Citation Impact
Citing Papers
Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water
2017 StandoutScienceNobel
Generation of ordered protein assemblies using rigid three-body fusion
2021 StandoutNobel
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
2005 StandoutScience
DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
2017 Science
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Computational design of closely related proteins that adopt two well-defined but structurally divergent folds
2020 StandoutNobel
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
2013 StandoutScience
Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
2009
Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering
2011
Mechanism of Release and Fate of Excised Oligonucleotides during Nucleotide Excision Repair
2012 StandoutNobel
DNA Ends Alter the Molecular Composition and Localization of Ku Multicomponent Complexes
2012
An Integrated Approach for Analysis of the DNA Damage Response in Mammalian Cells
2015 StandoutNobel
Directing polymorph specific calcium carbonate formation with de novo protein templates
2023 StandoutNobel
The DNA-damage response in human biology and disease
2009 StandoutNature
An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells
2013
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
2005 Nature
Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine
2004
The role of DNA dependent protein kinase in synapsis of DNA ends
2003
Quality control of DNA break metabolism: in the ‘end’, it's a good thing
2008
Spontaneous tumor development in bone marrow-rescued DNA-PKcs3A/3A mice due to dysfunction of telomere leading strand deprotection
2015
The DNA-dependent Protein Kinase Catalytic Subunit Phosphorylation Sites in Human Artemis
2005
DNA-PKcs and ATM co-regulate DNA double-strand break repair
2009
Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes
2009
Cell-cycle checkpoints and cancer
2004 StandoutNature
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK
2007
Cryo-EM Structure of the DNA-Dependent Protein Kinase Catalytic Subunit at Subnanometer Resolution Reveals α Helices and Insight into DNA Binding
2008
The DNA Damage Response Kinases DNA-dependent Protein Kinase (DNA-PK) and Ataxia Telangiectasia Mutated (ATM) Are Stimulated by Bulky Adduct-containing DNA
2011 StandoutNobel
Ataxia Telangiectasia Mutated (ATM) Is Essential for DNA-PKcs Phosphorylations at the Thr-2609 Cluster upon DNA Double Strand Break
2006
Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase
2004
Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source
2013
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
The FATC Domains of PIKK Proteins Are Functionally Equivalent and Participate in the Tip60-dependent Activation of DNA-PKcs and ATM
2006
ATM and related protein kinases: safeguarding genome integrity
2003 Standout
Amyloid‐β‐induced toxicity of primary neurons is dependent upon differentiation‐associated increases in tau and cyclin‐dependent kinase 5 expression
2003
Mechanism and regulation of human non-homologous DNA end-joining
2003
N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku
2011
The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining
2008
Regulation of DNA double-strand break repair pathway choice
2007
A DNA damage checkpoint response in telomere-initiated senescence
2003 StandoutNature
Immunogenicity of induced pluripotent stem cells
2011 StandoutNature
Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair
2006
A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining
2008
DNA Damage, Aging, and Cancer
2009 Standout
Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break
2008 StandoutNobel
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses
2003
Deconstructing the photon stream from single nanocrystals: from binning to correlation
2013 StandoutNobel
Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining
2015
Co-ordination of base excision repair and genome stability
2013
Accurate SAXS Profile Computation and its Assessment by Contrast Variation Experiments
2013
Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)
2011 StandoutNobel
Lymphocyte-Specific Compensation for XLF/Cernunnos End-Joining Functions in V(D)J Recombination
2008
Hindlimb Suspension and SPE-Like Radiation Impairs Clearance of Bacterial Infections
2014 StandoutNobel
Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site
2017 StandoutNobel
De novo design of bioactive protein switches
2019 StandoutNatureNobel
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation
2010
BODIPY–Thiophene Copolymers as p‐Channel Semiconductors for Organic Thin‐Film Transistors
2013 StandoutNobel
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
2014
Software for the high-throughput collection of SAXS data using an enhancedBlu-Ice/DCScontrol system
2010
Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System
2014 StandoutNobel
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV
2004
Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis
2006
Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod‐Debye law
2011
A Cell-permeable, Activity-based Probe for Protein and Lipid Kinases
2005
The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle
2008
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Coordinate 5′ and 3′ endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase
2008
Exploring the repeat protein universe through computational protein design
2015 StandoutNatureNobel
Programmable design of orthogonal protein heterodimers
2018 StandoutNatureNobel
Phosphorylation and Regulation of DNA Ligase IV Stability by DNA-dependent Protein Kinase
2004
Controlling protein assembly on inorganic crystals through designed protein interfaces
2019 StandoutNatureNobel
Implication of DNA Polymerase λ in Alignment-based Gap Filling for Nonhomologous DNA End Joining in Human Nuclear Extracts
2003
The Mechanism of Human Nonhomologous DNA End Joining
2007
Chapter 2 DNA-PK
2008
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
2012 StandoutNobel
Initiating Cellular Stress Responses
2004
Processing of 3′-Phosphoglycolate-terminated DNA Double Strand Breaks by Artemis Nuclease
2006
High-Throughput SAXS for the Characterization of Biomolecules in Solution: A Practical Approach
2013
XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase
2011
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
Accurate design of megadalton-scale two-component icosahedral protein complexes
2016 StandoutScienceNobel
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation
2014
ATM Activation and Signaling under Hypoxic Conditions
2008
Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1.
2003
Mechanisms of double-strand break repair in somatic mammalian cells
2009
Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres
2006 StandoutNobel
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
2016 StandoutScienceNobel
Super-Resolution in Solution X-Ray Scattering and Its Applications to Structural Systems Biology
2013
Inhibition of Homologous Recombination by DNA-Dependent Protein Kinase Requires Kinase Activity, Is Titratable, and Is Modulated by Autophosphorylation
2011
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
2011
Fluorescence Correlation Spectroscopy: Novel Variations of an Established Technique
2007
Modulating DNA Repair Pathways to Improve Precision Genome Engineering
2017
BODIPY Dyes and Their Derivatives: Syntheses and Spectroscopic Properties
2007 Standout
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
In Vitro Analysis of the Role of Replication Protein A (RPA) and RPA Phosphorylation in ATR-mediated Checkpoint Signaling
2012 StandoutNobel
Replication protein A: directing traffic at the intersection of replication and repair
2010
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
Modular repeat protein sculpting using rigid helical junctions
2020 StandoutNobel
Computational design of mechanically coupled axle-rotor protein assemblies
2022 StandoutScienceNobel
Designing and defining dynamic protein cage nanoassemblies in solution
2016
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Restoration of ATM Expression in DNA-PKcs–Deficient Cells Inhibits Signal End Joining
2016
ATR-Dependent Phosphorylation of DNA-Dependent Protein Kinase Catalytic Subunit in Response to UV-Induced Replication Stress
2006
Simultaneous precise editing of multiple genes in human cells
2019 StandoutNobel
Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination
2019
Murine Prkdc Polymorphisms Impact DNA-PKcs Function
2011
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
2007 StandoutScience
Functional Intersection of ATM and DNA-Dependent Protein Kinase Catalytic Subunit in Coding End Joining during V(D)J Recombination
2013
De novo design of protein homodimers containing tunable symmetric protein pockets
2022 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends
2007
De novo design of protein logic gates
2020 StandoutScienceNobel
Non-homologous end-joining, a sticky affair
2007
Works of Yaping Yu being referenced
XRCC4's interaction with XLF is required for coding (but not signal) end joining
2012
The Expression of Cdk5, p35, p39, and Cdk5 Kinase Activity in Developing, Adult, and Aged Rat Brains
2000
Dual Modes of Interaction between XRCC4 and Polynucleotide Kinase/Phosphatase
2010
DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination
2003
Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex
2009
XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair
2011
DNA‐PK autophosphorylation facilitates Artemis endonuclease activity
2006
XLF Regulates Filament Architecture of the XRCC4·Ligase IV Complex
2010
Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage
2011
The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1
2009
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase
2002
The DNA-Dependent Protein Kinase Catalytic Subunit Is Phosphorylated In Vivo on Threonine 3950, a Highly Conserved Amino Acid in the Protein Kinase Domain
2006
Analysis of DNA-Dependent Protein Kinase-Mediated DNA End Joining by Two-Photon Fluorescence Cross-Correlation Spectroscopy
2006
Autophosphorylation of DNA-Dependent Protein Kinase Regulates DNA End Processing and May Also Alter Double-Strand Break Repair Pathway Choice
2005
The DNA-Dependent Protein Kinase Interacts with DNA To Form a Protein−DNA Complex That Is Disrupted by Phosphorylation
2002