Standout Papers
Citation Impact
Citing Papers
Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
2008 StandoutScienceNobel
Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability
2016 Science
Molecular Coupling of Xist Regulation and Pluripotency
2008 Science
Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells
2017
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response
2007 Science
In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles
2009 StandoutNobel
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
Transposition-Driven Genomic Heterogeneity in the Drosophila Brain
2013 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Signal integration in the endoplasmic reticulum unfolded protein response
2007 Standout
Stem-Cell-like Properties and Epithelial Plasticity Arise as Stable Traits after Transient Twist1 Activation
2015
Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases
2011 StandoutNobel
Direct conversion of fibroblasts to functional neurons by defined factors
2010 StandoutNatureNobel
Nanog Is the Gateway to the Pluripotent Ground State
2009 StandoutNobel
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
Induction of human neuronal cells by defined transcription factors
2011 StandoutNatureNobel
The 2014 Society of Surgical Oncology Susan G. Komen for the Cure Symposium: Triple-Negative Breast Cancer
2014
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells
2015
Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response
2006
An integrated encyclopedia of DNA elements in the human genome
2012 StandoutNature
Distinct EMT programs control normal mammary stem cells and tumour-initiating cells
2015 Nature
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Phosphorylation of ETS1 by Src Family Kinases Prevents Its Recognition by the COP1 Tumor Suppressor
2014 StandoutNobel
KRAB–Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading
2010
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals
2001
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum
2010
Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells
2007 StandoutNobel
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
2002 StandoutNature
Control of the Embryonic Stem Cell State
2011
Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1
2011 StandoutNatureNobel
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Genetic Interactions Due to Constitutive and Inducible Gene Regulation Mediated by the Unfolded Protein Response in C. elegans
2005
Intestinal homeostasis and its breakdown in inflammatory bowel disease
2011 StandoutNature
γ-Secretase: proteasome of the membrane?
2004
A transgenic mouse model for monitoring endoplasmic reticulum stress
2003
ER stress and the unfolded protein response
2004
Cleavage of the membrane‐bound transcription factor OASIS in response to endoplasmic reticulum stress
2006
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
2007
An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells
2008
Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment
2017 StandoutNobel
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Macrophages in the Pathogenesis of Atherosclerosis
2011 Standout
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
2012 Standout
The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology
2011
Signalling Pathways in the Unfolded Protein Response: Development from Yeast to Mammals
2009
Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease
2004
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages
2014
The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis
2005
ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
2005
Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response
2006
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
2018 Standout
Tumor Necrosis Factor α (TNFα) Induces the Unfolded Protein Response (UPR) in a Reactive Oxygen Species (ROS)-dependent Fashion, and the UPR Counteracts ROS Accumulation by TNFα
2005
Pax6 Is a Human Neuroectoderm Cell Fate Determinant
2010
Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
2014 StandoutNobel
Forcing cells to change lineages
2009 Nature
XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor
2001 Standout
Differential Contributions of ATF6 and XBP1 to the Activation of Endoplasmic Reticulum Stress-Responsive cis-Acting Elements ERSE, UPRE and ERSE-II
2004
Orchestrating the unfolded protein response in health and disease
2002
Gene function in mouse embryogenesis: get set for gastrulation
2007
Endoplasmic reticulum stress: cell life and death decisions
2005 Standout
Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression
2005
Coupling endoplasmic reticulum stress to the cell death program
2004
Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model
2012 Nobel
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
The endoplasmic reticulum stress response in immunity and autoimmunity
2008
Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells
2010
Protein-tyrosine Phosphatase 1B Potentiates IRE1 Signaling during Endoplasmic Reticulum Stress
2004
IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level
2010
Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1
2007
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Oct-3/4 Dose Dependently Regulates Specification of Embryonic Stem Cells toward a Cardiac Lineage and Early Heart Development
2006
Two Distinct Stress Signaling Pathways Converge Upon the CHOP Promoter During the Mammalian Unfolded Protein Response
2002
Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming
2008
ER chaperone functions during normal and stress conditions
2004
Quality control in the endoplasmic reticulum protein factory
2003 Nature
Roles of CHOP/GADD153 in endoplasmic reticulum stress
2003 Standout
CBF/NF‐Y controls endoplasmic reticulum stress induced transcription through recruitment of both ATF6(N) and TBP
2008
The epigenetics of epithelial-mesenchymal plasticity in cancer
2013
Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance
2014
ATF6α Optimizes Long-Term Endoplasmic Reticulum Function to Protect Cells from Chronic Stress
2007
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis
2011
Mechanisms involved in the regulation of histone lysine demethylases
2008
A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response
2003
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1
2011
Regulation of apoptosis by endoplasmic reticulum pathways
2003
What fraction of the human genome is functional?
2011
Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins
2006
IRE1-Independent Gain Control of the Unfolded Protein Response
2004
Structural and Functional Analysis of JMJD2D Reveals Molecular Basis for Site-Specific Demethylation among JMJD2 Demethylases
2012
The role of the unfolded protein response in tumour development: friend or foe?
2004
ChIP-seq: Using high-throughput sequencing to discover protein–DNA interactions
2009
A Fresh Look at iPS Cells
2009 StandoutNobel
Delineation of a Negative Feedback Regulatory Loop That Controls Protein Translation during Endoplasmic Reticulum Stress
2003
ATF6 modulates SREBP2‐mediated lipogenesis
2004
Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming
2010
GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice
2009
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Misfolded proteins, endoplasmic reticulum stress and neurodegeneration
2004
Tackling the cancer stem cells — what challenges do they pose?
2014
Protein folding stress in neurodegenerative diseases: a glimpse into the ER
2011
Underglycosylation of ATF6 as a Novel Sensing Mechanism for Activation of the Unfolded Protein Response
2004
Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development
2001
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
2011 Standout
Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes
2008
Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response
2004
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
COPII and the regulation of protein sorting in mammals
2011 StandoutNobel
Hypoxia upregulates the histone demethylase JMJD1A via HIF-1
2008
Requirements for Signal Peptide Peptidase-Catalyzed Intramembrane Proteolysis
2002
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
2002
Animal Models in the Study of the Unfolded Protein Response
2011
Gcn4p and Novel Upstream Activating Sequences Regulate Targets of the Unfolded Protein Response
2004
Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome
2009
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping
2014 Standout
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells
2010
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Dissecting direct reprogramming through integrative genomic analysis
2008 Nature
The unfolded protein response—a stress signaling pathway of the endoplasmic reticulum
2004
Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response
2006
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
2009 StandoutNatureNobel
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Amyotrophic Lateral Sclerosis Pathogenesis: A Journey Through the Secretory Pathway
2010
Transmembrane bZIP Transcription Factors in ER Stress Signaling and the Unfolded Protein Response
2007
How Transmembrane Proteins Sense Endoplasmic Reticulum Stress
2007
Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword?
2007
The Endoplasmic Reticulum: Folding, Calcium Homeostasis, Signaling, and Redox Control
2006
Nuclear Reprogramming in Cells
2008 StandoutScienceNobel
Coping with Protein Quality Control Failure
2017
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response
2006
Transient Cerebral Ischemia Activates Processing of xbp1 Messenger RNA Indicative of Endoplasmic Reticulum Stress
2003
Heat induces the splicing by IRE1 of a mRNA encoding a transcription factor involved in the unfolded protein response in Arabidopsis
2011
Intracellular Signaling by the Unfolded Protein Response
2006
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones
2004
A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1
2004
The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α
2011
Practical Approach to Triple-Negative Breast Cancer
2017
Intrinsic Capacities of Molecular Sensors of the Unfolded Protein Response to Sense Alternate Forms of Endoplasmic Reticulum Stress
2006
Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
2008 StandoutScienceNobel
NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling
2016
Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans
2018 StandoutNobel
Nitric Oxide and Endoplasmic Reticulum Stress
2006
Small Increases in the Level of Sox2 Trigger the Differentiation of Mouse Embryonic Stem Cells
2008
Luminal Domain of ATF6 Alone Is Sufficient for Sensing Endoplasmic Reticulum Stress and Subsequent Transport to the Golgi Apparatus
2010
Regulation of basal cellular physiology by the homeostatic unfolded protein response
2010
The Oct4 homologue PouV and Nanog regulate pluripotency in chicken embryonic stem cells
2007
DNA-dependent Oct4–Sox2 interaction and diffusion properties characteristic of the pluripotent cell state revealed by fluorescence spectroscopy
2012
Structure, Regulation, and Functional Diversity of Microvilli on the Apical Domain of Epithelial Cells
2015
Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress
2010
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
2017 Standout
Orchestrating the unfolded protein response in health and disease
2002
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis
2005
THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
2005 Standout
p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition
2014
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response
2003 Standout
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Luman/CREB3 Induces Transcription of the Endoplasmic Reticulum (ER) Stress Response Protein Herp through an ER Stress Response Element
2006
The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P
2001
The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation
2007
The role of Foxp3 and Tbet co-expressing Treg cells in lung carcinoma
2018
Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein
2011
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α
2008 StandoutNobel
A survival pathway forCaenorhabditis eleganswith a blocked unfolded protein response
2002
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress
2011
Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins
2007
BBF2H7, a Novel Transmembrane bZIP Transcription Factor, Is a New Type of Endoplasmic Reticulum Stress Transducer
2006
Role of Disulfide Bridges Formed in the Luminal Domain of ATF6 in Sensing Endoplasmic Reticulum Stress
2006
Quality control in the endoplasmic reticulum
2003 Standout
The Unfolded Protein Response: A Novel Component of the Hypoxic Stress Response in Tumors
2005
Activation of mammalian IRE1α upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins
2009
Works of Xi Chen being referenced
Sall4 Interacts with Nanog and Co-occupies Nanog Genomic Sites in Embryonic Stem Cells
2006
T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt
2010
Transcriptional Regulatory Networks in Embryonic Stem Cells
2008
Yeast Nej1 Is a Key Participant in the Initial End Binding and Final Ligation Steps of Nonhomologous End Joining
2010
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells
2007
Myosin VIIA regulates microvillus morphogenesis and interacts with cadherin Cad99C in Drosophila oogenesis
2014
Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection
2016
ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
2000
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
2011 Standout
Evolution of the mammalian transcription factor binding repertoire via transposable elements
2008
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
2010
The Luminal Domain of ATF6 Senses Endoplasmic Reticulum (ER) Stress and Causes Translocation of ATF6 from the ER to the Golgi
2002
ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals
2002
Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells
2013
Reciprocal Transcriptional Regulation of Pou5f1 and Sox2 via the Oct4/Sox2 Complex in Embryonic Stem Cells
2005
Zic3 Is Required for Maintenance of Pluripotency in Embryonic Stem Cells
2007