Standout Papers
Citation Impact
Citing Papers
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Direct and Catalytic C ‐Glycosylation of Arenes: Expeditious Synthesis of the Remdesivir Nucleoside**
2021 StandoutNobel
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
2019 StandoutNobel
Identification of a Small Interface between the Methyltransferase and RNA Polymerase of NS5 that is Essential for Zika Virus Replication
2018 StandoutNobel
Direct Synthesis of Fluorinated Heteroarylether Bioisosteres
2013
Catalytic Selective Synthesis
2012
Manganese‐Catalyzed Selective Oxidation of Aliphatic CH groups and Secondary Alcohols to Ketones with Hydrogen Peroxide
2013 StandoutNobel
Regioselective C–H bond functionalizations of acridines using organozinc reagents
2011
A broadly applicable [18F]trifluoromethylation of aryl and heteroaryl iodides for PET imaging
2013
Regioselective trifluoromethylation of N-heteroaromatic compounds using trifluoromethyldifluoroborane activator
2014
Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis
2011 Nature
A scalable and operationally simple radical trifluoromethylation
2015
Copper‐Catalyzed Oxidative Trifluoromethylthiolation of Aryl Boronic Acids with TMSCF3 and Elemental Sulfur
2012
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Introduction of Fluorine and Fluorine‐Containing Functional Groups
2013 Standout
Trifluoromethylation of Allylsilanes under Copper Catalysis
2012
6‐Trifluoromethyl‐Phenanthridines through Radical Trifluoromethylation of Isonitriles
2013
In Situ Generation of PhI+CF3 and Transition‐Metal‐Free Oxidative sp2 CH Trifluoromethylation
2013
Ortho‐Trifluoromethylation of Functionalized Aromatic Triazenes
2012
Photochemical Perfluoroalkylation with Pyridine N -Oxides: Mechanistic Insights and Performance on a Kilogram Scale
2016
Copper-mediated C–H trifluoromethylation of quinones
2013
Iron(II)‐Catalyzed Trifluoromethylation of Potassium Vinyltrifluoroborates
2012
A “Renaissance” in Radical Trifluoromethylation
2012
Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation
2013
C–H activation reactions as useful tools for medicinal chemists
2016
Visible‐Light Photoredox Catalysis
2012 Standout
Exceedingly Fast Copper(II)‐Promoted ortho CH Trifluoromethylation of Arenes using TMSCF3
2014
Copper‐Catalyzed Tandem Trifluoromethylation/Semipinacol Rearrangement of Allylic Alcohols
2013
Continuous‐Flow Technology—A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients
2015 Standout
Copper-catalyzed synthesis of trifluoromethyl-substituted isoxazolines
2013
Recent advances in fluorination techniques and their anticipated impact on drug metabolism and toxicity
2015
tBuLi‐Mediated One‐Pot Direct Highly Selective Cross‐Coupling of Two Distinct Aryl Bromides
2015 StandoutNobel
CuCl-catalyzed ortho trifluoromethylation of arenes and heteroarenes with a pivalamido directing group
2013
Direct Selective Oxidative Cross‐Coupling of Simple Alkanes with Heteroarenes
2013
Practical and innate carbon–hydrogen functionalization of heterocycles
2012 Nature
A General Strategy for the Perfluoroalkylation of Arenes and Arylbromides by Using Arylboronate Esters and [(phen)CuRF]
2011
The Cross‐Dehydrogenative Coupling of CH Bonds: A Versatile Strategy for CC Bond Formations
2013 Standout
Radical CH Functionalization of Heteroarenes under Electrochemical Control
2014
Late‐Stage Functionalization of Biologically Active Heterocycles Through Photoredox Catalysis
2014
Transition‐Metal‐Free Trifluoromethylaminoxylation of Alkenes
2012
Transition-metal-free oxidative trifluoromethylation of unsymmetrical biaryls with trifluoromethanesulfinate
2013
Metal‐Free Photochemical Aromatic Perfluoroalkylation of α‐Cyano Arylacetates
2014
Investigations into Transition-Metal-Catalyzed Arene Trifluoromethylation Reactions
2012
Diaryliodoniums by Rhodium(III)‐Catalyzed CH Activation: Mild Synthesis and Diversified Functionalizations
2015
Dehydrogenative alkenylation of uracils via palladium-catalyzed regioselective C–H activation
2013
Copper‐Catalyzed Trifluoromethylation‐Initiated Radical 1,2‐Aryl Migration in α,α‐Diaryl Allylic Alcohols
2013
Trifluoromethylation of Alkenes with Concomitant Introduction of Additional Functional Groups
2014
PhI(OAc)2‐Mediated Radical Trifluoromethylation of Vinyl Azides with Me3SiCF3
2013
Beyond Directing Groups: Transition‐Metal‐Catalyzed CH Activation of Simple Arenes
2012 Standout
Recent Developments on the Trifluoromethylation of (Hetero)Arenes
2012
Alcohols as alkylating agents in heteroarene C–H functionalization
2015 Nature
Synthetic Organic Electrochemistry: An Enabling and Innately Sustainable Method
2016
Photoredox-Catalyzed Tandem Radical Cyclization of N-Arylacrylamides: General Methods To Construct Fluorinated 3,3-Disubstituted 2-Oxindoles Using Fluoroalkylsulfonyl Chlorides
2014
Nickel‐Catalyzed Cross‐Coupling of Organolithium Reagents with (Hetero)Aryl Electrophiles
2015 StandoutNobel
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Eosin Y (EY) Photoredox‐Catalyzed Sulfonylation of Alkenes: Scope and Mechanism
2016
Photoexcitation of flavoenzymes enables a stereoselective radical cyclization
2019 Science
Iron Catalysis in Organic Synthesis
2015 Standout
3d Transition Metals for C–H Activation
2018 Standout
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Copper-Catalyzed Direct C–H Oxidative Trifluoromethylation of Heteroarenes
2011
Novel Multicomponent Reactions via Trapping of Protic Onium Ylides with Electrophiles
2013 Standout
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Innate and Guided C–H Functionalization Logic
2011
Direct Access to α-Trifluoromethyl Enones via Efficient Copper-Catalyzed Trifluoromethylation of Meyer–Schuster Rearrangement
2014
Radicals: Reactive Intermediates with Translational Potential
2016
PhI(OAc)2-mediated oxidative trifluoromethylation of arenes with CF3SiMe3 under metal-free conditions
2012
Carbon Trifluoromethylation Reactions of Hydrocarbon Derivatives and Heteroarenes
2015
Organic Photoredox Catalysis
2016 Standout
Ortho‐Trifluormethylierung funktionalisierter aromatischer Triazene
2012
Silver-Mediated Methoxycarbonyltetrafluoroethylation of Arenes
2013
Fe-Catalyzed Nucleophilic Activation of C–Si versus Allylic C–O Bonds: Catalytic Trifluoromethylation of Carbonyl Groups versus Tandem Trifluormethylation–Allylation of Olefins
2014
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
A Decade of Advancements in Pauson–Khand‐Type Reactions
2009
Oxidative Coupling between Two Hydrocarbons: An Update of Recent C–H Functionalizations
2015 Standout
Catalyst-controlled reverse selectivity in C–C bond formation: NHC-Cu-catalyzed α-selective allylic alkylation with organolithium reagents
2015 StandoutNobel
A Metal‐Free Route to CF3‐Containing Oxindoles by PhI(OAc)2‐Mediated Trifluoromethylation of N‐Arylacrylamides with TMSCF3
2013
Redox chemistry of trifluoromethyl sulfonium salts as CF3 radical sources
2013
Copper-Catalyzed Direct C–H Trifluoromethylation of Quinones
2013
Introducing a new radical trifluoromethylation reagent
2015
A General Strategy for the Perfluoroalkylation of Arenes and Arylbromides by Using Arylboronate Esters and [(phen)CuRF]
2011
Pd(II)-Catalyzed Ortho Trifluoromethylation of Arenes and Insights into the Coordination Mode of Acidic Amide Directing Groups
2012
Photoinduced Cobalt(III)−Trifluoromethyl Bond Activation Enables Arene C−H Trifluoromethylation
2017
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
Late-Stage Deoxyfluorination of Alcohols with PhenoFluor
2013
Photoredox-Induced Three-Component Oxy-, Amino-, and Carbotrifluoromethylation of Enecarbamates
2014
Mild metal-catalyzed C–H activation: examples and concepts
2016 Standout
Oxidation of Alkenes with H2O2 by an in-Situ Prepared Mn(II)/Pyridine-2-carboxylic Acid Catalyst and the Role of Ketones in Activating H2O2
2012 StandoutNobel
The ProTide Prodrug Technology: From the Concept to the Clinic
2017
Recent advances in the trifluoromethylation methodology and new CF3-containing drugs
2014
Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis
2014
Kinetic Resolution of Benzylamines via Palladium(II)-Catalyzed C–H Cross-Coupling
2016
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Catalytic hydrotrifluoromethylation of styrenes and unactivated aliphatic alkenes via an organic photoredox system
2013
Rapid Trifluoromethylation of Indole Derivatives
2012
Copper‐Catalyzed Oxidative Trifluoromethylthiolation of Aryl Boronic Acids with TMSCF3 and Elemental Sulfur
2012
Palladium-Catalyzed Transformations of Alkyl C–H Bonds
2016 Standout
Highly Efficient Synthesis of HIV NNRTI Doravirine
2015
Titanium Enolate Chemistry at the Beginning of the 21st Century
2016
Metal-mediated radical perfluoroalkylation of organic compounds
2013
Academia–Industry Symbiosis in Organic Chemistry
2015
Copper(i)-catalyzed diastereoselective hydroxytrifluoromethylation of dienes accelerated by phosphine ligands
2013
The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
2015
Progress in Copper‐Mediated Formation of Trifluoromethylated Arenes
2012
Application of Langlois’ Reagent in Trifluoromethylation Reactions
2014
Electrophilic Trifluoromethylation by Copper-Catalyzed Addition of CF3-Transfer Reagents to Alkenes and Alkynes
2012
Direct Selective Oxidative Cross‐Coupling of Simple Alkanes with Heteroarenes
2013
A New Reagent for Direct Difluoromethylation
2012
Site-Selective Functionalization of Hydroxyl Groups in Carbohydrate Derivatives
2018
Visible-Light-Promoted Radical C–H Trifluoromethylation of Free Anilines
2014
Copper-Catalyzed C–H Difluoroalkylations and Perfluoroalkylations of Alkenes and (Hetero)arenes
2017
Azine Activation via Silylium Catalysis
2021 StandoutNobel
Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents
2014 Standout
PhI(OAc)2-Mediated Synthesis of 6-(Trifluoromethyl)phenanthridines by Oxidative Cyclization of 2-Isocyanobiphenyls with CF3SiMe3 under Metal-Free Conditions
2013
Copper-Mediated Aerobic Fluoroalkylation of Arylboronic Acids with Fluoroalkyl Iodides at Room Temperature
2012
Metal-Free Direct 1,6- and 1,2-Difunctionalization Triggered by Radical Trifluoromethylation of Alkenes
2015
Novel Method to Assess the Molecular Weights of Fluoropolymers by Radical Copolymerization of Vinylidene Fluoride with Various Fluorinated Comonomers Initiated by a Persistent Radical
2013
Cross Dehydrogenative Coupling via Base-Promoted Homolytic Aromatic Substitution (BHAS): Synthesis of Fluorenones and Xanthones
2013
Diastereoselective Allylation of Carbonyl Compounds and Imines: Application to the Synthesis of Natural Products
2013 Standout
Direct Trifluoromethylation of the CH Bond
2013
Aerobic Copper-Catalyzed Organic Reactions
2013 Standout
Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
2017 Standout
Copper- and Iron-Catalyzed Decarboxylative Tri- and Difluoromethylation of α,β-Unsaturated Carboxylic Acids with CF3SO2Na and (CF2HSO2)2Zn via a Radical Process
2013
Catalytic Asymmetric Synthesis of the anti‐COVID‐19 Drug Remdesivir
2020
Continuous Flow Homolytic Aromatic Substitution with Electrophilic Radicals: A Fast and Scalable Protocol for Trifluoromethylation
2016
Practical Method for the Cu-Mediated Trifluoromethylation of Arylboronic Acids with CF3 Radicals Derived from NaSO2CF3 and tert-Butyl Hydroperoxide (TBHP)
2012
C–H Functionalization of Azines
2017
Chiral Diarylmethanes via Copper-Catalyzed Asymmetric Allylic Arylation with Organolithium Compounds
2015 StandoutNobel
Silver-Mediated Trifluoromethylation of Arenes Using TMSCF3
2011
Merging Visible-Light Photocatalysis and Transition-Metal Catalysis in the Copper-Catalyzed Trifluoromethylation of Boronic Acids with CF3I
2012
Dual Catalysis Strategies in Photochemical Synthesis
2016 Standout
Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
2011 Standout
Advances in Synthetic Applications of Hypervalent Iodine Compounds
2016 Standout
Trifluoromethylation of 1‐Aryl‐3,3‐diisopropyltriazenes
2013
Asymmetric Catalysis of the Carbonyl-Amine Condensation: Kinetic Resolution of Primary Amines
2017 StandoutNobel
Trifluoromethyltrimethylsilane: Nucleophilic Trifluoromethylation and Beyond
2014
Photoredox Catalysis in Organic Chemistry
2016 Standout
Einführung von Fluor und fluorhaltigen funktionellen Gruppen
2013
Metal-Free Direct Intramolecular Carbotrifluoromethylation of Alkenes to Functionalized Trifluoromethyl Azaheterocycles
2013
Natural Products as Sources of New Drugs from 1981 to 2014
2016 Standout
Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
2013 Standout
Catalytic Asymmetric Synthesis of the anti‐COVID‐19 Drug Remdesivir
2020
Visible‐Light Photocatalysis: Does It Make a Difference in Organic Synthesis?
2018 Standout
DIAD-mediated metal-free cross dehydrogenative coupling between tertiary amines and α-fluorinated sulfones
2012
Organocatalysis emerging as a technology
2021 StandoutNobel
Applications of Fluorine in Medicinal Chemistry
2015 Standout
CF2H, a Hydrogen Bond Donor
2017 Standout
Silver-mediated fluorination, trifluoromethylation, and trifluoromethylthiolation of arynes
2013
Strong and Confined Acids Enable a Catalytic Asymmetric Nazarov Cyclization of Simple Divinyl Ketones
2019 StandoutNobel
Solar Synthesis: Prospects in Visible Light Photocatalysis
2014 StandoutScience
Asymmetric organocatalysis: an enabling technology for medicinal chemistry
2021
Synthesis of Chiral Cyclopentenones
2016
Synthesis and Applications of tert-Butanesulfinamide
2010
Nickel-catalyzed C H trifluoromethylation of pyridine N-oxides with Togni’s reagent
2018
Trifluoromethylation of heterocycles via visible light photoredox catalysis
2012
Asymmetric synthesis of N,O-heterocycles via enantioselective iridium-catalysed intramolecular allylic amidation
2014 StandoutNobel
Übergangsmetallfreie Trifluormethylaminoxylierung von Alkenen
2012
Iron(II)‐Catalyzed Trifluoromethylation of Potassium Vinyltrifluoroborates
2012
Rhenium-Catalyzed Trifluoromethylation of Arenes and Heteroarenes by Hypervalent Iodine Reagents
2012
Highly mono-selective ortho-trifluoromethylation of benzamides via 8-aminoquinoline assisted Cu-promoted C–H activations
2016
Direct (Hetero)arylation Polymerization: Simplicity for Conjugated Polymer Synthesis
2016
Works of Yining Ji being referenced
A multifunctional catalyst that stereoselectively assembles prodrugs
2017 Science
Highly Enantioselective Synthesis of 3‐Substituted Furanones by Palladium‐Catalyzed Kinetic Resolution of Unsymmetrical Allyl Acetates
2012 StandoutNobel
Facile Quantum Yield Determination via NMR Actinometry
2018
Stereoselective titanium-mediated aldol reactions of (S)-2-tert-butyldimethylsilyloxy-3-pentanone
2006
Asymmetric Hydrogen Bonding Catalysis for the Synthesis of Dihydroquinazoline-Containing Antiviral, Letermovir
2017
Asymmetric Intermolecular Pauson−Khand Reaction of Symmetrically Substituted Alkynes
2009
Mono-Oxidation of Bidentate Bis-phosphines in Catalyst Activation: Kinetic and Mechanistic Studies of a Pd/Xantphos-Catalyzed C–H Functionalization
2015
Innate C-H trifluoromethylation of heterocycles
2011
Tetramethylnorbornadiene, a Versatile Alkene for Cyclopentenone Synthesis through Intermolecular Pauson–Khand Reactions
2012