Standout Papers
Citation Impact
Citing Papers
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Control of Excitatory and Inhibitory Synapse Formation by Neuroligins
2005 Science
Interaction of the Plasma Membrane Ca2+ Pump 4b/CI with the Ca2+/Calmodulin-dependent Membrane-associated Kinase CASK
2003
Latrophilins Function as Heterophilic Cell-adhesion Molecules by Binding to Teneurins
2013 StandoutNobel
Association of Junctional Adhesion Molecule with Calcium/calmodulin-dependent Serine Protein Kinase (CASK/LIN-2) in Human Epithelial Caco-2 Cells
2001
Ca2+-dependent splicing of neurexin IIα
2006
Small GTP-Binding Proteins
1992
Structure and Evolution of Neurexin Genes: Insight into the Mechanism of Alternative Splicing
2002 StandoutNobel
SNARE Complex Formation Is Triggered by Ca 2+ and Drives Membrane Fusion
1999
The Location of HumanCASKat Xp11.4 Identifies This Gene as a Candidate for X-Linked Optic Atrophy
1998
CRIPT, a Novel Postsynaptic Protein that Binds to the Third PDZ Domain of PSD-95/SAP90
1998
Neuroligin 2 is exclusively localized to inhibitory synapses
2004
Molecular domains of myelinated axons
2000
Syntaxin and synaptobrevin function downstream of vesicle docking in drosophila
1995
Sec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles
1996
Selective Capability of SynCAM and Neuroligin for Functional Synapse Assembly
2005 StandoutNobel
Neurexins: Three genes and 1001 products
1998 StandoutNobel
LRRTM2 Interacts with Neurexin1 and Regulates Excitatory Synapse Formation
2009
Distinct domains of syntaxin are required for synaptic vesicle fusion complex formation and dissociation
1995
Important Contribution of α-Neurexins to Ca2+-Triggered Exocytosis of Secretory Granules
2006
LRRTM2 Functions as a Neurexin Ligand in Promoting Excitatory Synapse Formation
2009 StandoutNobel
Synaptic trafficking of glutamate receptors by MAGUK scaffolding proteins
2007
Cartography of neurexins: More than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons
1995 StandoutNobel
CASK and Protein 4.1 Support F-actin Nucleation on Neurexins
2001 StandoutNobel
Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2
2000 Nature
A novel SNARE complex implicated in vesicle fusion with the endoplasmic reticulum
1997
Neurexin Iα Is a Major α-Latrotoxin Receptor That Cooperates in α-Latrotoxin Action
1998 StandoutNobel
Functional and physical coupling of voltage‐sensitive calcium channels with exocytotic proteins: ramifications for the secretion mechanism
2001
Mixed and Non-cognate SNARE Complexes
1999
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
1998 StandoutNature
α-Latrotoxin and Its Receptors
2007
A Splice Code for trans-Synaptic Cell Adhesion Mediated by Binding of Neuroligin 1 to α- and β-Neurexins
2005 StandoutNobel
Neurotransmitter release — four years of SNARE complexes
1997
The GTPase superfamily: a conserved switch for diverse cell functions
1990 StandoutNature
N-Ethylmaleimide-sensitive Factor Acts at a Prefusion ATP-dependent Step in Ca2+-activated Exocytosis
1996
Presynaptic Neurexin-3 Alternative Splicing trans-Synaptically Controls Postsynaptic AMPA Receptor Trafficking
2013 StandoutNobel
Polarized signaling: basolateral receptor localization in epithelial cells by PDZ-containing proteins
1997
Botulinum neurotoxin light chains inhibit both Ca2+‐induced and GTP analogue‐induced catecholamine release from permeabilised adrenal chromaffin cells
1996
Rab proteins and the road maps for intracellular transport
1993
A small GTP-binding protein dissociates from synaptic vesicles during exocytosis
1991 Nature
Vam3p structure reveals conserved and divergent properties of syntaxins.
2001
Interaction of ion channels and receptors with PDZ domain proteins
1997
Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition
1998
Ykt6p, a Prenylated SNARE Essential for Endoplasmic Reticulum-Golgi Transport
1997 StandoutNobel
Complexins: Cytosolic proteins that regulate SNAP receptor function
1995
Snares and munc18 in synaptic vesicle fusion
2002 StandoutNobel
Formation of a yeast SNARE complex is accompanied by significant structural changes
1997
SNAREs and the specificity of transport vesicle targeting
1995
Inhibition of SNARE Complex Assembly Differentially Affects Kinetic Components of Exocytosis
1999 Nobel
Structure and function of fusion pores in exocytosis and ectoplasmic membrane fusion
1995
Functional dependence of neuroligin on a new non-PDZ intracellular domain
2011
Identification of an Evolutionarily Conserved Heterotrimeric Protein Complex Involved in Protein Targeting
1998
Small GTP-binding proteins in vesicular transport
1990
SNAREpins: Minimal Machinery for Membrane Fusion
1998 StandoutNobel
A Structural Change Occurs upon Binding of Syntaxin to SNAP-25
1997
Postsynaptic organisation and regulation of excitatory synapses
2000
Structural insights into the function of the Rab GDI superfamily
1996
High frequency of neurexin 1β signal peptide structural variants in patients with autism
2006
The G Protein-coupled Receptor CL1 Interacts Directly with Proteins of the Shank Family
2000 StandoutNobel
Mechanism of Action of rab3A in Mossy Fiber LTP
1998 StandoutNobel
Neurexin–neuroligin signaling in synapse development
2007
Synapse formation: If it looks like a duck and quacks like a duck…
2000
Initial docking of ER-derived vesicles requires Uso1p and Ypt1p but is independent of SNARE proteins
1998
Neuroligin Expressed in Nonneuronal Cells Triggers Presynaptic Development in Contacting Axons
2000
Neurexins Are Functional α-Latrotoxin Receptors
1999 StandoutNobel
Neurexin mediates the assembly of presynaptic terminals
2003
Dissection of Synapse Induction by Neuroligins
2005 StandoutNobel
SNAP-25 Is Required for a Late Postdocking Step in Ca2+-dependent Exocytosis
1996
Neuroligins Determine Synapse Maturation and Function
2006 StandoutNobel
Extracellular Domains of α-Neurexins Participate in Regulating Synaptic Transmission by Selectively Affecting N- and P/Q-Type Ca2+Channels
2005 StandoutNobel
Distinct Ca2+-dependent Properties of the First and Second C2-domains of Synaptotagmin I
1996 StandoutNobel
Selective Interaction of Complexin with the Neuronal SNARE Complex
2000 StandoutNobel
Camguk/CASK Enhances Ether-Á-Go-Go Potassium Current by a Phosphorylation-Dependent Mechanism
2005
Structural Organization of the Synaptic Exocytosis Core Complex
1997
The N-Ethylmaleimide-sensitive Fusion Protein and α-SNAP Induce a Conformational Change in Syntaxin
1995
Disorder-associated mutations lead to functional inactivation of neuroligins
2004
Membrane Fusion
2003 StandoutNobel
An autism‐associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor‐mediated synaptic transmission in hippocampus
2011 StandoutNobel
Neuroligin 1: A splice site-specific ligand for β-neurexins
1995 StandoutNobel
Regulation of the Ca2+/CaM-Responsive Pool of CaMKII by Scaffold-Dependent Autophosphorylation
2003
SNARE Interactions Are Not Selective
1999
The PDZ Domain of Human Erythrocyte p55 Mediates Its Binding to the Cytoplasmic Carboxyl Terminus of Glycophorin C
1997
Regulation of LNS Domain Function by Alternative Splicing: The Structure of the Ligand-Binding Domain of Neurexin Iβ
1999 StandoutNobel
A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins.
1995 StandoutNobel
GTP-binding proteins in intracellular transport
1992
Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins
1995 StandoutNatureNobel
High Affinity Neurexin Binding to Cell Adhesion G-protein-coupled Receptor CIRL1/Latrophilin-1 Produces an Intercellular Adhesion Complex
2012 StandoutNobel
Structure and function of tetanus and botulinum neurotoxins
1995
Synapse-Specific and Developmentally Regulated Targeting of AMPA Receptors by a Family of MAGUK Scaffolding Proteins
2006
The LIN-2/LIN-7/LIN-10 Complex Mediates Basolateral Membrane Localization of the C. elegans EGF Receptor LET-23 in Vulval Epithelial Cells
1998
Purification of component A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product
1992 StandoutNobel
Rab GTPases: master regulators of membrane trafficking
1994
A Novel Multiple PDZ Domain-containing Molecule Interacting withN-Methyl-d-aspartateReceptors and Neuronal Cell Adhesion Proteins
1998 StandoutNobel
DrosophilaCAKI/CMG Protein, a Homolog of Human CASK, Is Essential for Regulation of Neurotransmitter Vesicle Release
2005
N-Terminal Palmitoylation of PSD-95 Regulates Association with Cell Membranes and Interaction with K+ Channel Kv1.4
1998
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
Structures, Alternative Splicing, and Neurexin Binding of Multiple Neuroligins
1996 StandoutNobel
The CASK/Lin-2 Drosophila Homologue, Camguk, Could Play a Role in Epithelial Patterning and in Neuronal Targeting
2001
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
Synaptotagmins: Why So Many?
2002 StandoutNobel
SNARE assembly and disassembly exhibit a pronounced hysteresis
2002
A Tripartite Protein Complex with the Potential to Couple Synaptic Vesicle Exocytosis to Cell Adhesion in Brain
1998 StandoutNobel
Neurexins Induce Differentiation of GABA and Glutamate Postsynaptic Specializations via Neuroligins
2004
A Conserved Membrane-spanning Amino Acid Motif Drives Homomeric and Supports Heteromeric Assembly of Presynaptic SNARE Proteins
2000
Proteins of synaptic vesicles involved in exocytosis and membrane recycling
1991
LRRTMs and Neuroligins Bind Neurexins with a Differential Code to Cooperate in Glutamate Synapse Development
2010
Neuroligins and neurexins: linking cell adhesion, synapse formation and cognitive function
2005
SNARE-mediated membrane fusion
2001
Structure and Conformational Changes in NSF and Its Membrane Receptor Complexes Visualized by Quick-Freeze/Deep-Etch Electron Microscopy
1997
Characterization of the Interaction of a Recombinant Soluble Neuroligin-1 with Neurexin-1β
2003 StandoutNobel
High Affinity Binding of α-Latrotoxin to Recombinant Neurexin Iα
1995 StandoutNobel
Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2
2007 StandoutNobel
Mints as Adaptors
2000 StandoutNobel
Structural Changes Are Associated with Soluble N-Ethylmaleimide-sensitive Fusion Protein Attachment Protein Receptor Complex Formation
1997
Calcium-dependent interaction of N-type calcium channels with the synaptic core complex
1996 Nature
Binding Properties of Neuroligin 1 and Neurexin 1β Reveal Function as Heterophilic Cell Adhesion Molecules
1997 StandoutNobel
Association of Neuronal Calcium Channels with Modular Adaptor Proteins
1999 StandoutNobel
β1-Adrenergic Receptor Association with PSD-95
2000 StandoutNobel
Protein modules as organizers of membrane structure
1999
Comparative Genome Analysis of the Neurexin Gene Family in Danio rerio: Insights into Their Functions and Evolution
2006
SNAREs and targeted membrane fusion
1995
Parkin and CASK/LIN-2 Associate via a PDZ-mediated Interaction and Are Co-localized in Lipid Rafts and Postsynaptic Densities in Brain
2002
Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C
1994 StandoutNobel
A Multiprotein Trafficking Complex Composed of SAP97, CASK, Veli, and Mint1 Is Associated with Inward Rectifier Kir2 Potassium Channels
2004
Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms
2007
hCASK and hDlg Associate in Epithelia, and Their Src Homology 3 and Guanylate Kinase Domains Participate in Both Intramolecular and Intermolecular Interactions
2000
Camguk, Lin-2, and CASK: novel membrane-associated guanylate kinase homologs that also contain CaM kinase domains
1997
Three-Dimensional Structure of the Complexin/SNARE Complex
2002 StandoutNobel
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ
1996 StandoutNobel
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
2003 StandoutNatureNobel
Synaptic Core Complex of Synaptobrevin, Syntaxin, and SNAP25 Forms High Affinity -SNAP Binding Site
1995 StandoutNobel
Syntaxin 5 Is a Common Component of the NSF- and p97-Mediated Reassembly Pathways of Golgi Cisternae from Mitotic Golgi Fragments In Vitro
1998
A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II
1998
α-Latrotoxin action probed with recombinant toxin: receptors recruit α-latrotoxin but do not transduce an exocytotic signal
1998 StandoutNobel
Synaptic transmission regulated by a presynaptic MALS/Liprin-α protein complex
2006
Citron Binds to PSD-95 at Glutamatergic Synapses on Inhibitory Neurons in the Hippocampus
1999
Cast
2002
Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily.
1991
THE SYNAPTIC VESICLE CYCLE
2004 StandoutNobel
The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo
2011 StandoutNobel
Gz, a guanine nucleotide-binding protein with unique biochemical properties.
1990 StandoutNobel
Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles
1997
Isolation of a candidate gene for choroideremia.
1992
Postsynaptic N -methyl- d -aspartate receptor function requires α-neurexins
2004 StandoutNobel
Input-specific synaptic plasticity in the amygdala is regulated by neuroligin-1 via postsynaptic NMDA receptors
2010 Nobel
Effect of Mutations in Vesicle-Associated Membrane Protein (VAMP) on the Assembly of Multimeric Protein Complexes
1997
Deletion of CASK in mice is lethal and impairs synaptic function
2007 StandoutNobel
Signaling Through Scaffold, Anchoring, and Adaptor Proteins
1997 StandoutScience
A Family of cAMP-Binding Proteins That Directly Activate Rap1
1998 StandoutScience
Comparison of Cysteine String Protein (Csp) and Mutant α-SNAP Overexpression Reveals a Role for Csp in Late Steps of Membrane Fusion in Dense-Core Granule Exocytosis in Adrenal Chromaffin Cells
2000
Specific interactions of Mss4 with members of the Rab GTPase subfamily.
1994
Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin.
1993
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
A stoichiometric complex of neurexins and dystroglycan in brain
2001 StandoutNobel
C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester.
1991
α-Latrotoxin and Its Receptors: Neurexins and CIRL/Latrophilins
2001 StandoutNobel
Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains
1997 Science
Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter
2005
Identification and Structure of Four Yeast Genes (SLY) That Are Able To Suppress the Functional Loss of YPT1, a Member of the RAS Superfamily
1991
Rab3C is a synaptic vesicle protein that dissociates from synaptic vesicles after stimulation of exocytosis
1994 StandoutNobel
Regulated Expression and Subcellular Localization of Syndecan Heparan Sulfate Proteoglycans and the Syndecan-Binding Protein CASK/LIN-2 during Rat Brain Development
1999
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Identification of a Minimal Core of the Synaptic SNARE Complex Sufficient for Reversible Assembly and Disassembly
1998
Regulation of APP-Dependent Transcription Complexes by Mint/X11s: Differential Functions of Mint Isoforms
2002 StandoutNobel
Membrane Fusion and Exocytosis
1999 StandoutNobel
Kinesin Superfamily Motor Protein KIF17 and mLin-10 in NMDA Receptor-Containing Vesicle Transport
2000 Science
Direct Interaction of CASK/LIN-2 and Syndecan Heparan Sulfate Proteoglycan and Their Overlapping Distribution in Neuronal Synapses
1998
Defining the functions of trans-SNARE pairs
1998 Nature
TheCaenorhabditis elegans unc-64Locus Encodes a Syntaxin That Interacts Genetically with Synaptobrevin
1998
Gene Selection, Alternative Splicing, and Post-translational Processing Regulate Neuroligin Selectivity for β-Neurexins
2006 StandoutNobel
Target-Specific Factors Regulate the Formation of Glutamatergic Transmitter Release Sites in Cultured Neocortical Neurons
1999
Signaling pathways are focused at specialized regions of the plasma membrane by scaffolding proteins of the MAGUK family
1999
Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons
2011 StandoutNobel
Neuroligation: building synapses around the neurexin–neuroligin link
2000
A novel prenyltransferase for a small GTP-binding protein having a C-terminal Cys-Ala-Cys structure.
1991
Modular organization of the PDZ domains in the human discs-large protein suggests a mechanism for coupling PDZ domain-binding proteins to ATP and the membrane cytoskeleton.
1996
Structure and Evolution of Neurexophilin
1996 StandoutNobel
Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses
1997 StandoutNobel
Functional interaction of syntaxin and SNAP-25 with voltage-sensitive L- and N-type Ca2+ channels.
1996
Assembly of SNARE Core Complexes Prior to Neurotransmitter Release Sets the Readily Releasable Pool of Synaptic Vesicles
2000 StandoutNobel
Synaptic Targeting of N-Type Calcium Channels in Hippocampal Neurons
2002
Disassembly of the reconstituted synaptic vesicle membrane fusion complex in vitro.
1995
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation
2013 StandoutNobel
Synaptic targeting and localization of Discs-large is a stepwise process controlled by different domains of the protein
2000
Characterization of MALS/Velis-1, -2, and -3: a Family of Mammalian LIN-7 Homologs Enriched at Brain Synapses in Association with the Postsynaptic Density-95/NMDA Receptor Postsynaptic Complex
1999
Neurotransmitter release regulated by a MALS–liprin-α presynaptic complex
2005
Rabphilin-3A, a Putative Target Protein for smg p25A/rab3A p25 Small GTP-Binding Protein Related to Synaptotagmin
1993
Functional Excitatory Synapses in HEK293 Cells Expressing Neuroligin and Glutamate Receptors
2003
Isoform-specific interaction of the alpha1A subunits of brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25.
1996
GTP cleavage by the small GTP-binding protein Rab3A is associated with exocytosis of synaptic vesicles induced by alpha-latrotoxin.
1994
Human CASK/LIN-2 Binds Syndecan-2 and Protein 4.1 and Localizes to the Basolateral Membrane of Epithelial Cells
1998
SNAP-25 and synaptotagmin involvement in the final Ca(2+)-dependent triggering of neurotransmitter exocytosis.
1996
Molecular Analysis of the X11–mLin-2/CASK Complex in Brain
1999
A Vacuolar v–t-SNARE Complex, the Predominant Form In Vivo and on Isolated Vacuoles, Is Disassembled and Activated for Docking and Fusion
1998
A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission
2003 StandoutNobel
Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs
1998
Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses
1999 StandoutNobel
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
2004 StandoutNobel
CASK Participates in Alternative Tripartite Complexes in which Mint 1 Competes for Binding with Caskin 1, a Novel CASK-Binding Protein
2002 StandoutNobel
Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
2009 StandoutNobel
SynCAM, a Synaptic Adhesion Molecule That Drives Synapse Assembly
2002 StandoutScienceNobel
Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins.
1993
Works of Y. Hata being referenced
Roles of postsynaptic density-95/synapse-associated protein 90 and its interacting proteins in the organization of synapses
1999
Phosphorylation of synaptotagmin I by casein kinase II.
1993 StandoutNobel
Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor.
1990
Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.
1994 StandoutNobel
Purification and Characterization from Bovine Brain Cytosol of Two Gtpase-Activating Proteins Specific for smg p21, a GTP-binding Protein Having the Same Effector Domain as c-ras p21s
1989
Enhancement of the actions of smg p21 GDP/GTP exchange protein by the protein kinase A-catalyzed phosphorylation of smg p21.
1991
Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s.
1990
Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins.
1994
Binding of Neuroligins to PSD-95
1997 StandoutScienceNobel
Role of the C-terminal region of smg p21, a ras p21-like small GTP-binding protein, in membrane and smg p21 GDP/GTP exchange protein interactions.
1991
Role of the C-terminal region of smg p25A in its interaction with membranes and the GDP/GTP exchange protein.
1991
Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding protein.
1990
Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein.
1990
CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins
1996