Standout Papers
Citation Impact
Citing Papers
A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection
2009
In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses
2008
Characterization of a canine homolog of hepatitis C virus
2011 StandoutNobel
A Combination of Chemoimmunotherapies Can Efficiently Break Self-Tolerance and Induce Antitumor Immunity in a Tolerogenic Murine Tumor Model
2007 StandoutNobel
Several rAAV Vectors Efficiently Cross the Blood–brain Barrier and Transduce Neurons and Astrocytes in the Neonatal Mouse Central Nervous System
2011
A Single Intravenous rAAV Injection as Late as P20 Achieves Efficacious and Sustained CNS Gene Therapy in Canavan Mice
2013
Short DNA Hairpins Compromise Recombinant Adeno-Associated Virus Genome Homogeneity
2017
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Thermal Stability as a Determinant of AAV Serotype Identity
2017
The Thermotolerant Yeast Kluyveromyces marxianus Is a Useful Organism for Structural and Biochemical Studies of Autophagy
2015 StandoutNobel
Enhanced efficacy of DNA vaccination against Her‐2/neu tumor antigen by genetic adjuvants
2004
Stereotactic body radiation therapy vs. radiofrequency ablation in Asian patients with hepatocellular carcinoma
2020
Emerging roles of PKM2 in cell metabolism and cancer progression
2012 StandoutNobel
Engineering adeno-associated viruses for clinical gene therapy
2014
In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy
2016
Robust cellular reprogramming occurs spontaneously during liver regeneration
2013
Parvovirus glycan interactions
2014
A view on drug resistance in cancer
2019 StandoutNature
Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia
2010
A multifunctional AAV–CRISPR–Cas9 and its host response
2016
AAV Capsid Structure and Cell Interactions
2011
Hepatocellular carcinoma
2018 Standout
mRNA vaccines — a new era in vaccinology
2018 StandoutNobel
Gene therapy for neurological disorders: progress and prospects
2018
Targeting cellular metabolism to improve cancer therapeutics
2013
The biology and management of non-small cell lung cancer
2018 StandoutNature
Adeno-associated virus (AAV) capsid genes isolated from rat and mouse liver genomic DNA define two new AAV species distantly related to AAV-5
2006
Redirecting N-acetylaspartate metabolism in the central nervous system normalizes myelination and rescues Canavan disease
2017
Isolation and evaluation of novel adeno-associated virus sequences from porcine tissues
2009
Nedaplatin: a cisplatin derivative in cancer chemotherapy
2013
Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
2016 Standout
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future
2017 Standout
A 10 Patient Case Report on the Impact of Plasmapheresis Upon Neutralizing Factors Against Adeno-associated Virus (AAV) Types 1, 2, 6, and 8
2011
Altering AAV tropism with mosaic viral capsids
2005
Osimertinib or Platinum–Pemetrexed in EGFR T790M–Positive Lung Cancer
2016 Standout
Precision Diagnosis and Treatment for Advanced Non–Small-Cell Lung Cancer
2017
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Effect of viral dose on neutralizing antibody response and transgene expression after AAV1 vector re-administration in mice
2007
Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection
2008
Autophagy: Renovation of Cells and Tissues
2011 Standout
Biomedical applications of biodegradable polymers
2011 Standout
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes
2008
MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production
2016
Lung cancer: current therapies and new targeted treatments
2016 Standout
The Evolving Landscape of Brain Metastasis
2018
Metazoan MicroRNAs
2018 Standout
A Rationally Engineered Capsid Variant of AAV9 for Systemic CNS-Directed and Peripheral Tissue-Detargeted Gene Delivery in Neonates
2018
Redefining Chronic Viral Infection
2009
Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration
2018
Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies
2016
Germline viral “fossils” guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus
2016
Worldwide Epidemiology of Neutralizing Antibodies to Adeno‐Associated Viruses
2009
DNA Shuffling of Adeno-associated Virus Yields Functionally Diverse Viral Progeny
2008
The Impact of the Gut Microbiota on Human Health: An Integrative View
2012 Standout
In vivo genome editing using Staphylococcus aureus Cas9
2015 StandoutNature
Autophagy in Human Health and Disease
2013 Standout
Role of radiotherapy in the management of hepatocellular carcinoma: A systematic review
2015
Distinct Neuronal Coding Schemes in Memory Revealed by Selective Erasure of Fast Synchronous Synaptic Transmission
2012 StandoutNobel
Directed evolution of adeno-associated virus yields enhanced gene delivery vectors
2006
Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease
2016
Gene Transfer Properties and Structural Modeling of Human Stem Cell-derived AAV
2014
In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector
2015
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
Autophagy modulation as a potential therapeutic target for diverse diseases
2012 Standout
AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity
2015
Adeno-associated virus vector as a platform for gene therapy delivery
2019 Standout
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Systemic Delivery of MeCP2 Rescues Behavioral and Cellular Deficits in Female Mouse Models of Rett Syndrome
2013
Phase 1 Gene Therapy for Duchenne Muscular Dystrophy Using a Translational Optimized AAV Vector
2011
MicroRNA-regulated, Systemically Delivered rAAV9: A Step Closer to CNS-restricted Transgene Expression
2010 Nobel
Autophagy as a target for anticancer therapy
2011
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
microRNA122-regulated transgene expression increases specificity of cardiac gene transfer upon intravenous delivery of AAV9 vectors
2010
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display Differential Efficiency and Cell Tropism after Delivery to Different Regions of the Central Nervous System
2004
Novel Adeno-associated Viruses Derived From Pig Tissues Transduce Most Major Organs in Mice
2014
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
The PI3K Pathway in Human Disease
2017 Standout
Clinicopathologic correlation of beclin-1 expression in pancreatic ductal adenocarcinoma
2011
Evidence for Health Decision Making — Beyond Randomized, Controlled Trials
2017
Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
2018 Standout
The status of platinum anticancer drugs in the clinic and in clinical trials
2010 Standout
VEGF in Signaling and Disease: Beyond Discovery and Development
2019 Standout
Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes
2017 StandoutNobel
Emerging Issues in AAV-Mediated In Vivo Gene Therapy
2017
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Adeno-Associated Virus Vectors for Short Hairpin RNA Expression
2005
Beclin 1 expression predicts favorable clinical outcome in patients with diffuse large B-cell lymphoma treated with R-CHOP
2011
Hepatocellular carcinoma
2022 Standout
Delivery and Specificity of CRISPR/Cas9 Genome Editing Technologies for Human Gene Therapy
2015
Unraveling the Complex Story of Immune Responses to AAV Vectors Trial After Trial
2017
Hepatic Gene Transfer in Neonatal Mice by Adeno-Associated Virus Serotype 8 Vector
2011
Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors
2010
Direct Intracranial Injection of AAVrh8 Encoding Monkey β-N-Acetylhexosaminidase Causes Neurotoxicity in the Primate Brain
2017
Adeno-Associated Virus Gene Therapy for Liver Disease
2016
Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC
2018 Standout
Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity
2013 StandoutScienceNobel
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
2016 Standout
Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models
2021
Gene therapy for dyslipidemia: a review of gene replacement and gene inhibition strategies
2010
Erratum: Gene therapy for neurological disorders: progress and prospects
2018
IL-10–Induced miR-155 Targets SOCS1 To Enhance IgE-Mediated Mast Cell Function
2016
Adeno-Associated Virus Type 2 VP2 Capsid Protein Is Nonessential and Can Tolerate Large Peptide Insertions at Its N Terminus
2004
TIMER2.0 for analysis of tumor-infiltrating immune cells
2020 Standout
Stimulation of the Glucocorticoid-Induced TNF Receptor Family-Related Receptor on CD8 T Cells Induces Protective and High-Avidity T Cell Responses to Tumor-Specific Antigens
2010 StandoutNobel
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection
2015
Capsid Antibodies to Different Adeno-Associated Virus Serotypes Bind Common Regions
2013
995. Effect of Viral Dose on Neutralizing Antibody Response and Transgene Expression after AAV1 Vector Re-Administration in Mice
2006
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
Molecular Characterization of Adeno-Associated Viruses Infecting Children
2005
Machine Learning in Medicine
2019 Standout
Adeno-Associated Virus Structural Biology as a Tool in Vector Development
2013
Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys
2013
In vivo genome editing improves motor function and extends survival in a mouse model of ALS
2017
Association Between Plasma Genotyping and Outcomes of Treatment With Osimertinib (AZD9291) in Advanced Non–Small-Cell Lung Cancer
2016
Characterization of Adeno-Associated Virus Genomes Isolated from Human Tissues
2005
Novel Caprine Adeno-Associated Virus (AAV) Capsid (AAV-Go.1) Is Closely Related to the Primate AAV-5 and Has Unique Tropism and Neutralization Properties
2005
Pre-existing Anti–Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy
2013
The Assembly-Activating Protein Promotes Capsid Assembly of Different Adeno-Associated Virus Serotypes
2011
Chimeric Antigen Receptor Therapy
2018 Standout
Improving the Quality of Adeno-Associated Viral Vector Preparations: The Challenge of Product-Related Impurities
2017
Adeno-associated Virus (AAV) Serotypes Have Distinctive Interactions with Domains of the Cellular AAV Receptor
2017
Complementary roles of gasotransmitters CO and H2S in sleep apnea
2017 StandoutNobel
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma
2018 Standout
Advances in Copper Complexes as Anticancer Agents
2013 Standout
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
Discovery and Characterization of Mammalian Endogenous Parvoviruses
2010
Comparative Analysis of Adeno-Associated Virus Capsid Stability and Dynamics
2013
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
External beam radiotherapy for unresectable hepatocellular carcinoma
2017
Transcatheter Arterial Chemoembolization Plus Radiotherapy Compared With Chemoembolization Alone for Hepatocellular Carcinoma
2015
Management of hepatocellular carcinoma: an overview of major findings from meta-analyses
2016
High Prevalence of Infectious Adeno-associated Virus (AAV) in Human Peripheral Blood Mononuclear Cells Indicative of T Lymphocytes as Sites of AAV Persistence
2016
Works of You Lü being referenced
Phase II evaluation of nedaplatin and paclitaxel in patients with metastatic esophageal carcinoma
2008
Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model
2010
Beclin-1 Expression is a Predictor of Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma and Correlated to Hypoxia-Inducible Factor (HIF)-1α Expression
2009
MicroRNA-155 is essential for TH2-mediated allergen-induced eosinophilic inflammation in the lung
2013
Immunophenotyping of Circulating T Helper Cells Argues for Multiple Functions and Plasticity of T Cells In Vivo in Humans - Possible Role in Asthma
2012
Transcatheter arterial chemoembolization in combination with radiotherapy for unresectable hepatocellular carcinoma: A systematic review and meta-analysis
2008
Assessment of a passive immunity mouse model to quantitatively analyze the impact of neutralizing antibodies on adeno-associated virus-mediated gene transfer
2012
Biology of AAV Serotype Vectors in Liver-Directed Gene Transfer to Nonhuman Primates
2005
A tumor hypoxic niche protects human colon cancer stem cells from chemotherapy
2012
Intrathecal chemotherapy as a treatment for leptomeningeal metastasis of non-small cell lung cancer: A pooled analysis
2016
One‐step preparation of poly(ϵ‐caprolactone)‐poly(ethylene glycol)‐poly(ε‐caprolactone) nanoparticles for plasmid DNA delivery
2007
Adjuvant Therapeutic Modalities in Primary Small Cell Carcinoma of Esophagus Patients
2016
Gefitinib plus chemotherapy versus placebo plus chemotherapy in EGFR-mutation-positive non-small-cell lung cancer after progression on first-line gefitinib (IMPRESS): a phase 3 randomised trial
2015
Molecular Analysis of Vector Genome Structures After Liver Transduction by Conventional and Self-Complementary Adeno-Associated Viral Serotype Vectors in Murine and Nonhuman Primate Models
2010
Gefitinib Plus Chemotherapy Versus Chemotherapy in Epidermal Growth Factor Receptor Mutation–Positive Non–Small-Cell Lung Cancer Resistant to First-Line Gefitinib (IMPRESS): Overall Survival and Biomarker Analyses
2017
High-Level Transgene Expression in Nonhuman Primate Liver with Novel Adeno-Associated Virus Serotypes Containing Self-Complementary Genomes
2006
Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues
2004
BEYOND: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase III Study of First-Line Carboplatin/Paclitaxel Plus Bevacizumab or Placebo in Chinese Patients With Advanced or Recurrent Nonsquamous Non–Small-Cell Lung Cancer
2015
Immunogene Therapy of Tumors with Vaccine Based on Xenogeneic Epidermal Growth Factor Receptor
2003
Adeno-associated viruses undergo substantial evolution in primates during natural infections
2003