Citation Impact
Citing Papers
TRP Channels as Potential Drug Targets
2017
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
2013 StandoutScience
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
2016 StandoutScience
Nucleic acid detection with CRISPR-Cas13a/C2c2
2017 StandoutScience
TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
2008 StandoutScience
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
2006 StandoutScience
Rationally engineered Cas9 nucleases with improved specificity
2015 StandoutScience
Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons
2008 StandoutScience
Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
2006 StandoutScience
Sculpting conducting nanopore size and shape through de novo protein design
2024 StandoutScienceNobel
Sporadic and hereditary amyotrophic lateral sclerosis (ALS)
2014
Probing the contribution of individual polypeptide GalNAc-transferase isoforms to the O-glycoproteome by inducible expression in isogenic cell lines
2018
Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9
2014
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome
2010
De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium
2017
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
A guide to genome engineering with programmable nucleases
2014 Standout
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
2015 Standout
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
2016 StandoutNature
Increased Basal Activity Is a Key Determinant in the Severity of Human Skeletal Dysplasia Caused by TRPV4 Mutations
2011
Wnt signaling in cancer
2016 Standout
Transient receptor potential channelopathies
2010
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors
2006
From charcot to lou gehrig: deciphering selective motor neuron death in als
2001
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
2013 Standout
Enabling functional genomics with genome engineering
2015
Easy quantitative assessment of genome editing by sequence trace decomposition
2014 Standout
Decoding ALS: from genes to mechanism
2016 StandoutNature
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
2013 Standout
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
Therapeutic genome editing: prospects and challenges
2015
<emph type="ital">SQSTM1</emph> Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
2011
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Minocycline Slows Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis
2002
TRPV4-pathy, a novel channelopathy affecting diverse systems
2010
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
MMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCh systems
2015
Loss of autophagy in the central nervous system causes neurodegeneration in mice
2006 StandoutNature
Identification of Two Novel Loci for Dominantly Inherited Familial Amyotrophic Lateral Sclerosis
2003 Nobel
Pore-forming toxins: ancient, but never really out of fashion
2015
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs
2004
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair
2016
The dTAG system for immediate and target-specific protein degradation
2018
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
2006
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Two Families with Familial Amyotrophic Lateral Sclerosis Are Linked to a Novel Locus on Chromosome 16q
2003
The Human Condition—A Molecular Approach
2014 StandoutNobel
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Genetically engineered mouse models of neurodegenerative diseases
2002
Progress and prospects in plant genome editing
2017
Modeling neurodevelopmental disorder-associated humanAGO1mutations inCaenorhabditis elegansArgonautealg-1
2024 StandoutNobel
Genome Editing B.C. (Before CRISPR): Lasting Lessons from the “Old Testament”
2018
EPIDEMIOLOGY OF NEURODEGENERATION
2003
Genetic disruption of the KLF1 gene to overexpress the γ‐globin gene using the CRISPR/Cas9 system
2016
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice
2017
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
CRISPR-CasΦ from huge phages is a hypercompact genome editor
2020 StandoutScienceNobel
Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms
2018
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
Rational design of a split-Cas9 enzyme complex
2015 StandoutNobel
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Selectable One-Step PCR-Mediated Integration of a Degron for Rapid Depletion of Endogenous Human Proteins
2016
Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs
2019 StandoutNobel
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Structural insight into TRPV5 channel function and modulation
2019 StandoutNobel
Neurological Aspects of Human Glycosylation Disorders
2015
UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS
2004
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel
2012
Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress
2020
Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
2009 StandoutNobel
A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia
2006 Nobel
Works of Yi Yang being referenced
A Chemical Genetics Approach for the Functional Assessment of Novel Cancer Genes
2015
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis
2001
Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases
2015
Targeted Genome Editing Tools for Disease Modeling and Gene Therapy
2014
DNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells
2014
Obligate Ligation-Gated Recombination (ObLiGaRe): Custom-designed nuclease-mediated targeted integration through nonhomologous end joining
2012
Comprehensive Transcriptome Profiling and Functional Analysis of the Frog (Bombina maxima) Immune System
2013
Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4
2009