Citation Impact
Citing Papers
DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
2017 Science
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination
2014
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
2013 StandoutScience
Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
2009
A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis
2006
Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer
2013
Mouse Embryonic Stem Cells, but Not Somatic Cells, Predominantly Use Homologous Recombination to Repair Double-Strand DNA Breaks
2010
Classical and Alternative End-Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks
2012
Tilt-Pair Analysis of Images from a Range of Different Specimens in Single-Particle Electron Cryomicroscopy
2011 StandoutNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
The DNA-damage response in human biology and disease
2009 StandoutNature
Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis
2009 StandoutNobel
Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress
2010 StandoutNobel
Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining
2014 StandoutNobel
A guide to genome engineering with programmable nucleases
2014 Standout
Spontaneous tumor development in bone marrow-rescued DNA-PKcs3A/3A mice due to dysfunction of telomere leading strand deprotection
2015
Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System
2013
DNA-PKcs and ATM co-regulate DNA double-strand break repair
2009
Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes
2009
Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes
2017 StandoutNobel
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK
2007
The DSIF Subunits Spt4 and Spt5 Have Distinct Roles at Various Phases of Immunoglobulin Class Switch Recombination
2012 StandoutNobel
Cryo-EM Structure of the DNA-Dependent Protein Kinase Catalytic Subunit at Subnanometer Resolution Reveals α Helices and Insight into DNA Binding
2008
Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability
2006
The DNA Damage Response Kinases DNA-dependent Protein Kinase (DNA-PK) and Ataxia Telangiectasia Mutated (ATM) Are Stimulated by Bulky Adduct-containing DNA
2011 StandoutNobel
Accessibility of chromosomal recombination breaks in nuclei of wild-type and DNA-PKcs-deficient cells
2009
CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions
2018 StandoutNobel
Long Noncoding RNAs in Cancer Pathways
2016 Standout
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats
2009 Nature
N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku
2011
Regulation of DNA double-strand break repair pathway choice
2007
Recombination centres and the orchestration of V(D)J recombination
2011
A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining
2008
The Histone Chaperone Spt6 Is Required for Activation-induced Cytidine Deaminase Target Determination through H3K4me3 Regulation
2012 StandoutNobel
Blinded by the Light: The Growing Complexity of p53
2009 Standout
DNA Damage, Aging, and Cancer
2009 Standout
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
Multiple functions of MRN in end-joining pathways during isotype class switching
2009
DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation
2011
The DNA Damage Response: Making It Safe to Play with Knives
2010 Standout
A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation
2009
MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings
2008
Telomere dysfunction and tumour suppression: the senescence connection
2008
Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining
2015
Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)
2011 StandoutNobel
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
2020 Standout
IgH class switching and translocations use a robust non-classical end-joining pathway
2007 Nature
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation
2010
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
2013 Standout
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
2014
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers
2009 StandoutNobel
DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks
2016
Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis
2006
Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair
2008
A Biochemically Defined System for Coding Joint Formation in V(D)J Recombination
2008
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
DNA‐PK autophosphorylation facilitates Artemis endonuclease activity
2006
The In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci
2010
The Hallmarks of Aging
2013 Standout
Chromosomal translocations in cancer
2008
Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?
2015
Regulation of Immunoglobulin Class-Switch Recombination
2014
The Mechanism of Human Nonhomologous DNA End Joining
2007
RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination
2007 Nature
Chapter 2 DNA-PK
2008
How does DNA break during chromosomal translocations?
2011
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
2012 StandoutNobel
Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
2020 StandoutNobel
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
Carboxy-terminal domain of AID required for its mRNA complex formation in vivo
2009 StandoutNobel
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation
2014
ATM Activation and Signaling under Hypoxic Conditions
2008
Mechanisms of double-strand break repair in somatic mammalian cells
2009
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV–deficient B cells
2008
Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems
2016 StandoutScience
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
An Evolutionary View of the Mechanism for Immune and Genome Diversity
2012 StandoutNobel
Inhibition of Homologous Recombination by DNA-Dependent Protein Kinase Requires Kinase Activity, Is Titratable, and Is Modulated by Autophosphorylation
2011
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
2011
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
In Vitro Analysis of the Role of Replication Protein A (RPA) and RPA Phosphorylation in ATR-mediated Checkpoint Signaling
2012 StandoutNobel
Replication protein A: directing traffic at the intersection of replication and repair
2010
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
Mechanisms that Promote and Suppress Chromosomal Translocations in Lymphocytes
2011
ATM Mediates Cytotoxicity of a Mutant Telomerase RNA in Human Cancer Cells
2008 StandoutNobel
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Restoration of ATM Expression in DNA-PKcs–Deficient Cells Inhibits Signal End Joining
2016
Simultaneous precise editing of multiple genes in human cells
2019 StandoutNobel
Production of IgG autoantibody requires expression of activation‐induced deaminase in early‐developing B cells in a mouse model of SLE
2014
Ionizing Radiation Selectively Reduces Skin Regulatory T Cells and Alters Immune Function
2014 StandoutNobel
Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination
2019
Mechanism and Regulation of Class Switch Recombination
2008
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation
2011 StandoutNobel
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
2010
How Shelterin Protects Mammalian Telomeres
2008 Standout
V(D)J Recombination: Mechanisms of Initiation
2011
Functional Intersection of ATM and DNA-Dependent Protein Kinase Catalytic Subunit in Coding End Joining during V(D)J Recombination
2013
Evolutionary Comparison of the Mechanism of DNA Cleavage with Respect to Immune Diversity and Genomic Instability
2012 StandoutNobel
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair
2010
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
Non-homologous end-joining, a sticky affair
2007
Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery
2014 StandoutNobel
Works of Xiaoping Cui being referenced
trans Autophosphorylation at DNA-Dependent Protein Kinase's Two Major Autophosphorylation Site Clusters Facilitates End Processing but Not End Joining
2007
Both CpG Methylation and Activation-Induced Deaminase Are Required for the Fragility of the Human bcl-2 Major Breakpoint Region: Implications for the Timing of the Breaks in the t(14;18) Translocation
2012
Rag mutations reveal robust alternative end joining
2007 Nature
The DNA-Dependent Protein Kinase Catalytic Subunit Is Phosphorylated In Vivo on Threonine 3950, a Highly Conserved Amino Acid in the Protein Kinase Domain
2006
Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway
2007
Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication
2004
Autophosphorylation of DNA-Dependent Protein Kinase Regulates DNA End Processing and May Also Alter Double-Strand Break Repair Pathway Choice
2005