Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis
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Structure-Based Discovery of A 2A Adenosine Receptor Ligands
2010
The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist
2008 StandoutScience
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
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Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
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Why Are A2B Receptors Low-Affinity Adenosine Receptors? Mutation of Asn273 to Tyr Increases Affinity of Human A2B Receptor for 2-(1-Hexynyl)adenosine
2000
Hydrophilic side chains in the third and seventh transmembrane helical domains of human A2A adenosine receptors are required for ligand recognition.
1996
Behavioral effects of A1- and A2-selective adenosine agonists and antagonists: evidence for synergism and antagonism.
1991
Cl-IB-MECA [2-Chloro-N6-(3-iodobenzyl)adenosine-5′-N-methylcarboxamide] Reduces Ischemia/Reperfusion Injury in Mice by Activating the A Adenosine Receptor
2006
A “one-pot” multicomponent approach to polysubstituted 4-aminopyridines
2012
Why Are A2BReceptors Low-Affinity Adenosine Receptors? Mutation of Asn273 to Tyr Increases Affinity of Human A2BReceptor for 2-(1-Hexynyl)adenosine
2000
1,3-dialkylxanthine derivatives having high potency as antagonists at human A2B adenosine receptors
1999
2-Dialkynyl derivatives of (N)-methanocarba nucleosides: ‘Clickable’ A3 adenosine receptor-selective agonists
2009
Adenosine receptors and Huntington's disease: implications for pathogenesis and therapeutics
2003
Cross-Talk between Gs- and Gq-Coupled Pathways in Regulation of Interleukin-4 by A2B Adenosine Receptors in Human Mast Cells
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Nucleotide signalling during inflammation
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Copper‐Catalyzed Direct C Arylation of Heterocycles with Aryl Bromides: Discovery of Fluorescent Core Frameworks
2009
Synthesis and antimicrobial activity of 2-alkenylchroman-4-ones, 2-alkenylthiochroman-4-ones and 2-alkenylquinol-4-ones
2008
Asymmetric Disulfonimide‐Catalyzed Synthesis of δ‐Amino‐β‐Ketoester Derivatives by Vinylogous Mukaiyama–Mannich Reactions
2014 StandoutNobel
In search of selective P2 receptor ligands: interaction of dihydropyridine derivatives at recombinant rat P2X2 receptors
2000
Animal models for the study of adenosine receptor function
2004
Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance
2008
Adenosine A2Breceptors are highly expressed on murine type II alveolar epithelial cells
2009
A3-adenosine receptors: Design of selective ligands and therapeutic prospects
1995
GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
2010 Standout
Synthesis and evaluation of antifungal properties of a series of the novel 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile and its analogues
2007
Differential allosteric modulation by amiloride analogues of agonist and antagonist binding at A1 and A3 adenosine receptors
2003
2-Phenylimidazo[2,1-i]purin-5-ones Structure–Activity relationships and characterization of potent and selective inverse agonists at Human A3 adenosine receptors
2003
Design of (N)-methanocarba adenosine 5′-uronamides as species-independent A3 receptor-selective agonists
2008
A Multicomponent Reaction of Arynes, Isocyanides, and Terminal Alkynes: Highly Chemo‐ and Regioselective Synthesis of Polysubstituted Pyridines and Isoquinolines
2009
International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
2011 Standout
Site-directed Mutagenesis Identifies Residues Involved in Ligand Recognition in the Human A2a Adenosine Receptor
1995
Binding of the radioligand [3H]‐SCH 58261, a new non‐xanthine A2A adenosine receptor antagonist, to rat striatal membranes
1996
Recent advances in transition-metal-free carbon–carbon and carbon–heteroatom bond-forming reactions using arynes
2012 Standout
Protein kinase C protects preconditioned rabbit hearts by increasing sensitivity of adenosine A2b-dependent signaling during early reperfusion
2007
Selective Allosteric Enhancement of Agonist Binding and Function at Human A3 Adenosine Receptors by a Series of Imidazoquinoline Derivatives
2002
Dual activation of adenosine A1 and A3 receptors mediates preconditioning of isolated cardiac myocytes
1997
Search for New Purine- and Ribose-Modified Adenosine Analogs as Selective Agonists and Antagonists at Adenosine Receptors
1995
Structure–activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1)
2008
Synthesis of 2-styrylchromones as a novel class of antiproliferative agents targeting carcinoma cells
2009
Adenosine A2 receptor-mediated excitatory actions on the nervous system
1996
Functional characterization of adenosine A2 receptors in Jurkat cells and PC12 cells using adenosine receptor agonists
1996
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
[3H]HEMADO— a novel tritiated agonist selective for the human adenosine A3 receptor
2006
In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-γ-pyrone skeleton
2012
Polyphenols: food sources and bioavailability
2004 Standout
Antagonist pharmacology of adenosine A2B receptors from rat, guinea pig and dog
2003
Molecular modeling of adenosine receptors: new results and trends
2007
2-Substitution of N6-Benzyladenosine-5'-uronamides Enhances Selectivity for A3 Adenosine Receptors
1994
Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis
2011 Standout
Phosphine‐Free, Palladium‐Catalyzed Arylation of Heterocycles through CH Bond Activation with Pivalic Acid as a Cocatalyst
2008
8‐(3‐Chlorostyryl)caffeine (CSC) is a selective A2‐adenosine antagonist in vitro and in vivo
1993
Cyclic AMP‐dependent inhibition of human neutrophil oxidative activity by substituted 2‐propynylcyclohexyl adenosine A2A receptor agonists
2001
Adenosine receptor agonists: from basic medicinal chemistry to clinical development
2003
The impact of flavonoids on memory: physiological and molecular considerations
2009
Memory of Extracellular Adenosine A2A Purinergic Receptor-mediated Signaling in Murine T Cells
1997 StandoutNobel
Adenosine A1 and A2 receptors: Structure–function relationships
1992
Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling
2003
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Adaptive changes in adenosine receptors following long-term treatment with the adenosine receptor agonist R-phenylisopropyl adenosine
1996
KF26777 (2-(4-bromophenyl)-7,8-dihydro-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one dihydrochloride), a new potent and selective adenosine A3 receptor antagonist
2002
Signalling from adenosine receptors to mitogen-activated protein kinases
2003
Adenosine receptors as drug targets — what are the challenges?
2013
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential
1992
Modulation of Apoptosis by Adenosine in the Central Nervous System: a Possible Role for the A3 Receptor
1997
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy
2006
"Cleavable Trifunctional" Approach to Receptor Affinity Labeling: Regeneration of Binding to A1-Adenosine Receptors
1995
Comparing the MicroRNA Spectrum between Serum and Plasma
2012
Selective glucocorticoid receptor nonsteroidal ligands completely antagonize the dexamethasone mediated induction of enzymes involved in gluconeogenesis and glutamine metabolism
2004
Characterization of the A2B Adenosine Receptor from Mouse, Rabbit, and Dog
2009
Transition‐Metal‐Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage
2009 Standout
Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors
1996
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry
2014 StandoutNobel
Covalent binding of a selective agonist irreversibly activates guinea pig coronary artery A2 adenosine receptors
1993
Adenosine receptor ligands: differences with acute versus chronic treatment
1996
A role for central A3‐adenosine receptors
1993
Recent developments in adenosine receptor ligands and their potential as novel drugs
2010
Adenosine A3Receptor Agonists Protect HL-60 and U-937 Cells from Apoptosis Induced by A3Antagonists
1997
Pharmacological profiles of cloned mammalian P2Y-receptor subtypes
2005
A3Adenosine Receptor Activation Triggers Phosphorylation of Protein Kinase B and Protects Rat Basophilic Leukemia 2H3 Mast Cells from Apoptosis
2001
Adenosine A3 receptor stimulation and cerebral ischemia
1994
A Metal‐Free Transfer Hydrogenation: Organocatalytic Conjugate Reduction of α,β‐Unsaturated Aldehydes
2004 StandoutNobel
Cloning, Expression and Pharmacological Characterization of Rabbit Adenosine A1 and A3 Receptors
1997
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
N6-Alkyl-2-alkynyl Derivatives of Adenosine as Potent and Selective Agonists at the Human Adenosine A3Receptor and a Starting Point for Searching A2BLigands
2002
3d Transition Metals for C–H Activation
2018 Standout
Fluorine in medicinal chemistry
2007 Standout
Activation of A3 adenosine receptors on human eosinophils elevates intracellular calcium
1996 StandoutNobel
Recent developments in the chemistry of dihydropyridines
2002
A revisit to the Hantzsch reaction: Unexpected products beyond 1,4-dihydropyridines
2009
Adenosine Receptor Antagonists: Translating Medicinal Chemistry and Pharmacology into Clinical Utility
2008
Polyamidoamine (PAMAM) Dendrimer Conjugates of “Clickable” Agonists of the A3Adenosine Receptor and Coactivation of the P2Y14Receptor by a Tethered Nucleotide
2010
BindingDB Entry 5256: [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.
2012
Receptors for Purines and Pyrimidines
1998 Standout
Chemical modification and irreversible inhibition of striatal A2a adenosine receptors.
1992
Potent antagonists for the human adenosine A2B receptor. Derivatives of the triazolotriazine adenosine receptor antagonist ZM241385 with high affinity
1999
Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub
2017 StandoutNobel
Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype.
1992
Imidazo[2,1-i]purin-5-ones and Related Tricyclic Water-Soluble Purine Derivatives: Potent A2A- and A3-Adenosine Receptor Antagonists
2002
Bis(imino)pyridines: Surprisingly Reactive Ligands and a Gateway to New Families of Catalysts
2007 Standout
Synthesis and use of FSCPX, an irreversible adenosine A1 antagonist, as a ‘Receptor Knock-Down’ tool
2001
Use of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors.
1999
Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition toN-Activated Pyridines
2012 Standout
A Comprehensive History of Arynes in Natural Product Total Synthesis
2012 Standout
Adenosine and Brain Ischemia
1995
Sulfonyl Fluorides (SFs): More Than Click Reagents?
2018
SuFEx Chemistry of Thionyl Tetrafluoride (SOF4) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides, and Sulfonimidates
2018 StandoutNobel
A3adenosine receptor activation attenuates neutrophil function and neutrophil-mediated reperfusion injury
1999
Addition of some aminoheterocycles to N-benzyl-3-cyanopyridinium chloride
2003
Structure−Activity Relationships at Human and Rat A2B Adenosine Receptors of Xanthine Derivatives Substituted at the 1-, 3-, 7-, and 8-Positions
2002
A3 Adenosine Receptor Ligands: History and Perspectives
2000
Essential role of adenosine, adenosine A1 receptors, and ATP-sensitive K+ channels in cerebral ischemic preconditioning.
1995
Experimental and Structural Evidence that Herpes 1 Kinase and Cellular DNA Polymerase(s) Discriminate on the Basis of Sugar Pucker
2003
BindingDB Entry 5069: Cloning, expression and pharmacological characterization of rabbit adenosine A1 and A3 receptors.
2012
De novo synthesis of substituted pyridines
2004 Standout
Chromone: A Valid Scaffold in Medicinal Chemistry
2014 Standout
Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope
2011 Standout
Copper‐Catalyzed Direct C Arylation of Heterocycles with Aryl Bromides: Discovery of Fluorescent Core Frameworks
2009
Design, Synthesis, and Biological Evaluation of New 8-Heterocyclic Xanthine Derivatives as Highly Potent and Selective Human A2BAdenosine Receptor Antagonists
2004
Isoquinoline and Quinazoline Urea Analogues as Antagonists for the Human Adenosine A3Receptor
2000
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Advances in the Chemistry of Tetrahydroquinolines
2011 Standout
Phenols in the plant and in man. The potential for possible nutritional enhancement of the diet by modifying the phenols content or profile
2000
Purinoceptors: From History to Recent Progress. A Review
1996
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Chemo- and Regioselective Assembly of Polysubstituted Pyridines and Isoquinolines from Isocyanides, Arynes, and Terminal Alkynes
2012
Pyridine-2,6-bis(oxazolines), Helpful Ligands for Asymmetric Catalysts
2003
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
2005 Standout
1-Alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: Development and Characterization of Adenosine A2BReceptor Antagonists and a New Radioligand with Subnanomolar Affinity and Subtype Specificity
2009
Glutamate residues in the second extracellular loop of the human A2a adenosine receptor are required for ligand recognition.
1996
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Further characterization of the binding of the adenosine receptor agonist [3H]CGS 21680 to rat brain using autoradiography
1995
Adenosine A1 Receptor Knockout Mice Develop Lethal Status Epilepticus after Experimental Traumatic Brain Injury
2005
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Sulfonyl fluorides as privileged warheads in chemical biology
2015
A2A adenosine receptors from rat striatum and rat pheochromocytoma PC12 cells: characterization with radioligand binding and by activation of adenylate cyclase.
1992
Mutagenesis Reveals Structure−Activity Parallels between Human A2AAdenosine Receptors and Biogenic Amine G Protein-Coupled Receptors
1997
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
2020 StandoutNobel
Molecular Approach to Adenosine Receptors: Receptor-Mediated Mechanisms of Tissue Protection
2001
A Heck–Matsuda Process for the Synthesis of β‐Arylethenesulfonyl Fluorides: Selectively Addressable Bis‐electrophiles for SuFEx Click Chemistry
2016 StandoutNobel
A highly efficient regioselective one-pot synthesis of 2,3,6-trisubstituted pyridines and 2,7,7-trisubstituted tetrahydroquinolin-5-ones using K5CoW12O40·3H2O as a heterogeneous recyclable catalyst
2007
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
2010 Standout
2-Triazole-Substituted Adenosines: A New Class of Selective A3Adenosine Receptor Agonists, Partial Agonists, and Antagonists
2006
Gold‐ and Silver‐Catalyzed Intramolecular Hydroamination of Terminal Alkynes: Water‐Triggered Chemo‐ and Regioselective Synthesis of Fused Tricyclic Xanthines
2009
Chapter 11 Adenosine and Neuroprotection
1996
International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
2001 Standout
Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion
1997 StandoutNobel
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Activation of Hippocampal Adenosine A3Receptors Produces a Desensitization of A1Receptor-Mediated Responses in Rat Hippocampus
1997
Gold-Catalyzed Carbon−Heteroatom Bond-Forming Reactions
2011 Standout
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Chiral Pyrrolo[2,3-d]pyrimidine and Pyrimido[4,5-b]indole Derivatives: Structure−Activity Relationships of Potent, Highly Stereoselective A1-Adenosine Receptor Antagonists,
1996
Direct C−H Transformation via Iron Catalysis
2010 Standout
Nomenclature and classification of purinoceptors.
1994 Standout
[3H]MRE 3008F20: A Novel Antagonist Radioligand for the Pharmacological and Biochemical Characterization of Human A3 Adenosine Receptors
2000
Hydrogen Transfer from Hantzsch 1,4-Dihydropyridines to Carbon-Carbon Double Bonds under Microwave Irradiation
2002
Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion
1997 StandoutNobel
Adenosine acting at an A1 receptor decreases N-type calcium current in mouse motoneurons
1994
Acidity of Hydroxyl Groups: An Overlooked Influence on Antiradical Properties of Flavonoids
2009
A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope
2017 StandoutNobel
Addition of organocopper reagents to N-alkylpyridinium salts. A flexible access to polysubstituted dihydropyridines
2001
Proton-Coupled Electron Transfer
2012 Standout
GPCR Ligand Dendrimer (GLiDe) Conjugates: Adenosine Receptor Interactions of a Series of Multivalent Xanthine Antagonists
2011
Metal-Free Multicomponent Syntheses of Pyridines
2014 Standout
Works of Xiao‐duo Ji being referenced
Quantitation of the P2Y1 Receptor with a High Affinity Radiolabeled Antagonist
2002
Agonist derived molecular probes for A2 adenosine receptors
1989
Structure-Activity Relationships of 1,3-Dialkylxanthine Derivatives at Rat A3 Adenosine Receptors
1994
Synthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba-pseudoribose rings
2001
Chapter 10 Molecular recognition in P2 receptors: Ligand development aided by molecular modeling and mutagenesis
1999
Molecular characterization of A1 and A2a adenosine receptors
1993
Pharmacological characterization of novel A3 adenosine receptor-selective antagonists
1997
Interactions of Flavones and Other Phytochemicals with Adenosine Receptors
2002
Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia
1994
Acyl-hydrazide derivatives of a xanthine carboxylic congener (XCC) as selective antagonists at human A2B adenosine receptors
1999
Gender Dependence for a Subset of the Low-Abundance Signaling Proteome in Human Platelets
2010
Chronic adenosine A1 receptor agonist and antagonist: effect on receptor density and induced seizures in mice
1994
Species differences in ligand affinity at central A3‐adenosine receptors
1994
Characterization of Human Striatal A2-Adenosine Receptors Using Radioligand Binding and Photoaffinity Labeling
1992
8‐(3‐Isothiocyanatostyryl)caffeine is a selective, irreversible inhibitor of striatal A2‐Adenosine receptors
1993
Structure−Activity Relationships and Molecular Modeling of 3,5-Diacyl-2,4-dialkylpyridine Derivatives as Selective A3 Adenosine Receptor Antagonists
1998
NovelN6-(Substituted-phenylcarbamoyl)adenosine-5‘-uronamides as Potent Agonists for A3Adenosine Receptors
1996
Synthesis and Biological Activity of a New Series of N6-Arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-Carboxamido Derivatives of Adenosine-5‘-N-ethyluronamide as A1 and A3 Adenosine Receptor Agonists
1998
6-Phenyl-1,4-dihydropyridine Derivatives as Potent and Selective A3 Adenosine Receptor Antagonists
1996
Anilide Derivatives of an 8-Phenylxanthine Carboxylic Congener Are Highly Potent and Selective Antagonists at Human A2B Adenosine Receptors
2000
Interactions of Flavonoids and Other Phytochemicals with Adenosine Receptors
1996
Chiral Resolution and Stereospecificity of 6-Phenyl-4-phenylethynyl- 1,4-dihydropyridines as Selective A3 Adenosine Receptor Antagonists
1999
Functionalized Congeners of 1,4-Dihydropyridines as Antagonist Molecular Probes for A3 Adenosine Receptors
1999
Structure−Activity Relationships of 4-(Phenylethynyl)-6-phenyl-1,4- dihydropyridines as Highly Selective A3 Adenosine Receptor Antagonists
1997
Methanocarba Analogues of Purine Nucleosides as Potent and Selective Adenosine Receptor Agonists
2000
Derivatives of the Triazoloquinazoline Adenosine Antagonist (CGS15943) Are Selective for the Human A3Receptor Subtype
1996
Fluorosulfonyl- and Bis-(β-chloroethyl)amino-phenylamino Functionalized Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine Derivatives: Irreversible Antagonists at the Human A3 Adenosine Receptor and Molecular Modeling Studies
2001
Synthesis and Biological Activities of Flavonoid Derivatives as A3 Adenosine Receptor Antagonists
1996
Survey of Nonxanthine Derivatives as Adenosine Receptor Ligands
1996
Synthesis, CoMFA Analysis, and Receptor Docking of 3,5-Diacyl-2,4-Dialkylpyridine Derivatives as Selective A3 Adenosine Receptor Antagonists
1999