Standout Papers

Four-component protein nanocages designed by ... 2021 2026 2022 202428
  1. Four-component protein nanocages designed by programmed symmetry breaking (2024)
    Sangmin Lee, Ryan D. Kibler et al. Nature
  2. Fast and versatile sequence-independent protein docking for nanomaterials design using RPXDock (2023)
    William Sheffler, Quinton M. Dowling et al. PLoS Computational Biology
  3. De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity (2024)
    Rubul Mout, Ross C. Bretherton et al. Proceedings of the National Academy of Sciences
  4. Computational design of mechanically coupled axle-rotor protein assemblies (2022)
    Alexis Courbet, Jesse M. Hansen et al. Science
  5. Generation of ordered protein assemblies using rigid three-body fusion (2021)
    Ivan Vulovic, Qing Yao et al. Proceedings of the National Academy of Sciences
  6. Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS (2018)
    Aniruddha Sahasrabuddhe, Yang Hsia et al. Proceedings of the National Academy of Sciences
  7. Design of multi-scale protein complexes by hierarchical building block fusion (2021)
    Yang Hsia, Rubul Mout et al. Nature Communications
  8. Design of a hyperstable 60-subunit protein icosahedron (2016)
    Yang Hsia, Jacob B. Bale et al. Nature
  9. Reconfigurable asymmetric protein assemblies through implicit negative design (2022)
    Danny D. Sahtoe, Florian Praetorius et al. Science
  10. De novo design of obligate ABC-type heterotrimeric proteins (2022)
    Ya‐Ting Chang, Andrew Norris et al. Nature Structural & Molecular Biology
  11. Hierarchical design of pseudosymmetric protein nanocages (2024)
    Quinton M. Dowling, Young‐Jun Park et al. Nature

Citation Impact

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Self-assembly of tetravalent Goldberg polyhedra from 144 small components
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Simple yet functional phosphate-loop proteins
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Accurate design of megadalton-scale two-component icosahedral protein complexes
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Improving Protein Expression, Stability, and Function with ProteinMPNN
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Exploration of Structured Symmetric Cyclic Peptides as Ligands for Metal-Organic Frameworks
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Principles of Designing Extra-Large Pore Openings and Cages in Zeolitic Imidazolate Frameworks
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Ion-dependent protein–surface interactions from intrinsic solvent response
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Self-Assembling 2D Arrays with de Novo Protein Building Blocks
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Computational design of mixed chirality peptide macrocycles with internal symmetry
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Rotational dynamics and transition mechanisms of surface-adsorbed proteins
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Engineering Biomolecular Self‐Assembly at Solid–Liquid Interfaces
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Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1
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Modular repeat protein sculpting using rigid helical junctions
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Evolutionary-scale prediction of atomic-level protein structure with a language model
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Rational Engineering of a Designed Protein Cage for siRNA Delivery
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Design of self-assembling transmembrane helical bundles to elucidate principles required for membrane protein folding and ion transport
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De novo design of small beta barrel proteins
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Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation
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Works of Yang Hsia being referenced

Fast and versatile sequence-independent protein docking for nanomaterials design using RPXDock
2023 StandoutNobel
Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS
2018 StandoutNobel
Generation of ordered protein assemblies using rigid three-body fusion
2021 StandoutNobel
Designed proteins induce the formation of nanocage-containing extracellular vesicles
2016 Nature
Design of multi-scale protein complexes by hierarchical building block fusion
2021 StandoutNobel
De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity
2024 StandoutNobel
Computational design of mechanically coupled axle-rotor protein assemblies
2022 StandoutScienceNobel
Design of a hyperstable 60-subunit protein icosahedron
2016 StandoutNatureNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Rankless by CCL
2026