Citation Impact
Citing Papers
PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors
2003 StandoutScience
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels
2006 StandoutNobel
Synovial Fibroblasts Promote the Expression and Granule Accumulation of Tryptase via Interleukin-33 and Its Receptor ST-2 (IL1RL1)
2010
Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis
2018 StandoutNobel
Mutations of c-kit JM domain are found in a minority of human gastrointestinal stromal tumors
1999
Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial
2009 Standout
DIFFERENTIAL microRNA EXPRESSION IN CHILDHOOD B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA
2009
Identification and expression cloning of a leptin receptor, OB-R
1995 Standout
Mast Cell-Deficient W-sash c-kit Mutant KitW-sh/W-sh Mice as a Model for Investigating Mast Cell Biology in Vivo
2005
Clustering of Activating Mutations in c-KIT’s Juxtamembrane Coding Region in Canine Mast Cell Neoplasms
1999
Oncogenic kinase signalling
2001 StandoutNature
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Efficacy of Gefitinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Symptomatic Patients With Non–Small Cell Lung Cancer
2003 Standout
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
1993 Standout
Structural Basis for Autoinhibition of the EphB2 Receptor Tyrosine Kinase by the Unphosphorylated Juxtamembrane Region
2001
Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal Stromal Tumor
2001 Standout
A Vast Repertoire of Dscam Binding Specificities Arises from Modular Interactions of Variable Ig Domains
2007 StandoutNobel
Molecular characterisation of soft tissue tumours: a gene expression study
2002 Standout
Germline-Activating Mutation in the Kinase Domain of KIT Gene in Familial Gastrointestinal Stromal Tumors
2000
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
Stat3 as an Oncogene
1999 Standout
Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in WsWs mutant rats
1995
Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
2003 Standout
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.
1993
Inflammatory cytokines: interleukin-1 and tumor necrosis factor as effector molecules in autoimmune diseases
1991
Soft-Tissue Sarcomas in Adults
2005 Standout
The biology of VEGF and its receptors
2003 Standout
Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein
1993 Standout
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial
2006 Standout
Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations
2002
Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF
2004 Standout
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
c‐kit proto‐oncogene exon 8 in‐frame deletion plus insertion mutations in acute myeloid leukaemia
1999
Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis
2001 Standout
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
1993 Standout
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
1994 StandoutNature
Lymphocyte responses and cytokines
1994 Standout
RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia
2000
The kit ligand: A cell surface molecule altered in steel mutant fibroblasts
1990
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
2005 Standout
Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial
2004 Standout
KIT Extracellular and Kinase Domain Mutations in Gastrointestinal Stromal Tumors
2000
Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy
2001
Modulation of Ocular Surface Glycocalyx Barrier Function by a Galectin-3 N-terminal Deletion Mutant and Membrane-Anchored Synthetic Glycopolymers
2013 StandoutNobel
c-Kit Point mutation in patients with myeloproliferative disorders
1997
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
2013 Standout
Survey of the year 2003 commercial optical biosensor literature
2004
In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor
2000 StandoutNobel
Paraffin section detection of the c-kit gene product (CD 117) in human tissues: Value in the diagnosis of mast cell disorders
1998
Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells
1999
Receptor tyrosine kinases in normal and malignant haematopoiesis
2003
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
2011 StandoutNobel
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
2010 StandoutNature
Microenvironmental regulation of tumor progression and metastasis
2013 Standout
The significant role of mast cells in cancer
2011
Oncogenic protein tyrosine kinases
2004
Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro
1991
A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders
2005 Standout
Early signaling pathways activated by c-Kit in hematopoietic cells
1999
Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme
1992 Standout
The Absence of Interleukin 1 Receptor–Related T1/St2 Does Not Affect T Helper Cell Type 2 Development and Its Effector Function
1999
I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development
2010 StandoutNobel
The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice.
1991
Role of the Carboxyl-Terminal Lectin Domain in Self-Association of Galectin-3
1998
Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor
1990 Standout
Activating and dominant inactivating c-KITcatalytic domain mutations in distinct clinical forms of human mastocytosis
1999
Coexpression of flt-3 ligand/flt-3 and SCF/c-kit signal transduction system in bile-duct-ligated SI and W mice.
1997
Phosphatidylinositol 3′-kinase associates with p145c-kit as part of a cell type characteristic multimeric signalling complex.
1993
Effects of Aging and Hypoxia-Inducible Factor-1 Activity on Angiogenic Cell Mobilization and Recovery of Perfusion After Limb Ischemia
2007 StandoutNobel
Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
2000
Biology of Gastrointestinal Stromal Tumors
2004 Standout
Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells
1993
Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation
1994
CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.
1996 Standout
In vitro duplication and in vivo cure of mast-cell deficiency of Sl/Sld mutant mice by cloned 3T3 fibroblasts.
1989
KIT activation is a ubiquitous feature of gastrointestinal stromal tumors.
2001
After chronic myelogenous leukemia: tyrosine kinase inhibitors in other hematologic malignancies
2004
Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors
1998 StandoutScience
The role of microRNA genes in papillary thyroid carcinoma
2005 Standout
Modulation of cell proliferation and cytokine production in acute myeloblastic leukemia by interleukin-1 receptor antagonist and lack of its expression by leukemic cells
1991
Normal and Oncogenic Forms of the Receptor Tyrosine Kinase Kit
2005
Nongenomic Steroid Action: Controversies, Questions, and Answers
2003
Flt3 ligand stimulates proliferation and inhibits apoptosis of acute myeloid leukemia cells: regulation of Bcl-2 and Bax
1996
Stem Cell Factor and Hematopoiesis
1997
Hematopoietic cytokines
2008
Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines
1995
The c-kit receptor, stem cell factor, and mast cells. What each is teaching us about the others.
1993
c-kit Gene was not transcribed in cultured mast cells of mast cell- deficient Wsh/Wsh mice that have a normal number of erythrocytes and a normal c-kit coding region
1992
W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.
1990
Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
2020 StandoutNobel
Immunobiology of Dendritic Cells
2000 Standout
Low c-kit expression of cultured mast cells of mi/mi genotype may be involved in their defective responses to fibroblasts that express the ligand for c-kit
1992
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
c-kit Ligand and Flt3 Ligand: Stem/Progenitor Cell Factors With Overlapping Yet Distinct Activities
1998
Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages
2004
Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant
2001
Bone Marrow as a Potential Source of Hepatic Oval Cells
1999 StandoutScience
Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor–, granulocyte-macrophage colony-stimulating factor–, and interleukin-3–expressing NOD-SCID IL2Rγnull humanized mice
2011 StandoutNobel
Interleukin-1 and interleukin-1 antagonism
1991 Standout
The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts
2001
Inhibition of KIT Tyrosine Kinase Activity: A Novel Molecular Approach to the Treatment of KIT-Positive Malignancies
2002
SHP-1 Binds and Negatively Modulates the c-Kit Receptor by Interaction with Tyrosine 569 in the c-Kit Juxtamembrane Domain
1998
Markedly Reduced Expression of Platelet c-mpl Receptor in Essential Thrombocythemia
1997
Lymphokine and Cytokine Production by FcεRI+ Cells
1993
Works of Y Kanakura being referenced
HOX Decoy Peptide Enhances the Ex Vivo Expansion of Human Umbilical Cord Blood CD34+ Hematopoietic Stem Cells/Hematopoietic Progenitor Cells
2006
Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome.
1998
The biologic properties of recombinant human thrombopoietin in the proliferation and megakaryocytic differentiation of acute myeloblastic leukemia cells
1996
Proliferative potential of degranulated murine peritoneal mast cells
1989
Constitutive activation of c-kit in FMA3 murine mastocytoma cells caused by deletion of seven amino acids at the juxtamembrane domain
1996
Constitutive activation of c-kit in FMA3 murine mastocytoma cells caused by deletion of seven amino acids at the juxtamembrane domain
1996
Demonstration of interleukin-1 beta transcripts in acute myeloblastic leukemic cells by in situ hybridization.
1990
Failure of W/Wv mouse-derived cultured mast cells to enter S phase upon contact with NIH/3T3 fibroblasts
1988
Expression and functional role of the proto-oncogene c-kit in acute myeloblastic leukemia cells
1991
Proliferation of human myeloid leukemia cell line associated with the tyrosine-phosphorylation and activation of the proto-oncogene c-kit product
1991
Multiple bidirectional alterations of phenotype and changes in proliferative potential during the in vitro and in vivo passage of clonal mast cell populations derived from mouse peritoneal mast cells
1988
Age-dependent amelioration of hypoplastic anemia in Ws/Ws rats with a small deletion at the kinase domain of c-kit
1993
Mast cell number in the skin of heterozygotes reflects the molecular nature of c-kit mutation
1993
Cellular localization of thrombopoietin mRNA in the liver by in situ hybridization.
1997