Standout Papers
Citation Impact
Citing Papers
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
MicroRNA-155 is induced during the macrophage inflammatory response
2007 StandoutNobel
RNA Polymerase II Is Required for RNAi-Dependent Heterochromatin Assembly
2005 Science
Redundancy and specialization among plant microRNAs: role of the MIR164 family in developmental robustness
2007
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
MicroRNAs Regulate Brain Morphogenesis in Zebrafish
2005 Science
Components of the Arabidopsis mRNA Decapping Complex Are Required for Early Seedling Development
2007
Transposition-Driven Genomic Heterogeneity in the Drosophila Brain
2013 StandoutScienceNobel
Distinct Populations of Primary and Secondary Effectors During RNAi in C. elegans
2006 StandoutScienceNobel
A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection
2019
Deletion of Human tarbp2 Reveals Cellular MicroRNA Targets and Cell-Cycle Function of TRBP
2014
Genomic Analysis Suggests that mRNA Destabilization by the Microprocessor Is Specialized for the Auto-Regulation of Dgcr8
2009
MicroRNA-298 and MicroRNA-328 Regulate Expression of Mouse β-Amyloid Precursor Protein-converting Enzyme 1
2008
Drosha regulates neurogenesis by controlling Neurogenin 2 expression independent of microRNAs
2012
Bioinformatic discovery of microRNA precursors from human ESTs and introns
2006
From snoRNA to miRNA: Dual function regulatory non-coding RNAs
2011
Posttranscriptional Regulation of miRNAs Harboring Conserved Terminal Loops
2008
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
MicroRNA Biogenesis: Drosha Can't Cut It without a Partner
2005
Autoinhibition of Human Dicer by Its Internal Helicase Domain
2008 StandoutNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
TDP-43 Regulates the Microprocessor Complex Activity During In Vitro Neuronal Differentiation
2013
Identification of soybean microRNAs and their targets
2008
Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
2013 StandoutNobel
Phosphorylation of the RNase III enzyme Drosha at Serine300 or Serine302 is required for its nuclear localization
2010
ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing
2013
Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein
2005
A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer
2014
RNA Helicase A Interacts with RISC in Human Cells and Functions in RISC Loading
2007
A human, ATP-independent, RISC assembly machine fueled by pre-miRNA
2005
Transcription and Processing of Human microRNA Precursors
2004
The RNA-binding region of human TRBP interacts with microRNA precursors through two independent domains
2013
Genome-wide identification of targets of the drosha–pasha/DGCR8 complex
2009 StandoutNobel
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Dynamic profiling of double-stranded RNA binding proteins
2015
Dicer is dispensable for asymmetric RISC loading in mammals
2011
RDE-4 preferentially binds long dsRNA and its dimerization is necessary for cleavage of dsRNA to siRNA
2006
Kinetic Analysis Reveals the Fate of a MicroRNA following Target Regulation in Mammalian Cells
2011
A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity
2008 StandoutNobel
Sorting of Drosophila Small Silencing RNAs
2007
Lessons from Nature: microRNA-based shRNA libraries
2006
Structural insights into RNA processing by the human RISC-loading complex
2009 StandoutNobel
Alternative Processing of Primary microRNA Transcripts by Drosha Generates 5′ End Variation of Mature microRNA
2009
DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures
2010
Crystal structure of human DGCR8 core
2007
Recognition of the pre-miRNA structure by Drosophila Dicer-1
2011
DGCR8 HITS-CLIP reveals novel functions for the Microprocessor
2012
Coordinated Activities of Human Dicer Domains in Regulatory RNA Processing
2012 StandoutNobel
Functional Anatomy of the Human Microprocessor
2015
Hierarchical Rules for Argonaute Loading in Drosophila
2009
Regulation of microRNA biogenesis
2014 Standout
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Targeting microRNAs in cancer: rationale, strategies and challenges
2010
Dicer-TRBP Complex Formation Ensures Accurate Mammalian MicroRNA Biogenesis
2014 StandoutNobel
MiRFinder: an improved approach and software implementation for genome-wide fast microRNA precursor scans
2007
MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex
2014
Drosophila microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1
2007
On the road to reading the RNA-interference code
2009 Nature
A miRacle in plant development: Role of microRNAs in cell differentiation and patterning
2008
Two molecular features contribute to the Argonaute specificity for the microRNA and RNAi pathways in C. elegans
2008
c-Myc-regulated microRNAs modulate E2F1 expression
2005 StandoutNature
Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs
2008
Structure of the Human Dicer-TRBP Complex by Electron Microscopy
2009
Substrate-Specific Kinetics of Dicer-Catalyzed RNA Processing
2010 StandoutNobel
Mono-Uridylation of Pre-MicroRNA as a Key Step in the Biogenesis of Group II let-7 MicroRNAs
2012
Role of Dicer in Posttranscriptional RNA Silencing
2007
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
2010
Origins and Mechanisms of miRNAs and siRNAs
2009 Standout
Argonaute2 expression is post-transcriptionally coupled to microRNA abundance
2013
Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor
2015
A novel noncoding RNA processed by Drosha is restricted to nucleus in mouse
2008
Plant microRNA: A small regulatory molecule with big impact
2005
Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection
2008
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Small silencing RNAs: an expanding universe
2009 Standout
Spatio‐temporal accumulation of microRNAs is highly coordinated in developing plant tissues
2006
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
2011 StandoutNatureNobel
MicroRNA biogenesis: coordinated cropping and dicing
2005 Standout
Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer
2014
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
The Human DiGeorge Syndrome Critical Region Gene 8 and Its D. melanogaster Homolog Are Required for miRNA Biogenesis
2004
Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis
2010
An Aptamer Targeting the Apical‐Loop Domain Modulates pri‐miRNA Processing
2010
An Optimized microRNA Backbone for Effective Single-Copy RNAi
2013
Posttranscriptional Crossregulation between Drosha and DGCR8
2009
SMAD proteins control DROSHA-mediated microRNA maturation
2008 Nature
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs
2008
Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha
2010
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Selective Degradation of Host MicroRNAs by an Intergenic HCMV Noncoding RNA Accelerates Virus Production
2013
Mature and functional viral miRNAs transcribed from novel RNA polymerase III promoters
2009
Modulation of microRNA processing and expression through RNA editing by ADAR deaminases
2005
Widespread microRNA repression by Myc contributes to tumorigenesis
2007
Regulation of Small RNA Accumulation in the Maize Shoot Apex
2009
Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway
2009
A role for the Dicer helicase domain in the processing of thermodynamically unstable hairpin RNAs
2008
Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi
2006 StandoutNobel
Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA
2008
A Mammalian Herpesvirus Uses Noncanonical Expression and Processing Mechanisms to Generate Viral MicroRNAs
2010
Metazoan MicroRNAs
2018 Standout
Structural determinants of RNA recognition and cleavage by Dicer
2007 StandoutNobel
Argonaute proteins: functional insights and emerging roles
2013
Evolution of microRNA diversity and regulation in animals
2011
Making RISC
2010
Epigenetic Modulation of miR-122 Facilitates Human Embryonic Stem Cell Self-Renewal and Hepatocellular Carcinoma Proliferation
2011
Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing
2005
The Menu of Features that Define Primary MicroRNAs and Enable De Novo Design of MicroRNA Genes
2015
Efficient Processing of Primary microRNA Hairpins by Drosha Requires Flanking Nonstructured RNA Sequences
2005
Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals
2012
Argonaute proteins: key players in RNA silencing
2007
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling
2009
Acetylation of Drosha on the N-Terminus Inhibits Its Degradation by Ubiquitination
2013
Small RNA sorting: matchmaking for Argonautes
2010
The Continuing Story of Endoribonuclease III
2004
Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5
2007
Differential regulation of microRNA stability
2010
Functional Anatomy of the Drosophila MicroRNA-generating Enzyme
2007
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Human microRNA prediction through a probabilistic co-learning model of sequence and structure
2005
Diversifying microRNA sequence and function
2013
Origin, Biogenesis, and Activity of Plant MicroRNAs
2009 Standout
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
2005 StandoutNature
RNA polymerase III transcribes human microRNAs
2006
Processing of Pre-microRNAs by the Dicer-1–Loquacious Complex in Drosophila Cells
2005
Dicer's helicase domain is required for accumulation of some, but not all, C. elegans endogenous siRNAs
2010
Versatile microRNA biogenesis in animals and their viruses
2014
The Microprocessor controls the activity of mammalian retrotransposons
2013
Ribonuclease revisited: structural insights into ribonuclease III family enzymes
2006 StandoutNobel
Non-coding RNAs in human disease
2011 Standout
Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing
2013
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions
2008
A Human snoRNA with MicroRNA-Like Functions
2008
Specialization and evolution of endogenous small RNA pathways
2007
Structure of Arabidopsis HYPONASTIC LEAVES1 and Its Molecular Implications for miRNA Processing
2010
MicroRNAs: a developing story
2005
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal
2007
The interaction between DCL1 and HYL1 is important for efficient and precise processing of pri-miRNA in plant microRNA biogenesis
2006
The next generation of CRISPR–Cas technologies and applications
2019
Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes
2007
Phosphorylation of DGCR8 Increases Its Intracellular Stability and Induces a Progrowth miRNA Profile
2013
Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila
2011
The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a
2007
Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss
2009
Inhibition of microRNA with antisense oligonucleotides
2007
siRNA Repositioning for Guide Strand Selection by Human Dicer Complexes
2011 StandoutNobel
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs
2007
Phosphate and R2D2 Restrict the Substrate Specificity of Dicer-2, an ATP-Driven Ribonuclease
2011
Small RNAs: Regulators and guardians of the genome
2007
Alternative miRNA Biogenesis Pathways and the Interpretation of Core miRNA Pathway Mutants
2011
MicroRNA promoter element discovery in Arabidopsis
2006
The let-7 family of microRNAs
2008
Glycogen Synthase Kinase 3 Beta (GSK3β) Phosphorylates the RNAase III Enzyme Drosha at S300 and S302
2011
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
2014 Standout
Posttranscriptional Regulation of MicroRNA Biogenesis in Animals
2010
Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins
2007
Canonical and alternate functions of the microRNA biogenesis machinery
2010
Drosha in Primary MicroRNA Processing
2006
Origins and evolution of eukaryotic RNA interference
2008
Essential and overlapping functions for mammalian Argonautes in microRNA silencing
2009
MicroRNA Biogenesis via Splicing and Exosome-Mediated Trimming in Drosophila
2010
Primary microRNA transcripts are processed co-transcriptionally
2008
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Human TRBP and PACT Directly Interact with Each Other and Associate with Dicer to Facilitate the Production of Small Interfering RNA
2007
Imprinted noncoding RNAs
2008
A call to arms: coevolution of animal viruses and host innate immune responses
2007
miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii
2007 Nature
Functions of microRNAs and related small RNAs in plants
2006
Target-Mediated Protection of Endogenous MicroRNAs in C. elegans
2011
Comparative Analysis of the MIR319a MicroRNA Locus in Arabidopsis and Related Brassicaceae
2008
dsRNA Binding Properties of RDE-4 and TRBP Reflect Their Distinct Roles in RNAi
2008
Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability
2007 StandoutNobel
Argonaute-Bound Small RNAs from Promoter-Proximal RNA Polymerase II
2014
Dicer recognizes the 5′ end of RNA for efficient and accurate processing
2011 Nature
Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila
2005
The Mirtron Pathway Generates microRNA-Class Regulatory RNAs in Drosophila
2007
3′ End Processing of a Long Nuclear-Retained Noncoding RNA Yields a tRNA-like Cytoplasmic RNA
2008
RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing
2005
Heme is involved in microRNA processing
2006
Evolution of plant microRNAs and their targets
2008
Long noncoding RNAs: functional surprises from the RNA world
2009 Standout
Large-Scale Sequencing Reveals 21U-RNAs and Additional MicroRNAs and Endogenous siRNAs in C. elegans
2006
Biogenesis of small RNAs in animals
2009 Standout
Structures of the first and second double‐stranded RNA‐binding domains of human TAR RNA‐binding protein
2010
Dual Role for Argonautes in MicroRNA Processing and Posttranscriptional Regulation of MicroRNA Expression
2007
A Primate Herpesvirus Uses the Integrator Complex to Generate Viral MicroRNAs
2011
Perspective: machines for RNAi
2005
Processing of intronic microRNAs
2007
Argonaute Proteins: Mediators of RNA Silencing
2007
Molecular Basis for Interaction of let-7 MicroRNAs with Lin28
2011
Multiple sensors ensure guide strand selection in human RNAi pathways
2013 StandoutNobel
Intronic microRNA precursors that bypass Drosha processing
2007 Nature
TALEN-based knockout library for human microRNAs
2013
Identification of microRNAs of the herpesvirus family
2005 StandoutNobel
Biochemical mechanisms of the RNA-induced silencing complex
2007
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Submergence-responsive MicroRNAs are Potentially Involved in the Regulation of Morphological and Metabolic Adaptations in Maize Root Cells
2008
Evolution and Functional Diversification of MIRNA Genes
2011
Mature clustered, regularly interspaced, short palindromic repeats RNA (crRNA) length is measured by a ruler mechanism anchored at the precursor processing site
2011
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Mechanisms of control of microRNA biogenesis
2010
Improved asymmetry prediction for short interfering RNA s
2013
microRNAs exhibit high frequency genomic alterations in human cancer
2006
Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes
2005
MicroRNAs in Cancer
2008
Re-evaluation of the roles of DROSHA , Exportin 5 , and DICER in microRNA biogenesis
2016
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing
2012
Frequency and fate of microRNA editing in human brain
2008
TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation
2009
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Drosha-independent DGCR8/Pasha pathway regulates neuronal morphogenesis
2014
Processing of microRNA primary transcripts requires heme in mammalian cells
2014
ATP-independent diffusion of double-stranded RNA binding proteins
2012 StandoutNobel
Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
2005
Expression of Arabidopsis MIRNA Genes
2005
Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production
2008
Coupled RNA Processing and Transcription of Intergenic Primary MicroRNAs
2009
Repression of α-synuclein expression and toxicity by microRNA-7
2009
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease
2008
RNA sequence analysis defines Dicer's role in mouse embryonic stem cells
2007
Functional Association of the Microprocessor Complex with the Spliceosome
2009
Recognition of siRNA Asymmetry by TAR RNA Binding Protein
2010
In vitro reconstitution of the human RISC-loading complex
2008 StandoutNobel
A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition
2008
NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
2006 StandoutNobel
RNA Scanning of a Molecular Machine with a Built-in Ruler
2016 StandoutNobel
MicroRNAs AND THEIR REGULATORY ROLES IN PLANTS
2006 Standout
Stress-Induced Phosphorylation of PACT Reduces Its Interaction with TRBP and Leads to PKR Activation
2011
Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8
2012
Myogenic factors that regulate expression of muscle-specific microRNAs
2006
A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure
2006
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
Dissecting the roles of TRBP and PACT in double‐stranded RNA recognition and processing of noncoding RNAs
2015
Lower and upper stem–single-stranded RNA junctions together determine the Drosha cleavage site
2013
The Multiple Functions of TRBP, at the Hub of Cell Responses to Viruses, Stress, and Cancer
2012
RNAi Mechanisms and Applications
2008
Works of Yoontae Lee being referenced
MicroRNA genes are transcribed by RNA polymerase II
2004 Standout
Genome-wide CRISPR/Cas9 Screen Identifies Host Factors Essential for Influenza Virus Replication
2018
microRNA‐directed cleavage of ATHB15 mRNA regulates vascular development in Arabidopsis inflorescence stems
2005
Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p
2013
Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing
2006
Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex
2006
The Drosha-DGCR8 complex in primary microRNA processing
2004 Standout
miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis
2008
The role of PACT in the RNA silencing pathway
2006