Standout Papers
Citation Impact
Citing Papers
Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay
2009
HSulf-1 Modulates FGF2- and Hypoxia-Mediated Migration and Invasion of Breast Cancer Cells
2011
Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses
2014
Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment
2018 StandoutNobel
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
2019 StandoutNobel
Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype
2016 StandoutNobel
Critical contribution of 3′ non-seed base pairing to the in vivo function of the evolutionarily conserved let-7a microRNA
2022 StandoutNobel
Pharmacologic Targeting of Hypoxia-Inducible Factors
2019 StandoutNobel
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
2019 StandoutNobel
Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis
2015
The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
2017 StandoutNobel
Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization
2019
Ferroptosis: molecular mechanisms and health implications
2020 Standout
Isolation and Characterization of mAMSA-hypersensitive Mutants
2008
The ever-expanding role of HIF in tumour and stromal biology
2016
The DNA-damage response in human biology and disease
2009 StandoutNature
Distinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA
2009
The LIN28/let-7 Pathway in Cancer
2017
Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3
2015 StandoutNobel
Advances in autism genetics: on the threshold of a new neurobiology
2008
Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c
2016 StandoutNobel
Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity
2021 Standout
Tyrosyl-DNA Phosphodiesterase as a Target for Anticancer Therapy
2008
Ageing as a risk factor for neurodegenerative disease
2019 Standout
A compendium of proteins that interact with HIF-1α
2017 StandoutNobel
Role of MicroRNAs in the Regulation of Redox-Dependent Processes
2019
Hypoxia-Inducible Factors: Master Regulators of Cancer Progression
2016 StandoutNobel
Maintenance of redox homeostasis by hypoxia-inducible factors
2017 StandoutNobel
Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1
2007
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
DNA Damage, Aging, and Cancer
2009 Standout
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
2018 Standout
The DNA Damage Response: Making It Safe to Play with Knives
2010 Standout
The Collagen Family
2010 Standout
Matricryptins derived from collagens and proteoglycans
2010
Serine and one-carbon metabolism in cancer
2016
The application of multiple miRNA response elements enables oncolytic adenoviruses to possess specificity to glioma cells
2014
Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach
2018 Standout
Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells
2012
Broadening horizons: the role of ferroptosis in cancer
2021 Standout
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
2016 Nature
Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy
2018 StandoutNobel
TDP1 facilitates chromosomal single‐strand break repair in neurons and is neuroprotective in vivo
2007
Oxidative Stress in Cancer
2020 Standout
Mycobacterium tuberculosis Rv3406 Is a Type II Alkyl Sulfatase Capable of Sulfate Scavenging
2013 StandoutNobel
PHD2 Targeting Overcomes Breast Cancer Cell Death upon Glucose Starvation in a PP2A/B55α-Mediated Manner
2017
BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair
2011 StandoutNobel
Cellular adaptation to hypoxia through hypoxia inducible factors and beyond
2020
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
2022 Standout
Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?
2007
DNA repair deficiency in neurodegeneration
2011
Cell cycle, CDKs and cancer: a changing paradigm
2009 Standout
Targeting DNA topoisomerase II in cancer chemotherapy
2009 Standout
AKT/PKB Signaling: Navigating the Network
2017 Standout
Deciphering synergistic regulatory networks of microRNAs in hESCs and fibroblasts
2018
CK1δ restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1α/ARNT complex formation
2015
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
Targeting the Achilles heel of the hepatitis B virus: a review of current treatments against covalently closed circular DNA
2015 StandoutNobel
A Protease Pathway for the Repair of Topoisomerase II-DNA Covalent Complexes
2006
Single-strand break repair and genetic disease
2008
Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man
2021
Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?
2016
A Neuroligin-4 Missense Mutation Associated with Autism Impairs Neuroligin-4 Folding and Endoplasmic Reticulum Export
2009 StandoutNobel
Topoisomerase I inhibitors: camptothecins and beyond
2006 Standout
Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors
2018 StandoutNobel
Repair of Topoisomerase I‐Mediated DNA Damage
2006
Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox
2016 StandoutNobel
Fundamentals of cancer metabolism
2016 Standout
DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition
2009 Standout
Clockophagy is a novel selective autophagy process favoring ferroptosis
2019
Processing of Damaged DNA Ends for Double-Strand Break Repair in Mammalian Cells
2012
Chromone: A Valid Scaffold in Medicinal Chemistry
2014 Standout
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
MYC, Metabolism, and Cancer
2015
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Drugging Topoisomerases: Lessons and Challenges
2012
Metabolic reprogramming and cancer progression
2020 StandoutScience
Evolution of Oncolytic Viruses: Novel Strategies for Cancer Treatment
2013
Characterization of the Intracellular Deproteinized Relaxed Circular DNA of Hepatitis B Virus: an Intermediate of Covalently Closed Circular DNA Formation
2007
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Systems biology of oxygen homeostasis
2017 StandoutNobel
Combination therapy strategies for improving PD‐1 blockade efficacy: a new era in cancer immunotherapy
2017 StandoutNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide
2011 StandoutScience
Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma
2017
Works of Xiaoping He being referenced
Regulation of HSulf-1 Expression by Variant Hepatic Nuclear Factor 1 in Ovarian Cancer
2009
HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression
2014 StandoutNobel
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions
2015
Human Fibroblast Reprogramming to Pluripotent Stem Cells Regulated by the miR19a/b-PTEN Axis
2014
The T4 Phage SF1B Helicase Dda Is Structurally Optimized to Perform DNA Strand Separation
2012
E1B-55kD-deleted oncolytic adenovirus armed with canstatin gene yields an enhanced anti-tumor efficacy on pancreatic cancer
2009
Effects of recombinant human canstatin protein in the treatment of pancreatic cancer
2006
E2F Promoter-Regulated Oncolytic Adenovirus with p16 Gene Induces Cell Apoptosis and Exerts Antitumor Effect on Gastric Cancer
2008
Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1
2014
Selective killing of lung cancer cells by miRNA-506 molecule through inhibiting NF-κB p65 to evoke reactive oxygen species generation and p53 activation
2014
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells
2018
Mutation of a Conserved Active Site Residue Converts Tyrosyl-DNA Phosphodiesterase I into a DNA Topoisomerase I-dependent Poison
2007
5/35 Fiber-Modified Conditionally Replicative Adenovirus Armed with p53 Shows Increased Tumor-Suppressing Capacity to Breast Cancer Cells
2010
Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage
2006