Standout Papers
- Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice (2008)
- Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis (2008)
- Synaptotagmins form a hierarchy of exocytotic Ca 2+ sensors with distinct Ca 2+ affinities (2002)
- Synaptotagmin-1 and -7 are functionally overlapping Ca 2+ sensors for exocytosis in adrenal chromaffin cells (2008)
- Synaptotagmin‐7 is a principal Ca2+ sensor for Ca2+‐induced glucagon exocytosis in pancreas (2009)
- Synaptotagmin VII as a Plasma Membrane Ca2+ Sensor in Exocytosis (2001)
- The C2B Domain of Synaptotagmin I Is a Ca2+-Binding Module (2001)
- N-Glycosylation Is Essential for Vesicular Targeting of Synaptotagmin 1 (2004)
Citation Impact
Citing Papers
Alternative Zippering as an On-Off Switch for SNARE-Mediated Fusion
2009 StandoutScienceNobel
Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A
2005
Augmenting neurotransmitter release by enhancing the apparent Ca 2+ affinity of synaptotagmin 1
2005 StandoutNobel
Visualization of synaptotagmin I oligomers assembled onto lipid monolayers
2003
SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open
2012 StandoutScienceNobel
Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion
2008 StandoutScienceNobel
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Video-Rate Far-Field Optical Nanoscopy Dissects Synaptic Vesicle Movement
2008 StandoutScienceNobel
Regulatory Functions of the N-terminal Domain of the 70-kDa Subunit of Replication Protein A (RPA)
2008
Cellular Functions of Human RPA1
2008
Structural and Mutational Analysis of Functional Differentiation between Synaptotagmins-1 and -7
2010 StandoutNobel
Synaptotagmin Interaction with the Syntaxin/SNAP-25 Dimer Is Mediated by an Evolutionarily Conserved Motif and Is Sensitive to Inositol Hexakisphosphate
2004
Close membrane-membrane proximity induced by Ca2+-dependent multivalent binding of synaptotagmin-1 to phospholipids
2006 StandoutNobel
NMR measurement of the off rate from the first calcium‐binding site of the synaptotagmin I C2A domain
2002
Phosphatidylinositol Phosphates as Co-activators of Ca2+ Binding to C2 Domains of Synaptotagmin 1
2006 StandoutNobel
Ca2+-Dependent Synaptotagmin Binding to SNAP-25 Is Essential for Ca2+-Triggered Exocytosis
2002
The Janus-faced nature of the C2B domain is fundamental for synaptotagmin-1 function
2008
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release
2009 StandoutNobel
Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release
2006
Dynamic control of neuroexocytosis by phosphoinositides in health and disease
2010
Regulated exocytosis and SNARE function (Review)
2003
Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release
2013 StandoutNobel
Synaptotagmin I and IX function redundantly in controlling fusion pore of large dense core vesicles
2007
Phosphorylation of replication protein A by S-phase checkpoint kinases
2006
C-terminal ECFP Fusion Impairs Synaptotagmin 1 Function
2004 StandoutNobel
Dual Roles of the C2B Domain of Synaptotagmin I in Synchronizing Ca2+-Dependent Neurotransmitter Release
2004
Molecular cloning and characterization of human, rat, and mouse synaptotagmin XV
2003
RIM1α and RIM1β Are Synthesized from Distinct Promoters of theRIM1Gene to Mediate Differential But Overlapping Synaptic Functions
2008 StandoutNobel
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
2013 StandoutNobel
Synaptotagmin-2 Is Essential for Survival and Contributes to Ca 2+ Triggering of Neurotransmitter Release in Central and Neuromuscular Synapses
2006 StandoutNobel
Regulation of Replication Protein A Functions in DNA Mismatch Repair by Phosphorylation
2006
Structure and function of SNARE and SNARE-interacting proteins
2005
Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+‐triggered neurotransmitter release
2006 StandoutNobel
Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes
2009
How Tlg2p/syntaxin 16 'snares' Vps45
2002
Membrane protein sequestering by ionic protein–lipid interactions
2011 StandoutNatureNobel
Membrane Fusion
2003 StandoutNobel
Evolutionarily Conserved Multiple C2 Domain Proteins with Two Transmembrane Regions (MCTPs) and Unusual Ca2+ Binding Properties
2004 StandoutNobel
The C2 domains of synaptotagmin – partners in exocytosis
2004
Molecular mechanism of the synaptotagmin–SNARE interaction in Ca2+-triggered vesicle fusion
2010 Nobel
Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP
2012 StandoutNobel
Protein complexes in nucleotide excision repair
1999
Synaptotagmin: A Ca2+ sensor that triggers exocytosis?
2002
Mechanisms of membrane fusion: disparate players and common principles
2008
Computational redesign of endonuclease DNA binding and cleavage specificity
2006 StandoutNatureNobel
A Quaternary SNARE–Synaptotagmin–Ca2+–Phospholipid Complex in Neurotransmitter Release
2007
Cloning and genomic characterization of sytdep, a new synaptotagmin XIV-related gene
2005
The Synaptotagmin C2A Domain Is Part of the Calcium Sensor Controlling Fast Synaptic Transmission
2003
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
Single-Molecule Studies of Synaptotagmin and Complexin Binding to the SNARE Complex
2005 Nobel
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
2007 StandoutNatureNobel
BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair
2011 StandoutNobel
Synaptotagmin mutants Y311N and K326/327A alter the calcium dependence of neurotransmission
2005
Synaptotagmin-1, -2, and -9: Ca2+ Sensors for Fast Release that Specify Distinct Presynaptic Properties in Subsets of Neurons
2007 StandoutNobel
Synaptotagmins: Why So Many?
2002 StandoutNobel
DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair
1998
Human replication protein A: Global fold of the N-terminal RPA-70 domain reveals a basic cleft and flexible C-terminal linker†
1999
A dynamic model for replication protein A (RPA) function in DNA processing pathways
2006
Molecular Cloning, Expression, and Characterization of a Novel Class of Synaptotagmin (Syt XIV) Conserved from Drosophila to Humans
2003
Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10
2011 StandoutNobel
Three-Dimensional Structure of the Synaptotagmin 1 C2B-Domain
2001 StandoutNobel
PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane
2003
Synaptotagmin VII Is Targeted to Dense-core Vesicles and Regulates Their Ca2+-dependent Exocytosis in PC12 Cells
2004
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
2004 StandoutNobel
A Gain-of-Function Mutation in Synaptotagmin-1 Reveals a Critical Role of Ca 2+ -Dependent Soluble N -Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Complex Binding in Synaptic Exocytosis
2006 StandoutNobel
Complexin Activates Exocytosis of Distinct Secretory Vesicles Controlled by Different Synaptotagmins
2013 StandoutNobel
Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells
2002 StandoutNobel
Reluctant Vesicles Contribute to the Total Readily Releasable Pool in Glutamatergic Hippocampal Neurons
2005
Neuronal Calcium Sensor Synaptotagmin-9 Is Not Involved in the Regulation of Glucose Homeostasis or Insulin Secretion
2010 StandoutNobel
Localization Versus Function of Rab3 Proteins
2002 StandoutNobel
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis
2006 StandoutNatureNobel
Presynaptic Capacitance Measurements and Ca2+ Uncaging Reveal Submillisecond Exocytosis Kinetics and Characterize the Ca2+ Sensitivity of Vesicle Pool Depletion at a Fast CNS Synapse
2003
THE SYNAPTIC VESICLE CYCLE
2004 StandoutNobel
Examining Synaptotagmin 1 Function in Dense Core Vesicle Exocytosis under Direct Control of Ca2+
2003 StandoutNobel
Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment
2004
Three distinct kinetic groupings of the synaptotagmin family: Candidate sensors for rapid and delayed exocytosis
2005
Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release
2006 StandoutNobel
Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems
1999 Nobel
Differential but convergent functions of Ca 2+ binding to synaptotagmin-1 C 2 domains mediate neurotransmitter release
2009 StandoutNobel
Miniature Transmitter Release: Accident of Nature or Careful Design?
2003
Functional Characterization of a Cancer Causing Mutation in Human Replication Protein A
2010
Impaired membrane resealing and autoimmune myositis in synaptotagmin VII–deficient mice
2003
Push-and-pull regulation of the fusion pore by synaptotagmin-7
2010 StandoutNobel
Synaptotagmin VII Is Targeted to Secretory Organelles in PC12 Cells, Where It Functions as a High-Affinity Calcium Sensor
2005
Synaptotagmin IX Regulates Ca2+-dependent Secretion in PC12 Cells
2002
Quality Control by DNA Repair
1999 StandoutScienceNobel
Quaternary Structure of ATR and Effects of ATRIP and Replication Protein A on Its DNA Binding and Kinase Activities
2004 StandoutNobel
Unexpected Ca 2+ -binding properties of synaptotagmin 9
2004 StandoutNobel
Structure/Function Analysis of Ca2+Binding to the C2A Domain of Synaptotagmin 1
2002 StandoutNobel
Function of a Conserved Checkpoint Recruitment Domain in ATRIP Proteins
2007
Short-Term Synaptic Plasticity
2002 Standout
Calcium-sensing beyond neurotransmitters: functions of synaptotagmins in neuroendocrine and endocrine secretion
2009
Rfc4 Interacts with Rpa1 and Is Required for Both DNA Replication and DNA Damage Checkpoints in Saccharomyces cerevisiae
2001
A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones
2002 StandoutNobel
How Does Synaptotagmin Trigger Neurotransmitter Release?
2008
Physical Interaction between Replication Protein A (RPA) and MRN: Involvement of RPA2 Phosphorylation and the N-Terminus of RPA1
2009
Sr2+ Binding to the Ca2+ Binding Site of the Synaptotagmin 1 C2B Domain Triggers Fast Exocytosis without Stimulating SNARE Interactions
2003 StandoutNobel
Emerging Roles of Presynaptic Proteins in Ca ++ -Triggered Exocytosis
2002 ScienceNobel
THE DNA REPLICATION FORK IN EUKARYOTIC CELLS
1998
Replication Protein A (RPA) Phosphorylation Prevents RPA Association with Replication Centers
2004
In Vitro Analysis of the Role of Replication Protein A (RPA) and RPA Phosphorylation in ATR-mediated Checkpoint Signaling
2012 StandoutNobel
Replication protein A: directing traffic at the intersection of replication and repair
2010
Bruchpilot Promotes Active Zone Assembly, Ca 2+ Channel Clustering, and Vesicle Release
2006 StandoutScienceNobel
Anatomy and Dynamics of a Supramolecular Membrane Protein Cluster
2007 StandoutScienceNobel
Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells
2003
Hepatitis C Virus IRES RNA-Induced Changes in the Conformation of the 40 S Ribosomal Subunit
2001 StandoutScienceNobel
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
DNA Damage Induced Hyperphosphorylation of Replication Protein A. 2. Characterization of DNA Binding Activity, Protein Interactions, and Activity in DNA Replication and Repair
2005
Synaptotagmin Isoforms Couple Distinct Ranges of Ca2+, Ba2+, and Sr2+Concentration to SNARE-mediated Membrane Fusion
2005
Formation, stabilisation and fusion of the readily releasable pool of secretory vesicles
2004
Human DNA Repair Genes
2001 StandoutScienceNobel
Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis
2010 StandoutNobel
RNA interference-mediated silencing of synaptotagmin IX, but not synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12 cells
2004
Different Effects on Fast Exocytosis Induced by Synaptotagmin 1 and 2 Isoforms and Abundance But Not by Phosphorylation
2006 StandoutNobel
Synaptotagmins I and IX function redundantly in regulated exocytosis but not endocytosis in PC12 cells
2007
Works of Ye Lao being referenced
Synaptotagmins form a hierarchy of exocytotic Ca 2+ sensors with distinct Ca 2+ affinities
2002 StandoutNobel
The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity
2003
N-Glycosylation Is Essential for Vesicular Targeting of Synaptotagmin 1
2004 StandoutNobel
The Phosphorylation Domain of the 32-kDa Subunit of Replication Protein A (RPA) Modulates RPA-DNA Interactions
2003
Synaptotagmin‐7 is a principal Ca2+ sensor for Ca2+‐induced glucagon exocytosis in pancreas
2009 StandoutNobel
Synaptotagmin VII as a Plasma Membrane Ca2+ Sensor in Exocytosis
2001 StandoutNobel
Replication Protein A Interactions with DNA. 1. Functions of the DNA-Binding and Zinc-Finger Domains of the 70-kDa Subunit
1999
Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis
2008 StandoutNobel
Synaptotagmin-1 and -7 are functionally overlapping Ca 2+ sensors for exocytosis in adrenal chromaffin cells
2008 StandoutNobel
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice
2008 StandoutNobel
Replication Protein A Interactions with DNA. III. Molecular Basis of Recognition of Damaged DNA
2000
Role of Protein−Protein Interactions in the Function of Replication Protein A (RPA): RPA Modulates the Activity of DNA Polymerase α by Multiple Mechanisms
1997
Replication Protein A Interactions with DNA. 2. Characterization of Double-Stranded DNA-Binding/Helix-Destabilization Activities and the Role of the Zinc-Finger Domain in DNA Interactions
1999
The C2B Domain of Synaptotagmin I Is a Ca2+-Binding Module
2001 StandoutNobel