Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
The role of binding site cluster strength in Bicoid-dependent patterning in Drosophila
2005
Spatially resolved, highly multiplexed RNA profiling in single cells
2015 StandoutScience
A genomic region associated with protection against severe COVID-19 is inherited from Neandertals
2021 StandoutNobel
Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons
2020 StandoutNobel
Denisovan ancestry and population history of early East Asians
2020 StandoutScienceNobel
High burden and pervasive positive selection of somatic mutations in normal human skin
2015 StandoutScience
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis
2012 StandoutNobel
The Ensembl Variant Effect Predictor
2016 Standout
Lysosomal Localization of TRPML3 Depends on TRPML2 and the Mucolipidosis-associated Protein TRPML1
2006
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
2017 StandoutNature
Evolutionary conservation and changes in insect TRP channels
2009
VIPER: Visualization Pipeline for RNA-seq, a Snakemake workflow for efficient and complete RNA-seq analysis
2018
dbNSFP v4: a comprehensive database of transcript-specific functional predictions and annotations for human nonsynonymous and splice-site SNVs
2020
Phenotypic plasticity and the epigenetics of human disease
2007 Nature
Polycystins: polymodal receptor/ion-channel cellular sensors
2005
Designing materials for biology and medicine
2004 StandoutNature
The embryo as a laboratory: quantifying transcription in Drosophila
2014
Epigenetic Transgenerational Actions of Endocrine Disruptors
2006
Phenotypic differences in genetically identical organisms: the epigenetic perspective
2005
Vcfanno: fast, flexible annotation of genetic variants
2016
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
GEMINI: Integrative Exploration of Genetic Variation and Genome Annotations
2013
Cancer Evolution Is Associated with Pervasive Positive Selection on Globally Expressed Genes
2014
A review of post-GWAS prioritization approaches
2013
Hsp90 as a capacitor for morphological evolution
1998 StandoutNature
Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes
2016
Inherited epigenetic variation — revisiting soft inheritance
2006
Creation of Functional Viruses from Non-Functional cDNA Clones Obtained from an RNA Virus Population by the Use of Ancestral Reconstruction
2015
Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria
1996
A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
2010 StandoutNobel
Epigenetic germline inheritance
2004
HSP90 and the chaperoning of cancer
2005 Standout
The heat shock protein 83(Hsp83) is required for Raf-mediated signalling in Drosophila
1997
Effect of hydro-osmotic pressure on polycystin-2 channel function in the human syncytiotrophoblast
2005
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
Enkurin is a novel calmodulin and TRPC channel binding protein in sperm
2004
The epigenetic progenitor origin of human cancer
2005
Molecular basis of infrared detection by snakes
2010 StandoutNatureNobel
The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue
1995 Nature
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Choice of transcripts and software has a large effect on variant annotation
2014
The major genetic risk factor for severe COVID-19 is inherited from Neanderthals
2020 StandoutNatureNobel
Non‐selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP
2004
Perceptions of epigenetics
2007 StandoutNature
Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans
2005
Polycystins, calcium signaling, and human diseases
2004
Mutations Modulating Raf Signaling in Drosophila Eye Development
1996
Cellular and molecular function of mucolipins (TRPML) and polycystin 2 (TRPP2)
2005
A survey of tools for variant analysis of next-generation genome sequencing data
2013
Transient Receptor Potential Cation Channels in Disease
2007 Standout
Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase
1994 StandoutScience
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
2010
The Ras signaling pathway in Drosophila
1995
A synthetic multicellular system for programmed pattern formation
2005 StandoutNatureNobel
Environmental epigenomics and disease susceptibility
2007 Standout
Mechanisms of developmental robustness
2012
Invertebrate TRP proteins as functional models for mammalian channels
2004
Molecular physiology and pathology of Ca2+-conducting channels in the plasma membrane of mammalian sperm
2005
Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells
2014
Pivoting the Plant Immune System from Dissection to Deployment
2013 StandoutScience
Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi
2005 Science
Origin, properties, and regulated expression of multiple mRNAs encoded by the protein kinase C1 gene of Caenorhabditis elegans.
1994
smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans
1997
A conserved helix motif complements the protein kinase core.
1993
Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster
2015
Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues
1995
Dynamical Analysis of Regulatory Interactions in the Gap Gene System of Drosophila melanogaster
2004
Gene Regulatory Networks and the Evolution of Animal Body Plans
2006 StandoutScience
STATs and Gene Regulation
1997 StandoutScience
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP- N - acetylgalactosamine, and UDP-galactose
2001 StandoutNobel
The TRP Superfamily of Cation Channels
2005
Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals
2016 StandoutScienceNobel
Hsp90 inhibitors deplete key anti‐apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin
2004
Altered Hsp90 function in cancer: A unique therapeutic opportunity
2004
CloudMap: A Cloud-Based Pipeline for Analysis of Mutant Genome Sequences
2012
Single chip CMOS imagers and flexible microelectronic stimulators for a retina implant system
2000
Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes
2019 StandoutNobel
Spermidine in health and disease
2018 StandoutScience
A New Concept Linking Observable Stable Isotope Fractionation to Transformation Pathways of Organic Pollutants
2005
The rise and fall of the Phytophthora infestans lineage that triggered the Irish potato famine
2013
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Worldwide emergence of resistance to antifungal drugs challenges human health and food security
2018 StandoutScience
Mercury Stable Isotope Fractionation during Reduction of Hg(II) to Hg(0) by Mercury Resistant Microorganisms
2007
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4
2009 StandoutNobel
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
1997 StandoutScience
RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
1998 StandoutNobel
The Guanine Nucleotide-Binding Switch in Three Dimensions
2001 StandoutScience
dbNSFP v3.0: A One-Stop Database of Functional Predictions and Annotations for Human Nonsynonymous and Splice-Site SNVs
2015
Mass-Dependent and -Independent Fractionation of Hg Isotopes by Photoreduction in Aquatic Systems
2007 StandoutScience
The Challenge of Micropollutants in Aquatic Systems
2006 StandoutScience
High-Throughput Cloning of Temperature-Sensitive Caenorhabditis elegans Mutants with Adult Syncytial Germline Membrane Architecture Defects
2015
Natural Variation in the Distribution and Abundance of Transposable Elements Across the Caenorhabditis elegans Species
2017
Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome
1996 StandoutScience
Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt
1997 StandoutScience
A high-coverage Neandertal genome from Chagyrskaya Cave
2020 StandoutNobel
Cancer immunotherapy using checkpoint blockade
2018 StandoutScience
The novel metallothionein genes of Caenorhabditis elegans. Structural organization and inducible, cell-specific expression.
1993 StandoutNobel
TRP Channels
2007 Standout
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress
2015 StandoutNobel
Under cover: causes, effects and implications of Hsp90‐mediated genetic capacitance
2004
Works of Xiangyi Lu being referenced
PKD2 Cation Channel Is Required for Directional Sperm Movement and Male Fertility
2003
Microelectronic components for a retina implant system
1999
Hsp90 and environmental impacts on epigenetic states: a model for the trans-generational effects of diethylstibesterol on uterine development and cancer
2005
Drosophila Pkd2 Is Haploid-insufficient for Mediating Optimal Smooth Muscle Contractility
2004
Evolutionary conservation of metabolism explains howDrosophila nutrigenomics can help us understand human nutrigenomics
2006
Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution
2002
Waddington’s widget: Hsp90 and the inheritance of acquired characters
2003
Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift
2012
Evolutionary Conservation of Drosophila Polycystin-2 as a Calcium-Activated Cation Channel
2004
A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff
2012 Standout
Multigenerational Selection and Detection of Altered Histone Acetylation and Methylation Patterns: Toward a Quantitative Epigenetics in <i>Drosophila</I>
2004
Activation of posterior gap gene expression in the Drosophila blastoderm
1995 Nature
Optimal methods for estimating kinetic isotope effects from different forms of the Rayleigh distillation equation
2004
Genetic and molecular analyses of mutations involved in Drosophila raf signal transduction.
1994
Cloning, characterization, and expression of the gene for the catalytic subunit of cAMP-dependent protein kinase in Caenorhabditis elegans. Identification of highly conserved and unique isoforms generated by alternative splicing.
1990
The torso pathway in Drosophila: a model system to study receptor tyrosine kinase signal transduction
1993