Citation Impact
Citing Papers
Visualizing enveloping layer glycans during zebrafish early embryogenesis
2010 StandoutNobel
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
2013 StandoutScience
Probing mucin-type O-linked glycosylation in living animals
2006 StandoutNobel
Spatially resolved, highly multiplexed RNA profiling in single cells
2015 StandoutScience
Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR)
2010 StandoutNobel
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation
2003 StandoutNobel
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
edgeR : a Bioconductor package for differential expression analysis of digital gene expression data
2009 Standout
A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals
2008 StandoutNobel
Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
2011 StandoutScience
Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT)
2006
Glycoprotein Enrichment Analytical Techniques
2017
Solid-phase extraction of N-linked glycopeptides
2007
A Universal Chemical Enrichment Method for Mapping the Yeast N-glycoproteome by Mass Spectrometry (MS)
2014
Sialic Acid-focused Quantitative Mouse Serum Glycoproteomics by Multiple Reaction Monitoring Assay
2010
An engineered high affinity Fbs1 carbohydrate binding protein for selective capture of N-glycans and N-glycopeptides
2017
N- and O-Glycosylation in the Murine Synaptosome
2013
Differential analysis of N-glycoproteome between hepatocellular carcinoma and normal human liver tissues by combination of multiple protease digestion and solid phase based labeling
2014
Targeted analysis of glycomics liquid chromatography/mass spectrometry data
2010
Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples
2012
N-GlycositeAtlas: a database resource for mass spectrometry-based human N-linked glycoprotein and glycosylation site mapping
2019
Hallmarks of Cancer: The Next Generation
2011 Standout
Biotin-transfer from a trifunctional crosslinker for identification of cell surface receptors of soluble protein ligands
2017
Meta-heterogeneity: Evaluating and Describing the Diversity in Glycosylation Between Sites on the Same Glycoprotein
2020
Combining Results from Lectin Affinity Chromatography and Glycocapture Approaches Substantially Improves the Coverage of the Glycoproteome
2008
Parallel Reaction Monitoring for High Resolution and High Mass Accuracy Quantitative, Targeted Proteomics
2012
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides
2015
Quantitative site-specific analysis of protein glycosylation by LC-MS using different glycopeptide-enrichment strategies
2009
Sequential phosphoproteomics and N-glycoproteomics of plasma-derived extracellular vesicles
2019
Modulation of the Phagosome Proteome by Interferon-γ
2007
Visualization of omics data for systems biology
2010
Chemical methods for glycoprotein discovery
2006
Computational methods for the comparative quantification of proteins in label-free LCn-MS experiments
2007
Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
2008 StandoutNature
Shotgun Glycopeptide Capture Approach Coupled with Mass Spectrometry for Comprehensive Glycoproteomics
2006
Chemical Technologies for Probing Glycans
2006 StandoutNobel
Recent Advances in Analytical Approaches for Glycan and Glycopeptide Quantitation
2020
Interaction modes and approaches to glycopeptide and glycoprotein enrichment
2013
Stable Isotope Labeling by Amino Acids in Cell Culture for Quantitative Proteomics
2007
Analytical and statistical approaches to metabolomics research
2009
Corra: Computational framework and tools for LC-MS discovery and targeted mass spectrometry-based proteomics
2008
Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation*
2015
Glycoproteomics based on tandem mass spectrometry of glycopeptides
2006
One-Step Enrichment of Intact Glycopeptides From Glycoengineered Chinese Hamster Ovary Cells
2020
Analysis of Mammalian O-Glycopeptides—We Have Made a Good Start, but There is a Long Way to Go
2017
Surface N-glycoproteome patterns reveal key proteins of neuronal differentiation
2015
Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins
2009
Current chemical tagging strategies for proteome analysis by mass spectrometry
2004
A peptide N-terminal protection strategy for comprehensive glycoproteome analysis using hydrazide chemistry based method
2015
Selected reaction monitoring–based proteomics: workflows, potential, pitfalls and future directions
2012
Quantitative proteome analysis using isotope-coded affinity tags and mass spectrometry
2006
Scoring proteomes with proteotypic peptide probes
2005
Protein Identification by Mass Spectrometry
2003
Understanding Alzheimer's disease by global quantification of protein phosphorylation and sialylated N-linked glycosylation profiles: A chance for new biomarkers in neuroproteomics?
2017
Isotope-targeted glycoproteomics (IsoTaG): a mass-independent platform for intact N- and O-glycopeptide discovery and analysis
2015 StandoutNobel
Glycoproteomics: A Balance between High-Throughput and In-Depth Analysis
2017
High-throughput analysis of N-glycans using AutoTip via glycoprotein immobilization
2017
Systems biology of innate immunity
2008
Comprehensive Protocol to Simultaneously Study Protein Phosphorylation, Acetylation, and N-Linked Sialylated Glycosylation
2015
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
2011 Nature
Recent progress in quantitative glycoproteomics
2012
Enhanced Mass Spectrometric Mapping of the Human GalNAc-type O-Glycoproteome with SimpleCells
2013
Targeted Identification of Metastasis-associated Cell-surface Sialoglycoproteins in Prostate Cancer
2011
O-GlcNAc profiling: from proteins to proteomes
2014
Intact glycopeptide characterization using mass spectrometry
2016
Sweet-Heart — An integrated suite of enabling computational tools for automated MS2/MS3 sequencing and identification of glycopeptides
2013
Characterization of intact N- and O-linked glycopeptides using higher energy collisional dissociation
2014
Mass Spectrometry Based Glycoproteomics—From a Proteomics Perspective
2010
Human Urinary Glycoproteomics; Attachment Site Specific Analysis of N- and O-Linked Glycosylations by CID and ECD
2011
Large-scale site-specific mapping of the O-GalNAc glycoproteome
2020
Targeting the glycoproteome
2012
Determination of glycosylation sites and site-specific heterogeneity in glycoproteins
2009
A High-Confidence Human Plasma Proteome Reference Set with Estimated Concentrations in PeptideAtlas
2011
Chemical remodelling of cell surfaces in living animals
2004 StandoutNatureNobel
Isotope-targeted glycoproteomics (IsoTaG) analysis of sialylated N- and O-glycopeptides on an Orbitrap Fusion Tribrid using azido and alkynyl sugars
2016 StandoutNobel
Precision Mapping of an In Vivo N-Glycoproteome Reveals Rigid Topological and Sequence Constraints
2010
Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation
2011 StandoutNobel
The Implications of Proteolytic Background for Shotgun Proteomics
2007
Mapping human N-linked glycoproteins and glycosylation sites using mass spectrometry
2019
Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars
2009 StandoutNobel
An enrichment method based on synergistic and reversible covalent interactions for large-scale analysis of glycoproteins
2018
Identification of sialylated glycoproteins from metabolically oligosaccharide engineered pancreatic cells
2015
Quantitative Membrane Proteomics Reveals New Cellular Targets of Viral Immune Modulators
2006
Affinity Enrichment and Characterization of Mucin Core-1 Type Glycopeptides from Bovine Serum
2009
N- and O-glycosylation Analysis of Human C1-inhibitor Reveals Extensive Mucin-type O-Glycosylation
2017
Widespread changes in protein synthesis induced by microRNAs
2008 StandoutNature
Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry
2017
Glycoproteomic Analysis of Prostate Cancer Tissues by SWATH Mass Spectrometry Discovers N-acylethanolamine Acid Amidase and Protein Tyrosine Kinase 7 as Signatures for Tumor Aggressiveness
2014
EMT, the cytoskeleton, and cancer cell invasion
2009
Understanding cellular networks to improve hematopoietic stem cell expansion cultures
2006
A potential pitfall in 18 O‐based N‐linked glycosylation site mapping
2007
Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs
2016
Low Density Lipoprotein Receptor Class A Repeats Are O-Glycosylated in Linker Regions
2014
limma powers differential expression analyses for RNA-sequencing and microarray studies
2015 Standout
Analytical glycobiology at high sensitivity: current approaches and directions
2012
Enrichment of glycopeptides for glycan structure and attachment site identification
2009
N-Glycoprotein SRMAtlas
2013
Analysis of Cell Surface Proteome Changes via Label-free, Quantitative Mass Spectrometry
2008
Mapping Yeast N-Glycosites with Isotopically Recoded Glycans
2012 StandoutNobel
Exploring the Sialiome Using Titanium Dioxide Chromatography and Mass Spectrometry
2007
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Mass spectrometric analysis of the N-glycoproteome in statin-treated liver cells with two lectin-independent chemical enrichment methods
2017
Lectin-based structural glycomics: Glycoproteomics and glycan profiling
2004
A lectin affinity workflow targeting glycosite-specific, cancer-related carbohydrate structures in trypsin-digested human plasma
2010
Sialic Acid Capture-and-Release and LC-MSn Analysis of Glycopeptides
2012
Applications of reversible covalent chemistry in analytical sample preparation
2012
A Pragmatic Guide to Enrichment Strategies for Mass Spectrometry–Based Glycoproteomics
2020 StandoutNobel
O-glycosylation sites identified from mucin core-1 type glycopeptides from human serum
2016
A FRET‐Based Fluorogenic Phosphine for Live‐Cell Imaging with the Staudinger Ligation
2008 StandoutNobel
Biomarkers for epithelial-mesenchymal transitions
2009 Standout
Viable circulating tumour cell detection using multiplex RNA in situ hybridisation predicts progression-free survival in metastatic breast cancer patients
2012
Application of a strong anion exchange material in electrostatic repulsion–hydrophilic interaction chromatography for selective enrichment of glycopeptides
2013
Perspectives of targeted mass spectrometry for protein biomarker verification
2009
Site-specific characterization of cell membrane N-glycosylation with integrated hydrophilic interaction chromatography solid phase extraction and LC–MS/MS
2014
The Mouse C2C12 Myoblast Cell Surface N-Linked Glycoproteome
2009
Global methods for protein glycosylation analysis by mass spectrometry
2006
Comparative glycoproteomics: approaches and applications
2008
A Guide to Mass Spectrometry-Based Quantitative Proteomics
2018
Glycoproteins Enrichment and LC-MS/MS Glycoproteomics in Central Nervous System Applications
2017
The Identification of Macrophage-enriched Glycoproteins Using Glycoproteomics
2017
Development of a Novel Method for Analyzing Collagen O-glycosylations by Hydrazide Chemistry
2012
Directed mass spectrometry: towards hypothesis-driven proteomics
2009
Modification‐specific proteomics: Strategies for characterization of post‐translational modifications using enrichment techniques
2009
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Mucin‐type O‐glycosylation – putting the pieces together
2009
The use of mass spectrometry for the proteomic analysis of glycosylation
2006
Recent Advances in Software Tools for More Generic and Precise Intact Glycopeptide Analysis
2020
Advances in mass spectrometry driven O-glycoproteomics
2014
Identification of Novel Tumor-Associated Cell Surface Sialoglycoproteins in Human Glioblastoma Tumors Using Quantitative Proteomics
2014
Glycoproteomics enabled by tagging sialic acid- or galactose-terminated glycans
2012
Characterization of intact sialylated glycopeptides and phosphorylated glycopeptides from IMAC enriched samples by EThcD fragmentation: Toward combining phosphoproteomics and glycoproteomics
2017
Global and site‐specific analysis of protein glycosylation in complex biological systems with Mass Spectrometry
2019
Site-specific characterization and quantitation ofN-glycopeptides in PKM2 knockout breast cancer cells using DiLeu isobaric tags enabled by electron-transfer/higher-energy collision dissociation (EThcD)
2018
Glycomics and glycoproteomics of membrane proteins and cell‐surface receptors: Present trends and future opportunities
2016
Metabolic cross-talk allows labeling of O-linked β- N -acetylglucosamine-modified proteins via the N -acetylgalactosamine salvage pathway
2011 StandoutNobel
Comparison of Three Glycoproteomic Methods for the Analysis of the Secretome of CHO Cells Treated with 1,3,4-O-Bu3ManNAc
2020
Signature-Ion-Triggered Mass Spectrometry Approach Enabled Discovery of N- and O-Linked Glycosylated Neuropeptides in the Crustacean Nervous System
2019
In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish
2008 StandoutScienceNobel
Site-Specific Quantification of Surface N-Glycoproteins in Statin-Treated Liver Cells
2016
Glycoproteomics-Based Identification of Cancer Biomarkers
2011
Development of IsoTaG, a Chemical Glycoproteomics Technique for Profiling Intact N- and O-Glycopeptides from Whole Cell Proteomes
2017 StandoutNobel
Chemoenzymatic Approach for the Proteomics Analysis of Mucin-Type Core-1 O-Glycosylation in Human Serum
2018
HILIC and ERLIC Enrichment of Glycopeptides Derived from Breast and Brain Cancer Cells
2016
Analytical Performance of Immobilized Pronase for Glycopeptide Footprinting and Implications for Surpassing Reductionist Glycoproteomics
2008
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Identification of Sialic Acid Linkages on Intact Glycopeptides via Differential Chemical Modification Using IntactGIG-HILIC
2018
Comprehensive Glycoproteomic Analysis of Chinese Hamster Ovary Cells
2018
Elucidation of N-Glycosylation Sites on Human Platelet Proteins
2005
Engineering enzymes for noncanonical amino acid synthesis
2018 StandoutNobel
Magnetic nanoparticles with dendrimer-assisted boronate avidity for the selective enrichment of trace glycoproteins
2013
Membrane Glycoproteins Associated with Breast Tumor Cell Progression Identified by a Lectin Affinity Approach
2008
Systematic and site-specific analysis of N-sialoglycosylated proteins on the cell surface by integrating click chemistry and MS-based proteomics
2015
Isotope Targeted Glycoproteomics (IsoTaG) to Characterize Intact, Metabolically Labeled Glycopeptides from Complex Proteomes
2016 StandoutNobel
Protein Analysis by Shotgun/Bottom-up Proteomics
2013
Highly Efficient Release of Glycopeptides from Hydrazide Beads by Hydroxylamine Assisted PNGase F Deglycosylation for N-Glycoproteome Analysis
2015
Chemical Deamidation: A Common Pitfall in Large-Scale N-Linked Glycoproteomic Mass Spectrometry-Based Analyses
2012
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
Sweetening the Pot: Adding Glycosylation to the Biomarker Discovery Equation
2009
Chemoenzymatic Method for Glycoproteomic N-Glycan Type Quantitation
2019
Targeted metabolic labeling of yeast N-glycans with unnatural sugars
2010 StandoutNobel
Hydrophilic interaction chromatography for the analysis of biopharmaceutical drugs and therapeutic peptides: A review based on the separation characteristics of the hydrophilic interaction chromatography phases
2018
A uniform proteomics MS/MS analysis platform utilizing open XML file formats
2005
Simultaneous and Extensive Site-specific N- and O-Glycosylation Analysis in Protein Mixtures
2011
Use of CID/ETD Mass Spectrometry to Analyze Glycopeptides
2012
Boronic Acid-Based Approach for Separation and Immobilization of Glycoproteins and Its Application in Sensing
2013
Current Technologies for Complex Glycoproteomics and Their Applications to Biology/Disease-Driven Glycoproteomics
2018
Structural analysis of glycoprotein sialylation – Part I: pre-LC-MS analytical strategies
2013
Identification of Glycoproteins in Human Cerebrospinal Fluid with a Complementary Proteomic Approach
2006
Modification of Sialic Acids on Solid Phase: Accurate Characterization of Protein Sialylation
2017
Simultaneous Characterization of Glyco- and Phosphoproteomes of Mouse Brain Membrane Proteome with Electrostatic Repulsion Hydrophilic Interaction Chromatography
2010
Solid Phase Extraction of N-Linked Glycopeptides Using Hydrazide Tip
2013
Glycocapture‐based proteomics for secretome analysis
2012
Specific Identification of Glycoproteins Bearing the Tn Antigen in Human Cells
2017
Enzymatic Tagging of Glycoproteins on the Cell Surface for Their Global and Site-Specific Analysis with Mass Spectrometry
2019
Finding the Sweet Spot in ERLIC Mobile Phase for Simultaneous Enrichment of N-Glyco and Phosphopeptides
2019
Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic β-Cells and Human Islets
2011
CPFP: a central proteomics facilities pipeline
2010
Mass Spectrometry Approaches to Glycomic and Glycoproteomic Analyses
2018
Parallel Comparison of N-Linked Glycopeptide Enrichment Techniques Reveals Extensive Glycoproteomic Analysis of Plasma Enabled by SAX-ERLIC
2017
Proteomics and the Analysis of Proteomic Data: An Overview of Current Protein‐Profiling Technologies
2005
Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification
2018 StandoutNobel
Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs
2019 StandoutNobel
Applications of targeted proteomics in systems biology and translational medicine
2015
Quantitative measurements of N ‐linked glycoproteins in human plasma by SWATH ‐MS
2013
Developing Workflow for Simultaneous Analyses of Phosphopeptides and Glycopeptides
2018
A Chemical Reporter Strategy to Probe Glycoprotein Fucosylation
2006 StandoutNobel
Amine Chemistry Method for Selective Enrichment of N-Linked Glycopeptides for Glycoproteomics Analysis
2015
Targeted methods for quantitative analysis of protein glycosylation
2014
Utilizing Ion-Pairing Hydrophilic Interaction Chromatography Solid Phase Extraction for Efficient Glycopeptide Enrichment in Glycoproteomics
2010
An overview on enrichment methods for cell surface proteome profiling
2019
Mapping the O‐glycoproteome using site‐specific extraction of O‐linked glycopeptides (EXoO)
2018
Automated measurement of site‐specific N‐glycosylation occupancy with SWATH‐MS
2015
Recent Advances in the Analysis of Complex Glycoproteins
2016
Defining Glycoprotein Cancer Biomarkers By MS in Conjunction With Glycoprotein Enrichment
2015
Imaging the glycome
2008 StandoutNobel
Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomics
2017 StandoutNobel
Rapid metabolic evolution in human prefrontal cortex
2011 StandoutNobel
Imaging Cell Surface Glycans with Bioorthogonal Chemical Reporters
2007 StandoutNobel
Multiplexed Targeted Mass Spectrometry-Based Assays for the Quantification of N-Linked Glycosite-Containing Peptides in Serum
2015
Analysis of PNGase F‐Resistant N‐Glycopeptides Using SugarQb for Proteome Discoverer 2.1 Reveals Cryptic Substrate Specificities
2018
Site-Specific Glycan-Peptide Analysis for Determination of N-Glycoproteome Heterogeneity
2013
Targeted glycoprotein enrichment and identification in stromal cell secretomes using azido sugar metabolic labeling
2013
Using lectins to harvest the plasma/serum glycoproteome
2012
Tailored Glycoproteomics and Glycan Site Mapping Using Saccharide-Selective Bioorthogonal Probes
2007
Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry
2017
Identification of Chemoresistance-Related Cell-Surface Glycoproteins in Leukemia Cells and Functional Validation of Candidate Glycoproteins
2014
Study on behaviors and performances of universal N-glycopeptide enrichment methods
2018
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
2009 StandoutScience
Chemoenzymatic method for glycomics: Isolation, identification, and quantitation
2015
Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics
2018 StandoutNobel
Mass Spectrometric Analysis of the Cell Surface N-Glycoproteome by Combining Metabolic Labeling and Click Chemistry
2014
An Integrated Workflow for Global, Glyco-, and Phospho-proteomic Analysis of Tumor Tissues
2019
Advances in mass spectrometry‐based glycoproteomics
2018
Recent Advances in Glycoproteomic Analysis by Mass Spectrometry
2019
Surface Glycoproteomic Analysis Reveals That Both Unique and Differential Expression of Surface Glycoproteins Determine the Cell Type
2019
Enrichment of O-GlcNAc Modified Proteins by the Periodate Oxidation−Hydrazide Resin Capture Approach
2010
Real-Time Bioluminescence Imaging of Glycans on Live Cells
2010 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry
2005
Glyco-seek: Ultrasensitive Detection of Protein-Specific Glycosylation by Proximity Ligation Polymerase Chain Reaction
2016 StandoutNobel
Quantitative mass spectrometric analysis of glycoproteins combined with enrichment methods
2014
N-Linked Glycopeptide Identification Based on Open Mass Spectral Library Search
2018
Mass Spectrometry and Protein Analysis
2006 StandoutScience
Advances in Chemical Protein Modification
2015
Works of Xiaojun Li being referenced
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry
2003
High Throughput Quantitative Analysis of Serum Proteins Using Glycopeptide Capture and Liquid Chromatography Mass Spectrometry
2004
Up-regulation of gastric cancer cell invasion by Twist is accompanied by N-cadherin and fibronectin expression
2007
The Application of New Software Tools to Quantitative Protein Profiling Via Isotope-coded Affinity Tag (ICAT) and Tandem Mass Spectrometry
2003
Lipid Raft Proteins and Their Identification in T Lymphocytes
2004
A Software Suite for the Generation and Comparison of Peptide Arrays from Sets of Data Collected by Liquid Chromatography-Mass Spectrometry
2005
System-based proteomic analysis of the interferon response in human liver cells
2004
Automated Statistical Analysis of Protein Abundance Ratios from Data Generated by Stable-Isotope Dilution and Tandem Mass Spectrometry
2003
Abundance Ratio-Dependent Proteomic Analysis by Mass Spectrometry
2003
A Tool To Visualize and Evaluate Data Obtained by Liquid Chromatography-Electrospray Ionization-Mass Spectrometry
2004