Citation Impact
Citing Papers
Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin β subunits
2001
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions
2012 StandoutNobel
Platelet gene expression and function in patients with COVID-19
2020 Standout
Taking Cell-Matrix Adhesions to the Third Dimension
2001 StandoutScience
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
2017 StandoutNobel
Functional specialization of β-arrestin interactions revealed by proteomic analysis
2007 StandoutNobel
Engagement of Platelet Toll-Like Receptor 9 by Novel Endogenous Ligands Promotes Platelet Hyperreactivity and Thrombosis
2012
A Sulfilimine Bond Identified in Collagen IV
2009 StandoutScienceNobel
Recreation of the terminal events in physiological integrin activation
2010
Tumour-cell invasion and migration: diversity and escape mechanisms
2003 Standout
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
2005 StandoutNature
Rational Design of Intercellular Adhesion Molecule-1 (ICAM-1) Variants for Antagonizing Integrin Lymphocyte Function-associated Antigen-1-dependent Adhesion
2005 StandoutNobel
Phosphatidylserine-mediated platelet clearance by endothelium decreases platelet aggregates and procoagulant activity in sepsis
2017
Rationally Designed Integrin β3 Mutants Stabilized in the High Affinity Conformation
2008 StandoutNobel
Dual Mechanism of Integrin αIIbβ3 Closure in Procoagulant Platelets
2013
Pleiotropic Coupling of G Protein-coupled Receptors to the Mitogen-activated Protein Kinase Cascade
1999 StandoutNobel
Modulation of Integrin Activation by an Entropic Spring in the β-Knee
2010 StandoutNobel
Direct Cell Surface Modification with DNA for the Capture of Primary Cells and the Investigation of Myotube Formation on Defined Patterns
2009 StandoutNobel
Mechanisms of Thrombus Formation
2008 Standout
Amino Acid Residues in the PSI Domain and Cysteine-rich Repeats of the Integrin β2 Subunit That Restrain Activation of the Integrin αxβ2
2001
Membrane-proximal α/β Stalk Interactions Differentially Regulate Integrin Activation
2005
CASK and Protein 4.1 Support F-actin Nucleation on Neurexins
2001 StandoutNobel
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation
2002
Nucleotide signalling during inflammation
2014 StandoutNature
The septic milieu triggers expression of spliced tissue factor mRNA in human platelets
2011
Structural and Functional Studies with Antibodies to the Integrin β2 Subunit
2000
Integrin activation and structural rearrangement
2002
Are changes in integrin affinity and conformation overemphasized?
1998
A reevaluation of integrins as regulators of angiogenesis
2002
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
2006 StandoutNatureNobel
The inner world of cell adhesion: integrin cytoplasmic domains
1994
Integrin modulating factor-1: A lipid that alters the function of leukocyte integrins
1992
Structure of integrin 5 1 in complex with fibronectin
2003
Two conformations of the integrin A-domain (I-domain): a pathway for activation?
1995
Platelet Membrane Glycoproteins: Functions in Cellular Interactions
1990
The Era of Thromboinflammation: Platelets Are Dynamic Sensors and Effector Cells During Infectious Diseases
2019
Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2
2004
The origin of pattern and polarity in the Drosophila embryo
1992 StandoutNobel
Protease-activating Receptor-4 Induces Full Platelet Spreading on a Fibrinogen Matrix
2007
Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability
2001
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
2005 StandoutNobel
Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage
2019
Rho GTPases in cell biology
2002 StandoutNature
Inflammation and wound healing: the role of the macrophage
2011 Standout
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Lymphocyte interactions with endothelial cells
1992
DANCE, a Novel Secreted RGD Protein Expressed in Developing, Atherosclerotic, and Balloon-injured Arteries
1999 StandoutNobel
The ATP-gated P2X1 Receptor Plays a Pivotal Role in Activation of Aspirin-treated Platelets by Thrombin and Epinephrine
2008 StandoutNobel
Potentiation of platelet activation through the stimulation of P2X1 receptors
2003
The postsynaptic density at glutamatergic synapses
1997
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12
2012
The biologic and clinical spectrum of Glanzmann's Thrombasthenia: implications of integrin αIIbβ3 for its pathogenesis
1997
Cell adhesion: integrating cytoskeletal dynamics and cellular tension
2010 Standout
Inside-out integrin signalling
1992
CD44 and Its Interaction with Extracellular Matrix
1993
GPIIb-IIIa: The responsive integrin
1991
Platelets and Infection – An Emerging Role of Platelets in Viral Infection
2014
Platelets and the immune continuum
2011 Standout
The Conserved Membrane-proximal Region of an Integrin Cytoplasmic Domain Specifies Ligand Binding Affinity
1995
Topography of Ligand-induced Binding Sites, Including a Novel Cation-sensitive Epitope (AP5) at the Amino Terminus, of the Human Integrin β3 Subunit
1995
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
1995 StandoutNature
A Novel Multiple PDZ Domain-containing Molecule Interacting withN-Methyl-d-aspartateReceptors and Neuronal Cell Adhesion Proteins
1998 StandoutNobel
Coordinated Signaling through Both G12/13 and Gi Pathways Is Sufficient to Activate GPIIb/IIIa in Human Platelets
2002
Integrins and Actin Filaments: Reciprocal Regulation of Cell Adhesion and Signaling
2000
Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration
2001
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
2004 Nature
Adhesive signaling in platelets
1994
C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1.
2001
Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis.
1992
Therapeutic antagonists and conformational regulation of integrin function
2003
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
1994 Standout
Small Molecule Integrin Antagonists that Bind to the β2 Subunit I-like Domain and Activate Signals in One Direction and Block Them in the Other
2003
Cutting to the chase: calpain proteases in cell motility
2002
Calpain Cleavage Promotes Talin Binding to the β3Integrin Cytoplasmic Domain
2001
Integrins
2002 Standout
The talin–tail interaction places integrin activation on FERM ground
2004
A Structural Mechanism of Integrin αIIbβ3 “Inside-Out” Activation as Regulated by Its Cytoplasmic Face
2002
Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling
2002
Thrombosis as an intravascular effector of innate immunity
2012 Standout
Costimulation of the Gi‐coupled ADP receptor and the Gq‐coupled TXA2 receptor is required for ERK2 activation in collagen‐induced platelet aggregation
2003
Physical and biochemical regulation of integrin release during rear detachment of migrating cells
1998
Platelets in Pulmonary Immune Responses and Inflammatory Lung Diseases
2016
Nouvelle Cuisine: Platelets Served with Inflammation
2015
Platelet endothelial cell adhesion molecule-1 (PECAM-1 / CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development
1994
BIOCHEMISTRY AND GENETICS OF VON WILLEBRAND FACTOR
1998 Standout
Epitope Mapping of Antibodies to the C-Terminal Region of the Integrin β2 Subunit Reveals Regions that Become Exposed Upon Receptor Activation
2001
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site
1997 StandoutScience
FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING
1996 Standout
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering
2001 StandoutNobel
Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin
2011 StandoutNobel
Advances in skin grafting and treatment of cutaneous wounds
2014 StandoutScience
The GPIIb/IIIa (integrin αIIbβ3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend
2008
Lymphocyte Homing and Homeostasis
1996 StandoutScience
Integrins: Versatility, modulation, and signaling in cell adhesion
1992 Standout
Mutation of a ligand binding domain of beta 3 integrin. Integral role of oxygenated residues in alpha IIb beta 3 (GPIIb-IIIa) receptor function.
1994
Crystal Structure of the Extracellular Segment of Integrin αVβ3
2001 Science
Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2
2004
Long-Term Potentiation--A Decade of Progress?
1999 StandoutScience
Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis
2014
Identification of a site in the alpha chain of platelet glycoprotein Ib that participates in von Willebrand factor binding.
1990
Adenosine A2B Receptor Blockade Slows Growth of Bladder and Breast Tumors
2011
14-3-3 Proteins: A Number of Functions for a Numbered Protein
2005
Complementary Roles for Receptor Clustering and Conformational Change in the Adhesive and Signaling Functions of Integrin αIIbβ3
1998
Integrin activation takes shape
2002
Integrin cytoplasmic domains mediate inside-out signal transduction
1994
Rho GTPases and cell migration
2001
The Calpain System
2003 Standout
Regulating cell migration: calpains make the cut
2005
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions
2009
Kindlin-2 controls bidirectional signaling of integrins
2008
Integrins and Signal Transduction Pathways: the Road Taken
1995 StandoutScience
Wound Healing--Aiming for Perfect Skin Regeneration
1997 StandoutScience
A Naturally Occurring Extracellular α−β Clasp Contributes to Stabilization of β3 Integrins in a Bent, Resting Conformation
2008
Minimum alpha chain cytoplasmic tail sequence needed to support integrin-mediated adhesion.
1994
Integrin Signaling
1999 StandoutScience
Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand
2003
14-3-3 Proteins: A Number of Functions for a Numbered Protein
2004
Interaction of α-Agglutinin and a -Agglutinin, Saccharomyces cerevisiae Sexual Cell Adhesion Molecules
2001
P2X1-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen
2002
Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.
1991
Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1
2002
Examination of the platelet membrane glycoprotein IIb-IIIa complex and its interaction with fibrinogen and other ligands by electron microscopy.
1992
14-3-3 Proteins: Structure, Function, and Regulation
2000 Standout
Conformational changes in tertiary structure near the ligand binding site of an integrin I domain
1999
The switchable integrin adhesome
2010
The Tail of Integrins, Talin, and Kindlins
2009 Science
Conformational Regulation of Integrin Structure and Function
2002
Wound repair, keratinocyte activation and integrin modulation
1992
Integrin-mediated cell adhesion: the extracellular face.
1994
Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis
2018
RIM1α phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning
2008 StandoutNobel
A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.
1993
Two Functional States of the CD11b A-Domain: Correlations with Key Features of Two Mn2+-complexed Crystal Structures
1998
Works of Xiaoping Du being referenced
IP-10 induces dissociation of newly formed blood vessels
2009
G Protein Subunit Gα 13 Binds to Integrin α IIb β 3 and Mediates Integrin “Outside-In” Signaling
2010 Science
Two Waves of Platelet Secretion Induced by Thromboxane A2 Receptor and a Critical Role for Phosphoinositide 3-Kinases
2003
A Mitogen-activated Protein Kinase-dependent Signaling Pathway in the Activation of Platelet Integrin αIIbβ3
2001
Calpain Cleavage of the Cytoplasmic Domain of the Integrin β2 Subunit
1995
A Novel Ligand-binding Site in the ζ-Form 14-3-3 Protein Recognizing the Platelet Glycoprotein Ibα and Distinct from the c-Raf-binding Site
1998
The Cytoplasmic Domain of the Platelet Glycoprotein Ibα Is Phosphorylated at Serine 609
1999
Calpain cleavage of integrin β cytoplasmic domains
1999
Identification of a Binding Sequence for the 14-3-3 Protein within the Cytoplasmic Domain of the Adhesion Receptor, Platelet Glycoprotein Ibα
1996
Platelet adhesion receptors
1995
Ristocetin-dependent reconstitution of binding of von Willebrand factor to purified human platelet membrane glycoprotein Ib-IX complex
1988
Ligands “activate” integrin αIIbβ3 (platelet GPIIb-IIIa)
1991
Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane
1987
Platelet Integrins
1993
Evidence That β3 Integrin-Induced Rac Activation Involves the Calpain-Dependent Formation of Integrin Clusters That Are Distinct from the Focal Complexes and Focal Adhesions That Form as Rac and Rhoa Become Active
2000
Long range propagation of conformational changes in integrin alpha IIb beta 3.
1993
A molecular switch that controls cell spreading and retraction
2007
Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK–dependent integrin outside-in retractile signaling pathway
2008
Platelet lntegrins
1995
Role for Platelet Glycoprotein Ib-IX and Effects of its Inhibition in Endotoxemia-Induced Thrombosis, Thrombocytopenia, and Mortality
2013
Long range propagation of conformational changes in integrin αIIbβ3
1994
Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation via TLR4/MyD88 and the cGMP-Dependent Protein Kinase Pathway
2009
New Concepts and Mechanisms of Platelet Activation Signaling
2017
A Stimulatory Role for cGMP-Dependent Protein Kinase in Platelet Activation
2003
An important role for Akt3 in platelet activation and thrombosis
2011
Critical roles for the COOH-terminal NITY and RGT sequences of the integrin β3 cytoplasmic domain in inside-out and outside-in signaling
2003