Standout Papers
Citation Impact
Citing Papers
The Atg5–Atg12 conjugate associates with innate antiviral immune responses
2007
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation
2016
Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis
2016 StandoutNobel
Essential role of IPS-1 in innate immune responses against RNA viruses
2006
Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor
2007
2016
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
2009 StandoutNobel
Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
2016
Ribonuclease H2 mutations induce a cGAS / STING ‐dependent innate immune response
2016
Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1
2016
Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4
2016
Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway
2015
The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis
2007
PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1
2015
Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells
2018
Dendritic cells in cancer immunology and immunotherapy
2019 Standout
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
2015 StandoutNobel
Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
2013
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis
2015
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
2016 Standout
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
2017
The role of myeloid cells in cancer therapies
2016
CD47 blockade triggers T cell–mediated destruction of immunogenic tumors
2015
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response
2017
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
2019 Standout
Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation
2017
Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures
2010 StandoutNobel
Regulation of hepatic innate immunity by hepatitis C virus
2013
Mitotic progression following DNA damage enables pattern recognition within micronuclei
2017 Nature
Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production
2016
Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells
2010 StandoutNobel
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
2015 Standout
Receptors and routes of dengue virus entry into the host cells
2015
Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein
2015
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
2018
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
Cytosolic Sensing of Viruses
2013
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity
2016
mda-5, but not RIG-I, is a common target for paramyxovirus V proteins
2006
The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA
2016
Immunogenic cell death in cancer and infectious disease
2016 Standout
Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses
2014
cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells
2016
Role of the gut microbiota in immunity and inflammatory disease
2013 Standout
Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors
2014
Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING
2014
Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling
2016
The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy
2015
STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease
2015
The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling
2014
The Next Hurdle in Cancer Immunotherapy: Overcoming the Non–T-Cell–Inflamed Tumor Microenvironment
2015
Immune-mediated mechanisms influencing the efficacy of anticancer therapies
2015
Targeting STING with covalent small-molecule inhibitors
2018 Nature
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs
2014
The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING
2014
Interferons and viruses: an evolutionary arms race of molecular interactions
2015 StandoutNobel
Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment
2017
Antigen cross-presentation and T-cell cross-priming in cancer immunology and immunotherapy
2017
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice
2017
Macrophages as regulators of tumour immunity and immunotherapy
2019 Standout
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
2014 Standout
MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response
2011
Radiotherapy: Changing the Game in Immunotherapy
2016
Expression of heterologous proteins flanked by NS3-4A cleavage sites within the hepatitis C virus polyprotein
2013 StandoutNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Ten Strategies of Interferon Evasion by Viruses
2017
Type I Interferon in Chronic Virus Infection and Cancer
2017
Endogenous and pharmacologic targeting of the STING pathway in cancer immunotherapy
2015
Newly described pattern recognition receptors team up against intracellular pathogens
2013
The history of Toll-like receptors — redefining innate immunity
2013
Convergent Evolution of Escape from Hepaciviral Antagonism in Primates
2012
In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment
2015
A genetically humanized mouse model for hepatitis C virus infection
2011 StandoutNatureNobel
Recognition of Endogenous Nucleic Acids by the Innate Immune System
2016
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
2007 Standout
Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape
2015
CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer
2016
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
2008 StandoutNature
Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA
2011
Type I interferons in anticancer immunity
2015
Toll-Like Receptor Signaling Pathways
2014 Standout
Innate Immune Receptors
2016
Autophagy in immunity and inflammation
2011 StandoutNature
HepG2 cells mount an effective antiviral interferon-lambda based innate immune response to hepatitis C virus infection
2014
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
2014
TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity
2010 Nature
Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development
2015
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome
2015
DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway
2015 Science
Replication of Hepatitis C Virus (HCV) RNA in Mouse Embryonic Fibroblasts: Protein Kinase R (PKR)-Dependent and PKR-Independent Mechanisms for Controlling HCV RNA Replication and Mediating Interferon Activities
2006
Flying Under the Radar: The Immunobiology of Hepatitis C
2006 StandoutNobel
Polymorphisms in melanoma differentiation‐associated gene 5 link protein function to clearance of hepatitis C virus
2014 StandoutNobel
The Hepatitis B Virus X Protein Disrupts Innate Immunity by Downregulating Mitochondrial Antiviral Signaling Protein
2010
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity
2017
Coinhibitory Pathways in Immunotherapy for Cancer
2016
Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS
2016
Ultrastructural analysis of hepatitis C virus particles
2013 StandoutNobel
Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
2014
cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection
2016
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
Characterization of nonprimate hepacivirus and construction of a functional molecular clone
2015 StandoutNobel
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
2012 StandoutNobel
Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy
2018
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Recognition of viruses by innate immunity
2007
Modeling hepatitis C virus infection using human induced pluripotent stem cells
2012 StandoutNobel
Mitochondrial DNA in innate immune responses and inflammatory pathology
2017
Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death
2017
ATP-independent diffusion of double-stranded RNA binding proteins
2012 StandoutNobel
Innate Immune Recognition of Cancer
2015
A bacterial Argonaute with noncanonical guide RNA specificity
2016 StandoutNobel
Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases
2006
The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication
2007 StandoutNobel
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
2019 Standout
Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex
2008
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
2015
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
Viruses transfer the antiviral second messenger cGAMP between cells
2015 Science
RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice
2016
Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING
2015
Emerging Opportunities and Challenges in Cancer Immunotherapy
2016
Establishment and Maintenance of the Innate Antiviral Response to West Nile Virus Involves both RIG-I and MDA5 Signaling through IPS-1
2007
MPYS/STING-Mediated TNF-α, Not Type I IFN, Is Essential for the Mucosal Adjuvant Activity of (3′–5′)-Cyclic-Di-Guanosine-Monophosphate In Vivo
2013
cGAS is essential for cellular senescence
2017
The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
2018
Fas-Associated Death Domain-Containing Protein-Mediated Antiviral Innate Immune Signaling Involves the Regulation of Irf7
2007
cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response to Francisella Infection
2015
The host STING pathway at the interface of cancer and immunity
2016
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
NS3 Helicase Domains Involved in Infectious Intracellular Hepatitis C Virus Particle Assembly
2008
The Role of Damage-Associated Molecular Patterns in Human Diseases : Part I - Promoting inflammation and immunity
2015
Transmission of innate immune signaling by packaging of cGAMP in viral particles
2015 Science
Cancer immunotherapy using checkpoint blockade
2018 StandoutScience
Positive Feedback Regulation of Type I IFN Production by the IFN-Inducible DNA Sensor cGAS
2015
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection
2016
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses
2012 StandoutNobel
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Xiao-Dong Li being referenced
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
2005
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
2014 Standout
Type I Interferon Production Induced by Streptococcus pyogenes-Derived Nucleic Acids Is Required for Host Protection
2011
Modified Vaccinia Virus Ankara Triggers Type I IFN Production in Murine Conventional Dendritic Cells via a cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway
2014
Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis
2015
Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling
2017
Tula hantavirus triggers pro-apoptotic signals of ER stress in Vero E6 cells
2005
Quantitative 3D Video Microscopy of HIV Transfer Across T Cell Virological Synapses
2009 Science
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
2015
Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis
2011
Sequence specific detection of bacterial 23S ribosomal RNA by TLR13
2012
Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
2013 Science