Standout Papers
Citation Impact
Citing Papers
LIM Protein KyoT2 Negatively Regulates Transcription by Association with the RBP-J DNA-Binding Protein
1998 StandoutNobel
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation
2004
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Protein O -fucosyltransferase 1 is an essential component of Notch signaling pathways
2003
Sculpting conducting nanopore size and shape through de novo protein design
2024 StandoutScienceNobel
Murine leukemia provirus‐mediated activation of the Notch1 gene leads to induction of HES‐1 in a mouse T lymphoma cell line, DL‐3
1999 StandoutNobel
Notch signalling controls pancreatic cell differentiation
1999 StandoutNatureNobel
Down-regulation of Delta by proteolytic processing
2002
The Notch 3 intracellular domain represses Notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters
1999
Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor
2001 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development
2003
Roles of Pofut1 and O-Fucose in Mammalian Notch Signaling
2008
Notch and Presenilin Regulate Cellular Expansion and Cytokine Secretion but Cannot Instruct Th1/Th2 Fate Acquisition
2008
A secreted Delta1‐Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling
2002
Hematopoietic stem cell fate is established by the Notch–Runx pathway
2005
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
Target Selectivity of Vertebrate Notch Proteins
2005
Roles of the ankyrin repeats and C-terminal region of the mouse Notch1 intracellular region
1998 StandoutNobel
Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways
2008
Nas transgenic mouse line allows visualization of Notch pathway activity in vivo
2006
Heteromultimeric channels formed by rat brain potassium-channel proteins
1990 StandoutNatureNobel
A molecular basis for familial hypertrophic cardiomyopathy: A β cardiac myosin heavy chain gene missense mutation
1990 Standout
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
2000
The Notch Ligands, Jagged and Delta, Are Sequentially Processed by α-Secretase and Presenilin/γ-Secretase and Release Signaling Fragments
2003
Regulation of αβ/γδ T Cell Lineage Commitment and Peripheral T Cell Responses by Notch/RBP-J Signaling
2004 StandoutNobel
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
1998 StandoutNatureNobel
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
2008 Standout
A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
2008
Molecular pathology of amyloidogenic proteins and the role of vascular amyloidosis in Alzheimer's disease
1989
Regulation of B cell development by Notch/RBP-J signaling
2003 StandoutNobel
The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans
1999 StandoutNobel
Delta-induced Notch Signaling Mediated by RBP-J Inhibits MyoD Expression and Myogenesis
1999 StandoutNobel
Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells
2008
Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas
2006 StandoutNobel
Notch Signaling – Constantly on the Move
2007
Inducible gene knockout of transcription factor recombination signal binding protein‐J reveals its essential role in T versus B lineage decision
2002 StandoutNobel
Regulation of lymphocyte development by Notch signaling
2007 StandoutNobel
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
2012 Nature
Notch regulation of lymphocyte development and function
2004
Delta1-Notch3 Interactions Bias the Functional Differentiation of Activated CD4+ T Cells
2003
Notch and the Immune System
2003
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells
2004
Regulation of T lymphopoiesis by Notch1 and Lunatic fringe–mediated competition for intrathymic niches
2006
Inflammatory Bowel Disease
1991 Standout
The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation
2015
Immunobiology and immunopathology of human gut mucosa: Humoral immunity and intraepithelial lymphocytes
1989
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease
1989 Standout
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
2008
Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3
2008
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
Cell Cycle Arrest and Apoptosis Induced by Notch1 in B Cells
2000
Evidence for a fruit fly hemangioblast and similarities between lymph-gland hematopoiesis in fruit fly and mammal aorta-gonadal-mesonephros mesoderm
2004
Notch and the Immune System
1999
Notch Signaling: Endocytosis Makes Delta Signal Better
2003
Cloning, sequencing, and mapping of an α‐actinin gene from the nematode Caenorhabditis elegans
1991
OSM-11 Facilitates LIN-12 Notch Signaling during Caenorhabditis elegans Vulval Development
2008
Assembly of Alzheimer‐like filaments from full‐length tau protein
1994
Functional redundancy of the Notch gene family during mouse embryogenesis: Analysis of Notch gene expression in Notch3-deficient mice
2005
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
Physical Interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 Receptors
2000
The many facets of Notch ligands
2008
Bare rudiments of notch signaling: how receptor levels are regulated
2007
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
1993 StandoutNobel
Glycosylation regulates Notch signalling
2003
Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells
2002 StandoutNobel
The microtubule binding domain of tau protein
1989
Ectodomain Shedding and Intramembrane Cleavage of Mammalian Notch Proteins Are Not Regulated through Oligomerization
2004
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo
2004
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Single amino-acid changes in HIV envelope affect viral tropism and receptor binding
1989 StandoutNatureNobel
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Systematic Discovery of Xist RNA Binding Proteins
2015
The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti
2001
A brain-specific activator of cyclin-dependent kinase 5
1994 StandoutNatureNobel
Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling
2005
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance
2005
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Localization of the Delta-like-1-binding Site in Human Notch-1 and Its Modulation by Calcium Affinity
2008
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
2004
Ikaros in immune receptor signaling, lymphocyte differentiation, and function
2010
Quantitative Dissection of the Notch:CSL Interaction: Insights into the Notch-mediated Transcriptional Switch
2006
DNER acts as a neuron-specific Notch ligand during Bergmann glial development
2005
Hedgehog Signaling Is Required for Adult Blood Stem Cell Formation in Zebrafish Embryos
2005
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
1989 Standout
HES and HERP families: Multiple effectors of the notch signaling pathway
2003
Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans
1996 Nature
Sequence analysis of the complete Caenorhabditis elegans myosin heavy chain gene family
1989
Human IgGFc Binding Protein (FcγBP) in Colonic Epithelial Cells Exhibits Mucin-like Structure
1997
The molecular pathology of Alzheimer's disease
1991 Standout
Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice
2002
Notch signaling controls the generation and differentiation of early T lineage progenitors
2005
Functional Replacement of the Intracellular Region of the Notch1 Receptor by Epstein-Barr Virus Nuclear Antigen 2
1998 StandoutNobel
High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy.
1994
Nuclear Reprogramming in Cells
2008 StandoutScienceNobel
Notch-dependent control of myelopoiesis is regulated by fucosylation
2008
RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development
2010 StandoutNobel
Amino acid sequence of rabbit skeletal muscle myosin. 50-kDa fragment of the heavy chain.
1990
Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.
1992
Tracing the first waves of lymphopoiesis in mice
2006
TCR-Mediated Notch Signaling Regulates Proliferation and IFN-γ Production in Peripheral T Cells
2003
REGULATION OF LYMPHOID DEVELOPMENT, DIFFERENTIATION, AND FUNCTION BY THE NOTCH PATHWAY
2005
Intracisternal Type A Particle-Mediated Activation of the Notch4/int3 Gene in a Mouse Mammary Tumor: Generation of Truncated Notch4/int3 mRNAs by Retroviral Splicing Events
1999 StandoutNobel
Identification of Notch1 as a Frequent Target for Provirus Insertional Mutagenesis in T-Cell Lymphomas Induced by Leukemogenic Mutants of Mouse Mammary Tumor Virus
2000 StandoutNobel
Recombination in mouse L cells between DNA introduced into cells and homologous chromosomal sequences.
1985
Fringe modulation of Jagged1-induced Notch signaling requires the action of β4galactosyltransferase-1
2001
High-efficiency transformation of mammalian cells by plasmid DNA.
1987 Standout
Cloning of the cDNA encoding the myosin heavy chain of a vertebrate cellular myosin.
1989
A Family of AMPA-Selective Glutamate Receptors
1990 StandoutScienceNobel
The molecular logic of Notch signaling – a structural and biochemical perspective
2008
Notch signalling via RBP-J promotes myeloid differentiation
2000
Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure.
1994
Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments.
1995
A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau
1991 Science
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
2008 Standout
Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro.
1992
Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene
1986 StandoutNatureNobel
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands
2005
Regulation of intrathymic T‐cell development by Lunatic Fringe– Notch1 interactions
2006
The Notch ligand Jagged1 is required for inner ear sensory development
2001
Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo
2007
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
The roles of receptor and ligand endocytosis in regulating Notch signaling
2005
HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo
2003
DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur
2007
Alz-50 recognizes a phosphorylated epitope of tau protein
1990
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
2007 StandoutNobel
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development
2004
Concise Review: Notch Signaling in Stem Cell Systems
2006
Body-Wall Muscle Formation in Caenorhabditis elegans Embryos that Lack the MyoD Homolog hlh-1
1992 StandoutScienceNobel
Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS
1990 StandoutScienceNobel
Notch2 Haploinsufficiency Results in Diminished B1 B Cells and a Severe Reduction in Marginal Zone B Cells
2003
RBP-Jκ/SHARP Recruits CtIP/CtBP Corepressors To Silence Notch Target Genes
2005
RBP-L, a Transcription Factor Related to RBP-Jκ
1997 StandoutNobel
Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.
1993
RBPjκ-dependent Notch function regulatesGata2and is essential for the formation of intra-embryonic hematopoietic cells
2005
Notch Signaling Through Jagged-1 Is Necessary to Initiate Chondrogenesis in Human Bone Marrow Stromal Cells but Must Be Switched off to Complete Chondrogenesis
2008
Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer's disease
2001
Analysis of Notch1 Function by In Vitro T Cell Differentiation of Pax5 Mutant Lymphoid Progenitors
2004
The human embryonic myosin heavy chain. Complete primary structure reveals evolutionary relationships with other developmental isoforms.
1990
Snail and E47 repressors ofE-cadherininduce distinct invasive and angiogenic properties in vivo
2004
Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination
1985 StandoutNatureNobel
Presenilin-1 regulates neuronal differentiation during neurogenesis
2000
The Neurofibrillary Pathology of Alzheimer's Disease
1997
Proteomic Analyses of the Two Mucus Layers of the Colon Barrier Reveal That Their Main Component, the Muc2 Mucin, Is Strongly Bound to the Fcgbp Protein
2009
Examination of phosphorylated tau protein as a PHF-precursor at early stage alzheimer's disease
1995
Works of Y. Hamada being referenced
In vitro anticolon antibody production by mucosal or peripheral blood lymphocytes from patients with ulcerative colitis.
1990
Functional Diversity among Notch1, Notch2, and Notch3 Receptors
2002
Primary structure of chicken skeletal muscle and fibroblast α‐actinins deduced from cDNA sequences
1988
Mouse Jagged1 Physically Interacts with Notch2 and Other Notch Receptors
1999
Regulation of Marginal Zone B Cell Development by MINT, a Suppressor of Notch/RBP-J Signaling Pathway
2003 StandoutNobel
The car☐yl third of tau is tightly bound to paired helical filaments
1988
Complete primary structure of vertebrate smooth muscle myosin heavy chain deduced from its complementary DNA sequence
1987
Functional conservation of mouse Notch receptor family members
1996 StandoutNobel
Notch1 but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells
2003
A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments
1989
Notch2 Is Preferentially Expressed in Mature B Cells and Indispensable for Marginal Zone B Lineage Development
2003
De novo design of a nanopore for single-molecule detection that incorporates a β-hairpin peptide
2021
Distribution and partial characterisation of IgG Fc binding protein in various mucin producing cells and body fluids
2002
Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression
2001
Notch2 expression negatively correlates with glial differentiation in the postnatal mouse brain
1999
Phage Particle-Mediated Gene Transfer to Cultured Mammalian Cells
1982
Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain
2002
Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality
1999
The molecular configuration and ultrastructural locations of an IgG Fc binding site in human colonic epithelium
1991
T lymphocyte subpopulations and immunoglobulin-containing cells in the colonic mucosa of ulcerative colitis; a morphometric and immunohistochemical study.
1988
Activated Notch2 Potentiates CD8 Lineage Maturation and Promotes the Selective Development of B1 B Cells
2003
R-spondin3 is required for mouse placental development
2006
Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2
2000