Standout Papers
Citation Impact
Citing Papers
Recognition of the amyloid precursor protein by human γ-secretase
2019 Science
A Small-Molecule Modulator of Poly-α2,8-Sialic Acid Expression on Cultured Neurons and Tumor Cells
2001 StandoutScienceNobel
De novo design of self-assembling helical protein filaments
2018 StandoutScienceNobel
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.
1988
Epitope map of neurofilament protein domains in cortical and peripheral nervous system Lewy bodies.
1991
Biochemical and anatomical redistribution of tau protein in Alzheimer's disease.
1993
Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau
2007
Roles of tau protein in health and disease
2017
Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins
2017
Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change
2008
The Lipid-binding Domain of Wild Type and Mutant α-Synuclein
2010
Elucidating Tau function and dysfunction in the era of cryo-EM
2019
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Regulation of Notch Signaling by Dynamic Changes in the Precision of S3 Cleavage of Notch-1
2007
Oxidative Stress and Genetics in the Pathogenesis of Parkinson's Disease
2000
Diffuse type of senile plaques in the brains of Alzheimer-type dementia
1988
Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
2002
Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease
1988
Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains
2002
Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
2000
Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?
2001
Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain
1995
Conformational constraints for amyloid fibrillation: the importance of being unfolded
2004
Epitopes that span the tau molecule are shared with paired helical filaments
1988
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease
1988
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
1994
Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease
2004
Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation
2003
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
2011 Standout
Temporal Profile of Amyloid-β (Aβ) Oligomerization in an in Vivo Model of Alzheimer Disease
2005
Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons
2021
Neurofibrillary changes confined to the entorhinal region and an abundance of cortical amyloid in cases of presenile and senile dementia
1990
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
2005
Peripheral Nervous System-specific Genes Identified by Subtractive cDNA Cloning
1995
Ca2+ and Mg2+ selectively induce aggregates of PHF-tau but not normal human tau
1999
Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease
2004
Amyloid β-Protein Inhibits Ubiquitin-dependent Protein Degradation in Vitro
1995
Interaction of Human α-Synuclein and Parkinson's Disease Variants with Phospholipids
2000
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Tau protein pathology in neurodegenerative diseases
1998
The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's disease
1990
Oxidative Damage Is the Earliest Event in Alzheimer Disease
2001 Standout
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
1998 StandoutNature
Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases
2004
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
2012 Standout
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 Standout
Restoration of biological activity of Alzheimer abnormally phosphorylated τ by dephosphorylation with protein phosphatase-2A, −2B and −1
1996
Plasma Levels of amyloid β proteins Aβ1–40 and Aβ1–42(43) are elevated in Down's syndrome
1997
Dephosphorylation of microtubule‐associated protein tau by protein phosphatase‐1 and ‐2C and its implication in Alzheimer disease
1994
Acute phase proteins are present in amorphous plaques in the cerebral but not in the cerebellar cortex of patients with Alzheimer's disease
1990
Presynaptic α-Synuclein Aggregates, Not Lewy Bodies, Cause Neurodegeneration in Dementia with Lewy Bodies
2007
Rapid induction of Alzheimer A beta amyloid formation by zinc
1994 Science
Copper, iron and zinc in Alzheimer's disease senile plaques
1998 Standout
Diffuse type of senile plaques in the cerebellum of Alzheimer-type dementia demonstrated by? protein immunostain
1989
Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain
1994
Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue
1997
The α‐Synucleinopathies: Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy
2000
Comparative Analysis of Amyloid-β Chemical Structure and Amyloid Plaque Morphology of Transgenic Mouse and Alzheimer's Disease Brains
2001
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Synoretin—A New Protein Belonging to the Synuclein Family
1999
Overactivation of glycogen synthase kinase‐3 by inhibition of phosphoinositol‐3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory
2003
Metallothioneins: new functional and structural insights
2000
Amino acid determinants of α‐synuclein aggregation: putting together pieces of the puzzle
2002
Molecular Dissection of Domains in Mutant Presenilin 2 That Mediate Overproduction of Amyloidogenic Forms of Amyloid β Peptides
1998
Molecular pathology of amyloidogenic proteins and the role of vascular amyloidosis in Alzheimer's disease
1989
Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model
2006
Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice
2006
Trafficking and Proteolytic Processing of APP
2012
The Endosomal-Lysosomal System of Neurons in Alzheimer's Disease Pathogenesis: A Review
2000
Presenilin: Running with Scissors in the Membrane
2007
Identification of two distinct synucleins from human brain
1994
Structural Principles of Tau and the Paired Helical Filaments of Alzheimer’s Disease
2007
Copper selectively triggers β-sheet assembly of an N-terminally truncated amyloid β-peptide beginning with Glu3
2003
Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis
1998
Amyloid β protein (Aβ) deposition in chromosome 14–linked Alzheimer's disease: Predominance of Aβ42(43)
1996
Unfolding the role of protein misfolding in neurodegenerative diseases
2003
Role of α-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice
2003 StandoutNobel
Homodimerization of Amyloid Precursor Protein and Its Implication in the Amyloidogenic Pathway of Alzheimer's Disease
2001
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
Development of α-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson’s disease
2007
Aggregation of Secreted Amyloid β-Protein into Sodium Dodecyl Sulfate-stable Oligomers in Cell Culture
1995
Immune System Response in Alzheimer'sDisease
1989
Glu332 in the Nicastrin Ectodomain Is Essential for γ-Secretase Complex Maturation but Not for Its Activity
2008
Constitutive Phosphorylation of the Parkinson's Disease Associated α-Synuclein
2000
Inflammation and Alzheimer's disease pathogenesis
1996
The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease
1991
Lipid interaction of α‐synuclein during the metal‐catalyzed oxidation in the presence of Cu2+and H2O2
2003
A Dynamic Relationship between Intracellular and Extracellular Pools of Aβ
2006
Efficacy of small‐molecule glycogen synthase kinase‐3 inhibitors in the postnatal rat model of tau hyperphosphorylation
2007
Neuropathological stageing of Alzheimer-related changes
1991 Standout
Hyperphosphorylation-induced self assembly of murine tau: a comparison with human tau
2004
Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts
1997
The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein
2006
Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer’s disease
2002
The Cellular Phase of Alzheimer’s Disease
2016
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption
1997
Age-related myelin degradation burdens the clearance function of microglia during aging
2016
Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
1995 Standout
Review: Alzheimer's Amyloid β-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity
2000
Tau phosphorylation: physiological and pathological consequences
2004
Protein aggregation and neurodegenerative disease
2004 Standout
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau
1998
Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons
1997
Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer’s Disease
2017
Structural Organization of α-Synuclein Fibrils Studied by Site-directed Spin Labeling
2003
Biochemistry of Amyloid -Protein and Amyloid Deposits in Alzheimer Disease
2012
Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding
1993
Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques
1989
Transgenic mouse models of Alzheimer’s disease
2000
Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline
2000
Structural and kinetic features of amyloid β-protein fibrillogenesis
1998
Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation
2004 StandoutNobel
Both Familial Parkinson's Disease Mutations Accelerate α-Synuclein Aggregation
1999
Aqueous Dissolution of Alzheimer's Disease Aβ Amyloid Deposits by Biometal Depletion
1999
The Levels of Soluble versus Insoluble Brain Aβ Distinguish Alzheimer's Disease from Normal and Pathologic Aging
1999
The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
1998
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease
1989 Standout
Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding
1993
Bioactivity of Metallothionein-3 Correlates with Its Novel .beta. Domain Sequence Rather Than Metal Binding Properties
1995
Rapid Alzheimer‐like phosphorylation of tau by the synergistic actions of non‐proline‐dependent protein kinases and GSK‐3
1995
NMR Structure of the Sea Urchin (Strongylocentrotus purpuratus) Metallothionein MTA
1999 StandoutNobel
Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons
2008 StandoutNobel
The widespread alteration of neurites in Alzheimer's disease may be unrelated to amyloid deposition
1989
Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease
1994
α-Synuclein is phosphorylated in synucleinopathy lesions
2002 Standout
Taking dendritic cells into medicine
2007 StandoutNatureNobel
NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease
1997
A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly
2001
BACE1 Suppression by RNA Interference in Primary Cortical Neurons
2004
APP Processing and Synaptic Plasticity in Presenilin-1 Conditional Knockout Mice
2001 Nobel
Alzheimer's disease
2006 Standout
Tau proteins with FTDP‐17 mutations have a reduced ability to promote microtubule assembly
1998
Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts
1989
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42
2007
Neprilysin-sensitive Synapse-associated Amyloid-β Peptide Oligomers Impair Neuronal Plasticity and Cognitive Function
2006
Assembly of Alzheimer‐like filaments from full‐length tau protein
1994
α-Synuclein Populates Both Elongated and Broken Helix States on Small Unilamellar Vesicles
2011
Molecular Interactions among Protein Phosphatase 2A, Tau, and Microtubules
1999
Dementia with Lewy Bodies. A Distinct Non‐Alzheimer Dementia Syndrome?
1998
Structure/function of α‐synuclein in health and disease: rational development of animal models for Parkinson's and related diseases
2002
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
2002
Switching and Signaling at the Telomere
2001 StandoutNobel
Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons
1992 Nature
Does my mouse have Alzheimer's disease?
2002
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
2003
Alzheimer’s amyloid fibrils: structure and assembly
2000
Isolation and characterization of cDNA clones encoding epitopes shared with alzheimer neurofibrillary tangles
1988
Intraneuronal Aβ42 Accumulation in Human Brain
2000
Alpha-synuclein and neurodegenerative diseases
2001
High Prevalence of Mutations in the Microtubule-Associated Protein Tau in a Population Study of Frontotemporal Dementia in the Netherlands
1999
Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A
1994
Selective Insolubility of α-Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model
2001
Molecular motors and mechanisms of directional transport in neurons
2005
Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease
2016
α‐Synuclein produces a long‐lasting increase in neurotransmitter release
2004
A Drosophila model of Parkinson's disease
2000 StandoutNature
Short Telomeres in Patients with Vascular Dementia: An Indicator of Low Antioxidative Capacity and a Possible Risk Factor?
2000
The microtubule binding domain of tau protein
1989
β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding
1995
Visualizing an Olfactory Sensory Map
1996 StandoutNobel
Phosphorylation of Ser-129 Is the Dominant Pathological Modification of α-Synuclein in Familial and Sporadic Lewy Body Disease
2006
Medical and Societal Consequences of the Human Genome Project
1999
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
1996 Nature
Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
1999 Standout
Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
2014
Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins
1997
Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms
1992
Transgenic mouse brain histopathology resembles early Alzheimer's disease
1994
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.
2000 Standout
Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease
1989 Nature
Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes
2004
Receptor-Mediated Transport of Human Amyloid β-Protein 1–40 and 1–42 at the Blood–Brain Barrier
1999
Morphology and Toxicity of Aβ-(1-42) Dimer Derived from Neuritic and Vascular Amyloid Deposits of Alzheimer's Disease
1996
Compartmentalization of β-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts
2001
Systematic Mutagenesis of α-Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
2012 StandoutNobel
Neurofibrillary degeneration and neuronal loss in alzheimer's disease
1989
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Binding of α-Synuclein to Brain Vesicles Is Abolished by Familial Parkinson's Disease Mutation
1998
A Loss of Function Mutation of Presenilin-2 Interferes with Amyloid β-Peptide Production and Notch Signaling
1999
α-Synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers
2006
Aggregates from mutant and wild‐type α‐synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β‐sheet and amyloid‐like filaments
1998
Sorting mechanisms of Tau and MAP2 in neurons: Suppressed axonal transit of MAP2 and locally regulated microtubule binding
1995
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
1998
A brain-specific activator of cyclin-dependent kinase 5
1994 StandoutNatureNobel
Vaccination with soluble Aβ oligomers generates toxicity‐neutralizing antibodies
2001
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Isolation of cDNAs coding for epitopes shared by microtubule‐associated proteins and neurofibrillary tangles in Alzheimer's disease
1987
Complementation Cloning of , a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs
1997 Nobel
Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
2016
Neural cell adhesion molecule (NCAM) as a quantitative marker in synaptic remodeling
1995
Immunoelectron microscopic localization of amyloid β protein in the diffuse plaques of Alzheimer-type dementia
1990
Mutagenesis Identifies New Signals for β-Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Aβ42
1999
Altered Tau and Neurofilament Proteins in Neuro‐Degenerative Diseases: Diagnostic Implications for Alzheimer's Disease and Lewy Body Dementias
1993
Tau pathology in Alzheimer disease and other tauopathies
2004
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
1989
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1
2002
Neuropil Threads Occur in Dendrites of Tangle—Bearing Nerve Cells
1988
Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease
1987
Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-Synuclein
2011
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Ubiquitination of α-Synuclein in Lewy Bodies Is a Pathological Event Not Associated with Impairment of Proteasome Function
2003
Alzheimer's disease: the cholesterol connection
2003
Domains of tau Protein and Interactions with Microtubules
1994
Aβ‐peptide length aid apolipoprotein E genotype in Alzheimer's disease
1996
Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
2000
Antibodies against β‐amyloid reduce aβ oligomers, glycogen synthase kinase‐3β activation and τ phosphorylation in vivo and in vitro
2005
Large amounts of neocortical βA4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person
1990
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases
2000
Self‐oligomerization of NACP, the precursor protein of the non‐amyloid β/A4 protein (Aβ) component of Alzheimer's disease amyloid, observed in the presence of a C‐terminal Aβ fragment (residues 25–35)
1998
Cryo-EM structures of tau filaments from Alzheimer’s disease
2017 Nature
Staging of Cytoskeletal and β-Amyloid Changes in Human Isocortex Reveals Biphasic Synaptic Protein Response during Progression of Alzheimer’s Disease
2000
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
1989 Standout
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
1996
Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans
1996 Nature
Neurodegeneration and neuroprotection in Parkinson disease
2004
Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase
1999
Expression of Alzheimer’s Disease-associated Presenilin-1 Is Controlled by Proteolytic Degradation and Complex Formation
1998
Aggregation of α-synuclein induced by the Cu,Zn-superoxide dismutase and hydrogen peroxide system
2002
Elucidation of Primary Structure Elements Controlling Early Amyloid β-Protein Oligomerization
2003
Structure and function of γ-secretase
2008
The molecular pathology of Alzheimer's disease
1991 Standout
Translating cell biology into therapeutic advances in Alzheimer's disease
1999 Nature
Structural basis of Notch recognition by human γ-secretase
2018 Nature
Neurofibrillary tangles of the Indiana kindred of Gerstmann-Stra¨ussler-Scheinker disease share antigenic determinants with those of Alzheimer disease
1990
The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology
1996
Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms
2006
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
1999 StandoutNature
The amyloid hypothesis of Alzheimer's disease at 25 years
2016 Standout
Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
2001
Amyloid β Protein Enhances the Survival of Hippocampal Neurons in Vitro
1989 Science
Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease
1999
Meeting of the minds: Metalloneurochemistry
2003
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.
1986
Conservation of Brain Amyloid Proteins in Aged Mammals and Humans with Alzheimer's Disease
1987 Science
Molecular motors implicated in the axonal transport of tau and α-synuclein
2005
Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments
2001
The Primary Structure and Heterogeneity of Tau Protein from Mouse Brain
1988 Science
SUBUNIT STRUCTURE OF THE ALZHEIMER TANGLE
1986
Alzheimer's paired helical filaments share epitopes with neurofilament side arms.
1986
Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.
1988
Isolation of Low‐Molecular‐Weight Proteins from Amyloid Plaque Fibers in Alzheimer's Disease
1986
Brain to Plasma Amyloid-β Efflux: a Measure of Brain Amyloid Burden in a Mouse Model of Alzheimer's Disease
2002 Science
β-Synuclein Inhibits α-Synuclein Aggregation
2001
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.
1988 StandoutNobel
Amyloidogenic Function of the Alzheimer's Disease-Associated Presenilin 1 in the Absence of Endoproteolysis
1999
Alzheimer's Disease
1986
The neuropathology of Alzheimer's disease: A review with pathogenetic, aetiological and therapeutic considerations
1985
γ‐Synuclein and the progression of cancer
2007
Deficiency of Aph1B/C-γ-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment
2008
Neurodegenerative Tauopathies
2001 Standout
Copper(II)-induced self-oligomerization of α-synuclein
1999
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.
1987
Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies
2004
Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.
1988
The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
1995
β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
2001
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Separation of the different microtubule-associated tau protein species from bovine brain and their mode II phosphorylation by Ca2+/phospholipid-dependent protein kinase C.
1987
Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids.
1987
Gene activation is required for developmentally programmed cell death.
1990
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies
1998 Standout
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
1996 StandoutScience
An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) Mutants
1994 StandoutScience
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
2003
Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants
1982 Nature
The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism
2006
Rapid Tyrosine Phosphorylation of Neuronal Proteins Including Tau and Focal Adhesion Kinase in Response to Amyloid-β Peptide Exposure: Involvement of Src Family Protein Kinases
2002
Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.
1993
Image reconstruction of the Alzheimer paired helical filament.
1985
Structure, Microtubule Interactions, and Paired Helical Filament Aggregation by Tau Mutants of Frontotemporal Dementias
2000
Specificity and Regulation of Casein Kinase-Mediated Phosphorylation of α-Synuclein
2008
A Century of Alzheimer's Disease
2006 StandoutScience
Tau is essential to β-amyloid-induced neurotoxicity
2002
Tau-beta-galactosidase, an axon-targeted fusion protein.
1994
γ-Cleavage Is Dependent on ζ-Cleavage during the Proteolytic Processing of Amyloid Precursor Protein within Its Transmembrane Domain
2005
Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease
1991
Mutations causing neurodegenerative tauopathies
2004
Trace amounts of copper in water induce β-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease
2003
Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders
2000 Science
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
1997 StandoutScience
Heparin and Other Glycosaminoglycans Stimulate the Formation of Amyloid Fibrils from α-Synuclein in Vitro
2002
Self-Assembly of Aβ1-42into Globular Neurotoxins
2003
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
A Neuronal Antigen in the Brains of Alzheimer Patients
1986 Science
Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2
1986
The Endogenous and Cell Cycle-dependent Phosphorylation of tau Protein in Living Cells: Implications for Alzheimer’s Disease
1998
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation
2000
Ubiquitin and microtubule-associated protein tau immunoreactivity each define distinct structures with differing distributions and solubility properties in Alzheimer brain.
1988
Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease.
1990
Medical and Ethical Consequences of the Human Genome Project
1991
The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer's disease brain
1988
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions
2013
Evidence that the 42- and 40-amino acid forms of amyloid β protein are generated from the β-amyloid precursor protein by different protease activities
1996
Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure.
1994
Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments.
1995
A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau
1991 Science
Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro.
1992
A Topological Model of the Interaction between α-Synuclein and Sodium Dodecyl Sulfate Micelles
2004
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
1997
Presenilin-Dependent γ-Secretase on Plasma Membrane and Endosomes Is Functionally Distinct
2006
A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.
1990
Double-knockout mice for α- and β-synucleins: Effect on synaptic functions
2004 StandoutNobel
Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease
2016
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
1998 Nobel
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles.
1984
Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo
2001
Tau protein binds to microtubules through a flexible array of distributed weak sites.
1991
Tau-Mediated Cytotoxicity in a Pseudohyperphosphorylation Model of Alzheimer's Disease
2002
Presenilin 1 Regulates the Processing of β-Amyloid Precursor Protein C-Terminal Fragments and the Generation of Amyloid β-Protein in Endoplasmic Reticulum and Golgi
1998
Decreased plasma β‐amyloid in the Alzheimer's disease APP A 673T variant carriers
2017
Recognition of tau epitopes by anti-neurofilament antibodies that bind to Alzheimer neurofibrillary tangles.
1987
Alzheimer's Disease--Genotypes, Phenotype, and Treatments
1997 Science
Neurofibrillary degeneration of cholinergic and noncholinergic neurons of the basal forebrain in Alzheimer's disease
1986
Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)
1986
In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to alzheimer's disease β-protein
1986
Structural characterization of the core of the paired helical filament of Alzheimer disease.
1988
Role of Tau Protein in Both Physiological and Pathological Conditions
2004
Fluorescent Sensors for Zn2+Based on a Fluorescein Platform: Synthesis, Properties and Intracellular Distribution
2001 StandoutNobel
Alz-50 recognizes a phosphorylated epitope of tau protein
1990
Paired helical filaments from Alzheimer disease patients contain cytoskeletal components.
1985
Diffuse plaques do not accentuate synapse loss in Alzheimer's disease.
1990
Seppuku and Autoimmunity
1992 StandoutScienceNobel
Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases.
1988
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.
1988 StandoutNobel
Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease.
1989
Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein.
1987
Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau
1997
Phosphorylation that Detaches Tau Protein from Microtubules (Ser262, Ser214) Also Protects It against Aggregation into Alzheimer Paired Helical Filaments
1999
Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.
1994
Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques.
1991
Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons
1999
Alz 50, a monoclonal antibody to Alzheimer's disease antigen, cross-reacts with tau proteins from bovine and normal human brain.
1988
Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.
1992
Protein kinase C phosphorylates tau and induces its functional alterations
1987
Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons
1998
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease
2010
Rapid Assembly of Alzheimer-like Paired Helical Filaments from Microtubule-Associated Protein Tau Monitored by Fluorescence in Solution
1998
Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS
1990 StandoutScienceNobel
Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice
2001
BACE inhibitors in clinical development for the treatment of Alzheimer’s disease
2018
Proline-directed phosphorylation of human Tau protein.
1992
Filaments of Lewy bodies contain insoluble cytoskeletal elements.
1992
Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.
1993
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
1985 Standout
Subunit structure of paired helical filaments in Alzheimer's disease.
1985
Persyn, a Member of the Synuclein Family, Has a Distinct Pattern of Expression in the Developing Nervous System
1998
Selective stabilization of tau in axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons.
1996
Neurofibrillary tangles in senile dementia of the Alzheimer type share an antigenic determinant with intermediate filaments of the vimentin class.
1983
Inositol Stereoisomers Stabilize an Oligomeric Aggregate of Alzheimer Amyloid β Peptide and Inhibit Aβ-induced Toxicity
2000
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.
1986
Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer's disease
2001
Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease
1997
Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin
2005
Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders.
1998
Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)
1990 Science
Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo
1995
Quantitative assessment of the density of neurofibrillary tangles and senile plaques in senile dementia of the Alzheimer type. Comparison of immunocytochemistry with a specific antibody and Bodian's protargol method
1987
Electron micrograph of diffuse plaques. Initial stage of senile plaque formation in the Alzheimer brain.
1989
MODELS OF AMYLOID SEEDING IN ALZHEIMER'S DISEASE AND SCRAPIE: Mechanistic Truths and Physiological Consequences of the Time-Dependent Solubility of Amyloid Proteins
1997
Activation-Induced Ubiquitination of the T Cell Antigen Receptor
1992 Science
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
The antimicrobial protection hypothesis of Alzheimer's disease
2018
Amyloid of neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence.
1987 Nobel
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
1998
Alzheimer's disease: Immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies
1984
Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons.
1995
The Presenilins in Alzheimer's Disease--Proteolysis Holds the Key
1999 Science
The Neurofibrillary Pathology of Alzheimer's Disease
1997
Immuno-electron-microscopic localization of complements in amyloid fibrils of senile plaques
1984
Evidence for a physical interaction between presenilin and Notch
1999
The crystal structure of yeast copper thionein: The solution of a long-lasting enigma
2004
X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation.
1986
α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins
1999
Examination of phosphorylated tau protein as a PHF-precursor at early stage alzheimer's disease
1995
Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation
1983 StandoutScience
The Oligomerization of Amyloid β-Protein Begins Intracellularly in Cells Derived from Human Brain
2000
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
1992
Works of Yasuo Ihara being referenced
Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease.
1996
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase
2013
Glypican‐1 as an Aβ binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease
2004
γ-Secretase Associated with Lipid Rafts
2013
γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43
2013
The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells
2015
Potent amyloidogenicity and pathogenicity of Aβ43
2011
Accumulation of Amyloid β-Protein in the Low-Density Membrane Domain Accurately Reflects the Extent of β-Amyloid Deposition in the Brain
2001
τ Is Widely Expressed in Rat Tissues
1996
Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments
1993
Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down Syndrome
1995
Molecular Analysis of Mutant and Wild-Type Tau Deposited in the Brain Affected by the FTDP-17 R406W Mutation
2001
A Novel Tubulin-Dependent Protein Kinase Forming a Paired Helical Filament Epitope on Tau
1988
Posttranslational Modifications of Tau in Paired Helical Filaments
1994
Amyloid β‐protein (Aβ) associated with lipid molecules: immunoreactivity distinct from that of soluble Aβ
1997
Amyloid β‐proteins 1—40 and 1—42(43) in the soluble fraction of extra‐ and intracranial blood vessels
1995
Immunocytochemical and ultrastructural studies of Pick's disease
1990
Hyperphosphorylation of Tau in PHF
1995
γ-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of β-Carboxyl Terminal Fragment
2009
Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics
1994
Mutant Presenilin 2 Transgenic Mouse: Effect on an Age‐Dependent Increase of Amyloid β‐Protein 42 in the Brain
1998
Active γ-Secretase Complexes Contain Only One of Each Component
2007
Deamidation and Isoaspartate Formation in Smeared Tau in Paired Helical Filaments
1999
Blocking the cleavage at midportion between γ‐ and ε‐sites remarkably suppresses the generation of amyloid β‐protein
2005
Proline-directed and Non-proline-directed Phosphorylation of PHF-tau
1995
Lewy bodies are ubiquitinated
1988
Random Mutagenesis of Presenilin-1 Identifies Novel Mutants Exclusively Generating Long Amyloid β-Peptides
2005
Immunocytochemical profile of neurofibrillary tangles in Down's syndrome patients of different ages
1989
Selective Deposition of Mutant Tau in the FTDP-17 Brain Affected by the P301L Mutation
2001
Molecular cloning of rat growth inhibitory factor cDNA and the expression in the central nervous system
1993
Characterization of mAb AP422, a novel phosphorylation‐dependent monoclonal antibody against tau protein
1996
Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein
2003
Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease
1990
Down's Syndrome: Up‐Regulation of β‐Amyloid Protein Precursor and τ mRNAs and Their Defective Coordination
1994
Stable Expression in Chinese Hamster Ovary Cells of Mutated Tau Genes Causing Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 (FTDP-17)
1999
Equimolar Production of Amyloid β-Protein and Amyloid Precursor Protein Intracellular Domain from β-Carboxyl-terminal Fragment by γ-Secretase
2006
Amyloid β/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia
1990
Appearance of Sodium Dodecyl Sulfate-Stable Amyloid β-Protein (Aβ) Dimer in the Cortex During Aging
1999
Anomalous accumulation of τ and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis?
1989
Molecular aging of tau: disulfide‐independent aggregation and non‐enzymatic degradation in vitro and in vivo
2004
The car☐yl third of tau is tightly bound to paired helical filaments
1988
Alzheimer's disease brain extract stimulates the survival of cerebral cortical neurons from neonatal rats
1988
Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques
1990
Free radicals and superoxide dismutase in blood of patients with Alzheimer's disease and vascular dementia
1997
Amyloid β‐protein deposition in the leptomeninges and cerebral cortex
1997
Amyloid β-protein (Aβ) Accumulation in the Leptomeninges during Aging and in Alzheimer Disease
1997
Alzheimer's disease: β‐Amyloid protein and tau
2002
Muscle fiber degeneration in distal myopathy with rimmed vacuole formation
1995
Dominant and differential deposition of distinct β-amyloid peptide species, AβN3(pE), in senile plaques
1995
Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments
1992
Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments
1993
Apolipoprotein E genotype, Alzheimer's pathologies and related gene expression in the aged population
1995
A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by? protein immunostaining
1988
Dissociation of β-amyloid from lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates β-amyloid-42 assembly
2011
Presence of Sodium Dodecyl Sulfate-Stable Amyloid β-Protein Dimers in the Hippocampus CA1 Not Exhibiting Neurofibrillary Tangle Formation
1999
Molecular diversity at the carboxyl terminus of human and rat tau
1994
Effect of Apolipoprotein E Allele ε4 on the Initial Phase of Amyloid β-Protein Accumulation in the Human Brain
2000
Longer Forms of Amyloid β Protein: Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase
2005
Alzheimer β Amyloid Deposition Enhanced by ApoE ɛ4 Gene precedes Neurofibrillary pathology in the Frontal Association Cortex of Nondemented Senior Subjects
2001
A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments
1989
The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein
1991
Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex
1997
τ in Paired Helical Filaments Is Functionally Distinct from Fetal τ: Assembly Incompetence of Paired Helical Filament‐τ
1993
Intracellular Generation and Accumulation of Amyloid β-Peptide Terminating at Amino Acid 42
1997
Microglial cells and amyloid ? protein (A?) deposition: association with A?40-plaques
1995
GM1 Ganglioside-Bound Amyloid β-Protein in Alzheimer’s Disease Brain
1998
Dephosphorylation of fetal-Tau and Paired Helical Filaments-Tau by Protein Phosphatases 1 and 2A and Calicineurin1
1995
GM1 ganglioside–bound amyloid β–protein (Aβ): A possible form of preamyloid in Alzheimer's disease
1995
Accumulation and Aggregation of Amyloid β-Protein in Late Endosomes of Niemann-Pick Type C Cells
2001
SP-40,40 is a constituent of Alzheimer's amyloid
1992
Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of Notch
2001
β‐Amyloid Protein Precursor and τ mRNA Levels Versus β‐Amyloid Plaque and Neurofibrillary Tangles in the Aged Human Brain
1993
Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia
1991
High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy.
1994
Gem GTPase and Tau
2004
Immunocytochemical study on senile plaques in Alzheimer's disease. II. Abnormal dendrites in senile plaques as revealed by antimicrotubule-associated proteins (MAPs) immunostaining.
1983
Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia.
1991
Immunocytochemical study on senile plaques in Alzheimer's disease. I. Preparation of an antimicrotubule-associated proteins (MAPs) antiserum and its specificity.
1983
Proteolytic Fragments of Alzheimer's Paired Helical Filaments1
1985
Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.
1992
Amyloid (B-protein (Aß) Accumulation in the Putamen and Mammillary Body during Aging and in Alzheimer Disease
1998
Alzheimer's Disease: Insolubility of Partially Purified Paired Helical Filaments in Sodium Dodecyl Sulfate and Urea
1982 Science
Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins
1983 Nature
Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease.
1998
Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease
1987 Science
Phosphorylated Tau Protein Is Integrated into Paired Helical Filaments in Alzheimer's Disease1
1986
Distinct Mechanisms by Mutant Presenilin 1 and 2 Leading to Increased Intracellular Levels of Amyloid β-Protein 42 in Chinese Hamster Ovary Cells
2003
Staining of Alzheimer's neurofibrillary tangles with antiserum against 200K component of neurofilament.
1981
Lack of ubiquitin immunoreactivities at both ends of neuropil threads. Possible bidirectional growth of neuropil threads.
1992
Oxidative Stress Induces Intracellular Accumulation of Amyloid β-Protein (Aβ) in Human Neuroblastoma Cells
2000
Molecular pathology of Alzheimer's disease
1997
One of the Antigenic Determinants of Paired Helical Filaments Is Related to Tau Protein1
1986
Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease.
1992
Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers.
1982
Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene.
1996
DAPT-Induced Intracellular Accumulations of Longer Amyloid β-Proteins: Further Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase
2006
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.
1993
Identification of key amino acids responsible for the distinct aggregation properties of microtubule‐associated protein 2 and tau
2015
γ-Secretase Activity Is Present in Rafts but Is Not Cholesterol-Dependent
2003
The Presence of Amyloid β-Protein in the Detergent-Insoluble Membrane Compartment of Human Neuroblastoma Cells
1998
Spatial resolution of the primary beta-amyloidogenic process induced in postischemic hippocampus.
1994
Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques.
1996
Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA.
1989
In vivo phosphorylation sites in fetal and adult rat tau.
1993
Truncated Carboxyl-Terminal Fragments of β-Amyloid Precursor Protein Are Processed to Amyloid β-Proteins 40 and 42
2004
Specific Increase in Amyloid β-Protein 42 Secretion Ratio by Calpain Inhibition
1997 StandoutNobel