Standout Papers
Citation Impact
Citing Papers
Combined Functional Genomic Maps of the C. elegans DNA Damage Response
2002 Science
A gene atlas of the mouse and human protein-encoding transcriptomes
2004 Standout
Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility
2021 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
A Visualizable Chain‐Terminating Inhibitor of Glycosaminoglycan Biosynthesis in Developing Zebrafish
2014 StandoutNobel
Specification of sense-organ identity by a Caenorhabditis elegans Pax-6 homologue
1995 Nature
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3
2003 Nature
Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans
1995 StandoutNatureNobel
Transcription factor modularity in a gene-centered C. elegans core neuronal protein–DNA interaction network
2007
A network of protein–protein interactions in yeast
2000
Yeast Two-Hybrid Systems and Protein Interaction Mapping Projects for Yeast and Worm
2000
The Concept of Synthetic Lethality in the Context of Anticancer Therapy
2005 StandoutNobel
The retinoblastoma gene family in differentiation and development
1999
Combinatorial Expression of TRPV Channel Proteins Defines Their Sensory Functions and Subcellular Localization in C. elegans Neurons
2002
Identification and characterization of the vesicular GABA transporter
1997 Nature
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
2002 StandoutNature
A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity
2008 StandoutNobel
lin-35 Rb Acts in the Major Hypodermis to Oppose Ras-Mediated Vulval Induction in C. elegans
2005
A Gateway-Compatible Yeast One-Hybrid System
2004
Genome‐wide protein interaction maps using two‐hybrid systems
2000
Male-specific fruitless specifies the neural substrates of Drosophila courtship behaviour
2005 StandoutNatureNobel
RbAp48 Belongs to the Histone Deacetylase Complex That Associates with the Retinoblastoma Protein
2000
Opposite thermosensor in fruitfly and mouse
2003 StandoutNatureNobel
Operons as a common form of chromosomal organization in C. elegans
1994 Nature
Excitatory Eph receptors and adhesive ephrin ligands
2001
Systematic and large-scale two-hybrid screens
2000
Insight into transcription factor gene duplication from Caenorhabditis elegans Promoterome-driven expression patterns
2007
Genetic knockouts and knockins in human somatic cells
2007
Mammalian Ras interacts directly with the serine/threonine kinase raf
1993 Standout
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
The C. elegans ksr-1 gene encodes a novel raf-related kinase involved in Ras-mediated signal transduction
1995
Heterochronic Genes Control Cell Cycle Progress and Developmental Competence of C. elegans Vulva Precursor Cells
1996 StandoutNobel
Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes
2000
Genome-Wide Protein Interaction Screens Reveal Functional Networks Involving Sm-Like Proteins
2000
Endophilin Is Required for Synaptic Vesicle Endocytosis by Localizing Synaptojanin
2003
The C. elegans E2F- and DP-Related Proteins Are Required for Embryonic Asymmetry and Negatively Regulate Ras/MAPK Signaling
2001
Matrix and Steiner-triple-system smart pooling assays for high-performance transcription regulatory network mapping
2007
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
2000 StandoutNatureNobel
The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible
2016 Standout
dpl-1 DP and efl-1 E2F Act with lin-35 Rb to Antagonize Ras Signaling in C. elegans Vulval Development
2001 StandoutNobel
Gene structure and organization in Caenorhabditis elegans
1996
The continued evolution of two-hybrid screening approaches in yeast: how to outwit different preys with different baits
2000
Ras pathways in Caenorhabditis elegans
1995
fzr-1 and lin-35 /Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen
2002
Trans-splicing and polycistronic transcription in Caenohabditis elegans
1995
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Genetics of signal transduction in invertebrates
1994
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
2000 StandoutNature
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
2005 StandoutNatureNobel
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
2014 StandoutNatureNobel
A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways
1994
Three-Dimensional Analysis of Vascular Development in the Mouse Embryo
2008
Gateway-Compatible Yeast One-Hybrid Screens
2006
The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour
2006
Visualizing Sexual Dimorphism in the Brain
2004 StandoutNobel
Molecular basis of infrared detection by snakes
2010 StandoutNatureNobel
Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3
1995 StandoutNatureNobel
A Gene-Centered C. elegans Protein-DNA Interaction Network
2006
Unraveling transcription regulatory networks by protein–DNA and protein–protein interaction mapping
2006
The RING finger/B-Box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans
1999 StandoutNobel
Genetics of RAS signaling in C. elegans
1998
Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based RNAi Library
2004
[34] GATEWAY recombinational cloning: Application to the cloning of large numbers of open reading frames or ORFeomes
2000
Angiogenic Signalling Pathways
2008
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex
2004
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans
2004 StandoutNatureNobel
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Proteomics to study genes and genomes
2000 StandoutNature
NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans
2000
The evolution of gene expression levels in mammalian organs
2011 StandoutNatureNobel
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
2003 StandoutNatureNobel
Signal transduction and cell fate specification during Caenorhabditis elegans vulval development
1994
A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval development
2002
MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans
2000 StandoutNatureNobel
The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway.
1995 StandoutNobel
lin-25, a gene required for vulval induction in Caenorhabditis elegans.
1995
The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination
2000
Coordinated Transcriptional Regulation of theunc-25Glutamic Acid Decarboxylase and theunc-47GABA Vesicular Transporter by theCaenorhabditis elegansUNC-30 Homeodomain Protein
1999 StandoutNobel
Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans
1995
A comprehensive two-hybrid analysis to explore the yeast protein interactome
2001 Standout
Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities.
1996 StandoutNobel
Protein localization studies in the age of ‘Omics’
2005
The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway
1999
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Binding of Neuroligins to PSD-95
1997 StandoutScienceNobel
lin-35/Rb andubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis inC. elegans
2003
A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae
2000
STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
2018 Standout
RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
1998 StandoutNobel
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1995 StandoutNobel
Two functionally dependent acetylcholine subunits are encoded in a single Caenorhabditis elegans operon
1998 StandoutNobel
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Human DNA Repair Genes
2001 StandoutScienceNobel
The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.
1995 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
EAT-4, a Homolog of a Mammalian Sodium-Dependent Inorganic Phosphate Cotransporter, Is Necessary for Glutamatergic Neurotransmission inCaenorhabditis elegans
1999 StandoutNobel
TheCaenorhabditis elegansGeneunc-25Encodes Glutamic Acid Decarboxylase and Is Required for Synaptic Transmission But Not Synaptic Development
1999 StandoutNobel
SynCAM, a Synaptic Adhesion Molecule That Drives Synapse Assembly
2002 StandoutScienceNobel
Integrative analysis of protein interaction data.
2000
Works of Xiaowei Lu being referenced
Gene targeting using a promoterless gene trap vector (“targeted trapping”) is an efficient method to mutate a large fraction of genes
2005
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
2004 Nature
The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins.
1994 StandoutNobel
Functional analysis of secreted and transmembrane proteins critical to mouse development
2001
Defining brain wiring patterns and mechanisms through gene trapping in mice
2001 Nature
Zim1, a Maternally Expressed Mouse Kruppel-Type Zinc-Finger Gene Located in Proximal Chromosome 7
1999
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex
2006 Nobel
Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila.
1993
Protein Interaction Mapping in C. elegans Using Proteins Involved in Vulval Development
2000 Science