Standout Papers
- The human skin microbiome (2018)
- Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid (2007)
- A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism (2007)
- CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity (2002)
- Role of the Microbiota in Immunity and Inflammation (2014)
Citation Impact
Citing Papers
Activation of β-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine
2010 Science
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Complement drives Th17 cell differentiation and triggers autoimmune arthritis
2010 StandoutNobel
Essential role for CD103 in the T cell–mediated regulation of experimental colitis
2005
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
2010 StandoutNobel
T Cell–specific Inactivation of the Interleukin 10 Gene in Mice Results in Enhanced T Cell Responses but Normal Innate Responses to Lipopolysaccharide or Skin Irritation
2004
Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production
2009
Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions
2009
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
2013 StandoutScience
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
2007 Standout
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
Antigen-independent memory CD8 T cells do not develop during chronic viral infection
2004
CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets
2013
Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy
2016
Coordination of Early Protective Immunity to Viral Infection by Regulatory T Cells
2008 Science
Inducible Foxp3 + regulatory T-cell development by a commensal bacterium of the intestinal microbiota
2010 Standout
Individual intestinal symbionts induce a distinct population of RORγ + regulatory T cells
2015 Science
Conversion of Th2 memory cells into Foxp3 + regulatory T cells suppressing Th2-mediated allergic asthma
2010
Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine
2016 Science
Stability of the Regulatory T Cell Lineage in Vivo
2010 Science
CD4+CD25−Foxp3− Th1 cells are the source of IL-10–mediated immune suppression in chronic cutaneous leishmaniasis
2007
Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4 + T cells
2015 Science
Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?
2010 Science
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
T Cells with a CD4 + CD25 + Regulatory Phenotype Suppress In Vitro Proliferation of Virus-Specific CD8 + T Cells during Chronic Hepatitis C Virus Infection
2005
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
2010 StandoutScience
Altering the distribution of Foxp3+ regulatory T cells results in tissue-specific inflammatory disease
2007
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Genomic definition of multiple ex vivo regulatory T cell subphenotypes
2010
Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo
2005
The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature
2012
Conventional T-bet+Foxp3− Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
2007
Stable inhibitory activity of regulatory T cells requires the transcription factor Helios
2015 Science
Umbilical cord blood–derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect
2015
Effective expansion of alloantigen-specific Foxp3 + CD25 + CD4 + regulatory T cells by dendritic cells during the mixed leukocyte reaction
2006 StandoutNobel
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
2010
Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells
2018
CD8+CD205+ Splenic Dendritic Cells Are Specialized to Induce Foxp3+ Regulatory T Cells
2008 StandoutNobel
Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis
2005
Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes
2011
Regulatory T Cells Dynamically Control the Primary Immune Response to Foreign Antigen
2007
Enteric Flora Expands Gut Lamina Propria CX3CR1+ Dendritic Cells Supporting Inflammatory Immune Responses under Normal and Inflammatory Conditions
2010
Human Circulating CD4+CD25highFoxp3+ Regulatory T Cells Kill Autologous CD8+ but Not CD4+ Responder Cells by Fas-Mediated Apoptosis
2009
The Initial Phase of an Immune Response Functions to Activate Regulatory T Cells
2009
Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis
2018 StandoutNobel
Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses
2015
Hallmarks of Cancer: The Next Generation
2011 Standout
The regulation of IL-10 production by immune cells
2010 Standout
Re-establishing immunological self-tolerance in autoimmune disease
2012 StandoutNobel
LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6
2015
Transcription factor Foxp3 and its protein partners form a complex regulatory network
2012
Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors
2004
Regulatory T-cell inhibition versus depletion: the right choice in cancer immunotherapy
2007
Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27
2011
Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets
2015
The lifestyle of naturally occurring CD4+CD25+Foxp3+ regulatory T cells
2006
Regulatory T‐cell physiology and application to treat autoimmunity
2006
T cell receptor signalling in the control of regulatory T cell differentiation and function
2016
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria
2010
C5a receptor‐deficient dendritic cells promote induction of Treg and Th17 cells
2009
Control of immune homeostasis by naturally arising regulatory CD4+ T cells
2003
Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
2008
Two modes of immune suppression by Foxp3+ regulatory T cells under inflammatory or non-inflammatory conditions
2011 StandoutNobel
Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis
2011 StandoutNobel
Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?
2009
Natural versus adaptive regulatory T cells
2003
Innate immune mechanisms of colitis and colitis-associated colorectal cancer
2010
Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis
2016
Role of TGF-β in the Induction of Foxp3 Expression and T Regulatory Cell Function
2008
Origin of the Lamina Propria Dendritic Cell Network
2009
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
2013
Regulatory T cell plasticity: beyond the controversies
2011
Intestinal homeostasis and its breakdown in inflammatory bowel disease
2011 StandoutNature
The microbiota in adaptive immune homeostasis and disease
2016 StandoutNature
Regulatory T cells in virus infections
2006
From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells
2006
Regulatory T cell adaptation in the intestine and skin
2019
Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice
2015
IL-25-responsive, lineage-negative KLRG1hi cells are multipotential ‘inflammatory’ type 2 innate lymphoid cells
2014
A peripheral circulating compartment of natural naive CD4+ Tregs
2005
Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells
2010
Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
2011
Function of a Foxp3 cis -Element in Protecting Regulatory T Cell Identity
2014
TH17 cells in development: an updated view of their molecular identity and genetic programming
2008
Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction
2008
Homing to suppress: address codes for Treg migration
2005
ATP drives lamina propria TH17 cell differentiation
2008 Nature
IRF4 Transcription-Factor-Dependent CD103+CD11b+ Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation
2013
Control of Foxp3+ CD25+CD4+ regulatory cell activation and function by dendritic cells
2004
Extrathymically generated regulatory T cells control mucosal TH2 inflammation
2012 Nature
Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis
2014 Standout
A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes
2015
Toll-like receptor 2 controls expansion and function of regulatory T cells
2006
Microbiotal influence on T cell subset development
2011
Regulatory T Cells in Cancer
2010
CD4+CD25+ suppressor T cells: more questions than answers
2002 Standout
Commensal-Induced Regulatory T Cells Mediate Protection against Pathogen-Stimulated NF-κB Activation
2008
Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation
2015
T regulatory cells and the control of allergic disease
2006
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Regulatory T cells for the prevention of graft‐versus‐host disease: Professionals defeat amateurs
2009
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
2009 Standout
Dendritic cells: versatile controllers of the immune system
2007 StandoutNobel
Phenotypic and Functional Differences Between Human CD4+CD25+ and Type 1 Regulatory T Cells
2005
Plasmacytoid Dendritic Cells Mediate Oral Tolerance
2008
Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2
2019 Nature
Nonself-Antigens Are the Cognate Specificities of Foxp3+ Regulatory T Cells
2007
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
2007 StandoutNature
Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis
2009
In Vivo Induction of Immune Responses to Pathogens by Conventional Dendritic Cells
2008
Dendritic cells as controllers of antigen-specific Foxp3+ regulatory T cells
2009 StandoutNobel
Helios Is Associated with CD4 T Cells Differentiating to T Helper 2 and Follicular Helper T Cells In Vivo Independently of Foxp3 Expression
2011
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
2008
Novel Foxo1-dependent transcriptional programs control Treg cell function
2012 Nature
Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery
2018 Nature
Phenotypical and functional specialization of FOXP3+ regulatory T cells
2011
Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells
2016
Intestinal Dendritic Cells
2010
An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses
2015
The interactions of dendritic cells with antigen-specific, regulatory T cells that suppress autoimmunity
2006 StandoutNobel
T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2
2012
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice
2005
Inducing and Administering Tregs to Treat Human Disease
2016
Peripheral education of the immune system by colonic commensal microbiota
2011 Nature
CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients
2010
Induction and effector functions of TH17 cells
2008 Nature
Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response
2013
The Multifaceted Influence of the Mucosal Microflora on Mucosal Dendritic Cell Responses
2009
Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery
2008
Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria
2011
Commensal bacteria–derived signals regulate basophil hematopoiesis and allergic inflammation
2012
Homeostasis and Inflammation in the Intestine
2010
Cytotoxic T lymphocyte antigen‐4‐dependent down‐modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T‐cell‐mediated suppression
2006
An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment
2017
Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease
2006 StandoutNobel
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
2009
Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages
2014
Human FoxP3+ regulatory T cells in systemic autoimmune diseases
2011 StandoutNobel
Basic principles of tumor-associated regulatory T cell biology
2012
Functional Impairment of CD8+ T Cells by Regulatory T Cells during Persistent Retroviral Infection
2004 StandoutNobel
Impaired Th1 responses in mice deficient in Epstein‐Barr virus‐induced gene 3 and challenged with physiological doses of Leishmania major
2005
Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression
2009
Focused specificity of intestinal TH17 cells towards commensal bacterial antigens
2014 Nature
Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis
2014
The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity
2015
Programming dendritic cells to induce TH2 and tolerogenic responses
2010
Regulatory T cells: stability revisited
2011
E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis
2010
Choreographing Immunity in the Skin Epithelial Barrier
2019
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
2011
Control of Regulatory T Cell Lineage Commitment and Maintenance
2009
Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4+Foxp3+ Regulatory T Cells
2015
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10
2007
Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions
2009
Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That Isolates Repertoires Undergoing Positive or Negative Selection
2005
Toll-like receptors on regulatory T cells: expanding immune regulation
2006
Regulatory T cells generated ex vivo as an approach for the therapy of autoimmune disease
2004
A Distinct Function of Regulatory T Cells in Tissue Protection
2015
Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice
2014
Regulatory T cells: how do they suppress immune responses?
2009 StandoutNobel
Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance
2014
How regulatory T cells work
2008 Standout
Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells
2010
Foxp3+ follicular regulatory T cells control the germinal center response
2011
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes
2007
Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages
2014
Regulatory T Cells Reinforce Intestinal Homeostasis
2009
Immune adaptations that maintain homeostasis with the intestinal microbiota
2010
Emerging Biological Principles of Metastasis
2017 Standout
Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity
2010
An enteric virus can replace the beneficial function of commensal bacteria
2014 Nature
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
Targeting Treg signaling for the treatment of autoimmune diseases
2015
Dendritic Cells In Vivo: A Key Target for a New Vaccine Science
2008 StandoutNobel
Visualization of immediate immune responses to pioneer metastatic cells in the lung
2016 Nature
Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
2004
DNA methylation controls Foxp3 gene expression
2008
Multiple treg suppressive modules and their adaptability
2012 StandoutNobel
Th17 and Regulatory T Cells in Mediating and Restraining Inflammation
2010
Monocytes and macrophages: developmental pathways and tissue homeostasis
2014
Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level
2005
Bacterial strain‐specific induction of Foxp3+ T regulatory cells is protective in murine allergy models
2010
Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
2016
FOXP3+ regulatory T cells in the human immune system
2010 StandoutNobel
Monocyte-Derived Dendritic Cells Formed at the Infection Site Control the Induction of Protective T Helper 1 Responses against Leishmania
2007
Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions
2009
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
2011 Nature
Genetics and pathogenesis of inflammatory bowel disease
2011 StandoutNature
MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health
2015
The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis
2016 StandoutNobel
Dendritic cells in intestinal immune regulation
2008
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
2008
Thymic development and peripheral homeostasis of regulatory T cells
2007
Positive and Negative Transcriptional Regulation of the Foxp3 Gene is Mediated by Access and Binding of the Smad3 Protein to Enhancer I
2010
Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells
2012
An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
2006
Interferon-producing cells: on the front line in immune responses against pathogens
2002
Regulatory T cells and intestinal homeostasis
2005
Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues
2017
Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells
2012
Natural immunity to cancer in humans
2010
Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans
2006
Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease
2014
Diversity in the contribution of interleukin‐10 to T‐cell‐mediated immune regulation
2008
A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells
2012
Toll-like receptors in inflammatory bowel diseases: A decade later
2010
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4+ T cell immunity
2013
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
2010
Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment
2014 Standout
Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β
2011
Role of LAG-3 in Regulatory T Cells
2004
Mechanisms of suppression by suppressor T cells
2005
Development and Maintenance of Regulatory T cells
2013 StandoutNobel
Functional Analysis of FOXP3
2008
Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion
2009 StandoutNobel
Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine
2014
Origin and Functions of Tissue Macrophages
2014
Skin-Resident T Cells: The Ups and Downs of On Site Immunity
2009
Epigenetic Control of the foxp3 Locus in Regulatory T Cells
2007
Barrier Epithelial Cells and the Control of Type 2 Immunity
2015
Gut CD103 + dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction
2010
Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis
2006 StandoutNobel
Interleukin-12 and -23 Control Plasticity of CD127+ Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria
2015
Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer
2019 StandoutNobel
Selection of regulatory T cells in the thymus
2012
Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10
2008
The gut microbiota shapes intestinal immune responses during health and disease
2009 Standout
Restricted Microbiota and Absence of Cognate TCR Antigen Leads to an Unbalanced Generation of Th17 Cells
2010
Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells
2006
A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota
2009
Regulatory Lymphocytes and Intestinal Inflammation
2009
Tissue Tregs
2016
TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
2005
Naturally Arising CD4+Regulatory T Cells for Immunologic Self -Tolerance and Negative Control of Immune Responses
2003 StandoutNobel
CD28 co-stimulation is dispensable for the steady state homeostasis of intestinal regulatory T cells
2018
De novogeneration of antigen-specific CD4+CD25+regulatory T cells from human CD4+CD25–cells
2005
Regulatory T Cells: Mechanisms of Differentiation and Function
2007 Standout
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells
2010
Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3 high regulatory T cells in humans
2015 StandoutNobel
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients
2006 StandoutNobel
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
2012
The Percentage of FoxP3+Helios+ Treg Cells Correlates Positively With Disease Activity in Systemic Lupus Erythematosus
2013
Homeostasis of Thymus-Derived Foxp3+ Regulatory T Cells Is Controlled by Ultraviolet B Exposure in the Skin
2014 StandoutNobel
Ultraviolet B–Induced Maturation of CD11b-Type Langerin− Dendritic Cells Controls the Expansion of Foxp3+ Regulatory T Cells in the Skin
2017 StandoutNobel
Ontogeny of CD4+CD25+ regulatory/suppressor T cells in human fetuses
2005
SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production
2011
Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone
2007
Intestinal Bacteria and the Regulation of Immune Cell Homeostasis
2010
Foxp3+ T reg cells control psoriasiform inflammation by restraining an IFN-I–driven CD8+ T cell response
2018
IL-10+CTLA-4+ Th2 Inhibitory Cells Form in a Foxp3-Independent, IL-2–Dependent Manner from Th2 Effectors during Chronic Inflammation
2012
Lineage stability and phenotypic plasticity of Foxp3+ regulatory T cells
2014
Modulation of Dendritic Cell Function by Naive and Regulatory CD4+ T Cells
2006
Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226
2015
IL-17 and Th17 Cells
2009 Standout
Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells
2004
Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy
2015
Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation
2006
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma
2008 StandoutNobel
Blockade of CTLA-4 on CD4+CD25+ Regulatory T Cells Abrogates Their Function In Vivo
2006
CD49d provides access to “untouched” human Foxp3+ Treg free of contaminating effector cells
2008
CX3CR1+ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22
2014
Cutting Edge: In Contrast to Effector T Cells, CD4+CD25+FoxP3+ Regulatory T Cells Are Highly Susceptible to CD95 Ligand- but Not to TCR-Mediated Cell Death
2005
Human Memory Helios− FOXP3+ Regulatory T Cells (Tregs) Encompass Induced Tregs That Express Aiolos and Respond to IL-1β by Downregulating Their Suppressor Functions
2013
IL-10–producing and naturally occurring CD4+ Tregs: limiting collateral damage
2004
Direct Expansion of Functional CD25+ CD4+ Regulatory T Cells by Antigen-processing Dendritic Cells
2003 StandoutNobel
A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2
2006
IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells
2004
CD4+ CD25+ Regulatory T Cells Control T Helper Cell Type 1 Responses to Foreign Antigens Induced by Mature Dendritic Cells In Vivo
2003
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Inflammatory Bowel Disease
2010 Standout
Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection
2014
Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice
2011
Helios+ and Helios− Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans
2013
The 4-1BB Costimulation Augments the Proliferation of CD4+CD25+ Regulatory T Cells
2004
A Field Guide to Foldamers
2001 Standout
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity
2016
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
2008
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Dendritic cells expand antigen‐specific Foxp3+CD25+CD4+ regulatory T cells including suppressors of alloreactivity
2006 StandoutNobel
The Ets-1 transcription factor controls the development and function of natural regulatory T cells
2010
Conditional stability of T cells
2010 StandoutNatureNobel
Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells
2012
Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity
2014
Innate lymphoid cells: A new paradigm in immunology
2015 Science
Dendritic cells are specialized accessory cells along with TGF-β for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3− precursors
2007 StandoutNobel
Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
2020 StandoutNobel
Ipilimumab Plus Sargramostim vs Ipilimumab Alone for Treatment of Metastatic Melanoma
2014
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
Dysfunctional T regulatory cells in multiple myeloma
2005
Induced CD4+Foxp3+Regulatory T Cells in Immune Tolerance
2012
Natural regulatory T cells: mechanisms of suppression
2007 StandoutNobel
Adaptive Immune Regulation in the Gut: T Cell–Dependent and T Cell–Independent IgA Synthesis
2010
IL-27 promotes T cell–dependent colitis through multiple mechanisms
2010
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells
2008
Concomitant Tumor Immunity to a Poorly Immunogenic Melanoma Is Prevented by Regulatory T Cells
2004
Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo
2007
Regulatory roles of IL-10–producing human follicular T cells
2019 StandoutNobel
Oral Anti-CD3 Antibody Treatment Induces Regulatory T Cells and Inhibits the Development of Atherosclerosis in Mice
2009
Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease
2013
Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses
2011
Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice
2011 StandoutNobel
IFN-γ– and IL-10–expressing virus epitope-specific Foxp3+ T reg cells in the central nervous system during encephalomyelitis
2011
High TCR Stimuli Prevent Induced Regulatory T Cell Differentiation in a NF-κB–Dependent Manner
2011
Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
2006
Microbiota regulates immune defense against respiratory tract influenza A virus infection
2011 Standout
Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor–, granulocyte-macrophage colony-stimulating factor–, and interleukin-3–expressing NOD-SCID IL2Rγnull humanized mice
2011 StandoutNobel
Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes
2004
Alloantigen-enhanced accumulation of CCR5+‘effector’ regulatory T cells in the gravid uterus
2006
Differentiation of Effector CD4 T Cell Populations
2010 Standout
Expression of Helios in Peripherally Induced Foxp3+ Regulatory T Cells
2011 StandoutNobel
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes
2009
Antigen-specific peripheral shaping of the natural regulatory T cell population
2008
Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis
2006 StandoutNobel
Regulatory T cells in inflammatory skin disease: from mice to humans
2019
Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo
2003
tTregs, pTregs, and iTregs: similarities and differences
2014
Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State
2003
Coexpression of TIGIT and FCRL3 Identifies Helios+ Human Memory Regulatory T Cells
2015
FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2−/−γC−/− mice in vivo
2008
Works of Yasmine Belkaid being referenced
CD4 + CD25 + T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
2005
Contextual control of skin immunity and inflammation by Corynebacterium
2018
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells
2014
The Role of Interleukin (IL)-10 in the Persistence of Leishmania major in the Skin after Healing and the Therapeutic Potential of Anti–IL-10 Receptor Antibody for Sterile Cure
2001
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
2007 Standout
Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis
2014 Science
Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens
2006
Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury
2018 Science
Acute Gastrointestinal Infection Induces Long-Lived Microbiota-Specific T Cell Responses
2012 Science
Interleukin 1α Promotes Th1 Differentiation and Inhibits Disease Progression in Leishmania major –susceptible BALB/c Mice
2003
Compartmentalized Control of Skin Immunity by Resident Commensals
2012 Science
Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells
2010
Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation
2008
The alarmin IL-33 promotes regulatory T-cell function in the intestine
2014 Nature
Commensal–dendritic-cell interaction specifies a unique protective skin immune signature
2014 Nature
Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105
2005
A method to recover, enumerate and identify lymphomyeloid cells present in an inflammatory dermal site: a study in laboratory mice
1996
Role of Endogenous and Induced Regulatory T Cells During Infections
2008
Small numbers of residual tumor cells at the site of primary inoculation are critical for anti-tumor immunity following challenge at a secondary location
2006
Regulatory T cells and infection: a dangerous necessity
2007
Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4+CD44hi Cells
2008
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance
2008 Nature
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
2002 StandoutNature
GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
2011
C5a Negatively Regulates Toll-like Receptor 4-Induced Immune Responses
2005
Leishmania major-infected murine Langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous Leishmaniasis
2000
Natural regulatory T cells and parasites: a common quest for host homeostasis
2006
A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells
2014
Essential Role for Retinoic Acid in the Promotion of CD4+ T Cell Effector Responses via Retinoic Acid Receptor Alpha
2011
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Natural regulatory T cells in infectious disease
2005
Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection
2009
Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection
2015
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche
2016
The role of CD4+CD25+ regulatory T cells in Leishmania infection
2003
Microbial control of regulatory and effector T cell responses in the gut
2010
Association ofCTLA4 polymorphism with regulatory T cell frequency
2005
Skin microbiota–host interactions
2018 Nature
Plasticity of Treg at infected sites
2010
Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune Responses
2008
Microbe–dendritic cell dialog controls regulatory T‐cell fate
2010
Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens
2011 Nature
The influence of skin microorganisms on cutaneous immunity
2016
Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes
2013
The Transcription Factor GATA3 Is Critical for the Development of All IL-7Rα-Expressing Innate Lymphoid Cells
2014
Tuning Microenvironments: Induction of Regulatory T Cells by Dendritic Cells
2008
Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection
2013
The human skin microbiome
2018 Standout
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont
2018 Nature
The Role of Retinoic Acid in Tolerance and Immunity
2011
Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway
2010
Distinct requirements for T-bet in gut innate lymphoid cells
2012
Protection Against Cutaneous Leishmaniasis Resulting from Bites of Uninfected Sand Flies
2000 Science
Uptake of Leishmania major Amastigotes Results in Activation and Interleukin 12 Release from Murine Skin–derived Dendritic Cells: Implications for the Initiation of Anti-Leishmania Immunity
1998
Dialogue between skin microbiota and immunity
2014 Science
Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity
2014 Science
Incomplete Depletion and Rapid Regeneration of Foxp3+ Regulatory T Cells Following Anti-CD25 Treatment in Malaria-Infected Mice
2007
Regulatory T Cells in the Control of Host-Microorganism Interactions
2009
The Pathogenesis of Schistosomiasis Is Controlled by Cooperating IL-10-Producing Innate Effector and Regulatory T Cells
2004
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
2007 Standout
CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence
2006
A Natural Model ofLeishmania majorInfection Reveals a Prolonged “Silent” Phase of Parasite Amplification in the Skin Before the Onset of Lesion Formation and Immunity
2000
Adaptive immunity to murine skin commensals
2014
Regulatory T Cells Selectively Control CD8+ T Cell Effector Pool Size via IL-2 Restriction
2011
Role for CD4+ CD25+ Regulatory T Cells in Reactivation of Persistent Leishmaniasis and Control of Concomitant Immunity
2004
The GARP/Latent TGF‐β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance
2016
Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis
2017
A Role for CD103 in the Retention of CD4+CD25+ Treg and Control of Leishmania major Infection
2005
Contextual functions of antigen‐presenting cells in the gastrointestinal tract
2014
Tyk2 Negatively Regulates Adaptive Th1 Immunity by Mediating IL-10 Signaling and Promoting IFN-γ-Dependent IL-10 Reactivation
2006
CD8+ T Cells Are Required for Primary Immunity in C57BL/6 Mice Following Low-Dose, Intradermal Challenge withLeishmania major
2002