Standout Papers
Citation Impact
Citing Papers
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
2006
Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
2015 StandoutNobel
MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription
2008 Science
Mapping brain networks in awake mice using combined optical neural control and fMRI
2010
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
A Neural Circuit for Memory Specificity and Generalization
2013 StandoutScienceNobel
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice
2007 StandoutScienceNobel
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
Transposition-Driven Genomic Heterogeneity in the Drosophila Brain
2013 StandoutScienceNobel
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex
2018 StandoutScienceNobel
The Human Language–Associated Gene SRPX2 Regulates Synapse Formation and Vocalization in Mice
2013 Science
NMR Structure Determination for Larger Proteins Using Backbone-Only Data
2010 StandoutScienceNobel
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
Regulation of Insulin Secretion by SIRT4, a Mitochondrial ADP-ribosyltransferase
2007
Sirtuins as regulators of metabolism and healthspan
2012 Standout
Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95
2012
Induction of human neuronal cells by defined transcription factors
2011 StandoutNatureNobel
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors
2014 StandoutNatureNobel
Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle
2010
The Plasticity of Aging: Insights from Long-Lived Mutants
2005
Nuclear Trapping of the Forkhead Transcription Factor FoxO1 via Sirt-dependent Deacetylation Promotes Expression of Glucogenetic Genes
2005
Caenorhabditis elegans HCF-1 Functions in Longevity Maintenance as a DAF-16 Regulator
2008
SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
2007
Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis
2010
Mechanism of Human SIRT1 Activation by Resveratrol
2005
The interaction between FOXO and SIRT1: tipping the balance towards survival
2004
Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
2005
The spindle checkpoint: structural insights into dynamic signalling
2002
MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System
2012
Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity
2008
A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells
2010
A systematic RNAi screen for longevity genes in C. elegans
2005 StandoutNobel
Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
2010
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Epigenetics in human disease and prospects for epigenetic therapy
2004 StandoutNature
The Sir2 family of protein deacetylases
2005
Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c
2016 StandoutNobel
SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α
2005
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis
2000 Standout
DBC1 is a negative regulator of SIRT1
2008 Nature
Conformation‐specific binding of p31comet antagonizes the function of Mad2 in the spindle checkpoint
2004
The Mad1/Mad2 Complex as a Template for Mad2 Activation in the Spindle Assembly Checkpoint
2005
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
The language of covalent histone modifications
2000 StandoutNature
SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons
2008
The Mad2 spindle checkpoint protein has two distinct natively folded states
2004
Scanless two-photon excitation of channelrhodopsin-2
2010
Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities
2012
Blood Pressure Regulation by the Rostral Ventrolateral Medulla in Conscious Rats: Effects of Hypoxia, Hypercapnia, Baroreceptor Denervation, and Anesthesia
2017
Sirtuins, Aging, and Medicine
2011
Recent progress on the Ada response for inducible repair of DNA alkylation damage
2002 StandoutNobel
The Story of Rett Syndrome: From Clinic to Neurobiology
2007
An Integrated Platform for Automated Analysis of Protein NMR Structures
2005
Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification
2008
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
2007
Molecular and Cellular Approaches for Diversifying and Extending Optogenetics
2010
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
Principles for designing ideal protein structures
2012 StandoutNatureNobel
Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1
2007
Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses
2005
Optical recording of action potentials in mammalian neurons using a microbial rhodopsin
2011
Activity-dependent neuronal signalling and autism spectrum disorder
2013 Nature
MeCP2 dysfunction in Rett syndrome and related disorders
2006
Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
2008
Transcriptional targets of sirtuins in the coordination of mammalian physiology
2008
Modeling Study of the Light Stimulation of a Neuron Cell With Channelrhodopsin-2 Mutants
2011
p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans
2006
Determinants of conformational dimerization of Mad2 and its inhibition by p31comet
2006
Hypoxic Induction of the Regulator of G-Protein Signalling 4 Gene Is Mediated by the Hypoxia-Inducible Factor Pathway
2012
Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint
2002
MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons
2010
Enrichment and Site Mapping of O-Linked N-Acetylglucosamine by a Combination of Chemical/Enzymatic Tagging, Photochemical Cleavage, and Electron Transfer Dissociation Mass Spectrometry
2009
PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
2011
Mitochondria, Oxidants, and Aging
2005 Standout
Optogenetic manipulation of neural activity in freely moving Caenorhabditis elegans
2011
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
2005
Mad2 phosphorylation regulates its association with Mad1 and the APC/C
2003
Searching for ways out of the autism maze: genetic, epigenetic and environmental clues
2006
Enhanced Archaerhodopsin Fluorescent Protein Voltage Indicators
2013
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
2007 Standout
Differential Targeting of Optical Neuromodulators to Ganglion Cell Soma and Dendrites Allows Dynamic Control of Center-Surround Antagonism
2011
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells
2004
The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine
2009
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase
2005
SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity
2006
Recent progress in the biology and physiology of sirtuins
2009 Nature
Editing DNA Methylation in the Mammalian Genome
2016
Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques
2012 StandoutNobel
Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
2005
Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons
2014 StandoutNobel
Phosphorylation of Cdc20 by Bub1 Provides a Catalytic Mechanism for APC/C Inhibition by the Spindle Checkpoint
2004
Toward a unified theory of caloric restriction and longevity regulation
2005
Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
2009
AMP-activated protein kinase and its downstream transcriptional pathways
2010
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
2005
The anaphase-promoting complex: it's not just for mitosis any more
2002
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
2004 StandoutNature
Mitochondrial sirtuins
2010
Postnatal Loss of Mef2c Results in Dissociation of Effects on Synapse Number and Learning and Memory
2015
Mad2-Independent Inhibition of APCCdc20 by the Mitotic Checkpoint Protein BubR1
2001
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9
2014
Negative regulation of the deacetylase SIRT1 by DBC1
2008 Nature
DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1
2010
Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins
2011
A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing
2010
Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?
2011
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
2006 Standout
SMK-1, an Essential Regulator of DAF-16-Mediated Longevity
2006
Widespread transcription at neuronal activity-regulated enhancers
2010 StandoutNature
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
2005 StandoutNature
Generation of neuronal variability and complexity
2006 Nature
SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells
2006
Active Regulator of SIRT1 Cooperates with SIRT1 and Facilitates Suppression of p53 Activity
2007
The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes Upon Binding to Either Mad1 or Cdc20
2002
On the road to cancer: aneuploidy and the mitotic checkpoint
2005
Refining the phenotype associated with MEF2C haploinsufficiency
2010
MEF2C haploinsufficiency caused by either microdeletion of the 5q14.3 region or mutation is responsible for severe mental retardation with stereotypic movements, epilepsy and/or cerebral malformations
2009
In Vivo Analysis of MEF2 Transcription Factors in Synapse Regulation and Neuronal Survival
2012
SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
2009
The Transcription Factor Mef2 Links the Drosophila Core Clock to Fas2, Neuronal Morphology, and Circadian Behavior
2013 StandoutNobel
Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans
2011
PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
2009
How Do so Few Control so Many?
2005
Cocaine Regulates MEF2 to Control Synaptic and Behavioral Plasticity
2008
Optogenetics in Neural Systems
2011 Standout
The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor
2007
SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
2010
Optical Silencing of C. elegans Cells with Arch Proton Pump
2012
Modulating Acetyl-CoA Binding in the GCN5 Family of Histone Acetyltransferases
2002
Optochemical Genetics
2011
Rapid optical control of nociception with an ion-channel photoswitch
2012
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
The spindle-assembly checkpoint in space and time
2007 Standout
Imaging neural spiking in brain tissue using FRET-opsin protein voltage sensors
2014
CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
2011
Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity
2013 StandoutScienceNobel
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine
2005 Standout
Metabolic cross-talk allows labeling of O-linked β- N -acetylglucosamine-modified proteins via the N -acetylgalactosamine salvage pathway
2011 StandoutNobel
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
2004
The Biochemistry of Sirtuins
2006
On Acetyl-CoA as a Gauge of Cellular Metabolic State
2011
Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo
2008
Microbial Opsins: A Family of Single-Component Tools for Optical Control of Neural Activity
2011
Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1
2011
DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
2003 Science
MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system
2013
Microtubule-dependent Changes in Assembly of Microtubule Motor Proteins and Mitotic Spindle Checkpoint Proteins at PtK1 Kinetochores
2001
Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway
2004 Science
Mammalian Sirtuins: Biological Insights and Disease Relevance
2010 Standout
Accumulation of Mad2–Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae
2006
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function
2011 StandoutNobel
A high-light sensitivity optical neural silencer: development, and application to optogenetic control of nonhuman primate cortex
2011
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss
2003
MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function
2008
Reversal of DNA alkylation damage by two human dioxygenases
2002 StandoutNobel
Optical Control of Neuronal Activity
2010
Sirtuins — novel therapeutic targets to treat age-associated diseases
2008
Automated Analysis of Protein NMR Assignments and Structures
2004
Two-photon single-cell optogenetic control of neuronal activity by sculpted light
2010
Circadian neuron feedback controls the Drosophila sleep–activity profile
2016 StandoutNatureNobel
The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways
2010
Chemical Glycoproteomics
2016 StandoutNobel
Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
2009 StandoutNobel
Works of Yingxi Lin being referenced
Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
2003 StandoutScience
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
2004 StandoutScience
Activity-dependent regulation of inhibitory synapse development by Npas4
2008 Nature
Bhlhb5 and Prdm8 Form a Repressor Complex Involved in Neuronal Circuit Assembly
2012
Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation
2006
An RNAi-Based Approach Identifies Molecules Required for Glutamatergic and GABAergic Synapse Development
2007
High-performance genetically targetable optical neural silencing by light-driven proton pumps
2010 Nature
Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A
1999 Nature
Efficient side-chain and backbone assignment in large proteins: Application to tGCN5
1999
Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20.
2000
Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number
2006 Science
Structural Basis for the Functional Switch of the E. coli Ada Protein,
2001