Citation Impact
Citing Papers
TRP channel activation by reversible covalent modification
2006 StandoutNobel
TRP Channels as Potential Drug Targets
2017
New fACEs to the Renin-Angiotensin System
2005
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
2011 StandoutNobel
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
2007 StandoutNobel
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex
2018 StandoutScienceNobel
Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades
2009
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
2020 StandoutScienceNobel
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
2020 StandoutScience
Dynamic regulation of TREK1 gating by Polycystin 2 via a Filamin A-mediated cytoskeletal Mechanism
2017
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
2003 StandoutNobel
Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling
2015
Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target
2020 Standout
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection
2020 Standout
Renal transplantation following previous heart, liver, and lung transplantation: An 8-year single-center experience
2001
The emerging role of ACE2 in physiology and disease
2007
Mechanisms of SARS-CoV-2 entry into cells
2021 Standout
The Primary cilium calcium channels and their role in flow sensing
2014
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
2020 Standout
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels
2005 StandoutNobel
Subcellular localization and trafficking of polycystins
2005
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
2020 Standout
Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects
2001
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
The genetics of IgA nephropathy
2007
Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ
2008
Predictors and Evolution of Renal Function during 9 Years Following Heart Transplantation
2000
Myocardial infarction increases ACE2 expression in rat and humans
2005
Predictors of renal function following lung or heart-lung transplantation
2002
HLA Has Strongest Association with IgA Nephropathy in Genome-Wide Analysis
2010 StandoutNobel
Transient receptor potential channelopathies
2010
Polycystin-1 expression in PKD1, early-onset PKD1, and TSC2/PKD1 cystic tissue
1999
Renal Failure in the Recipients of Nonrenal Solid Organ Transplants
1999
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
2003 StandoutNature
The incidence of renal failure in one hundred consecutive heart-lung transplant recipients
1995
Regulation of ACE2 in cardiac myocytes and fibroblasts
2008
Just the Beginning: Novel Functions for Angiotensin-Converting Enzymes
2002
Ion Transport in Sperm Signaling
2001
Vitamin D Deficiency
2007 Standout
Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation
1997
ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis
2004
Pharmacokinetics and Pharmacodynamics of Recombinant Human Angiotensin-Converting Enzyme 2 in Healthy Human Subjects
2013
A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
2010 StandoutNobel
Chronic cyclosporine nephropathy: The Achilles' heel of immunosuppressive therapy
1996
The pathogenesis of autosomal dominant polycystic kidney disease: an update
2000
ACE2 gene expression is up-regulated in the human failing heart
2004
The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism
2000
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
2003 Standout
Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents
2000 Nature
Angiotensin-Converting Enzyme 2 — A New Cardiac Regulator
2002
Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2
2018
Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme
2002
Mechanically Activated Ion Channels
2015 StandoutNobel
Novel Peptide Inhibitors of Angiotensin-converting Enzyme 2
2003
Chronic Renal Failure after Transplantation of a Nonrenal Organ
2003 Standout
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
2011 StandoutNatureNobel
Effect of hydro-osmotic pressure on polycystin-2 channel function in the human syncytiotrophoblast
2005
Polycystin-2 Is a Novel Cation Channel Implicated in Defective Intracellular Ca2+ Homeostasis in Polycystic Kidney Disease
2001
Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis
2004 Standout
The Polycystic Kidney Disease Proteins, Polycystin-1, Polycystin-2, Polaris, and Cystin, Are Co-Localized in Renal Cilia
2002
Structural Conservation of the Genes Encoding CaT1, CaT2, and Related Cation Channels
2001
Racial and Genetic Factors in IgA Nephropathy
2008
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
2020 Standout
TRP channels as cellular sensors
2003 StandoutNature
Chronic cyclosporine nephrotoxicity
1998
The Position of the Polycystic Kidney Disease 1 (PKD1) Gene Mutation Correlates with the Severity of Renal Disease
2002
Molecular Genetics and Mechanism of Autosomal Dominant Polycystic Kidney Disease
2000
Interaction of ACE2 and integrin β1 in failing human heart
2004
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
Role of polycystins in renal tubulogenesis
2003
Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels
2019
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
Transport Function of the Naturally Occurring Pathogenic Polycystin-2 Mutant, R742X
2001
The ciliary flow sensor and polycystic kidney disease
2013
The genetics and physiology of polycystic kidney disease
2001
Drugs acting on renin angiotensin system and use in ill patients with COVID-19
2020
Hypertension as a marker for later development of end-stage renal failure after lung and heart-lung transplantation: A cohort study
2004
Polycystin expression during embryonic development of human kidney in adult tissues and ADPKD tissue
1997
Angiotensin-converting enzyme 2 protects from severe acute lung failure
2005 StandoutNature
Risk Factors for Chronic Renal Dysfunction in Cardiac Allograft Recipients
2000
Constitutive Activation of G-proteins by Polycystin-1 Is Antagonized by Polycystin-2
2002
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Expression and regulation of the neutral amino acid transporter B0AT1 in rat small intestine
2017
Cyclosporin nephrotoxicity in heart and lung transplant patients
1996
Polycystin
2001
Polycystin-2 is an intracellular calcium release channel
2002
The Role of ACE2 in Cardiovascular Physiology
2003
Angiotensin-(1-7) and its receptor as a potential targets for new cardiovascular drugs
2005
Physiology of Local Renin-Angiotensin Systems
2006 Standout
TRP channels: An overview
2005
Cardiac defects and renal failure in mice with targeted mutations in Pkd2
2000
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
2020 StandoutNature
Somatic Inactivation of Pkd2 Results in Polycystic Kidney Disease
1998
A Flagellar Polycystin-2 Homolog Required for Male Fertility in Drosophila
2003
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells
2019
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
Identification and Characterization of a Novel Polycystin Family Member, Polycystin-L2, in Mouse and Human: Sequence, Expression, Alternative Splicing, and Chromosomal Localization
2000
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
2006 StandoutNobel
A local pancreatic renin-angiotensin system: endocrine and exocrine roles
2003
Transient Receptor Potential Cation Channels in Disease
2007 Standout
Current advances in molecular genetics of autosomal-dominant polycystic kidney disease
2001
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
Combinatorial Signal Perception in the BMP Pathway
2017
Identification of a Potential Peptide Inhibitor of SARS-CoV-2 Targeting its Entry into the Host Cells
2020
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2
2020 Standout
Urinary Angiotensin-Converting Enzyme 2 in Hypertensive Patients May Be Increased by Olmesartan, an Angiotensin II Receptor Blocker
2014
ACE2: A New Target for Cardiovascular Disease Therapeutics
2007
Role of YAP/TAZ in mechanotransduction
2011 StandoutNature
Human genetics, animal models and computer simulations for studying hypertension☆
2004 StandoutNobel
Tissue-Specific Amino Acid Transporter Partners ACE2 and Collectrin Differentially Interact With Hartnup Mutations
2008
Invertebrate TRP proteins as functional models for mammalian channels
2004
Specific association of the gene product of PKD2 with the TRPC1 channel
1999
A protein complex in the brush‐border membrane explains a Hartnup disorder allele
2008
TRP Channels in Disease
2005
Piezo1‐dependent stretch‐activated channels are inhibited by Polycystin‐2 in renal tubular epithelial cells
2013
Pathological Role of Angiotensin II in Severe COVID-19
2020
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Extrarenal Manifestations of Autosomal Dominant Polycystic Kidney Disease
1991
Angiotensin-Converting Enzyme 2: The First Decade
2011
Angiotensin-Converting Enzyme II in the Heart and the Kidney
2006
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene
2001 StandoutNobel
The TRP Superfamily of Cation Channels
2005
Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals
2007 StandoutNobel
Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene
2001
Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels
2001
Polycystin 1 is required for the structural integrity of blood vessels
2000
Autosomal dominant polycystic kidney disease: Molecular genetics and pathophysiology
2003
Increased ACE 2 and Decreased ACE Protein in Renal Tubules From Diabetic Mice
2004
Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca 2+ -permeable nonselective cation channel
2000
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
2020 StandoutScience
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Polycystins and partners: proposed role in mechanosensitivity
2014
Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels
2001
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4
2009 StandoutNobel
Gating of the polycystin ion channel signaling complex in neurons and kidney cells
2004
Angiotensin-(1–7) Acts as a Vasodepressor Agent Via Angiotensin II Type 2 Receptors in Conscious Rats
2005
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
2018 StandoutNobel
Recent Developments in Vascular Endothelial Cell Transient Receptor Potential Channels
2005
AN INTRODUCTION TO TRP CHANNELS
2005 Standout
Role and mechanism of angiotensin‐converting enzyme 2 in acute lung injury in coronavirus disease 2019
2020
ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension
2015
CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus
2004
Asymmetric mechanosensitivity in a eukaryotic ion channel
2017
Polycystins: inhibiting the inhibitors
2005
Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry
2005
Severely Reduced Production of Klotho in Human Chronic Renal Failure Kidney
2001
Increased Angiotensin-(1-7)–Forming Activity in Failing Human Heart Ventricles
2003
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
2002 StandoutScienceNobel
Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation
2020
Bone metabolism and disease in chronic kidney disease
2003
Polycystin channels and kidney disease
2001
Native Polycystin 2 Functions as a Plasma Membrane Ca2+-Permeable Cation Channel in Renal Epithelia
2003
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2
2015
De novo design of protein logic gates
2020 StandoutScienceNobel
Works of York Pei being referenced
Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients.
1997
A novel frameshift mutation induced by an adenosine insertion in the polycystic kidney disease 2 (PKD2) gene
1998
Angiotensin-converting enzyme 2 is an essential regulator of heart function
2002 Nature
The spectrum of bone disease in end-stage renal failure—An evolving disorder
1993
Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling
2008
A RANDOMIZED CONTROLLED TRIAL OF VERAPAMIL ON CYCLOSPORINE NEPHROTOXICITY IN HEART AND LUNG TRANSPLANT RECIPIENTS1
1997
Non-invasive prediction of aluminum bone disease in hemo- and peritoneal dialysis patients
1992
Renal osteodystrophy in diabetic patients
1993
Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations
2000
Aplastic osteodystrophy without aluminum: The role of “suppressed” parathyroid function
1993
IL5RA and TNFRSF6B Gene Variants Are Associated With Sporadic IgA Nephropathy
2008
Somatic PKD2 Mutations in Individual Kidney and Liver Cysts Support a “Two-Hit” Model of Cystogenesis in Type 2 Autosomal Dominant Polycystic Kidney Disease
1999
Mechanoprotection by Polycystins against Apoptosis Is Mediated through the Opening of Stretch-Activated K2P Channels
2012
Identification and localization of polycystin, the PKD1 gene product.
1996
Coordinate Expression of the Autosomal Dominant Polycystic Kidney Disease Proteins, Polycystin-2 And Polycystin-1, in Normal and Cystic Tissue
1999
Identification of PKDL, a Novel Polycystic Kidney Disease 2-Like Gene Whose Murine Homologue Is Deleted in Mice with Kidney and Retinal Defects
1998
Screening plasma aluminum levels in relation to aluminum bone disease among asymptomatic dialysis patients
1999
Relationship between intact 1–84 parathyroid hormone and bone histomorphometric parameters in dialysis patients without aluminum toxicity
1995
Association of mutation position in polycystic kidney disease 1 (PKD1) gene and development of a vascular phenotype
2003
Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease
2017
Chronic Nephrotoxicity in Psoriatic Patients Treated With Low-dose Cyclosporine
1994
CYCLOSPORINE NEPHROTOXICITY IN LUNG TRANSPLANT RECIPIENTS
1992
Genome-Wide Linkage Scan of a Large Family with IgA Nephropathy Localizes a Novel Susceptibility Locus to Chromosome 2q36
2007
Polycystin-1 and polycystin-2 regulate the cell cycle through the helix–loop–helix inhibitor Id2
2005
Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks
2009
Bilineal Disease and Trans-Heterozygotes in Autosomal Dominant Polycystic Kidney Disease
2001
BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis
1997
A spectrum of mutations in the polycystic kidney disease-2 (PKD2) gene from eight Canadian kindreds.
1998
Is there a third gene for autosomal dominant polycystic kidney disease?
1998
Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease
2011
Risk factors for renal osteodystrophy: A multivariant analysis
1995