aerobic reaction of 2-alkynylbenzaldehydes and primary amines: synthesis of 4-bromoisoquinolones
2012
Direct Borylation of Primary CH Bonds in Functionalized Molecules by Palladium Catalysis
2014
Oxidizing Directing Groups Enable Efficient and Innovative CH Activation Reactions
2011
PdII‐Catalysed CH Functionalisation of Indoles and Pyrroles Assisted by the Removable N‐(2‐Pyridyl)sulfonyl Group: C2‐Alkenylation and Dehydrogenative Homocoupling
2010
An overview of N-heterocyclic carbenes
2014 StandoutNature
Recent developments in natural product synthesis using metal-catalysed C–H bond functionalisation
2011 Standout
Ligand-enabled cross-coupling of C(sp3)–H bonds with arylboron reagents via Pd(II)/Pd(0) catalysis
2014
Manganese‐Catalyzed Synthesis of cis‐β‐Amino Acid Esters through Organometallic CH Activation of Ketimines
2015
Copper‐Promoted Site‐Selective Acyloxylation of Unactivated C(sp3)H Bonds
2014
Iron‐Catalyzed Oxidative CH/CH Cross‐Coupling: An Efficient Route to α‐Quaternary α‐Amino Acid Derivatives
2013
Preparation of conjugated 1,3-enynes by Rh(iii)-catalysed alkynylation of alkenes via C–H activation
2014
Beyond Directing Groups: Transition‐Metal‐Catalyzed CH Activation of Simple Arenes
2012 Standout
Development of Modifiable Bidentate Amino Oxazoline Directing Group for Pd‐Catalyzed Arylation of Secondary CH Bonds
2015
Ruthenium‐Catalyzed Direct CH Amidation of Arenes Including Weakly Coordinating Aromatic Ketones
2013
Rhodium‐Catalyzed CH Alkynylation of Arenes at Room Temperature
2014
Nickel‐Catalyzed CH Alkylations: Direct Secondary Alkylations and Trifluoroethylations of Arenes
2014
Recent advances in Sonogashira reactions
2011 Standout
Nickel Catalysts/N,N′-Bidentate Directing Groups: An Excellent Partnership in Directed C–H Activation Reactions
2015
Anthranilamide: A Simple, Removable ortho-Directing Modifier for Arylboronic Acids Serving also as a Protecting Group in Cross-Coupling Reactions
2011
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Iron Catalysis in Organic Synthesis
2015 Standout
3d Transition Metals for C–H Activation
2018 Standout
Palladium-catalyzed oxygenation of C(sp2)–H and C(sp3)–H bonds under the assistance of oxalyl amide
2015
Palladium-catalyzed unactivated β-methylene C(sp3)–H bond alkenylation of aliphatic amides and its application in a sequential C(sp3)–H/C(sp2)–H bond alkenylation
2014
Carboxylate‐Directed CH Functionalization
2014
β-C(sp3)–H Arylation of α-Hydroxy Acid Derivatives Utilizing Amino Acid as a Directing Group
2015
Bond Formations between Two Nucleophiles: Transition Metal Catalyzed Oxidative Cross-Coupling Reactions
2011 Standout
8‐Aminochinolin: eine wirkungsvolle dirigierende Gruppe in der metallkatalysierten direkten Funktionalisierung von C‐H‐Bindungen
2013
Palladium-Catalyzed Stereoretentive Olefination of Unactivated C(sp3)–H Bonds with Vinyl Iodides at Room Temperature: Synthesis of β-Vinyl α-Amino Acids
2014
Cobalt-Catalyzed, Aminoquinoline-Directed Functionalization of Phosphinic Amide sp2 C–H Bonds
2015
Cobalt(III)-Catalyzed C–H Alkynylation with Bromoalkynes under Mild Conditions
2015
Nickel‐Catalyzed Electrooxidative C−H Amination: Support for Nickel(IV)
2018
Palladium-catalyzed methylene C(sp3)–H arylation of the adamantyl scaffold
2015
Oxidative C−H Activation Approach to Pyridone and Isoquinolone through an Iron‐Catalyzed Coupling of Amides with Alkynes
2015
Copper(II)/Silver(I)‐Catalyzed Sequential Alkynylation and Annulation of Aliphatic Amides with Alkynyl Carboxylic Acids: Efficient Synthesis of Pyrrolidones
2015
Organic Photoredox Catalysis
2016 Standout
Nickel promoted switchable hydroheteroarylation of cyclodienes via C–H bond activation of heteroarenes
2015
Direct Arylation of Primary and Secondary sp3 C–H Bonds with Diarylhyperiodonium Salts via Pd Catalysis
2013
Methods Utilizing First-Row Transition Metals in Natural Product Total Synthesis
2017
Efficient Palladium-Catalyzed C–H Fluorination of C(sp3)–H Bonds: Synthesis of β-Fluorinated Carboxylic Acids
2015
Iron-catalyzed C–H/N–H activation by triazole guidance: versatile alkyne annulation
2017
Ruthenium-catalyzed ortho-C–H bond alkylation of aromatic amides with α,β-unsaturated ketones via bidentate-chelation assistance
2013
Gold-Catalyzed Direct Arylation
2012 Science
Oxidative Coupling between Two Hydrocarbons: An Update of Recent C–H Functionalizations
2015 Standout
Nickel‐Catalyzed Sulfonylation of C(sp2)–H Bonds with Sodium Sulfinates
2017
Copper‐Mediated ortho‐Nitration of Arene and Heteroarene CH Bonds Assisted by an 8‐Aminoquinoline Directing Group
2015
Nickel-Catalyzed Stereoselective Alkenylation of C(sp3)–H Bonds with Terminal Alkynes
2017
Metal Catalysts for Heterogeneous Catalysis: From Single Atoms to Nanoclusters and Nanoparticles
2018 Standout
Strong and Confined Acids Catalyze Asymmetric Intramolecular Hydroarylations of Unactivated Olefins with Indoles
2021 StandoutNobel
Engineered Biosynthesis of β‐Alkyl Tryptophan Analogues
2018 StandoutNobel
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
Controlled Regiodivergent C–H Bond Activation of Imidazo[1,5-a]pyridine via Synergistic Cooperation between Aluminum and Nickel
2014
Rhodium-Catalyzed ortho-Benzoxylation of sp2 C−H Bond
2009
Direct Functionalization of C−H Bonds by Iron, Nickel, and Cobalt Catalysis
2017
Understanding the Effects of Bidentate Directing Groups: A Unified Rationale for sp2 and sp3 C–H Bond Activations
2015
Synthesis of Nitrogen‐Containing Polyaromatics by Aza‐Annulative π‐Extension of Unfunctionalized Aromatics
2020
Mild metal-catalyzed C–H activation: examples and concepts
2016 Standout
Palladium-Catalyzed C–H Bond Direct Alkynylation of 5-Membered Heteroarenes: A Well-Defined Synthetic Route to Azole Derivatives Containing Two Different Alkynyl Groups
2012
Nickel-Catalyzed Alkynylation of a C(sp2)–H Bond Directed by an 8-Aminoquinoline Moiety
2015
Palladium-catalyzed trifluoroacetate-promoted mono-arylation of the β-methyl group of alanine at room temperature: synthesis of β-arylated α-amino acids through sequential C–H functionalization
2014
Nickel-Catalyzed Reaction of C–H Bonds in Amides with I2: ortho-Iodination via the Cleavage of C(sp2)–H Bonds and Oxidative Cyclization to β-Lactams via the Cleavage of C(sp3)–H Bonds
2016
Cobalt(II)-catalyzed C H functionalization using an N,N′-bidentate directing group
2017
Cobalt(III)−Catalyzed C−H Activation: A Secondary Amide Directed Decarboxylative Functionalization of Alkynyl Carboxylic Acids Wherein Amide NH‐group Remains Unreactive
2018
Iron-Catalyzed Ortho-Allylation of Aromatic Carboxamides with Allyl Ethers
2013
Rh(III)- and Ir(III)-Catalyzed C–H Alkynylation of Arenes under Chelation Assistance
2014
Auxiliary-Directed Pd-Catalyzed γ-C(sp3)–H Bond Activation of α-Aminobutanoic Acid Derivatives
2015
Homologation of the Fischer Indolization: A Quinoline Synthesis via Homo‐Diaza‐Cope Rearrangement
2020 StandoutNobel
Phosphine Organocatalysis
2018 Standout
Catalytic Silylation of Unactivated C–H Bonds
2015
Nickel-Catalyzed Direct Arylation of C(sp3)–H Bonds in Aliphatic Amides via Bidentate-Chelation Assistance
2013
Nickel-catalyzed chelation-assisted direct arylation of unactivated C(sp3)–H bonds with aryl halides
2014
The Regioselective Switch for Amino-NHC Mediated C–H Activation of Benzimidazole via Ni–Al Synergistic Catalysis
2012
Iron-Catalyzed Ortho C–H Methylation of Aromatics Bearing a Simple Carbonyl Group with Methylaluminum and Tridentate Phosphine Ligand
2016
Nickel-catalyzed synthesis of diarylsulfides and sulfones via C–H bond functionalization of arylamides
2015
Palladium-Catalyzed Selective β-Arylation of Aliphatic Amides Using a Removable N,O-Bidentate Auxiliary
2015
A sustainable and simple catalytic system for direct alkynylation of C(sp2)–H bonds with low nickel loadings
2015
Rhodium(iii )-catalyzed C–H alkynylation of azomethine ylides under mild conditions
2014
Selective fluorination of alkyl C–H bonds via photocatalysis
2014
Expedient Cobalt-Catalyzed C–H Alkynylation of (Enantiopure) Benzylamines
2016
Copper(II)-catalyzed direct thiolation of C–H bonds in aromatic amides with aryl and aliphatic thiols
2014
Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope
2011 Standout
Diiodoacetylene: compact, strong ditopic halogen bond donor
2012
Ni(II)-Catalyzed C(sp2)–H Alkynylation/Annulation with Terminal Alkynes under an Oxygen Atmosphere: A One-Pot Approach to 3-Methyleneisoindolin-1-one
2016
C–H Functionalization of Cyclopropanes: A Practical Approach Employing a Picolinamide Auxiliary
2013
Palladium-Catalyzed Transformations of Alkyl C–H Bonds
2016 Standout
Gold‐Catalyzed Alkynylation: Acetylene‐Transfer instead of Functionalization
2013
Palladium-catalyzed oxidative alkynylation of arene C–H bond using the chelation-assisted strategy
2012
Chiral N-Heterocyclic Carbene Ligand Enabled Nickel(0)-Catalyzed Enantioselective Three-Component Couplings as Direct Access to Silylated Indanols
2016
Palladium(II)-Catalyzed Regioselective Arylation of Naphthylamides with Aryl Iodides Utilizing a Quinolinamide Bidentate System
2013
Nickel-Catalyzed Direct Amination of Arenes with Alkylamines
2015
Pd(II)-Catalyzed Intermolecular Arylation of Unactivated C(sp3)–H Bonds with Aryl Bromides Enabled by 8-Aminoquinoline Auxiliary
2014
Metal-Catalyzed Decarboxylative C–H Functionalization
2017 Standout
Copper-Mediated Dehydrogenative Biaryl Coupling of Naphthylamines and 1,3-Azoles
2013
Mild CH Halogenation of Anilides and the Isolation of an Unusual Palladium(I)–Palladium(II) Species
2011
Density Functional Theory Study of N–CN and O–CN Bond Cleavage by an Iron Silyl Complex
2012
Ni(II)-Catalyzed Sulfonylation of ortho C–H Bonds in Aromatic Amides Utilizing an N,N-Bidentate Directing Group
2015
Iron‐Catalyzed C−H Alkynylation through Triazole Assistance: Expedient Access to Bioactive Heterocycles
2017
Oxalyl amide assisted palladium-catalyzed synthesis of pyrrolidones via carbonylation of γ-C(sp3)–H bonds of aliphatic amine substrates
2015
Regioselective Introduction of Heteroatoms at the C-8 Position of Quinoline N-Oxides: Remote C–H Activation Using N-Oxide as a Stepping Stone
2014
Ruthenium-catalyzed cyclocarbonylation of aliphatic amides through the regioselective activation of unactivated C(sp3)–H bonds
2013
Ruthenium-catalyzed direct arylation of C–H bonds in aromatic amides containing a bidentate directing group: significant electronic effects on arylation
2012
Nickel-Catalyzed Oxidative Decarboxylative (Hetero)Arylation of Unactivated C–H Bonds: Ni and Ag Synergy
2017
Nickel-catalyzed ortho-halogenation of unactivated (hetero)aryl C–H bonds with lithium halides using a removable auxiliary
2016
Direct Arylation of C(sp3)–H Bonds in Aliphatic Amides with Diaryliodonium Salts in the Presence of a Nickel Catalyst
2014
Highly Diastereoselective Synthesis of Tetrahydropyridines by a C–H Activation–Cyclization–Reduction Cascade
2012
Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds
2011 Standout
Nickel- and Copper-Catalyzed Direct Alkynylation of Azoles and Polyfluoroarenes with Terminal Alkynes under O2 or Atmospheric Conditions
2010
Bimetallic Nickel Complexes for Aniline C–H Alkylations
2018
Complementary Strategies for Directed C(sp3)−H Functionalization: A Comparison of Transition‐Metal‐Catalyzed Activation, Hydrogen Atom Transfer, and Carbene/Nitrene Transfer
2017
Nickel(II)-Catalyzed Direct Arylation of C–H Bonds in Aromatic Amides Containing an 8-Aminoquinoline Moiety as a Directing Group
2014
Iridium(III)-Catalyzed C-7 Selective C–H Alkynylation of Indolines at Room Temperature
2015
Pd(II)-Catalyzed Primary-C(sp3)–H Acyloxylation at Room Temperature
2012
Tandem Isomerization and C–H Activation: Regioselective Hydroheteroarylation of Allylarenes
2013
Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents
2014 Standout
Ni(ii )–salt catalyzed activation of primary amine-sp3Cα–H and cyclization with 1,2-diketone to tetrasubstituted imidazoles
2013
Ruthenium‐Catalyzed Carbonylation of ortho CH Bonds in Arylacetamides: CH Bond Activation Utilizing a Bidentate‐Chelation System
2012
Mild Palladium‐Catalyzed Oxidative Direct ortho‐CH Acylation of Anilides under Aqueous Conditions
2013
Ruthenium(II)-Catalyzed C–H Arylation of Azoarenes by Carboxylate Assistance
2015
Copper-Catalyzed Direct Alkynylation of Electron-Deficient Polyfluoroarenes with Terminal Alkynes Using O2 as an Oxidant
2010
Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups
2015
Para-Selective Gold-Catalyzed Direct Alkynylation of Anilines
2012
Carboxylate-Assisted Ruthenium-Catalyzed Alkyne Annulations by C–H/Het–H Bond Functionalizations
2013 Standout
Copper-Catalyzed Etherification of Arene C–H Bonds
2013
Pd(II)-Catalyzed ortho-C–H Oxidation of Arylacetic Acid Derivatives: Synthesis of Benzofuranones
2014
1,1-Dibromo-1-alkenes as Valuable Partners in the Copper-Catalyzed Direct Alkynylation of Azoles
2010
Nickel-catalyzed direct alkynylation of C(sp2)–H bonds of amides: an “inverse Sonogashira strategy” to ortho-alkynylbenzoic acids
2015
Palladium–Silver Cooperativity in an Aryl Amination Reaction through C–H Functionalization
2015
Asymmetric Palladium-Catalyzed Directed Intermolecular Fluoroarylation of Styrenes
2014
Well-defined palladium(ii ) complexes for ligand-enabled C(sp3)-alkynylation
2015
A Practical Strategy for the Structural Diversification of Aliphatic Scaffolds through the Palladium‐Catalyzed Picolinamide‐Directed Remote Functionalization of Unactivated C(sp3)H Bonds
2011
Aerobic Copper-Catalyzed Organic Reactions
2013 Standout
Nickel-Catalyzed Site-Selective Alkylation of Unactivated C(sp3)–H Bonds
2014
Photochemical Nickel-Catalyzed C–H Arylation: Synthetic Scope and Mechanistic Investigations
2016
Nickel-Catalyzed Direct Alkynylation of Azoles with Alkynyl Bromides
2009
Highly Efficient and Versatile Pd-Catalyzed Direct Alkynylation of Both Azoles and Azolines
2010
The Nickel(II)-Catalyzed Direct Benzylation, Allylation, Alkylation, and Methylation of C–H Bonds in Aromatic Amides Containing an 8-Aminoquinoline Moiety as the Directing Group
2015
Transition metal-catalyzed direct remote C–H functionalization of alkyl groups via C(sp3)–H bond activation
2014
Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization
2012 Standout
Photoredox Activation for the Direct β-Arylation of Ketones and Aldehydes
2013 Science
Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes
2015 Standout
Metal and Metal Oxide Nanoparticles: A Lever for C–H Functionalization
2016
Palladium-Catalyzed Oxidative C–H Bond Coupling of Steered Acetanilides and Aldehydes: A Facile Access to ortho-Acylacetanilides
2011
A General Strategy for the Nickel‐Catalyzed C−H Alkylation of Anilines
2016
Mild and Efficient Ir(III)-Catalyzed Direct C–H Alkynylation of N-Phenoxyacetamides with Terminal Alkyne
2015
Cobalt‐Catalyzed sp2‐C−H Activation: Intermolecular Heterocyclization with Allenes at Room Temperature
2016
Nickel-Catalyzed Direct Alkylation of C–H Bonds in Benzamides and Acrylamides with Functionalized Alkyl Halides via Bidentate-Chelation Assistance
2013
Silver-Free Palladium-Catalyzed sp3 and sp2 C–H Alkynylation Promoted by a 1,2,3-Triazole Amine Directing Group
2016
Ligand-Enabled, Copper-Promoted Regio- and Chemoselective Hydroxylation of Arenes, Aryl Halides, and Aryl Methyl Ethers
2016
Nickel-Catalyzed C–H Coupling with Allyl Phosphates: A Site-Selective Synthetic Route to Linear Allylarenes
2014
Ni(i )–Ni(iii ) vs. Ni(ii )–Ni(iv ): mechanistic study of Ni-catalyzed alkylation of benzamides with alkyl halides
2017
Dual Catalysis Strategies in Photochemical Synthesis
2016 Standout
Manganese‐Catalyzed C−H Alkynylation: Expedient Peptide Synthesis and Modification
2017
Ohne dirigierende Gruppen: übergangsmetallkatalysierte C‐H‐Aktivierung einfacher Arene
2012
Eine formale inverse Sonogashira‐Reaktion: direkte Alkinylierung von Arenen und Heterocyclen mit Alkinylhalogeniden
2010
Directing‐Group‐mediated C−H‐Alkynylations
2018
Nickel(II)‐Mediated Regioselective CH Monoiodination of Arenes and Heteroarenes by using Molecular Iodine
2016
Advances in Synthetic Applications of Hypervalent Iodine Compounds
2016 Standout
Sulfoximine Assisted Pd(II)-Catalyzed Bromination and Chlorination of Primary β-C(sp3)–H Bond
2014
Ruthenium(II)-Catalyzed C–H Alkynylation of Weakly Coordinating Benzoic Acids
2017
Broad-Scope Rh-Catalyzed Inverse-Sonogashira Reaction Directed by Weakly Coordinating Groups
2018
Ligand‐Assisted Palladium(II)/(IV) Oxidation for sp3 CH Fluorination
2016
Nickel-catalyzed thiolation of unactivated aryl C–H bonds: efficient access to diverse aryl sulfides
2015
Ruthenium-Catalyzed C–H Alkynylation of Aromatic Amides with Hypervalent Iodine–Alkyne Reagents
2016
Nickel-Catalyzed C–H Alkynylation of Anilines: Expedient Access to Functionalized Indoles and Purine Nucleobases
2016
The Halogen Bond
2016 Standout
High-Valent Co(III)- and Ni(II)-Catalyzed C–H Activation
2014
Cu(II)-Mediated Ortho C–H Alkynylation of (Hetero)Arenes with Terminal Alkynes
2014
Cp∗Co(III)-catalyzed direct functionalization of aromatic C–H bonds with α-diazomalonates
2015
1,2,3-Triazoles as versatile directing group for selective sp2 and sp3 C–H activation: cyclization vs substitution
2013
Palladium-Catalyzed Remote C(sp3)–H Arylation of 3-Pinanamine
2014
Iron‐Catalyzed Diastereoselective Synthesis of α‐(Methoxycarbonyl)allylsilanes
2012
Rh(III)-Catalyzed Regioselective Functionalization of C–H Bonds of Naphthylcarbamates for Oxidative Annulation with Alkynes
2014
Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
2013 Standout
Copper-Mediated Tandem Oxidative C(sp2)–H/C(sp)–H Alkynylation and Annulation of Arenes with Terminal Alkynes
2014
Stereoselective Synthesis of β-Alkylated α-Amino Acids via Palladium-Catalyzed Alkylation of Unactivated Methylene C(sp3)–H Bonds with Primary Alkyl Halides
2013
Kinetic Isotope Effects in the Study of Organometallic Reaction Mechanisms
2011
Copper-Mediated Direct Aryloxylation of Benzamides Assisted by an N,O-Bidentate Directing Group
2014
Cobalt-Catalyzed Cyclization of Aliphatic Amides and Terminal Alkynes with Silver-Cocatalyst
2015
Palladium-Catalyzed Picolinamide-Directed Alkylation of Unactivated C(sp3)–H Bonds with Alkyl Iodides
2013
Palladium(0)-Catalyzed Alkynylation of C(sp3)–H Bonds
2013
A Density Functional Theory (DFT) Mechanistic Study of Gold(I)-Catalyzed Alkynylation of the Indole and Pyrrole Substrates, Using a Hypervalent Iodine Reagent
2014
Transition Metal-Catalyzed C–H Amination: Scope, Mechanism, and Applications
2017 Standout
Ligand-Accelerated C−H Activation Reactions: Evidence for a Switch of Mechanism
2010
Direct C−H Transformation via Iron Catalysis
2010 Standout
Asymmetric C–H functionalization of cyclopropanes using an isoleucine-NH2 bidentate directing group
2015
Nickel-catalyzed direct thiolation of unactivated C(sp3)–H bonds with disulfides
2015
Nickel-Catalyzed Oxidative Coupling of Unactivated C(sp3)–H Bonds in Aliphatic Amides with Terminal Alkynes
2016
Nickel-catalyzed and benzoic acid-promoted direct sulfenylation of unactivated arenes
2015
Oxidierende dirigierende Gruppen ermöglichen effiziente und innovative C‐H‐Aktivierungsreaktionen
2011
Catalytic CC bond forming transformations via direct β-CH functionalization of carbonyl compounds
2014
Cobalt(III)-Catalyzed Synthesis of Indazoles and Furans by C–H Bond Functionalization/Addition/Cyclization Cascades
2014
The mechanism of directed Ni(ii )-catalyzed C–H iodination with molecular iodine
2017
Pd(ii)-catalyzed alkoxylation of unactivated C(sp3)–H and C(sp2)–H bonds using a removable directing group: efficient synthesis of alkyl ethers
2013
β-Arylation of Carboxamides via Iron-Catalyzed C(sp3)–H Bond Activation
2013
Palladium-Catalyzed Alkenylation and Alkynylation of ortho-C(sp2)–H Bonds of Benzylamine Picolinamides
2012
Heterocyclic Nanographenes and Other Polycyclic Heteroaromatic Compounds: Synthetic Routes, Properties, and Applications
2016 Standout
Cu-Catalyzed Radical Cascade Annulations of Alkyne-Tethered N-Alkoxyamides with Air: Facile Access to Isoxazolidine/1,2-Oxazinane-Fused Isoquinolin-1(2H)-ones
2018
Rhodium(iii )-catalyzed C7-position C–H alkenylation and alkynylation of indolines
2014
Iridium-Catalyzed Arene Ortho-Silylation by Formal Hydroxyl-Directed C−H Activation
2010
Formal SN‐Type Reactions in Rhodium(III)‐Catalyzed CH Bond Activation
2014
Cobalt-Catalyzed Bis-alkynylation of Amides via Double C–H Bond Activation
2016
Nickel-Catalyzed Addition-Type Alkenylation of Unactivated, Aliphatic C–H Bonds with Alkynes: A Concise Route to Polysubstituted γ-Butyrolactones
2015
Highly Efficient and Versatile Synthesis of Polyarylfluorenes via Pd-Catalyzed C−H Bond Activation
2009
Palladium-catalyzed N-(2-pyridyl)sulfonyl-directed C(sp3)–H γ-arylation of amino acid derivatives
2012
Z-Selective Copper-Catalyzed Asymmetric Allylic Alkylation with Grignard Reagents
2012 StandoutNobel
Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site
2023 StandoutNobel
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
2010 Standout
Copper‐Mediated CH/CH Biaryl Coupling of Benzoic Acid Derivatives and 1,3‐Azoles
2013
Scandium‐Catalyzed Silylation of Aromatic CH Bonds
2011
Transition‐Metal‐Catalyzed Direct C–H Alkenylation, Alkynylation, Benzylation, and Alkylation of (Hetero)arenes
2010
Stereoselective Synthesis of Chiral α‐Amino‐β‐Lactams through Palladium(II)‐Catalyzed Sequential Monoarylation/Amidation of C(sp3)H Bonds
2013
Modern Transition-Metal-Catalyzed Carbon–Halogen Bond Formation
2016
Enzymatic Nitrogen Insertion into Unactivated C–H Bonds
2022 Nobel
An Approach to Five‐Membered Lactams from Aliphatic Amides and Terminal Acetylenes by Nickel Catalysis
2016
Rhenium-Catalyzed Trifluoromethylation of Arenes and Heteroarenes by Hypervalent Iodine Reagents
2012
Ligand-Enabled Methylene C(sp3)–H Bond Activation with a Pd(II) Catalyst
2012
Synthesis of Primary and Secondary Alkylboronates through Site-Selective C(sp3)–H Activation with Silica-Supported Monophosphine–Ir Catalysts
2013
Nickel‐Catalyzed Stereospecific C−H Coupling of Benzamides with Epoxides
2018
Applications of C–H Functionalization Logic to Cyclobutane Synthesis
2014
Reusable directing groups [8-aminoquinoline, picolinamide, sulfoximine] in C(sp3)–H bond activation: present and future
2015
Auxiliary-assisted palladium-catalyzed halogenation of unactivated C(sp3)–H bonds at room temperature
2016
Palladium-Catalyzed Asymmetric Arylation of C(sp3)–H Bonds of Aliphatic Amides: Controlling Enantioselectivity Using Chiral Phosphoric Amides/Acids
2015
Ir-catalyzed highly selective addition of pyridyl C–H bonds to aldehydes promoted by triethylsilane
2010
Palladium-Catalyzed Cs2CO3-Promoted Arylation of Unactivated C(sp3)–H Bonds by (Diacetoxyiodo)arenes: Shifting the Reactivity of (Diacetoxyiodo)arenes from Acetoxylation to Arylation
2015
Nickel‐Catalyzed Directed Benzylation of Ortho C−H Bonds in Aromatic Amides through C−H/C−N Cleavage
2017
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme
2017 StandoutNobel
Understanding Ni(II)-Mediated C(sp3)–H Activation: Tertiary Ureas as Model Substrates
2018
Cobalt-catalyzed ortho-alkenylation of aromatic aldimines via chelation-assisted C–H bond activation
2013
Works of Yusuke Ano being referenced
Rhodium‐Catalyzed Silylation of Aromatic Carbon–Hydrogen Bonds in 2‐Arylpyridines with Disilane
2008
Bidentate Directing Groups: An Efficient Tool in C–H Bond Functionalization Chemistry for the Expedient Construction of C–C Bonds
2020
Palladium Nanoparticle‐Catalyzed Direct Ethynylation of Aliphatic Carboxylic Acid Derivatives via C(sp3)H Bond Functionalization
2014
Ruthenium-Catalyzed Direct ortho-Alkynylation of Arenes with Chelation Assistance
2012
Nickel-Catalyzed Chelation-Assisted Transformations Involving Ortho C–H Bond Activation: Regioselective Oxidative Cycloaddition of Aromatic Amides to Alkynes
2011
Nickel-catalyzed C–H/N–H annulation of aromatic amides with alkynes in the absence of a specific chelation system
2017
Nickel‐Catalyzed Benzylation of C−H Bonds in Aromatic Amides with Benzyltrimethylammonium Halides
2017
Nickel-catalyzed oxidative C–H/N–H annulation of N-heteroaromatic compounds with alkynes
2019
Palladium-Catalyzed Direct Alkynylation of C−H Bonds in Benzenes
2009
Rhodium-Catalyzed Silylation and Intramolecular Arylation of Nitriles via the Silicon-Assisted Cleavage of Carbon−Cyano Bonds
2008
Palladium-Catalyzed Direct Ethynylation of C(sp3)–H Bonds in Aliphatic Carboxylic Acid Derivatives
2011
Palladium-Catalyzed Direct ortho-Alkynylation of Aromatic Carboxylic Acid Derivatives
2011