Citation Impact
Citing Papers
Human Hypertension Caused by Mutations in WNK Kinases
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MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
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The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
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Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: influences on genomic stability, chromatin organization, and carcinogen cytotoxicity.
1994
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
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Poly(ADP‐ribose) polymerase: Molecular biological aspects
1991
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
2005 StandoutNature
Spatio-temporal Dynamics of Protein Kinase B/Akt Signaling Revealed by a Genetically Encoded Fluorescent Reporter
2004 StandoutNobel
The regulation of aldosterone synthase expression
2003
Apoptosis in the nervous system
2000 StandoutNature
Stromal fibroblasts in cancer initiation and progression
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A Polymer-Based, Paclitaxel-Eluting Stent in Patients with Coronary Artery Disease
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Influence of Metabolism on Epigenetics and Disease
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AKT/PKB Signaling: Navigating Downstream
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Chromatin Modifications and Their Function
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Oncogenic kinase signalling
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Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene
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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
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Cell Signaling by Receptor Tyrosine Kinases
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Poly(ADP-ribose)polymerase: a perplexing participant in cellular responses to DNA breakage
1991
Death by TNF: a road to inflammation
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p38 Mitogen-activated Protein Kinase Pathway Protects Adult Rat Ventricular Myocytes against β-Adrenergic Receptor-stimulated Apoptosis
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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
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Molecular Mechanisms of Human Hypertension
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Proliferation, cell cycle and apoptosis in cancer
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Deletion Hybrid Genes, due to Unequal Crossing Over betweenCYP11B1(11β-Hydroxylase) andCYP11B2(Aldosterone Synthase) Cause Steroid 11β-Hydroxylase Deficiency and Congenital Adrenal Hyperplasia1
2001
Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway
2002
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
2003
Cellular survival: a play in three Akts
1999 Standout
Chicken poly(ADP-ribose) synthetase: complete deduced amino acid sequence and comparison with mammalian enzyme sequences
1991
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
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The molecular machinery of regulated cell death
2019 Standout
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
Primary Hyperaldosteronism in Essential Hypertensives: Prevalence, Biochemical Profile, and Molecular Biology1
2000
The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB
1999
Carriers for type II 3β‐hydroxysteroid dehydrogenase (HSD3B2) deficiency can only be identified by HSD3B2 genotype study and not by hormone test
2003
Molecular mechanisms of cisplatin resistance
2011 Standout
Poly(ADP-ribose)polymerase: a novel finger protein
1989
CYP11B1 Mutations Causing Non-Classic Adrenal Hyperplasia due to 11 -Hydroxylase Deficiency
1997
RecombinantCYP11BGenes Encode Enzymes that Can Catalyze Conversion of 11-Deoxycortisol to Cortisol, 18-Hydroxycortisol, and 18-Oxocortisol1
1998
Congenital adrenal hyperplasia due to point mutations in the type II 3β–hydroxysteroid dehydrogenase gene
1992
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
2000
Isolation and Characterization of the cDNA Encoding Bovine Poly(ADP-ribose) Glycohydrolase
1997
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy
2003
Role of poly(ADP-ribose) formation in DNA repair
1992 StandoutNatureNobel
Construction and characterization of a catalytic fusion protein system: P-45011β-adrenodoxin reductase-adrenodoxin
2000
Cloning and functional expression of poly(ADP‐ribose) polymerase cDNA from Sarcophaga peregrina
1994
Inhibition of cell proliferation in Saccharomyces cerevisiae by expression of human NAD+ ADP-ribosyltransferase requires the DNA binding domain (“zinc fingers”)
1992
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Polypeptide domains of ADP-ribosyltransferase obtained by digestion with plasmin
1988
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Met, metastasis, motility and more
2003 Standout
PI3K/Akt: getting it right matters
2008
Necroptosis in development, inflammation and disease
2016
Differentiation-dependent Suppression of Platelet-derived Growth Factor Signaling in Cultured Adipocytes
1999
Phosphoinositides in cell regulation and membrane dynamics
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Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase
1992
The PTEN, Mdm2, p53 tumor suppressor–oncoprotein network
2002
Type 1 Aldosterone Synthase Deficiency Presenting in a Middle-Aged Man1
2001
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Interaction of the Transcription Factor YY1 with Human Poly(ADP-Ribosyl) Transferase
1997
Liver Regeneration after Partial Hepatectomy
2009
The Product of the CYP11B2 Gene Is Required for Aldosterone Biosynthesis in the Human Adrenal Cortex
1991
A chimaeric llβ-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension
1992 StandoutNature
Expression in Escherichia coli of the 36 kDa domain of poly(ADP-ribose) polymerase and investigation of its DNA binding properties
1993
Review: Modulation of chromatin structure by poly(ADP-ribosyl)ation
1988
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
2003 StandoutNature
Molecular and biochemical features of poly (ADP-ribose) metabolism
1993
Cloning of a full-length cDNA encoding bovine thymus poly(ADP-ribose) synthetase: evolutionarily conserved segments and their potential functions
1990
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
2006
Molecular Genetics of Human Blood Pressure Variation
1996 Science
Angiotensin II and Potassium Regulate Human CYP11B2 Transcription through Common cis-Elements
1997
Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism
1991
Cloning of cDNA encoding Drosophila poly(ADP-ribose) polymerase: leucine zipper in the auto-modification domain.
1993
DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions.
1993 StandoutNobel
Glucocorticoid-Remediable Aldosteronism
1999
Amino acid substitution R384P in aldosterone synthase causes corticosterone methyloxidase type I deficiency.
1995
Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.
1992
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
2002 StandoutScienceNobel
The biochemical phenotypes of two inborn errors in the biosynthesis of aldosterone.
1992
Purification and characterization of NAD+:ADP-ribosyltransferase (polymerizing) from Dictyostelium discoideum
1993
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
PKB/Akt
2001
Mutation T318M in the CYP11B2 gene encoding P450c11AS (aldosterone synthase) causes corticosterone methyl oxidase II deficiency.
1995
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency.
1992
Isolated Aldosterone Synthase Deficiency Caused by Simultaneous E198D and V386A Mutations in the CYP11B2 Gene1
1998
Hereditary Defect in Biosynthesis of Aldosterone: Aldosterone Synthase Deficiency 1964–19971
1997
Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue.
1993
The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.
1990
Functional Consequences of Seven Novel Mutations in theCYP11B1Gene: Four Mutations Associated with Nonclassic and Three Mutations Causing Classic 11β-Hydroxylase Deficiency
2010
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
2011 Standout
A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.
2003
A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells.
1996
Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.
2003
Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity.
1990
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
trans-Dominant Inhibition of Poly(ADP-Ribosyl)ation Sensitizes Cells against γ-Irradiation and N-Methyl-N′-Nitro-N-Nitrosoguanidine but Does Not Limit DNA Replication of a Polyomavirus Replicon
1995
Genetic Analysis of Aldosterone Synthase in Patients with Idiopathic Hyperaldosteronism1
1999
Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner
1998 StandoutNobel
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
1999 Standout
Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer
2001
Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models
2001
PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase
1999
Human nuclear NAD+ ADP-ribosyltransferase: localization of the gene on chromosome 1q41-q42 and expression of an active human enzyme in Escherichia coli.
1989
Identification of potential active-site residues in the human poly(ADP-ribose) polymerase.
1993
Influence of poly(ADP-ribose) polymerase on the enzymatic synthesis of SV40 DNA.
1991
A Role for Protein Kinase Bβ/Akt2 in Insulin-Stimulated GLUT4 Translocation in Adipocytes
1999
Genetic variation in P450c11AS in Chilean patients with low renin hypertension.
1996
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA.
1990
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Poly(ADP-ribose) polymerase is a catalytic dimer and the automodification reaction is intermolecular.
1993
Aromatase—A Brief Overview
2002
NAD(+)-dependent repair of damaged DNA by human cell extracts.
1993 StandoutNobel
The Phosphoinositide 3-Kinase Pathway
2002 StandoutScience
The Orphan Nuclear Receptors NURR1 and NGFIB Regulate Adrenal Aldosterone Production
2003
Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries.
1993
Molecular phenotyping for analyzing subtle genetic effects in mice: Application to an angiotensinogen gene titration
2002 StandoutNobel
Works of Yasuhiro Mitsuuchi being referenced
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
2015
Cloning of cDNA and genomic DNA for human cytochrome P‐45011β
1990
Structural and functional characterization of human aromatase P‐450 gene
1990
A nonsense mutation (TGG [Trp116]-->TAG [Stop]) in CYP11B1 causes steroid 11 beta-hydroxylase deficiency.
1993
Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin
1998
Alternative usage of different poly(A) addition signals for two major species of mRNA encoding human aromatase P‐450
1989
Human poly(ADP‐ribose) polymerase gene
1990
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2
1999
Inborn errors of aldosterone biosynthesis in humans
1995
Congenitally Defective Aldosterone Biosynthesis in Humans: Inactivation of the P450C18 Gene (CYP11B2) Due to Nucleotide Deletion in CMO I-Deficient Patients
1993
Activation of Akt2 Inhibits anoikis and apoptosis induced by myogenic differentiation
2001
The phosphatidylinositol 3-kinase/AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel.
2000
Translocation and activation of AKT2 in response to stimulation by insulin
1998
Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.
1992
Cell Cycle Withdrawal Promotes Myogenic Induction of Akt, a Positive Modulator of Myocyte Survival
1999
The chimeric gene linked to glucocorticoid-suppressible hyperaldosteronism encodes a fused P-450 protein prssessing aldosterone synthase activity
1992
Translocation and activation of AKT2 in response to stimulation by insulin.
1998
Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism
1990
Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways
2000
Congenitally defective aldosterone biosynthesis in humans: The involvement of point mutations of the P-450C18 gene (CYP11B2) in CMO II deficient patients
1992
Primary structure of human poly(ADP-ribose) synthetase as deduced from cDNA sequence.
1987